• Title/Summary/Keyword: Jaummi-dan (Ciyinmei-dan)

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Protective Effects of Jaummi-dan (Ciyinmei-dan) against Skin Photoaging in Hairless Mouse Model and UVB-induced Damage in Human Fibroblasts (한방미용제제(자음미단)의 Hairless Mouse Model에서의 피부광노화 억제 및 섬유아세포의 UVB손상 저해효과)

  • 김선영;안덕균;박성규;이진영;김완기;심영철;이상준
    • The Journal of Korean Medicine
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    • v.23 no.3
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    • pp.43-53
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    • 2002

  • Objectives : To investigate the photoprotective effects and efficacy of Jaummi-dan (Ciyinmei-dan) on UV damage to animal skin/fibroblast cultures. Methods and Results : Hairless mice were orally administered Jaummi-dan (Ciyinmei-dan) extract and irradiated with UV for four weeks. In the Jaummi-dan (Ciyinmei-dan) treated group, a better skin appearance and less wrinkles were observed when compared to the control group. In addition, immunostaining for type 1 pN collagen showed that the amount of collagen deposition was higher in the Jaummi-dan (Ciyinmei-dan) treated group. The interstitial collagenase was measured in the cultured medium of fibroblasts after UVB irradiation using ELISA for MMP-l. Jaummi-dan (Ciyinmei-dan) treatment resulted in a significant decrease in MMP-1 secretion compared to the UVB-irradiated, untreated group. Conclusions : The results of our study indicate that orally administered Jaummi-dan (Ciyinmei-dan) seems to have photoprotective effects on UV damaged hairless mouse skin partly due to an inhibitory effect on collagen breakdown.

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