• 한국환경생태학회지
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• 제35권5호
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• pp.569-575
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• 2021

도심 교통섬과 도시숲 내부에서 미세먼지 농도와 영향 인자를 조사하여 숲의 미세먼지 효과를 분석하였다. 서울시 동대문구 홍릉시험림(도시숲)과 동대문구 청량리역 교차로에 조성된 숲(교통섬)에서 미세먼지 농도를 2018년 1월부터 11월까지 광산란법 기기를 적용하여 측정하였다. 연구 기간 동안 도시숲과 교통섬의 PM₁₀ 평균농도는 12.5 ㎍/m³, 15.7 ㎍/m³으로 나타났으며, PM_2.5의 평균농도는 6.6 ㎍/m³, 6.9 ㎍/m³으로 나타났다. 환경부 도시대기 측정망과 도시숲의 농도를 비교해본 결과, PM₁₀의 저감율은 도시숲에서 66.9±28.6%, 교통섬에서 58.6±44.1%로 나타났고, PM_2.5의 경우 71.3±23.0%, 64.9±31.3%로 각각 나타났다. 미세먼지 저감율의 차이는 도시숲의 규모와 구조의 차이와 관련이 있을 것이며, 풍속은 저감 요인으로 판단된다.

• 대한응급의학회지
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• 제29권5호
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• pp.509-518
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• 2018

Objective: The evidence that hyperbaric oxygen (HBO) therapy is more effective for improving the acute neuropsychological status (ANS) of carbon monoxide poisoning than normobaric oxygen (NBO) therapy is not convincing. This is because the levels of carboxyhemoglobin (COHb) do not correlate with the clinical severity of carbon monoxide poisoning and there is no universally accepted severity scale of carbon monoxide poisoning. This paper suggests a new scale for the clinical and neurological severity of carbon monoxide poisoning, called the ANS, and assesses the effect of HBO therapy for each level of ANS compared to NBO therapy. Methods: A total of 217 patients who had been hospitalized because of carbon monoxide poisoning from January 2009 to July 2013 were studied. ANS was suggested as a new severity scale of carbon monoxide poisoning considered in the Glasgow Coma Scale, acute neuro-psychologic signs and symptoms, or cardiac ischemia on the initial medical contact. HBO therapy is indicated in those who have a loss of consciousness, seizure, coma, abnormal findings on a neurological examination, pregnancy, persistent cardiac ischemia, level of COHb >25%, or severe metabolic acidosis (pH <7.2). The end point is the day of discharge, and recovery is defined as a normal neuro-psychological status without any sequelae. Results: The levels of troponin T and creatinine increased significantly with increasing ANS score. In the moderate to severe group (ANS 2 and 3), the recovery rate was significantly higher when treated with HBO therapy than with NBO therapy (P=0.030). On the other hand, the development of delayed neuro-psychological sequelae (DNS) did not correlate with any level of ANS, type of oxygen therapy, or recovery on discharge. Conclusion: In the moderate to severe poisoned group, HBO therapy is more effective for improving the ANS from carbon monoxide poisoning than NBO therapy. On the other hand, the development of DNS of HBO therapy is no more preventable than with NBO therapy. Although the level of ANS is low, the patient needs to be provided with sufficient information and a follow-up visit is recommended for any abnormal symptoms because the ANS does not correlate with the development and degree of DNS.

• 디지털융복합연구
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• 제19권6호
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• pp.133-141
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• 2021

각국 정부는 코로나19 이후 실물경기와 경제회복을 위해 재정확대정책을 적극적으로 실시하고 있다. 우리나라도 재난지원금과 복지정책의 시행으로 인해 시중에 유동성이 증가하면서 주식시장과 주택시장이 크게 영향을 받고 있다. 본 연구의 목적은 주식시장 및 주택시장의 동향과 유동성과의 관계를 분석하는데 있다. 한국은행과 국민은행에서 자료를 수집하였고 분석기간은 2000년 1월부터 2020년 12월까지 월간자료를 사용하였다. 실증분석을 위해 각 변수별로 전년 동월대비 변동률이나 상승률을 산출하여 수치분석과 지표분석, 모형분석을 수행하였다. 분석결과 주가지수는 주택가격과 양(+)의 관계를 보인 반면 M2와는 음(-)의 관계로 나타났다. 유동성이 증가하면 주식시장과 주택시장에 영향을 미치고 물가도 상승하는 것으로 기존 연구를 통해 살펴보았다. 하지만 본 연구에서 주식시장과 주택시장은 서로 영향을 미치는 것으로 나타났으나 유동성은 주식시장과 역의 관계를 보이고 주택시장과는 아무런 관계가 없는 것으로 조사되었다. 이를 통해 본 연구는 유동성과 주식시장 및 주택시장과의 관계에서 시간차가 존재하는 것으로 판단되었다.

• 해양환경안전학회지
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• 제27권1호
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• pp.113-118
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• 2021

The International Maritime Organization(IMO)는 2020년 1월 1일부터 국제항해 선박에 사용되는 모든 연료의 황분을 0.5 % 이하로 제한하고 있다. 연료유 황 함유량 규제 대응을 위해 LNG 선박, SOx scrubbers, 저유황유(Very Low-Sulfur Fuel Oil, VLSFO) 사용 등이 고려되고 있으며, 이 중 투자비용이 상대적으로 적은 저유황유가 선호되고 있다. 따라서 저유황유를 사용하는 선박이 증가함에 따라 오염사고 위험성이 높아질 것으로 예상된다. 특히, 해수 온도가 저유황유의 유동점 이하로 유출될 경우 고형화됨에 따라 방제에 어려움을 겪고 있는 사례도 나타나고 있다. 본 논문에서는 국내서 생산되는 저유황유 6종과 고유황유(MF380) 1종에 대해 해수 온도 조건에 따라 유처리제의 분산 능력을 평가하였다. 연구결과, 저유황유는 국내 기준(0.5 min 정치 60 % 이상, 10 min 정치 20 % 이상)을 만족하지 못했으며, 고유황유에 비해 상대적으로 낮은 유화율을 보였다. 본 연구결과는 저유황유가 해상에 유출될 경우, 방제방향을 설정하는 데 활용될 수 있을 것으로 기대된다.

• 한국임상약학회지
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• 제31권1호
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• pp.44-52
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• 2021

Background: Post-transplant immunosuppression with calcineurin inhibitors (CNIs) is associated with kidney function impairment while mammalian target of rapamycin (mTOR) inhibitors, such as everolimus, can be used for its renal-sparing effects. In this study, we compared the efficacy and safety of everolimus with low dose tacrolimus (EVR+Low TAC) and conventional dose tacrolimus (TAC) in liver transplantation recipients. Methods: Medical records of recipients who received liver transplantation at Seoul National University Bundang Hospital from January 1st 2009 to December 31st 2018 were retrospectively reviewed. Cohort entry date was defined as the day everolimus was initiated and tacrolimus dosage was reduced. All patients were followed up for 1 year. Indicator of efficacy was the incidence of rejection and safety was evaluated by incidence of drug adverse events including renal function. Results: Among 118 patients, there were 40 patients (33.9%) in EVR+Low TAC group. Incidence of rejection, including both biopsy proven acute rejection and clinical rejection, was similar in two groups [7.5% (n=3) vs. 6.4% (n=5), p=1.000]. Renal dysfunction was less frequent in EVR+Low TAC [17.5% (n=7) vs. 35.9% (n=28), p=0.038]. However, incidence rates of dyslipidemia, oral ulcer were more frequent in EVR+Low TAC [45.0% (n=18) vs. 21.8% (n=17), p=0.009; 15.0% (n=6) vs. 1.3% (n=1), p=0.006]. Conclusions: In terms of prevention of rejection, EVR+Low TAC was as effective as TAC and had renal-sparing effect but was associated with increased risk of dyslipidemia and oral ulcer. This study demonstrates that EVR+Low TAC could be an alternative to liver transplant recipients with nephrotoxicity after administration of conventional dose tacrolimus.

• Fisheries and Aquatic Sciences
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• 제24권11호
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• pp.360-369
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• 2021

Paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) are neurotoxins that display pharmacological activity that is similar to that of specific sodium channel blockers; they are the principle toxins involved in shellfish and puffer fish poisoning. In Korea, puffer fish is a very popular seafood, and several cases of accidental poisoning by TTX have been reported. Therefore, it is necessary to determine whether puffer fish poisoning incidents are caused by PSTs or by TTX. In this study, we used mouse bioassay (MBA) and liquid chromatograph-tandem mass spectrometry (LC-MS/MS) to determine the presence of PSTs and TTX in puffer fish from an area near Mireuk-do, Tong-Yeong on the southern coast of Korea from January through March, 2014. The toxicity of PSTs and TTX extracts prepared from three organs of each specimen was analyzed by MBA. Most of the extracts killed mice with typical signs of TTX and PSTs. The LC-MS/MS analysis of seven specimens of Takifugu pardalis and Takifugu niphobles, each divided into muscles, intestines, and liver, were examined for TTX. In T. pardalis, the TTX levels were within the range of 1.3-1.6 ㎍/g in the muscles, 18.8-49.8 ㎍/g in the intestines, and 23.3-96.8 ㎍/g in the liver. In T. niphobles, the TTX levels were within the range of 2.0-4.5 ㎍/g in the muscles, 23.9-71.5 ㎍/g in the intestines, and 28.1-114.8 ㎍/g in the liver. Additionally, the toxicity profile of the detected PSTs revealed that dcGTX3 was the major component in T. pardalis and T. niphobles. When PSTs were calculated as saxitoxin equivalents the levels were all less than 0.5 ㎍/g, which is below the permitted maximum standard of 0.8 ㎍/g. These findings indicate that the toxicity of T. pardalis and T. niphobles from the southern coast of Korea is due mainly to TTX and that PSTs do not exert an effect.

• 해양환경안전학회지
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• 제28권1호
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• pp.83-90
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• 2022

부선을 예인하는 예인선은 90.5 %가 총톤수 200톤 미만으로 대부분 선장 혼자 승무하고, 선원법상 근로시간 및 승무정원에 관한 규정을 적용받지 않는다. 따라서 부선을 예인하는 예인선의 선장은 항해당직 중 적절한 휴식을 취하지 못해 피로하게 되고, 부선을 예인하는 예인선은 불가피하게 무자격자인 갑판장과 교대로 항해당직을 수행하며 인적 감항능력을 충족하지 못한다. 또한 예인선의 선장 또는 소유자는 예인선이 부선을 예인할 때 선박직원법상 추가적으로 요구되는 최저승무기준을 준수하지 못하는 사례가 자주 발생하고 있다. 본 연구에서는 먼저 다음 사항에 대해 살펴보았다. (1) 선원법상 근로시간 및 승무정원에 관한 규정, (2) 선박직원법상 예인선의 갑판부 선박직원의 최저승무기준에 관한 규정, (3) 부선을 예인하는 예인선의 해양사고 사례. 그리고 예인선의 실효적인 해양사고 예방을 위해 예인선이 부선을 예인하는 경우에는 항해사 1명이 추가적으로 승무하도록 갑판부 선박직원의 최저승무기준을 개정할 것을 제안하였다. 특히 중대재해 처벌 등에 관한 법률은 2022. 1. 27. 시행되었다. 해양에서 인명사고가 동일한 원인으로 계속 발생하고, 그 원인이 제도적 미비로 인한 항해사의 피로라고 판단된다면 해양항만관청은 처벌을 받게 될 수 있으므로 이에 대해 대비할 필요가 있다고 본다.

• Journal of Korean Neurosurgical Society
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• 제65권1호
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• pp.96-106
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• 2022

Objective : The most common complication of anterior cervical discectomy and fusion (ACDF) is cage subsidence and maintenance of disc height affects postoperative clinical outcomes. We considered cage subsidence as an inappropriate indicator for evaluating preservation of disc height. Thus, this study aimed to consider patients with complications such as reduced total disc height compared to that before surgery and evaluate the relevance of several factors before ACDF. Methods : We retrospectively reviewed the medical records of 40 patients who underwent stand-alone single-level ACDF using a polyetheretherketone (PEEK) cage at our institution between January 2012 and December 2018. Our study population comprised 19 male and 21 female patients aged 24-70 years. The minimum follow-up period was 1 year. Twenty-seven patients had preoperative bone mineral density (BMD) data on dual-energy X-ray absorptiometry. Clinical parameters included sex, age, body mass index, smoking history, and prior medical history. Radiologic parameters included the C2-7 cobb angle, segmental angle, sagittal vertical axis, disc height, and total intervertebral height (TIH) at the preoperative and postoperative periods. Cage decrement was defined as the reduction in TIH at the 6-month follow-up compared to preoperative TIH. To evaluate the bone quality, Hounsfield unit (HU) value was calculated in the axial and sagittal images of conventional computed tomography. Results : Lumbar BMD values and cervical HU values were significantly correlated (r=0.733, p<0.001). We divided the patients into two groups based on cage decrement, and 47.5% of the total patients were regarded as cage decrement. There were statistically significant differences in the parameters of measuring the HU value of the vertebra and intraoperative distraction between the two groups. Using these identified factors, we performed a receiver operating characteristic (ROC) curve analysis. Based on the ROC curve, the cut-off point was 530 at the HU value of the upper cortical and cancellous vertebrae (p=0.014; area under the curve [AUC], 0.727; sensitivity, 94.7%; specificity, 42.9%) and 22.41 at intraoperative distraction (p=0.017; AUC, 0.722; sensitivity, 85.7%; specificity, 57.9%). Using this value, we converted these parameters into a bifurcated variable and assessed the multinomial regression analysis to evaluate the risk factors for cage decrement in ACDF. Intraoperative distraction and HU value of the upper vertebral body were independent factors of postoperative subsidence. Conclusion : Insufficient intraoperative distraction and low HU value showed a strong relationship with postoperative intervertebral height reduction following single stand-alone PEEK cage ACDF.

• Journal of Korean Neurosurgical Society
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• 제65권4호
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• pp.558-571
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• 2022

Objective : The primary objective of this study was to identify predicting factors for local control (LC) of atypical meningioma, and we validated them with comparing the predicting factors for recurrence-free survival (RFS). We also examined the rate of LC after surgical resection with or without adjuvant treatment and RFS. Methods : Clinical and radiological records of patients with atypical meningiomas diagnosed at two institutes from January 2000 to December 2018 were reviewed retrospectively. Histopathological features were also reviewed using formalin-fixed paraffin embedded samples from pathological archives. Results : Of the 99 atypical meningiomas eligible for analysis, 36 (36.4%) recurred during the follow-up period (mean, 83.3 months; range, 12-232 months). The rate of 3-year LC and 5-year LC was 80.8% and 74.7%, respectively. The mean time-to-recurrence was 49.4 months (range, 12-150). The mean RFS was 149.3 months (95% confidence interval, 128.8-169.8 months) during the mean follow-up duration of 83.3 months (range, 12-232 months). Multivariate analysis using Cox proportional-hazard regression model showed that the extent of resection (hazard ratio [HR], 4.761; p=0.013), Ki67 index (HR, 8.541; p=0.004), mitotic index (HR, 3.275; p=0.044), and tumor size (HR, 3.228; p=0.041) were independently associated with LC. These factors were also statistically associated with RFS. In terms of radiotherapy after surgical resection, the recurrence was not prevented by immediate radiotherapy because of the strong effect of proliferative index on recurrence. Conclusion : The present study suggests that the extent of resection, proliferative index (according to Ki67 expression) and mitotic index, and tumor size are associated with recurrence of atypical meningiomas. However, our results should be further validated through prospective and randomized clinical trials to overcome the inborn bias of retrospective nature of the study design.

• 한국환경생태학회지
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• 제36권4호
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• pp.402-412
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• 2022

본 연구는 주요 난대 상록활엽수종인 붉가시나무, 구실잣밤나무, 동백나무, 황칠나무 등 4종 임분과 곰솔림을 대상으로 2019년 5월~2020년 1월까지 각 산림의 임분 특성 및 NVOCs 발산특성을 알아보고자 수행되었다. 분석 결과, 각 조사구의 계절별 기온 및 습도는 여름철에 고온다습하고 겨울철 저온건조한 일반적 우리나라의 기후적 특성을 보였고 기압은 대체적으로 겨울이 높았으며 봄, 여름보다 가을과 겨울의 기압이 높았다. 조사구 5개소의 총 NVOCs는 전체적으로 여름철에 가장 높았으며 봄, 겨울은 황칠나무림, 가을은 구실잣밤나무림, 여름은 붉가시나무림의 NVOCs량이 상대적으로 높은 특성을 보였다. 수종별로 살펴보면, 침엽수종인 곰솔림보다 난대 상록활엽수종인 붉가시나무, 구실잣밤나무, 동백나무, 황칠나무의 NVOCs 발산량이 낮지 않거나 오히려 높은 것을 확인하였다. NVOCs 발산에 기온(r=0.590, P=0.000), 습도(r=0.655, P=0.000)는 양(+)의 상관관계, 기압(r=-0.384, P=0.000)과 풍속(r=-0.263, P=0.018)은 낮은 음(-)의 영향이 있었다. 미기상인자 중 습도(β=0.507, P=0.000)가 NVOC 발산량에 가장 크게 영향을 미치는 것으로 나타났으며 기온, 기압, 풍속 순으로 영향을 미치는 것으로 분석되었다.