• Journal of Preventive Medicine and Public Health
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• 제47권1호
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• pp.7-17
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• 2014

Risk assessment considers the situations and characteristics of the exposure environment and host. Various physiological variables of the human body reflects the characteristics of the population that can directly influence risk exposure. Therefore, identification of exposure factors based on the Korean population is required for appropriate risk assessment. It is expected that a handbook about general exposure factors will be used by professionals in many fields as well as the risk assessors of the health department. The process of developing the exposure factors handbook for the Korean population will be introduced in this article, with a specific focus on the general exposure factors including life expectancy, body weight, surface area, inhalation rates, amount of water intake, and soil ingestion targeting the Korean population. The researchers used national databases including the Life Table and the 2005 Time Use Survey from the National Statistical Office. The anthropometric study of size in Korea used the resources provided by the Korean Agency for Technology and Standards. In addition, direct measurement and questionnaire surveys of representative samples were performed to calculate the inhalation rate, drinking water intake, and soil ingestion.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.30-30
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• 2020

본 연구는 현재 공주대학교 포장에 유전자원으로 보존하는 재래종의 매실나무 열매(청매실)에 대한 활용 가능성의 유익한 정보 및 식품학적 특성과 효능의 기초 정보를 제공하기 위하여 실시하였다. 대한민국 매실나무 집단의 열매(청매실) 무게는 평균 10.5±5.2g이었고, 범위 3.0~35.4g, 변이계수 49.5%를 나타내어 매우 다양한 무게 분포를 보였다. 청매실의 무게별 분포비율은 무게 5.1~10.0g이 50.5%로서 가장 높았고 다음으로 무게 10.1~15.0g이 27.1%, 15.1~20.0g이 10.4%, 5.0g 이하가 8.3% 순이었다. 청매실의 과육색은 백록색이 50.5%로 가장 많았으며, 다음으로 연등색이 36.5%, 등색이 12.5%, 유백색과 암등색이 각각 0.5% 순이었다. 그러나 청매실의 과육색은 황매실 성숙기 및 성숙도에 따라 과피색과 과육색이 다를 것으로 판단되었다. 청매실의 당도는 평균 6.84±0.93이었으며, 범위 4.45~8.76 °Brix로 다양하였다. 당도는 동일한 무게 집단 내에서 개체 자원 간에 다양한 변이를 나타내었으나 무게 집단별 차이를 나타내지 않았으며 변이계수도 유사한 수치이었다.

• Molecular & Cellular Toxicology
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• 제5권4호
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• pp.317-322
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• 2009

Hepatic fibrosis is one of chronic liver diseases which spread in worldwide and it has high risk to turn advanced cirrhosis and hepatocellualr carcinoma. Brassica family has been produced for commercial purpose and in Korea Brassica rapa (Turnip) is cultivated in Ganghwa County, Gyeonggi-do Korea and used for making Kimchi. Recently pharmacological effects of turnip have been known; diabete mellitus modulation, alcohol oxidization, and fibrosis inhibition. In previous study we found antifibrogenic effect of turnip water extract and in this study we made turnip nanoparticle to promote turnip delivery into liver. At the same time we assessed the biological safety of turnip nanoparticle. Thioacetamide (TAA) induced hepatic nodular formation and fibrosis (mean of fibrosis score: 4). However, 1% turnip nanoparticle inhibited TAA-induced hepatic nodular formation and fibrosis (mean of fibrosis score: 2-3). Activities of serum enzymes (aspartic acid transaminase (AST), alanine transaminase (ALT), and total bilirubin (T-Bil)), complete blood count (CBC), and the appearance of organs were not different from control and 1% turnip nanoparticle treatment. Conclusively 1% turnip nanoparticle significantly reduced TAA-induced hepatic fibrosis and was safe in 7-weeks feeding.

• 한국의류산업학회지
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• 제9권5호
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• pp.486-492
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• 2007

The purpose of this study is to investigate the characteristics of the men's costumes of the ruling class of the Heian period by studying the costumes demonstrated in the ${\ll}$Won-si-mul-eo-heo-gwon${\gg}$, a picture album of the Heian period. The findings of this study are as follows. The costumes shown in the ${\ll}$Won-si-mul-eo-heo-gwon${\gg}$, can be classified into two types. One of the types is the costumes that were newly made in the Heian period such as Jik-eui, Su-eui, Ha-seub, Sok-dae-jang-sok. The other type, period including Omoja, Ji-gwan, Pyo-go is the costumes that were made by modifying the costumes of the previous. The costumes of the Heian period were evolved into a new type of outfit by changing the way of wearing them, their form, and their color. The costumes became various in types, became bigger in form, and used various colors. As a result, the costumes of the Heian period were developed into more colorful and fancier compared to those of the previous period. The costumes of the Heian period can be interpreted as japanized-embracing and japanizing the culture of the continent-costumes of the previous period rather than as simply copying the costumes of the continent. The driving force of this phenomenon can be analyzed as the effect of japanization that was widespread in the culture in general of the Heian period. This japanization made it possible to create peculiar and genuine costumes of the Heian period.

• 한국버섯학회지
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• 제6권3_4호
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• pp.111-114
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• 2008

신품종 노랑느타리 "금빛" 과 분홍느타리 "노을" 의 아미노산을 분석하기 위해서 AccQ-Tag 방법을 통하여 수행하였다. 총 17종의 아미노산을 분석한 결과 노랑느타리 "금빛" 에서는 16종의 아미노산이, 분홍느타리 "노을"에서는 15종의 아미노산이 각각 관찰되었다. 노랑느타리 "금빛" 에서의 아미노산 분석결과 시스테인의 함량이 가장 높았으며, 글라이신, 글루타믹산, 프롤린 순이었으며, 분홍느타리 "노을" 에서는 시스테인의 함량이 가장 높았으며, 글라이신, 라이신, 메치오닌 순으로 아미노산 함량을 나타냈다. 알라닌은 노랑느타리 "금빛" 에서만 관찰되었으며 페닐알라닌은 두 가지 버섯 모두에서 관찰되지 않았다. 이것은 품종간의 다양한 아미노산 함량을 나타내며 추후 품종육성 연구에 이용가치가 높을 것으로 판단된다.

• Experimental and Molecular Medicine
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• 제51권2호
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• pp.1.1-1.14
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• 2019

Hypoxia-inducible factor-$1{\alpha}$ ($HIF-1{\alpha}$) mediates tumor cell adaptation to hypoxic conditions and is a potentially important anticancer therapeutic target. We previously developed a method for synthesizing a benzofuran-based natural product, (R)-(-)-moracin-O, and obtained a novel potent analog, MO-460 that suppresses the accumulation of $HIF-1{\alpha}$ in Hep3B cells. However, the molecular target and underlying mechanism of action of MO-460 remained unclear. In the current study, we identified heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) as a molecular target of MO-460. MO-460 inhibits the initiation of $HIF-1{\alpha}$ translation by binding to the C-terminal glycinerich domain of hnRNPA2B1 and inhibiting its subsequent binding to the 3'-untranslated region of $HIF-1{\alpha}$ mRNA. Moreover, MO-460 suppresses $HIF-1{\alpha}$ protein synthesis under hypoxic conditions and induces the accumulation of stress granules. The data provided here suggest that hnRNPA2B1 serves as a crucial molecular target in hypoxiainduced tumor survival and thus offer an avenue for the development of novel anticancer therapies.

• 한국전통조경학회지
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• 제35권3호
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• pp.13-21
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• 2017

순천시 송광면 삼청리 왕대마을에 자리하고 있는 초연정이 왕의 피난처, 제각, 별업, 강학공간으로 변모되는 양상에 착안하여, 시기별로 변모되는 장소성과 문화경관의 변용양상을 탐색하고 그 의미를 추적한 연구결과는 다음과 같다. 첫째, 연재 송병선이 명명한 '초연'이란 정자명칭은 노자의 도덕경에 연원하는데, 순천 초연정을 비롯하여 포천 초연대, 가평 초연대, 창덕궁 후원 초연대, 유성 옥류각의 초연물외 등 정(亭), 대(臺), 각(閣) 등 공간속에 다양하게 투영되고 있어 도가적 풍류가 유가적 공간에 자연스럽게 접목되는 유불도 습합양상을 도출할 수 있다. 둘째, 초연정은 모후산 풍수경관과 수목석이 어우러진 계류풍광과 암경, 월출경, 도가적 이상향을 반영한 동천복지, 성리학적 이상향을 반영한 구곡처 등 승경향유의 요처에 절묘하게 자리하고 있으며, 왕대마을(왕의 주둔지), 유경(留京), 왕대사적 바위글씨, 그리고 오장대(장군기를 꽂아 놓은 자리), 모후산 등 고려말 공민왕의 피난처였다는 전설이 전해지는 장소성을 갖는다. 셋째, 초연정의 아름다운 계류 암벽 바위글씨(趙鎭忠別業, 宋秉璿)를 통해 유가적 가치를 반영한 거점(별업)뿐만 아니라 도가적 동천복지로서의 영역성(1km 이내에 월청, 풍청, 수청 각자와 삼청동천), 그리고 외원권역을 확장하여 수변계류에 9곡 <세록교(洗鹿橋) 봉일대(捧日臺) 자미구(紫薇鳩) 운매대(雲梅臺) 와룡총(臥龍叢) 광석대(廣石臺) 은선굴(隱仙窟) 벽옥담(碧玉潭) 와석포(臥石布)>을 설정하고 산수유상과 강학, 경관미학적감수성 제고 등 수심양성을 위한 성리학적 낙토를 원림속에 담아낸 복합 문화경관 향유 양상을 보여준다. 넷째, 초연정은 1778년 대광사 승려의 수도처(水石亭)로서 선원 기능을 하던 장소인데, 1836년 조진충이 선조의 묘 앞에 제각을 지어 별업을 초창했고, 1864년 조재호는 기와로 중수하여 선조를 기리는 별업기능과 도가적 은일처로 활용하는 확장성을 추적할 수 있다. 이후 1890년 조준섭은 스승 연재 송병선에게 '초연'이라는 정자 명칭을 받아 강학처로 활용하는 등 (1)불교 수도처${\rightarrow}$(2)유교 별업처${\rightarrow}$(3)별업+도교적 풍류처${\rightarrow}$(4)별업+도교적 풍류처+강학처(성리학적 낙토)로 용도가 확장 변용되는 양상을 추적할 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제47권1호
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• pp.18-26
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• 2014

The purpose of this study was to establish food ingestion factors needed to assess exposure to contaminants through food ingestion. The study reclassified the raw data of the Korean National Health and Nutrition Examination Survey in 2001 into 12 subcategories including grain products, meat products, fish and shellfish, and vegetables for international comparability of exposure evaluation. The criteria for food intake calculation were unified according to the characteristics of food groups, and recommended values for food ingestion factors were calculated through moisture correction and recategorization of cooked, processed, and mixed foods for each group. The average intake rate for grain and grain products was 6.25 g/kg-d per capita and the men's intake rate was approximately 8% higher than that of the women. The average intake rate of meat and meat products was 1.62 g/kg-d per capita and the men's intake rate was 30% higher than that of the women, on average. The average intake rate of fish and shellfish was 1.53 g/kg-d per capita, and the age groups of 1 to 2 and 3 to 6 recorded higher capita intake rates than other age groups, 2.62 g/kg-d and 2.25 g/kg-d, respectively. The average intake rate of vegetables was 6.47 g/kg-d per capita, with the age group of 1 to 2 recording the highest per capita intake rate of 9.79 g/kg-d and that of 13 to 19 recording the lowest mean. The study also offers recommended values for food ingestion factors of other food groups by gender, age, and region. The food ingestion exposure factors will need future updates in consideration of ongoing changes in food consumption behavior.

• Journal of Acupuncture Research
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• 제33권2호
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• pp.151-164
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• 2016

Objectives : The purpose of this study is to review clinical studies about the efficacy of fire needling for the treatment of acne vulgaris. Methods and Results : In this review, Oasis, NDSL, CNKI, PubMed, Cochrane, J STAGE and CINII were used as the main databases for searching for medical journals, using the keywords "acne and fire needling"," acne and fire needle"," acne and fire acupuncture", and" acne and red hot needle". The initial search range included only randomized controlled trials (RCTs), and papers not matching inclusion criteria were excluded. Initially a total of 108 studies were found, with ten being excluded during title and abstract screening. After scanning 98 papers, a total of 31 RCTs were selected and analyzed. In the 31 RCTs, patients with acne were randomized into groups for treatment and control. Specifically, the treatment group received fire needling, while the control group were concurrently given other treatments. The results of the completed studies have shown that the treatment group receiving fire needling demonstrated significant improvement compared to the control group. Conclusion : During our study, it was verified that the efficacy of fire needling for the treatment of acne vulgaris was both significant and meaningful. Therefore, fire needling can be a safe and effective alternative treatment for acne. However, to confirm this result, further investigation in a traditional clinic is required, accompanied by high quality studies including randomized, placebo-controlled double-blind trials.

• 중환자간호학회지
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• 제13권2호
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• pp.12-23
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• 2020

Purpose : This study aimed to evaluate the clinical outcomes of direct interhospital transfers (IHTs) of patients with acute aortic syndrome (AAS) led by advanced practice nurses (APNs). Methods : From September 2014 to June 2017, the study retrospectively investigated 183 patients with AAS who were transferred to a high-volume tertiary hospital. Results : One hundred forty-eight (81%) patients were admitted through direct IHTs, and 35 (19%) patients were admitted through non-direct IHTs. The direct IHT group had a significantly shorter time from symptom onset to hospital arrival than the non-direct IHT group (11.4 vs. 32.1 h, p=.043). There were no significant differences in other clinical outcomes, such as peri-transfer status, mortality, hospital length of stay, and readmission, between the two groups. In the direct IHT group, 55% of transfers were led by APNs. There was no significant difference in outcomes between APN- and physician-led transfers. Conclusions : Implementation of direct IHTs markedly shortened the time from symptom onset to hospital arrival in patients with AAS. Finally, direct IHTs can potentially improve the outcomes of patients with AAS, a condition with time-dependent mortality and morbidity. In addition, APNs can effectively lead the direct IHT of patients with AAS.