• 대한약침학회지
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• 제3권1호
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• pp.35-51
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• 2000

The purpose of this study is to prove the analgesic effects of apitoxin and its mechanism via jaw-opening reflex(JOR) and measuring expression of mRNA in Phospholipase and Tryptophan hydroxylase(TPH) using RT-PCR. The experiments were carried out on Sprague-Dawley rats(300-400g) and mastocytoma(P-185 HTR) for JOR and RT-PCR, respectively. Rats anesthetized with thiopental sodium (80mg/kg) were used in the Tooth Pulp stimulation induced JOR. The amplitude of a digastric electromyogram (dEMG) was recorded during the stimulation at an intensity of 1.5 times the threshold for JOR. Apitoxin used in this experiment was diluted with normal saline by 1:1000. Apitoxin was injected intravenously into the test group while normal saline to the control group. However, it was injected directly into the cell of mastocytoma. We referred to base sequence registered in Genbank in designing primers for RT-PCR. The results were as follows; (1)Compared with control group, analgesic effect started to show right after Sprague-Dawely rats were treated with apitoxin($71.50{\pm}8.08$) and lasted for 50 minutes. (2)As a result of the experiment of RT-PCR, we witnessed significant changes in the degree of expression of phospholipase or rate-limiting enzyme of biosynthesis of prostaglandins with $10{\mu}g/ml$ apitoxin.($31.74{\pm}18.98%$, P<0.05) (3)As a result of the experiment of RT-PCR, we witnessed significant changes in the degree of expression of TPH or rate-limiting enzyme in biosynthesis of serotonin with $10{\mu}g/ml$ apitoxin.($131.37{\pm}16.87%$, P<0.05). These results suggest that $10{\mu}g/ml$ apitoxin have the most analgesic effects. This study showed that apitoxin has analgesic effects and held good for 50 minutes. The injection of apitoxin has brought out changes in the degree of expression of phospholipase and TPH. These results strongly suggest that analgesic mechanism by apitoxin is closely related to prostaglandins and serotonin.

• Bulletin of the Korean Chemical Society
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• 제16권2호
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• pp.183-186
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• 1995

• 대한한의학회지
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• 제20권3호
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• pp.36-44
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• 1999

Objectives: It has been well known that electroacupuncture(EA) has an analgesic effect and there is a pain control system in the central nervous system(CNS). The pain control system is composed of three major nuclei, which are periaqueductal gray(PAG), raphe nuclei, and the pain inhibitory complex located in the spinal cord. It has been suggested that the analgesic effect of EA might be the result of activation of the pain control system in the CNS. However, there may be a possibility that other nuclei are also involved in this pain modulation. Thus, we investigated whether the posterior intralaminar thalamic nuclei (PTIN) are involved in the pain modulation. Methods: To measure the level of pain, the jaw opening reflex (JOR) was used as a pain index. The magnitude of JOR is estimated by averaging the area of 10 successive responses. JOR was evoked by tooth-pulp stimulation with bipolar electrode carrying stimulus with the following parameters: intensity ranging from 420uA to 680ulA, 0.3ms duration of square pulse, and 0.5 Hz. Hapkog($LI_4$) and Taechung ($LR_3$) were the chosen acupoints. The Hapkog point was stimulated ipsilaterally at 5V, 3 Hz, for 15min in total, and the Taechung was stimulated at 2-3 V, 3 Hz, and for a total of 15 or 30 minutes. Different intensities of stimulation were given the PITN; one was given at $300{\mu}A$ and the other was at 500uA. The position stimulated in these nuclei by Paxinos Atlas was AP; from bregma $-4.0{\sim}-4.3mm,\;L; 0.5{\sim}1.8mm,\;D;\;4.8{\sim}6.3mm$. Results: The Hapkog point had a significant analgesic effect (P<0.05). However, the Taechung point had no effect. Both types of stimulation in the PITN did not reveal any analgesic effects. Conclusions: From these results, it was suggested that the posterior intralaminar thalamic nuclei are not involved in the modulation of pain.

• Bulletin of the Korean Chemical Society
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• 제21권4호
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• pp.425-428
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• 2000

Arenealdehyde 2-benzothiazolylhydrazone in thianthrene cation radicalafforded triazolo[3,4-b]benzothiazoles and 1,2,4-triazoles as major and minor product, respectively. On the contrary the similar reaction in tris(2,4-dibromophenyl)aminium hexachloroantimonate gave 1,2,4-triazoles and triazolo[3,4-b]benzothiazoles as ma-jor and minor product, respectively.

• Nuclear Engineering and Technology
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• 제42권3호
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• pp.231-236
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• 2010

The growth in global energy demand and the increased recognition of the impacts of carbon dioxide emissions from fossil fuel plants have aroused a renewed interest on nuclear energy. Many countries are looking afresh at building more nuclear power stations to deal with the twin problems of global warming and the need for more generating capacity. Many in the nuclear community are also anticipating a significant growth of new nuclear generation in the coming decades. If there is a nuclear renaissance, will the expansion of nuclear power be compatible with global non-proliferation and security? or will it add to the environmental burden from the large inventory of spent nuclear fuel already produced in existing nuclear power reactors? We learn from past peaceful nuclear activities that significant concerns associated with nuclear proliferation and spent-fuel management have resulted in a decrease in public acceptance for nuclear power in many countries. The terrorist attack in the United States (US) on September 11, 2001 also raised concern for security and worry that nuclear materials may fall into the wrong hands. As we increase the use of nuclear power, we must simultaneously reduce the proliferation, security and environmental risks in managing spent-fuel below where they are today.

• Computers and Concrete
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• 제29권2호
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• pp.93-105
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• 2022

The degrees of freedom (DOFs) of high-rise structures increase rapidly due to the need for refined analysis, which poses a challenge toward a computationally efficient method for numerical analysis of high-rise structures using the finite element method (FEM). This paper presented an efficient iterative method, an algebraic multigrid (AMG) with a Jacobi overrelaxation smoother preconditioned conjugate gradient method (AMG-CG) used for solving large-scale structural system equations running on heterogeneous platforms with parallel accelerator graphics processing units (GPUs) enabled. Furthermore, an AMG-CG FEM application framework was established for the numerical analysis of high-rise structures. In the proposed method, the coarsening method, the optimal relaxation coefficient of the JOR smoother, the smoothing times, and the solution method for the coarsest grid of an AMG preconditioner were investigated via several numerical benchmarks of high-rise structures. The accuracy and the efficiency of the proposed FEM application framework were compared using the mature software Abaqus, and there were speedups of up to 18.4x when using an NVIDIA K40C GPU hosted in a workstation. The results demonstrated that the proposed method could improve the computational efficiency of solving structural system equations, and the AMG-CG FEM application framework was inherently suitable for numerical analysis of high-rise structures.

• 대한소아치과학회지
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• 제25권4호
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• pp.788-796
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• 1998

The purpose of this study was to investigate the effect of various electroacupuncture duration induced by acupuncture point-Zusanli ($S_{36}$) electrical stimulation on inhibition of amplitude of digastric electromyogram (dEMG) evoked by noxious electrical stimuli around the mental foramen. intraperitoneal sodium pentobarbital in an initial dose of 50mg/kg and maintenance doses of 4.5mg/kg/h were given through a cannula in the femoral vein using a constant infusion pump. A pair of stimulating electrodes were inserted for noxious stimuli around the mental foramen. An irritant electronic stimuli pulse (0.2 Hz, 0.1 ms duration) was produced with an intensity of about $1.5{\times}2$ times threshold for evoking the dEMG. The anterior belly of the digastric muscle was exposed and a pair of 0.1mm wire electrodes were inserted for dEMG recording. Acupuncture point stimulation on Zusanli (2 Hz, 250 ${\mu}s$, biphasic pulse, 2 V) was delivered by Dental Electronic Anesthesia (3M, U.S.A). For periods of electronic stimulation of 10, 20, and 30min, the amplitudes of dEMG were measured on the oscilloscope and on the monitor connected to the amplifier. The following results were obtained: The dEMG was decreased to 73.4% of that in the control set after 10 min electroacupunture stimulation (Group I); The dEMG was decreased to 77.1% (10min), 54.0.% (20min) of that in the control set after 20minutes of electroacupunture stimulation (Group II). The dEMG was decreased to 73.3% (10min), 61.9% (20min), 76.2% (30min) of that in the control set after 30 min of electroacupunture stimulation (Group III). From these results, it may be that in the electroacupuncture stimulation on the Zusnali resulted in a reduction of amplitude of dEMG and that the most effective electroacupuncture stimulation period was 20min.

• 한국전통조경학회지
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• 제34권1호
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• pp.18-39
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• 2016

본 연구는 조선시대 궁궐에 나타난 핵심전각의 배치형식을 주산과의 관계로 검토하여 궁궐 축선에 투영된 풍수개념과 그에 따른 계획원리를 고찰하는 것이다. 조선 건국 직후 창건된 경복궁은 거대한 분지의 중앙에 입지한 자금성과는 달리 도성 서북쪽에 치우친 곳이면서 백악산의 산줄기가 끝나는 지점에 입지하였다. 태종 때 창건된 창덕궁도 마찬가지로서 삼각산의 또 다른 지맥인 응봉 아래에 궁궐터가 마련되었는데, 모두 산의 정기를 궁궐에 담으려 했던 의도를 담고 있다. 이러한 관념은 구체적으로, 궁궐 내부의 정전, 편전, 침전 등 임금과 관련된 주요 건물의 배치가 주산의 내맥에 따라 배치되는 것으로 이행되었다. 특히 대내에 들어와 있는 아미사는 궁궐터가 정해졌던 근거지형이기도 했지만 전각배치가 이루어진 기준점으로 작용하였다. 아미사를 기점으로 하는 축선은 풍수적 의미의 좌향이 건축적 형식으로 구현되는 형식이었으며, 주례에 근거한 전조후침과 삼문삼조를 실현하는 형식으로 통합되어 나타났다. 한편 양궐 모두 아미사가 혈진처(穴盡處)를 이루고 있는 곳 가까이에는 임금의 정침이 우선적으로 입지되었다. 침전의 남쪽에는 보통 편전이 배치되었는데, 이는 임금이 아미사 혈의 순수한 지기를 가장 먼저 점유하고 누리고자 하는 실리를 따른 결과로 판단된다. 중축선 배치가 뚜렷한 경복궁의 경우, 하나의 주맥 하에 침전, 편전, 정전이 일원적으로 배치되었고, 내맥이 분산된 창덕궁은 정전과 침전의 축이 형편에 따라 나뉘어 졌다. 정전의 입지형식은 최소한의 풍수적 이점을 취하되 왕의 권위를 드러내는 공간의 질서와 형식이 보다 중시된 것으로 조사되었다.