• Korean Journal of Plant Resources
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• v.24 no.5
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• pp.604-612
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• 2011

The purpose of this study was to investigate anti-inflammatory effect of Ixeris dentata ethanol extract in lipopolysaccharide-exposed rats and Raw 264.7 cells. Plasma concentrations of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ were lower in Ixeris dentata-treated groups than in control group. Concentration of plasma IL-10 was higher in Ixeris dentata-treated groups than in control group. Concentrations of liver IL-$1{\beta}$ and IL-6 were lower in the Ixeris dentata-treated groups than in control group. However, concentrations of liver TNF-${\alpha}$ and IL-10 were not significantly different among all treatment groups. In the study using lipopolysaccharide-exposed Raw 264.7 cells, concentrations of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ tended to be decreased, but concentration of IL-10 tended to be increased in Ixeris dentata-treated groups. Plasm concentrations of total protein and albumin appeared to be increased in Ixeris dentata-treated groups.