• Journal of Chest Surgery
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• 제31권11호
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• pp.1037-1042
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• 1998

연구배경 : 승모판의 노출을 위한 여러 접근방식 중, 확장시킨 경중격 절개방식은 다른 방법에 비하여 쉽고 빠르게 승모판막에 접근할 수 있으며 모든 판막구조물의 노출이 잘 되어 월등한 방법이라 할 수 있다. 그러나, 이러한 장점에도 불구하고 혹자는 광범위한 절개 및 동방결절 동맥의 손상으로 치명적인 부정맥이 발생하지 않을까 우려하여 이용을 기피하는 경향이 있고 반론을 재기하는 사람들도 많이 있다. 재료 및 방법 : 따라서 본 교실에서는 1992년 9월부터 1997년 7월까지, 모두 80명의 환자에서 확장시킨 경중격 절개방식을 적용한 후, 어떠한 장·단점이 있나 알아보고 수술후 심장율동에 미치는 영향을 알아보았다. 결과 : 78명의 환자가 승모판 치환수술을 받았고 2명은 좌심방 점액종 제거수술을 받았다. 승모판 치환수술을 받은 78명중 38명의 환자가 동시에 대동맥판 치환수술(n=22), 삼첨판성형술(n=14), 관상동맥 우회로조성술(n=1), 심실중격결손증 교정수술(n=1) 등을 받았다. 수술 후 총 74명에서 평균 23.3개월간 외래추적관찰을 하였다. 병원사망률은 3.8%(3례)를 보였고, 술전 심방세동을 보이던 46명의 환자중 1명이 수술후 정상 동조율로 전환 되었으며, 술전 정상동조율을 보였던 34명은 술후에도 계속 정상 동조율을 유지하였다. 평균 대동맥 차단시간은 71분이었고, 승모판막 단일 수술인 경우는 평균 62분이었다. 수술후 가장 흔한 부정맥은 서맥으로 일시적인 심장조율로 호전되었으며 다른 수술과 연관된 특별한 합병증은 없었다. 결론 : 승모판막수술시 확장시킨 경중격 절개방식의 적용으로 특별한 합병증 없이 좋은 결과를 얻을 수 있고 특히 좌심방의 크기가 작은 경우 많은 도움이 될 것으로 사료된다

• Journal of Chest Surgery
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• 제23권4호
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• pp.646-653
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• 1990

Currently numerous methods are in use for myocardial protection from the ravages of ischemia and hypoxia. This study was designed to compare with FDP-GIK[Group II, n=8] and GIK cardioplegic solution[Group I, n=8] in ability of myocardial protection and was examined in the isolated working rat heart subjected to long period[120 min] of hypothermic[10 - 15K] ischemic arrest with multidose[every 30 min] cardioplegic infusion. During postischemic reperfusion period 20 min, hemodynamic functions[aortic flow, coronary flow, peak aortic pressure, cardiac output, heart rate], biochemical enzymatic & electrical activities were evaluated. The time from onset of reperfusion to the return of regular sinus rhythm was significantly reduced from 87$\pm$3 sec to 17$\pm$2 sec[P<0.05]. The postischemic recovery of aortic flow was better in the group II [95.1$\pm$3.3% of its preischemic control level] than in the Group I [75.4$\pm$6.8%] [P<0.05]. Cardiac output and stroke volume was also better in the group[91.3$\pm$1.6%, 89.4$\pm$2.6%, respectively] than in the Group I [79.1$\pm$3.7%, 77.0$\pm$4.8%, respectively] [P<0. 05]. Creatine kinase leakage was also significantly reduced from 33.8$\pm$4.9 IU /10 min / gm * dry weight to 15.4$\pm$3.6 IU /10 min /gm * dry weight[P<0.05]. It is suggested that adding FDP to GIK cardioplegic solution improves its ability to protect the heart against long period of hypoxic ischemia.

• Journal of Chest Surgery
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• 제35권1호
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• pp.56-59
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• 2002

우심방과 관상정맥동의 선천성 기형은 크게 4 가지로 분류되는데, 전반적으로 확장된 우심방, 단일 낭성 게실(saccular diverticula), 다발성 낭성 게실, 그리고 우심방이나 관상정맥동에서 발생한 류(aneurysm)이다. 환아는 평소 건강하였으며, 우연히 시작된 상기도 감염증상으로 내원하여 시행한 단순 흉부 촬영 및 심초음파에서 다른 동반 기형 없이 우심방의 심한 확장을 발견하였다. 확장된 우심방은 심폐기 보조하에서 광범위한 절제를 시행하였으며, 병리학적 검사에서는 심내막 및 심외막에 경도의 섬유화를 동반한 국소 다발성 심근소실의 소견을 보였다. 본원에서는 6세 환아의 선천성 우심방 류를 광범위한 우심방 절제를 통해 교정했기에 이에 문헌 고찰과 더불어 증례 보고하는 바이다.

• Journal of Chest Surgery
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• 제18권1호
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• pp.1-6
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• 1985

Isolated sinus node cells of the rabbit were used to assess the effects of extracellular Na, K, Ca and Mg concentrations on cardiac pacemaker activity. With intracellular glass micro-electrodes spontaneous action potentials of SA node were recorded and the effects of various ions and their blockers were analyzed in terms of the cycle length, the amplitude and the duration of action potentials, the results obtained were as follows. 1. Sodium reduction [up to 30%] decreased the amplitude of action potential and lengthened the cycle length. TTX, specific blocker of Na channel slightly lengthened the cycle length. 2. Increasing potassium ion concentration, the duration of action potential decreased and the frequency increased in 6mM, however, spontaneous action potential was stopped in 24 mM. Barium ion known to be decreasing K conductance increased the duration of action potential but no significant change in the cycle length was noticed. 3. Calcium ion has shortening effect on the duration and the cycle length of action potential but not with dose-dependent manner. Cadmium ion .[0.02mM] lengthened cycle length and the duration of action potential. 4. Increasing the concentration of magnesium ion the cycle length was lengthened, significantly.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2006년도 제23차 정기총회 및 학술발표회
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• pp.88-89
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• 2006

Fowl cholera is an infectious disease caused by .Pasteurella multocida, affecting domesticated and wild birds. It usually appears as a septicemia of sudden onset with high morbidity and mortality, but chronic conditions that characterized by localized infections often occur. 13wks broiler breeders were submitted to the Kyung-pook national university for diagnosis. Clinical signs included approximately 1% mortality, severe lameness, ruffled feathers and swollen and/or cloudy eyes. At necropsy, the outstanding lesions were seen swollen hock joint, which were suppurative or caseous exudates, inflammation of conjunctiva, severe pneumonia and epicarditis. The causative agent was isolated from the hock joint, liver, sinus and sternum of the chickens, and performed physiological and biochemical test. To identify the serotype of P. multocida, capsular serotyping was conducted by multiplex polymerase chain reaction (PCR). In the antimicrobial susceptibility test, the isolates were resistance to the aminoglycosides. In this study, we confirmed chronic fowl cholera (FC) caused by P. multocida in broiler breeders in Korea.

• Biomolecules & Therapeutics
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• 제4권2호
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• pp.174-183
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• 1996

The general pharmacological properties of Artemisia extract powder (DA-9601) produced from Artemisia asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800 mg/kg po had no influences on general behaviour, barbital sleeping time and motor coordination of mice. The material at the oral dose of 800 mg/kg did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800 mg/kg po. In the isolated ileum and trachea of guinea pig, the material did not show direct erect and inhibitory action of chemically or electrically stimulated contraction at the concentration of $2\times10^{-5}$g/ml. The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of $2\times10^{-5}$g/ml. No influences on blood pressure and respiration were observed at 40 mg/kg iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120 mg/kg in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in $Na^+$ and $K^+$ excretion.

• Biomolecules & Therapeutics
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• 제11권1호
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• pp.41-50
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• 2003

General pharmacological properties of DA-8159, a new pyrazolopyrimidinone derivative were examined in laboratory animals to investigate its safety profile. The oral administration of DA-8159 (1, 5 or 30 mg/kg) in mice and rats had no effect on general behaviors and central nervous system of the animals in test systems, such as hexobarbital-induced sleeping time, motor coordination, normal body temperature, writhing syndromes induced by 0.75% acetic acid solution, chemo-shock produced by pentetrazole solution and rotar rod test. Anesthetized cats treated intravenously with DA-8159 (0.1, 0.3, 1, 3 or 10 mg/kg) showed transient and mild decrease in blood pressure. However, heart rate, respiration rate and tidal volume were not changed by intravenous DA-8159. In the isolated organs including ileum, heart (sinus rate of atria and contractility of papillary muscle), trachea of guinea pigs and phrenic nerve of rats, DA-8159 ($10^{-8}$ ∼$10^{-5}$ mg/L) did not elicit any effect or inhibitory action on the chemically or electrically stimulated contraction. DA-8159 did not influence gastric secretion, pH and total acid output in rats and intestinal propulsion in mice. The administration of DA-8159 in rats had no effect on the platelet aggregation induced by ADP in rabbit plasma, urinary volume and electrolyte ion ($Na^{+}$, $K^{+}$, $Cl^{-}$) excretion in rats. Prothrombin time (PT) of the rats showed a mild but significant increase after administration of DA-8159. Activated partial thromboplastin time (APTT), however, was not affected by DA-8159. These results indicate that DA-8159 does not exert any of serious pharmacological effects.

• 대한본초학회지
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• 제30권3호
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• pp.55-61
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• 2015

Objectives : This study aimed to investigate the effects of Shingi-whan(SG) on the male reproductive and sexual function, so we measured the spermatogenesis and the testicular toxicity in mice and the vasorelaxation in isolated rabbit corpus cavernosum smooth muscle. Methods : To evaluate effect on the spermatogenesis in mice, we prepared two groups, control group and SG group that was orally administered SG(1,000mg/kg) for 20 days, and compared. To analyze testicular toxicity in mice, we also prepared two groups, doxo group that was injected with doxorubicin (3mg/kg) on three times and doxo + SG group that was injected with doxorubicin and SG for 20 days, and compared. To investigate sexual function of SG in mice, we prepared three groups, normal group and aging elicited group consisting of 18-month-old mice, SG treated aging group that was orally administered SG for 60 days, and compared using histochemical staining on mice corpus cavernous tissues. In order to define the relaxation effects of SG, rabbit corpus cavernous tissues were prepared in $2{\times}2{\times}6mm$ sized strip. Then the dose-dependent relaxation responses of SG at 0.01-3.0 mg/ml in contracted strips induced by phenylephrine were measured. Results : The sperm density in dutus epididymis and the diameter of seminiferous tubules of SG group was significantly increased when compared to control group. The testicular weight and the diameter and height of epithelial layer of seminiferous tubules of doxo + SG group was significantly increased when compared to doxo group. The cavernous strips were significantly relaxed by SG extract In SG treated aging group, ratio of smooth muscles to collagen fibers and red blood cell count in venous sinus was increased as compared to aging elicited group. Conclusions : Our findings have shown that SG extract have effect on spermatogenesis and mitigating effect on doxo-induced testicular toxicity. Further, it also have the vasorelaxant effect on rabbit corpus cavernosum.

• Journal of Chest Surgery
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• 제12권3호
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• pp.297-305
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• 1979

Occlusive coronary artery disease presents a potential threat to a significant population in the United States. According to many case reports, the increasing incidence of coronary artery disease due to atherosclerosis is noted in Korean, recently. Operative vascular procedures have increased steadily in number over the past 20 years in the United States. There have been many isolated case reports about coronary artery surgery, but these had little clinical impact. Nowadays, major three coronary bypass surgery has developed principally at three cardiac centers in the United States since 1967. Among three coronary bypass operation, the aorta-coronary artery saphenous vein bypass graft was first demonstrated by Favolaro and Effler at the Cleveland Clinic in 1967. We experienced one case of coronary artery disease, which was treated successfully by aorta-coronary saphenous vein graft with mild hypothermia under extracorporeal circulation in May, 1977. Saphenous vein was removed from above the knee and was 2.5 mm in diameter. The left ventricle was not vented for the left ventricle was not overdistended. Temporary artificial pace-maker-Medtronic-was implanted for the prevention and treatment of post-operative arrhythmia and heart block in post-operative first day. He is a 57 year old male businessman who had been suffered from hypertension [200 mmHg in systolic pressure] since 4 years ago, who had intermittent conservative treatment at local clinic. He had been afflicted with severe chest pain with choking sensation for 50 days. This symptom was aggravated exposing cold weather, or cold water, but was respond to rest. Pre-operative ECG revealed no any other ischemic sign except sinus bradycardia. Significant S-T segment depression was noted at lead II, AVF after double 5 minutes exercise, indicating positive Master`s test. Serum cholesterol was slight elevated to 253 mg/dl. Final pre-operative diagnosis was made by coronary arteriogram, which showed about 1.0-cm segmental 90 % occlusive atherosclerotic lesion in the proximal part of right coronary artery above the origin of acute marginal artery. Left coronary artery revealed good patency and there was no collateral circulation between right and left coronary artery .Hospital course was not eventful. He was discharged with good result on the post-operative day. He has been free from chest pain for longer than 2 years. And also the arterial flow in the coronary bypass graft is auscultated with the pocket-sized ultrasonic velocity detector, which shows the patency of the coronary bypass graft good.

• 대한세포병리학회지
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• 제18권1호
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• pp.87-91
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• 2007

Langerhans cell histiocytosis (LCH) is a pleomorphic disease entity characterized by local or disseminated atypical Langerhans cells (LCs) found most commonly in bone, lungs, mucocutaneous structures and endocrine organs. Among different sites, unifocal disease confined to a lymph node (LN) is rare. We report a case of LCH confined to a LN in a 38-year-old male who presented with a 2 cm-sized cervical mass. The fine needle aspiration (FNA) smears of cervical LN showed high cellularity having isolated LCs with contorted nuclei and nuclear grooves mixed in multinucleated giant cells, small lymphocytes and eosinophils. Charcot-Leyden crystals were also seen, as were a few dendritic-like cells and intranuclear inclusions. Confirmation of LCH was made by histopathologic studies, positive reactions for S-100 protein and CD1a immunohistochemical staining and by the demonstration of Birbeck granules on electron microscopy. The differentials to be considered include dermatopathic lymphadenitis, sinus histiocytosis with massive lymphadenopathy, Hodgkin's lymphoma and malignant histiocytosis. The characteristic cytomorphologic pattern of LCH in a LN FNA smear plays an important role in suggesting the diagnosis of LCH.