• Journal of Yeungnam Medical Science
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• v.4 no.1
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• pp.123-128
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• 1987

To estimate the prevalence of hypertension among the aged in urban area, the blood pressure was examined on the subjects of 565 men and 762 women of 65 years old and older among the residents of Nam-Ku and Soosung-Ku in Taegu between January and December, 1986. The mean systolic blood pressure was $136.0{\pm}25.01mmHg$ in male and $133.0{\pm}24.56mmHg$ in female. The mean diastolic blood pressure was $83.7{\pm}14.41mmHg$ in male and $82.4{\pm}14.43mmHg$ in female. There was no significant differences between male and female in both mean systolic and diastolic blood pressure. According to WHO category, the prevalence of pure systolic hypertension (${\geq}$160/<95mmHg) was 7.8% in male and 6.8% in female. The prevalence of pure diastolic hypertension(<160/${\geq}$95mmHg) was 6.0% in male and 3.9% in female. The prevalence of both systolic and diastolic hypertension (${\geq}160/{\geq}95mmHg$) was 13.5% in male and 12.9% in female. According to joint National Committee category, the percentage of normal blood pressure (/<90mmHg) was 46.7% in male and 50.8% in female. The prevalence of mild hypertension (/90=104mmHg) was 34.5% in male and 34.6% in female. The prevalance of moderate hypertension (/105=144mmHg) was 5.1% in male and 2.5% in female. The prevalence of severe hypertension (/${\geq}$115mmHg) was 2.3% in male and 3.0% in female. The prevalence of borderline isolated systolic hypertension (140-159/<90mmHg) was 9.0% in male and 6.6% in female. The prevalence of isolated systolic hypertension (${\geq}$160/<90mmHg) was 2.3% in male and 2.5% in female.

• Journal of Medicine and Life Science
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• v.19 no.3
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• pp.79-89
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• 2022

Whereas systolic blood pressure (SBP) continuously rises with age, diastolic blood pressure (DBP) gradually decreases after the age of 55 years. Therefore, hypertension in the elderly shows the pattern of isolated systolic hypertension. There is evidence on the benefits of controlling blood pressure (BP) in elderly patients with hypertension. The BP lowering effect has also been demonstrated in patients over 80 years of age with hypertension. The BP threshold for the initiation of antihypertensive drug treatment for older adults with hypertension is gradually decreasing. The antihypertensive treatment is recommended if, despite therapeutic lifestyle modifications, SBP ≥140 mmHg or DBP ≥90 mmHg in those aged 65-79 years old, and SBP ≥140-160 mmHg or DBP ≥90 mmHg in those aged ≥80 years old. Although there is no consensus on the target BP for older adults with hypertension, a target SBP of <130-140 mmHg and DBP of <80-90 mmHg are recommended. In older adults over 80 years of age with hypertension, the target SBP is <140-150 mmHg. When the dose of antihypertensive drugs is increased to reach the target SBP, DBP may decrease to less than 70 mmHg, but it should not be <60 mmHg. Thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers can be selected as the first-line drug for older adults with hypertension. Beta-blockers may be selected in case of compelling indications.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.621-628
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• 2016

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.