• Clinical and Experimental Pediatrics
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• 제49권7호
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• pp.777-783
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• 2006

목 적 : 최근 소아 요로감염의 가장 흔한 원인균인 E. coli에 대한 항생제 내성 문제가 점차 대두되고 있다. 본 연구에서는 소아 원외 요로감염 환아에서 분리된 E. coli에 대한 cefixime을 포함하여 흔히 사용되고 있는 경구용 항생제의 시험관 내 감수성 연구를 시행하여 적합한 치료 항생제 선택의 기초 자료를 얻고자 하였다. 방 법 : 2004년 10월부터 2005년 9월까지 연구 참여 병원 소아과 외래에서 요로감염으로 진단된 206명 환아의 요 배양검사에서 동정된 211개 균주 중 188개 E. coli를 대상으로 경구용 항생제(ampicillin, amoxillin, ampicillin-sulbactam, cefaclor, TMP-SMX, cefixime)에 대한 시험관 내 감수성 검사를 실시하였다. 결 과 : 분리된 E. coli 균주에 대한 항생제별 감수성 결과에서 내성률은 각각 ampicillin 81.4%, amoxicillin 85.6%, ampicillin-Sulbactam 77.2%, cefaclor 93.6%, TMP-SMX 50.5%, cefixime 13.3%이었다. ESBL 생성 E. coli는 7.0%이었다. 결 론 : Aminopenicillins계, cefaclor, sulfa약제들은 E. coli에 대한 내성률이 매우 높아 소아 요로감염의 일차 선택 항생제로 유용하지 못한 것으로 추정할 수 있었다. 그러나 cefixime과 같은 3세대 cephalosporin은 일차 치료 실패할 경우 이차 선택항생제로 유용할 수 있으며, 일차 선택 항생제로도 사용될 수 있을 것으로 추정되었다. E. coli의 항생제 내성 양상에 대한 광범위한 연구와 지속적 감시를 통하여 소아 원외 요로감염 치료에서 1차적으로 선택될 수 있는 경구용 항생제에 대한 지침 자료가 요구된다.

• Archives of Plastic Surgery
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• 제45권2호
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• pp.128-134
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• 2018

Background Non-syndromic craniosynostosis causes craniofacial asymmetry and may persist after cranioplasty. These postoperative asymmetries are primarily depressions. In some cases, patients may be subjected to pranks and harassment by their peers, affecting their psychosocial development. We propose lipoinjection enriched with adipose stem cells (ASCs) to treat the sequelae of craniosynostosis in the fronto-orbital and temporal complex in cranioplasty patients, with the goal of improving the appearance of the upper third of the face. Methods Twelve children (four boys and eight girls) between 4 and 8 years of age (mean age, 6 years) in the postoperative period after treatment for plagiocephaly, brachycephaly, and trigonocephaly were included, with a follow-up period of 1 to 18 months. Fat tissue was obtained from the lower abdomen, and ASCs were isolated using the Yoshimura technique. Lipoinjection was performed using several mini-approaches to ensure adequate distribution. Results Two different scales were used to evaluate the aesthetic outcomes. At 6 months, three plastic surgeons independent of the study classified the results using a Likert scale. The patients' parents categorized the results using a visual analog scale at 6, 9, and 18 months. R esults were favorable on both scales, as the patients' facial appearance improved and they reported increased happiness and self-esteem due to their remodeled facial appearance. Conclusions We suggest that lipoinjection enriched with ASCs is a good alternative for correcting asymmetry of the fronto-orbital and temporal contour in patients with sequelae of craniosynostosis. This treatment will help boost patients' self-esteem starting at an early age.

• 대한화학회지
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• 제41권9호
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• pp.471-482
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• 1997

기체크로마토그래피/질량분석법(GC/MS)을 이용하여 소변 내에 존재하는 유기산들을 동시에 분리 정량분석할 수 있는 최적의 분석조건을 확립하기 위해 액체-액체추출법을 이용하여 분리하였고 이 때 pH의 영향 및 역추출방법과 그리고 옥심화 과정 첨가의 효과를 알아보았다. 그 결과 옥심화 과정 없이 pH가 0.5일 때 회수율이 좋았고 RSD값은 0.3-12.4%로 가장 적었다. 역추출과정을 통하여 방해물질이 제거되어 15-16분대의 머무름 값을 갖는 몇가지 유기산 검출이 확실시 되었다. 이를 토대로 51종의 유기산들에 대한 검량곡선을 작성하여 한국 정상어린이(n=16) 요시료 중의 유기산 함량분포를 얻었다.

• 대한소아치과학회지
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• 제26권3호
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• pp.466-472
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• 1999

치태의 주요성분인 비수용성 글루캔의 형성을 억제시키는 세균을 분리하기 위하여 유치원 원아 만여명으로부터 타액을 채취하였다. 일회용 큐벧을 사용하여 비수용성 글루캔의 형성을 억제시킨 세균을 분리하였다. 분리된 세균을 그람 염색과 API 20S kit와 API 50 CHL kit를 사용하여 당발효 및 생화학적 특성을 검사한 결과, Streptococcus oralis, Streptococcus mitis, Streptococcus mitior, Streptococcus sanguis, Enterococcus durans, Lactococcus lactis로 동정되었다. 비수용성 글루캔 형성 억제 정도를 판정하기 위하여 일회용 큐벧에서 S. mutans 단독 배양시에는 550nm에서의 흡광도가 1.503이었으나, S. mutans와 Streptococcus oralis, Streptococcus mitis, Streptococcus mitior, Streptococcus sanguis, Enterococcus durans, Lactococcus lactis, Lactobacillus acidophilus 혼합 배양시에는 각각의 흡광도가 0.823, 0.912, 0.894, 0.878, 0.753, 0.845, 1.021로 감소되었다.

• 가정과삶의질연구
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• 제10권1호통권19호
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• pp.229-238
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• 1992

According as the modern form of the family becomes nuclearized, inevitable is the isolation of the family. The relationship of the neighborhood and the kinsmen are being dissolved, making the isolated and unsteady nuclear family. We need a community in the modern society, for we are facing a lot of social problems as the nuclear family. The problems are as follows ; the rearing of the children, the alienation of a woman and the woman's roles in the society. In addition to those problems, there are also such some other problems as the alienation of the old man and the social roles of them. That is to say, the community appeared as a kind of attempt to overcome the above-mentioned problems, Kibbutz may be itself called and enlarged family to function as one family even though it is not just a blood relationship. The American commune is a large family community as a group to overcome the alienation and solitude of the nuclear family. On the other hand, the urban community is the small-scaled and cooperative family to solve the problem that the modern nuclear family is a unit living solitarily and unsteadily. But in fact, even in such a community, there are much tension and conflict against its establishing purpose. In my opinion, if those communities have to surmount the tension and conflict which are derived from the process in a bid to overcome the troubles like the alienation and solitude of the nuclear family. The bond of family must be consolidated among all the members of the community. And then community may be co-existed with the traditional family as the alternative family in the future, which can supply the deficiency of the unsteady unclear family.

• 한국식품조리과학회지
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• 제14권1호
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• pp.76-83
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• 1998

The purpose of this study was to evaluate the foodservice management practices and productivity in elementary schools in order to provide basic information for an efficient food service management. This approach was achieved using a variety quantitative and qualitative information including general foodservice management, managerial and operational factors, and the productivity in elementary school foodservice systems. The labor productivity in 28 school foodservice system was assessed and related to a number of influencing variables within the system. The productivity measurement was based upon the total meal equivalents as a ratio of the total direct and non-direct labor hours required to prepare these meals. Twenty-eight elementary schools located in Seoul and Kangnung were surveyed to get data for the variables. Questionnaire and a survey form were mailed. Statistical methods used in this study were descriptive analysis, $\chi$$^2$-test, 1-test and one-way ANOVA analysis. Elementary schools in Seoul were all located in urban areas, whereas elementary schools in Kangnung were in urban areas (40.0%), provincial areas (40.0%) and in isolated areas (20.0%). Total average number of meals including children and staff was 928.2${\pm}$ 650.0 with a yery significant difference (p<0.001) between Seoul and Kangnung. The average cost of school meal in Seoul and Kangnung were 1191.0 won and 1526.2 won, respectively. The result of Pearson Correlation analysis indicated that labor cost per meal, 1-week meal equivalents and meal equivalents per labor were significantly correlated with the productivity.

• 한국지역사회생활과학회지
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• 제18권1호
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• pp.147-160
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• 2007

This research challenges the general notion of one-person households of the elderly during widowhood as impoverished, isolated, and vulnerable. Recognizing a high potential vulnerability, however, this research attempts to describe the diverse composition of one-person households of the elderly. For this purpose, relying on 2% sample data from the 2000 census, it examines regional distribution, socio-economic characteristics, and determinants of one-person households of the elderly during widowhood. Socio-economic characteristics of one-person households of the elderly differ by region. Jeju island is distinct in terms of sex and age distribution, and residence area of children. In general, rates of economic activity and self-subsistence are higher in provinces than in cities. Compared to the elderly living with family, the elderly living alone show high rates of economic activity, self-subsistence, and capability of physical activity. Results of logistic regression analysis of determinants of living arrangement are consistent with those of descriptive statistics. Those who are economically active and able to move around without assistance tend to live alone after the death of a spouse. Number of sons and living in an urban area are negatively associated with living alone, whereas females are more likely than males to live alone. According to the separate analysis by age, the positive effect of economic activity is greater in the oldest of the old than in other age groups. Those who possess high educational attainment tend to live alone when they are 80 and older, unlike other age groups. Based on these findings, this paper finds that one-person households of the elderly nay not always be the most vulnerable group, and are diverse in terms of socioeconomic characteristics.

• Journal of Chest Surgery
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• 제18권1호
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• pp.46-53
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• 1985

A single aortic valve replacement using the lonescu-Shiley bovine pericardial xenograft valve was performed in 66 consecutive patients during the period from February, 1979 to June, 1984. They were 49 males and 17 females with ages ranging from 9 to 61 [mean, 31.113.1] years, and 9 of them were children younger than 15 years of age. Twenty-seven patients [40.9%] required the combined operative procedures to either other valvular lesions or congenital defects. There were 9 early deaths within 30 days of surgery [operative mortality rate, 13.6%] and 2 late deaths thereafter [late mortality rate, 3.0%; or 1.75%/patient-year]. The 57 early survivors were followed for a total duration of 114.2 patient-years [mean, 24.016.0 months]. Four patients experienced thromboembolic complication with no death [3.50%/patient-year]; one died from intracranial bleeding related to anticoagulation [0.88%/patient-year]; one recovered from prosthetic valve endocarditis [0.88%/patient-year]; and four developed aortic regurgitant murmur with none or minimal cardiac symptoms and they were classified into cases of tissue valve failure [3.50%/patient-year]. The actuarial survival rate was 82.34.7% at 6 years, and the actuarial probabilities of freedom from thromboembolism and valve failure were 93.33.9% and 89.15.8% at postoperative 6 years respectively Symptomatic improvement was excellent in most late survivors at the follow-up end with the mean of NYHA Classes of 1.040.19 while the one was 2.290.67 at the time of operation. Excluding the higher operative mortality rates, these clinical results are fully comparable with the ones of reports from the major institutions using the porcine aortic or the bovine pericardial tissue valves and warrants the continued use of the xenograft valve in the aortic position. The importance of more detailed preoperative evaluation of the myocardial function and the need of improved myocardial preservation during surgery for the improved early clinical results were discussed.

• 한국환경보건학회지
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• 제39권5호
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• pp.447-455
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• 2013

Objectives: This study aims to understand the concentration, diversity, and antibiotic characteristics of staphylococci present in the indoor air of child-care facilities. Methods: Air sampling was performed from October 2012 to January 2013 in 120 child-care facilities in Seoul, Korea. Methicillin-resistant bacteria were selected from the total obtained airborne bacteria and subjected to 16S rRNA analysis for methicillin-resistant staphylococcal species determination. Identified staphylococcal strains were tested for resistance to a range of antibiotics. Results: Average total airborne bacterial concentration was $508.9{\pm}246.3CFU/m^3$. Indoor concentration of total airborne bacteria had a significant positive correlation with the $CO_2$ concentration in the child-care facilities. Methicillin-resistant staphylococci were present in 13.3% of the child-care facilities studied. A total of four species (S. epidermidis, S. cohnii, S. saprophyticus, S. sp.) and 55 strains were identified from the indoor air of the child-care facilities. Staphylococcus cohnii was the most common species (54.5%), followed by S. epidermidis (38.2%). All of the isolated staphylococcal strains exhibited high resistance to oxacillin, erythromycin, mupirocin, and ceftizoxime. Especially, S. saprophyticus strains showed more multidrug resistance to oxacillin, vancomycin, clindamycin, erythromycin, lincomycin, ceftizoxime, mupirocin, and tetracycline than did other species. Conclusion: The results of this study showed that a monitoring system for multidrug-resistant bacteria is needed in facilities for children, as the community-associated infections of these bacteria are increasing.

• Childhood Kidney Diseases
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• 제10권2호
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• pp.182-191
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• 2006

Purpose : We studied the degree of changes in antibiotic sensitivity toward causative organisms, prevalence and clinical manifestations of extended-spectrum $\beta$-lactamase(ESBL)-producers of urinary tract infection(UTI) for a period of three years. This serves to provide useful information in selecting adequate drugs for the treatment of UTI. Methods : We recruited 137 patients who grew more than $10^5$ CFU/mL in their urine culture among 250 patients who visited and were admitted to Handong University's Sunlin Hospital for UTI treatment from January 2003 to December 2005. We retrospectively analyzed the data from the medical records. Results : The common pathogenic organisms were Escherichia coli(65.0%), Klepsiella pneumoniae(14.0%), Enterococcus faecalis(5.8%) and Proteus vulgaris(2.9%) in consecutive order. The prevalence of ESBL-producers among isolated E. coli and K. pneumoniae was 4.5%(4 cases) and 14.3%(2 cases), respectively. The antibiotic sensitivity rates of E. coli were relatively high to amikacin(100%), imipenem(100%), ceftriaxone(95.5%) and tobramycin(91.4%) while relatively low to TMP/SMZ(55.4%), ampicillin/sulbactam(29.4%) and ampicillin(24.2%). Conclusion : The use of ampicillin, ampicillin/sulbactam and TMP/SMZ, which have been the first choices in the treatment of UTI, should be reconsidered due to the low sensitivity rates towards these antibiotics. Due to the high incidence and antibiotic tolerance of ESBL that might have risen from the development of new antibiotics and increased antibiotic use, it is necessary to consider changing the standard antibiotics that have been used in the treatment of UTI.