• Bulletin of the Korean Chemical Society
• /
• 제28권3호
• /
• pp.481-484
• /
• 2007

• Archives of Pharmacal Research
• /
• 제27권6호
• /
• pp.589-593
• /
• 2004

Two pterocarpans ［(6aR,11aR）-maackiain, (6aR,11aR）-medicarpin］, one flavanone ［(2S）-7-hydroxy-G-methoxy-flavanone］, one isoflavan (sativan） and two isoflavones (pseudobaptigenin, genistein） were isolated from the Spatholobus suberectus (Leguminosae）. Their chemical structures were determined by comparison of their spectroscopic parameters of CD, ElMS, 1D-NMR and 2D-NMR with those reported in the literatures. All of these compounds are reported for the first time from this plant through the present study.

• Bulletin of the Korean Chemical Society
• /
• 제30권2호
• /
• pp.415-418
• /
• 2009

Concerned with ambiguous stereochemistry assignment of natural (+)-glabridin, absolute configurations of (${\pm}$)-glabridin enantiomers were studied with synthetic glabridin. Synthetic glabridin enantiomers were separated by semi-preparative Sumi-chiral column chromatography, and characterized by UV-Vis and NMR spectroscopy. Three-dimensional molecular structure of glabridin was obtained as equatorial Ph-3 half chair chroman ring from semi-empirical PM3 calculation, and refined by coupling constants in $^1H$ NMR spectrum. Finally, absolute configurations of two enantiomers were determined by circular dichroism spectroscopy based on the empirical helicity rules. Absolute configuration of natural (+)-glabridin was confirmed as (R)-glabridin, as known.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
• /
• pp.202.1-202.1
• /
• 2003

Six compounds were isolated from the 90% MeOH fraction of the vine stem of Spatholobus suberectus Dunn (Leguminosae) using silica gel, reverse phase column chromatography and RP-HPLC. Structures of compounds 1-6 were elucidated by spectroscopic parameters of IR, E1 MS, FAB MS, lD-NMR and 2D-NMR spectrum and identified as pseudobaptigenin (1), genistein (2), (2R)-7-hydroxy-6-methoxyflavanone (3), (3R,4R)-2",4"-dihydroxy-6,7-methylenedioxy-isoflavan-4-ol (4), (3R,4R)-7,2" -dihydroxy- 4"-methoxyisoflavan-4-ol (5), sativan (6), respectively. Compounds 3, 4 and 5 have been newly reported in nature.

• 한국식품과학회지
• /
• 제34권5호
• /
• pp.893-897
• /
• 2002

강진향(Dalbergia odorifera T.CHEN)은 콩과에 속하는 한약재로 한방에서는 진통(鎭痛), 지혈(止血)의 목적으로 사용되어 왔다. Rancimat method로 항산화 활성이 인정된 강진향 75% 에탄올 추출물의 클로로포름 층을 가지고 항산화 활성 물질을 확인하기 위하여 silica gel chromatography 와 thin layer chromatography로 물질을 분리하고, mass spectrometer, $^1H-NMR$ 및 $^{13}C-NMR$을 통해 순수물질을 동정하였다. 순수 분리된 물질은 flavonoid 화합물 중 isoflavan 골격을 가지는 mucronulatol(3(R&S)-3',7-dihydroxy-2',4-dimethoxyisoflavan) 로 동정되었다. 이 물질에 대한 ascorbic acid, citric acid 및 ${\delta}-tocopherol$과의 synergist 효과를 비교하기 위해 돈지, 함유, 대두유, 옥배유를 기질로 하여 Rancimat 방법으로 시험한 결과, 돈지에 대해서는 mucronulatol(600 ppm)만 처리시 AI가 7.71, ${\delta}-tocopherol(200ppm)$과의 병용시 AI가 10.97로 약 1.5배의 상승효과가 있었으며, 식물성 유지인 팜유에 대해서는 mucronulatol(600 ppm)만 처리시 AI가 1.42, ascorbic acid(200 ppm), citric acid(200 ppm) 첨가시 AI가 각각 2.04, 2.04로 약 1.5배의 상승효과를 보였으며, 대두유와 옥배유에 대해서는 뚜렷한 상승효과를 보이지 않았다.