• Korean Journal of Clinical Pharmacy
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• v.21 no.2
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• pp.122-130
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• 2011

Objective: Although recombinant human erythropoietin (rhEPO) has revolutionized the treatment of anemia in chronic kidney disease (CKD) receiving hemodialysis (HD) with no need of blood transfusion, some patients have a blunted or appear to be resistant to rhEPO. There is a controversy in the causes of rhEPO resistance in maintenance HD patients with anemia. This study is to examine current anemia treatment outcomes and the factors influencing the rhEPO responsiveness in HD patient with CKD. Methods: The clinical parameters or factors relating to erythrompoietin treatment outcomes and erythropoietin responsiveness were collected from the HD patients in two large dialysis centers for three months. The collected paramenters included serum iron, total iron biding capacity (TIBC), transferrin saturation rate, ferritin, albumin, intact PTH, C-reactive protein (CRP), nPCR and medications such as an angiotensin converting enzyme inhbitor, an angiotension II receptor blocker and an HMG-CoA reductase inhibitor (HMG-CoA RI). The data were analyzed to examine the degree of acheiveing the anemia treatment goal and factors relating to ERI. Results: Among total 111 patients, 42 (42.3%) and 47 (37.8%) patients achieved the target Hct and Hb based on the Health Insurance Review and Assessment Services (HIRA) reimbursement criteria. In the higher ERI group (upper quartile), the patients had higher CRP levels (0.5 mg/dl) (p=0.0096), and lower TIBC score (<$240{\mu}g/dl$) (p=0.0027), and less patients were taking HMG-CoA RI (p=0.0019). Male patients (p=0.0204), patients with high TIBC score ($R^2$=0.084, p=0.0021) and patients taking HMG-CoA RI (p=0.0052) required to administer less dose of rhEPO meaning higher erythropoietin responsiveness. Conclusion: Less than 50% of CKD patients were achieving the goals of anemia by erythropoietin administration in large hospitals in Korea even though the goals were lower than those of NKF-K/DOQI practice guideline. The factors influencing ERI were sex, TIBC and HMG-CoA RI administration status, and neither an ACEI nor an ARB did not influence ERI.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.11
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• pp.2573-2584
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• 1997

In this paper, Ca, Sn substitute YIC(Yttrium Iron Garnet) ceramics were fabricated with Al substitutions in Fe sites. The strip-line circulator was designed and the properties of fabricated ciculator were measured. When the electric, magnetic and microwave properties were measured in Ca, Sn substituted YIG with Al subsititions, the relative permittivity and perfmeability in microwave frequencies were 15.623 and 0.972, repectively. For $Y_{2.4}Ca_{0.3}Sn_{0.3}Fe_{5-x}Al_xO_{12}$ garnet ceramics sintered at $1450^{\circ}C$, the ferrimagnetic resonance line width $\Delta{H}$) of 42 Oe and the saturation magnetization of 487 G were measured at 10 GHz. The strip-line circulator was simulated with 3-D FEM(Finite Element Method) software and designed to have insertion loss of 0.8dB, return loss of 25dB, isolation of 35dB at the center frequency of 1.9GHz. The fabricated strition loss of 0.8B, reture loss of 25dB, isolation of 35dB at the center frequency of 1.9GHz. The fabricated strip-line junction circulator using above YIG ceramics had insertion loss of 0.869dB, return loss of 26.955dB, isolation of 44.409dB at the center frequency of 1.9GHz.

• Korean Journal of Soil Science and Fertilizer
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• v.7 no.3
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• pp.127-135
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• 1974

The samples were taken from the following localities previously classified as "Akiochi" area: Yangpyung, Puchun, and Pyungtaik, all of Kyonggi-do province. Five soil profiles were described in the field, and taken to the laboratory for physical and chemical analysis and mineralogical analysis by X-ray diffraction. The predominant clay minerals consist mainly of illite, vermiculite, chlorites and intergrade with vermiculite, and kaolinite. Illite or mica was found present in all samples and in all horizons. This was identified by the 9.83 to $10{\AA}$ (0.01) and $3.32{\AA}$ (003) basal reflections, Interhorizontal variations in mineral content and crystallinity are illustrated in their respective Xray diffractogram. Comparing the peak intensity, of the $14{\AA}$, $10{\AA}$ and $7{\AA}$ indicated the degree of weathering from the surface to the lower horizons. In general, the weathering of illite on the surface produced less pronounced $10{\AA}$ and $14{\AA}$ peak as compared to the lower horizons. The same may be said with kaolinite. On K-saturation, the $14{\AA}$ peak broadening on the low angle side was observed. This is interpreted to be due to chlorization. Heat treament from $100^{\circ}C$, $200^{\circ}C$, $400^{\circ}C$, $600^{\circ}C$, and $800^{\circ}C$. caused significant changes in the different diffractograms. Heating caused collasped of the $14{\AA}$ to $10{\AA}$ and the appearance of scattered peaks between $10-14{\AA}$. This is interpreted to the presence of vermiculite chlorite intergradient. The complete collapse of the $14{\AA}$ at $800^{\circ}C$ to $10{\AA}$ with increased intensity was attributed to the preservce of vermiculite. The principal difference among the clay minerals in each horizon is the concomitant increase and decrease in intensity with depth of the $14{\AA}$, $10{\AA}$ and $7{\AA}$ diffraction spacings. Apparently the weathering of illite ($10{\AA}$) is resulting in the formation of vermiculite ($14{\AA}$) and the interstratified material being an intermediate stage and the beginning of the formation of vermiculite. Some broadening- in the 17 to $18{\AA}$ was observed in Puchun-1 Pyungtaik-1 and Pyungtaik-2 specially so in the lower horizon in the Ca or Mg-saturated sample. Heated treatment tend to shift this peak to $14{\AA}$ indicating the presence of regular layering of the interstratified complex. The high amount of extractable aluminum and iron coupled with low exchange capacity indicate that iron and aluminum plays an important role in the weathering of these soils and is responsible to the low exchange capacity, high acidity and high phosphate absorptive capacity. The results presented substantiated the weathering sequence of Jackson in that mica ${\rightarrow}$ vermiculite ${\rightarrow}$ chloritezed vermiculite ${\rightarrow}$ kaolinite.

• Journal of Microbiology and Biotechnology
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• v.26 no.11
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• pp.1951-1964
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• 2016

1,4-Dioxane-degrading bacterial consortia were enriched from forest soil (FS) and activated sludge (AS) using a defined medium containing 1,4-dioxane as the sole carbon source. These two enrichments cultures appeared to have inducible tetrahydrofuran/dioxane and propane degradation enzymes. According to qPCR results on the 16S rRNA and soluble di-iron monooxygenase genes, the relative abundances of 1,4-dioxane-degrading bacteria to total bacteria in FS and AS were 29.4% and 57.8%, respectively. For FS, the cell growth yields (Y), maximum specific degradation rate ($V_{max}$), and half-saturation concentration ($K_m$) were 0.58 mg-protein/mg-dioxane, $0.037mg-dioxane/mg-protein{\cdot}h$, and 93.9 mg/l, respectively. For AS, Y, $V_{max}$, and $K_m$ were 0.34 mg-protein/mg-dioxane, $0.078mg-dioxane/mg-protein{\cdot}h$, and 181.3 mg/l, respectively. These kinetics data of FS and AS were similar to previously reported values. Based on bacterial community analysis on 16S rRNA gene sequences of the two enrichment cultures, the FS consortium was identified to contain 38.3% of Mycobacterium and 10.6% of Afipia, similar to previously reported literature. Meanwhile, 49.5% of the AS consortium belonged to the candidate division TM7, which has never been reported to be involved in 1,4-dioxane biodegradation. However, recent studies suggested that TM7 bacteria were associated with degradation of non-biodegradable and hazardous materials. Therefore, our results showed that previously unknown 1,4-dioxane-degrading bacteria might play an important role in enriched AS. Although the metabolic capability and ecophysiological significance of the predominant TM7 bacteria in AS enrichment culture remain unclear, our data reveal hidden characteristics of the TM7 phylum and provide a perspective for studying this previously uncultured phylotype.

• Journal of Yeungnam Medical Science
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• v.18 no.2
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• pp.226-238
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• 2001

Background: Anemia in chronic renal failure plays an important role in increasing morbidity of dialysis patients. The causes of the anemia are multifactorial. With using of erythropoietin(EPO) most of uremia-induced anemia can be overcome. However, about 10% of renal failure patients shows EPO-resistant anemia. Hyporesponsiveness to EPO has been related to many factors: iron deficiency, aluminum intoxication, inflammations, malignancies and secondary hyperparathyroidism. So I evaluated the improvement of EPO responsiveness after correction of above several factors. Materials and Methods: Seventy-two patients on hemodialysis over 6 months were treated with intravenous ascorbic acid(IVAA, 300 mg t.i.w. for 12 weeks), After administration of IVAA for 12 weeks, patients were classified into several groups according to iron status, serum aluminum levels and i-PTH levels. Indivisualized treatments were performed: increased iron supplement for absolute iron deficiency, active vitamin D3 for secondary hyperparathyroidism and desferrioxamine(DFO, 5 mg/kg t.i.w.) for aluminum intoxication or hyperferritinemia. Results: 1) Result of IVAA therapy for 12 weeks on all patients(n=72). Hemoglobin levels at 2, 4, 6 week were significantly elevated compared to baseline, but those of hemoglobin at 8, 10, 12 week were not significantly different. 2) Result of IVAA therapy for 20 weeks on patients with 100 ${\mu}g/l$ ${\leq}$ ferritin < 500 ${\mu}g/l$ and transferrin saturation(Tsat) below 30%(n=30). After treatment of IV AA for 12 weeks, patients were evaluated the response of therapy according to iron status. Patients with 100 ${\mu}g/l$ ${\leq}$ ferritin < 500 ${\mu}g/l$ and Tsat below 30% showed the most effective response. These patients were treated further for 8 weeks. Hemoglobin levels at 2, 4 week were significantly increased compared to baseline with significantly reduced doses of EPO at 2, 4, 6, 10, 12, 16, 20 week. Concomitantly significantly improvement of Tsat at 2, 6, 16, 20 week compared to baseline were identified. 3) Result of IVAA therapy for 12 weeks followed by DFO therapy for 8 weeks on patients with serum aluminum above 4 ${\mu}g/l$(n=12) Hemoglobin levels were not significantly increased during IVAA therapy for 12 weeks but dosages of EPO were significantly decreased at 2, 4, 6, 8 week during DFO therapy compared to pre-treatment status. Conclusion: IVAA can be helpful for the treatment of the anemia caused by functional iron deficiency and can reduce the dosage of EPO for anemia correction. And administration of low dose DFO, in cases of increased serum aluminum level, can reduce the requirement of EPO.

• Journal of Ecology and Environment
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• v.43 no.2
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• pp.129-160
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• 2019

Background: Characterizing and describing soils and land use and make a suggestion for sustainable utilization of land resources in the Ethiopian Rift valley flat plain areas of Lake Chamo Sub-Basin (CSB) are essential. Objectives: To (1) characterize soils of experimental area according to World Reference Base Legend and assess the nature and extent of salinity problems; (2) characterize land use systems and their role in soil properties; and (3) identify best land use practices used for both environmental management and improve agricultural productivity. Methods: Twelve randomly collected soil samples were prepared from the above land uses into 120 composites and analyzed. Results: Organic carbon (OC) and total nitrogen (TN) were varied along different land uses and depleted from the surface soils. The soil units include Chernozems (41.67%), Kastanozems (25%), Solonchaks (16.67%), and Cambisols (16.67%). The identified land uses are annual crops (AA), perennial crops (PA), and natural forest (NF). Generally, organic carbon, total nitrogen, percentage base saturation (PBS), exchangeable (potassium, calcium, and magnesium), available phosphorus (P₂O₅), manganese, copper, and iron contents were decreased in cultivated soils. Soil salinity problem was observed in annuals. Annuals have less nutrient content compared to perennials in irrigated agriculture while it is greater in annuals under rainfed. Clay, total nitrogen, available phosphorus, and available potassium (K₂O) contents were correlated positively and highly significantly with organic carbon and electrical conductivity. Conclusion: Management practices that improve soil quality should be integrated with leguminous crops when the land is used for annual crops production.

• Journal of Nutrition and Health
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• v.18 no.2
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• pp.115-125
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• 1985

This study was undertaken to make comparative study on the effect of kinds(Cellulose, Agar) & contents(2.5%, 5%, 10%) of the dietary fiber with the normal Fe intakes(66ppm) on the Fe metabolism in rats during the four weeks of growth period Sixty-four male rats of wistar strain weighing $76.2\pm2.5g$ were randomly designed to one of the 8 groups. All the groups received basal diet with 9% casein and no acorbic acid. The results obtained are summarized following; 1) Feed consumption per 100g b.w. & body weight gain in normal Fe intake groups tended to be higher than Fe deficient groups, but, there was no significant difference among the 8 groups. However, body weight gain & feed consumption in cellulose sloops were significantly higher than agar groups in all the levels tested.(P<0.01). 2) Fecal Fe excretion per 100g b.w. increased significantly with increase in dietary fiber during the four weeks, but there was no significant increase in fecal weight per l00g b.w. & urinary Fe excretion. 3) Hemoglobin concentration & hematocrit decreased slightly in SFe-10% up with SFe - C group after fourth weeks, but, the difference was not significant. 4) In cellulose groups, serum-Fe remakendly decreased & TIBC increased with increase in the levels of cellulose during the fourth weeks. In agar groups, serum-Fe & TIBC tended to decrease with increased dietary fiber intake. Therefore, at high intakes of both fibers, the levels of transferrin saturation were similar to that of DFe group. 5) Contents of Fe in liver, kidney & spleen increased significantly only in 10% agar diet. The remaining 7 groups did not differ significantly. It may imply agar affect in Fe utilization from storage in rats. In conclusion, inhibitory effect of dietary fiber on Fe absorption depended upon the kinds & level of consumption Results from the present study shoves the effects of purified dietary fiber on Fe absorption in gastrointestinal tract and it may be different from those of dietary fibers consumed as a part of complex diet.

• Korean Journal of Clinical Pharmacy
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• v.22 no.3
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• pp.202-210
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• 2012

Methoxy polyethylene glycol-epoetin beta (MPG-EPO), a continuous erythropoietin receptor activator, is a new erythropoiesis-stimulating agent with a long half-life. The purpose of this prospective study is to assess the effects of once-monthly subcutaneous MPG-EPO on hematological responses and nutritional status in peritoneal dialysis patients. Forty four patients undergoing stable peritoneal dialysis were enrolled into the study. Darbepoetin alfa therapy, in peritoneal dialysis patients, was converted to the monthly administration of subcutaneous MPG-EPO for 6 months. The starting dose of MPG-EPO was based on the previous weekly dose of darbepoetin alfa. The dose adjustments were performed to maintain the hemoglobin (Hb) levels in a target range of 10.5-11.0 g/dL. If the Hb levels exceeded 11.0 g/dL, MPG-EPO was temporarily interrupted for 1 month. The mean Hb levels were stable with the values of $9.5{\pm}1.1$ g/dL at baseline, and $10.4{\pm}0.9$ g/dL at the 6th month after conversion. The mean differences in the changes of Hb levels between the baseline and the 6th month were $0.9{\pm}1.4$ g/dL, which was statistically significant. However, the mean differences of iron, transferrin saturation and ferritin concentrations were not significant. It did not show significant differences in the changes of the nutritional parameters. These results suggest that the once-monthly subcutaneous administration of MPG-EPO for 6 months effectively maintains the Hb levels and nutritional status in peritoneal dialysis patients. Taken together, the once-monthly subcutaneous administration of MPG-EPO was practical and might improve the clinical compliance for the management of renal anemia in peritoneal dialysis patients.

• Journal of Korean Society on Water Environment
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• v.24 no.6
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• pp.701-708
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• 2008

As a countermeasure for reduction of corrosion in the delivery and distribution pipes used for tap water, materials for the pipelines in-houses and the effect of water quality on corrosivity of water pipelines were investigated in the distribution system of Han river. As the corrosion index at 6 water purification facilities of Han river, average Langelier Saturation Index (LI) of raw and finished water were -1.0 and -1.4 respectively and average Larson Index (LR) were 9.5 and 9.9, respectively. And also corrosion potential showed corrosivity in finished water (-431~-462 mV) as well as raw water (-426~-447 mV). This results indicate that tap water quality of han river have corrosivity. To understand the corrosivity effect in pipe material used for premise distribution system, water quality of stagnant tap water and tap water were analyzed and the differences between them were calculated. The difference concentration of iron, copper and zinc were $12.9{\mu}g/L$, $31.0{\mu}g/L$ and $45.0{\mu}g/L$ respectively in galvanized steel pipe for use more than 15 years and showed highest concentration. As a result, the control to corrosivity in the water pipelines, corrosivity control treatment in the water purification system can be applied. In advance it is necessary to monitor corrosivity of water quality using corrosive index because corrosivity may differ from the seasonal and regional characteristics and water chemicals dosage. For the future the guideline for corrosion index have to be established.

• Composites Research
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• v.30 no.1
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• pp.41-45
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• 2017

Magnetite nanoparticles were synthesized by adding an ammonium hydroxide to a mixed solution of iron (II) and (III) chlorides. A silicon surfactant of ${\alpha},{\omega}$-(3-aminopropyl)polydimethylsiloxane was adsorbed on the particles as dispersant and a polydimethylsiloxane polymer was used to prepare ferrofluids of silicone oil base. Fluorinated surfactants of anionic ammoniated perfluoroalkyl sulfonamide and nonionic fluoroaliphatic polymeric esters were applied to the particles and a perfluoropolyether was used to prepare ferrofluids of fluorine oil base. The experimental conditions were used for preparing the ferrofluids with concentrations of 200, 300 and 400 mg/mL, and density, magnetization and viscosity of the products were characterized. The density values increased in proportion to the concentration, indicating 1.11-1.27 g/mL for silicone-oil-based fluids and 1.95-2.10 g/mL for fluorine-oil-based fluids in the range of 200-400 mg/mL. The saturation magnetization of the silicone-oil-based and fluorine-oil-based fluids indicated 14.7, 24.4, and 30.7 mT and 15.8, 23.3, and 33.7 mT for 200, 300, and 400 mg/mL, respectively, depending on the content of magnetic particles in the fluid. The viscosity of the silicone-oil-based ferrofluids was highly stable compared to that of the fluorine-oil-based with increasing temperatures. The ferrofluids are usually applied to seals and speakers with the silicone base and to seals with the fluorine base.