• Archives of Craniofacial Surgery
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• v.10 no.2
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• pp.138-141
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• 2009

Purpose: Squamous cell carcinoma of the scalp sometimes exhibits unusually aggressive behavior. We report a case of extradordinarily aggressive squamous cell carcinoma of the scalp with invasion into the skull and dura mater. Method: The patient is a 38-year-old man with two cystic masses on the occipital area. He was diagnosed as squamous cell carcinoma in that region and have undergone surgical resections including cortical osteotomy of the skull, several years ago. On this occasion, 3-dimensional computed tomographic imaging revealed an erosive lesion on the occipital bone and magnetic resonance imaging showed two cystic masses invasion into the skull and dura mater. Results: He has undergone wide resection of the masses and cranioplasty with dural repair. Histopathologic examination indicated squamous cell carcinoma with moderate differentiation of the masses, bone marrow and dura mater. Conclusion: Squamous cell carcinoma on the scalp can readily penetrate the full thickness of the cranium and invade the dura mater, sagittal sinus and brain. We suggest wide resection of the scalp and split thickness skin graft with sentinel lymph node biopsy, following by postoperative radiation therapy.

• BMB Reports
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• v.52 no.12
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• pp.712-717
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• 2019

Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this study was to elucidate the underlying molecular mechanism of TOMM20's contribution to tumorigenesis and to explore the possibility of its therapeutic potential using colorectal cancer as a model. The results show that TOMM20 overexpression resulted in an increase in cell proliferation, migration, and invasion of colorectal cancer (CRC) cells, while siRNA-mediated inhibition of TOMM20 resulted in significant decreases in cell proliferation, migration, and invasion. TOMM20 expression directly impacted the mitochondrial function including ATP production and maintenance of membrane potential, which contributed to tumorigenic cellular activities including regulation of S phase cell cycle and apoptosis. TOMM20 was overexpressed in CRC compared to the normal tissues and increased expression of TOMM20 to be associated with malignant characteristics including a higher number of lymph nodes and perineural invasion in CRC. Notably, knockdown of TOMM20 in the xenograft mouse model resulted in a significant reduction of tumor growth. This is the first report demonstrating a relationship between TOMM20 and tumorigenesis in colorectal cancer and providing promising evidence for the potential for TOMM20 to serve as a new therapeutic target of colorectal cancer.

• The Journal of Korean Medical History
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• v.22 no.2
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• pp.23-31
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• 2009

Jecheon is a place of Korean Medicine with many historical characters, medical tales and cultures. One of the most renowned characters is Lee Gong Gi(李公沂), a 扈聖功臣 (title given to the 86 people that escorted king Seonjo during the Japanese Invasion of Korea in 1592) at the level of Huh Jun(許浚) and famous royal physician of Joseon who served King Seonjo and reached the highest position of chief physician. He was recognized for his talent as a royal physician and was conferred with the title of 扈聖功臣 Rank 3 after attending on King Seonjo during the Japanese Invasion of Korea in 1592. Despite the fact that he was a renowned man of medicine, he didn't get as much attention as 許浚 or Yang Ye Soo(楊禮壽) because documents on his work had not been studied. In this study, the author was able to study Lee Gong Gi(李公沂) based on documents such as "朝鮮王朝實錄(True Record of the Joseon Dynasty)", "內醫院先生案(Naeeuiwonseonsengan)", "醫科先生案(Euigwaseonsengan)" and on "避難行錄(Pinanhengrok)" by Yakpo Jeongtak (1526~1605) who was a govemmental pharmacist at the time of Japanese Invasion of Korea in 1592. According to "內醫院先生案" and "醫科先生案", Lee Gong Gi's son Lee Young Nam followed his father's footsteps and became the chief royal pharmacist and 崇政大夫(one of the governmental titles of Joseon Dynasty). As for Jecheon's Korean medical traditions, many forms of medical tales and cultures are preserved such as the tales of Neokgogae, Mountain Ami's medical water cave, Otmaru and Seonsimgol. These tales are divided into various types of great doctors, medical herbs and devoted sons and have been passed down With the origin of traditional medicine still intact. Moreover, ancient documents and artifacts on Traditional Korean Medicine that reflect the area's medical culture have been discovered. Not only is Jecheon a place of medical culture but along with Jecheon Drug Market it also carries on the tradition of medical herbs production and possesses the largest new medical herbs market in Korea. In conclusion, Jecheon is a traditional place of Korean Medicine with many medical cultures and characters from a unique history.

• Korean Journal of Bronchoesophagology
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• v.3 no.2
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• pp.287-292
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• 1997

We report 22 cases of well -differentiated thyroid carcinoma infiltrating the upper airway tract. This retrospective study was undertaken to evaluate the prognosis md to determine optimal therapy for thyroid carcinoma adhering to or invading the trachea or larynx from 1984.3 to 1996.12. The treatment was individualized depending on the extent of the cancer. There were 12 cases dissected free by an laryngotracheal shaving, 7 cases removed by an tracheal resection with end to end anastomosis, 3 cases removed by an total laryngectomy. In all of these cases, we performed a total thyroidectomy with an accompanying neck dissection. There were no major complications during the operation. Over the 5-years observation period, 11 patients are alive without a sign of recurrence, 4 Patients are alive with recurrence, 7 died of thyroid carcinoma; 2 of 12 in an laryngotracheal shaving cases, 2 of 7 in an tracheal resection with end to end anastomosis case, 3 of 3 in an total laryngectomy case. The result showed an radical operation for thyroid carcinoma invading the laryngotrachea improves the survival rate, but limits improving the cure rate, and the invasion of the thrchea or larynx must be treated whenever possible by an total resection followed by radioiodine and external beam radiation.

• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.370-379
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• 2020

Econazole, a potent broad-spectrum antifungal agent and a Ca²⁺ channel antagonist, induces cytotoxicity in leukemia cells and is used for the treatment of skin infections. However, little is known about its cytotoxic effects on solid tumor cells. Here, we investigated the molecular mechanism underlying econazole-induced toxicity in vitro and evaluated its regulatory effect on the metastasis of gastric cancer cells. Using the gastric cancer cell lines AGS and SNU1 expressing wild-type p53 we demonstrated that econazole could significantly reduce cell viability and colony-forming (tumorigenesis) ability. Econazole induced G0/G1 phase arrest, promoted apoptosis, and effectively blocked proliferation- and survival-related signal transduction pathways in gastric cancer cells. In addition, econazole inhibited the secretion of matrix metalloproteinase- 2 (MMP-2) and MMP-9, which degrade the extracellular matrix and basement membrane. Econazole also effectively inhibited the metastasis of gastric cancer cells, as confirmed from cell invasion and wound healing assays. The protein level of p53 was significantly elevated after econazole treatment of AGS and SNU1 cells. However, apoptosis was blocked in econazole-treated cells exposed to a p53-specific small-interfering RNA to eliminate p53 expression. These results provide evidence that econazole could be repurposed to induce gastric cancer cell death and inhibit cancer invasion.

• International journal of thyroidology
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• v.11 no.2
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• pp.99-108
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• 2018

Most thyroid cancers are well-differentiated cancers and have a very good prognosis. About 10% of thyroid cancer, however, invades the surrounding tissues, causing local recurrence and distant metastasis, and eventually affecting survival rate. In locally advanced thyroid cancers, the invasion of trachea, larynx and esophagus, can be occurred by primary tumor and may also result in lymph nodes metastasis. Surgical resection is still mainstay for the treatment of locally advanced thyroid cancer. The main purpose of the surgical resection is to eliminate the cancer completely, therefore, it can cause many complications such as dysfunction of the larynx, trachea and esophagus. It can have a serious effect on the quality of life, therefore there is still controversy on the extent of the surgery. The authors compare and analyze the opinions which were already discussed in the literatures published so far. These will help to select the surgical method.

• Journal of the Korean Society of Costume
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• v.52 no.7
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• pp.45-55
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• 2002

This study aimed at proving the fact that Men also wear SOKGOT similar to women's pants in early Chosun era unlike the general opinion that the men's pants is SAPOK-BAJI. From what SAPOK-BAJI didn't show up in the contemporary remains and the fact that men also wear GAE-DANG-GO (the pants opened low parts). which is one of SOKGOT types in ancient time of China, the assumption above can be guessed. Since the clothes style in Chosun era centered on PO. and the pants were designed not to show out. it can be considered there are any troubles for men to wear the SOKGOT style pants. But through Japanese invasion of Korea in 1592 and Chinese invasion of Korea in 1636. changes happened. Due to reflection and awaking about wide and burdensome clothes. the change seemed to be happened from wide SOKGOT style to narrow SAPOK style. The SOKGOT style pants seemed to settle down for women's only as men's pants become SAPOK-BAJI.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.911-914
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• 2014

The internet is established as the basic infrastructure of our life and we live in cyberspace on internet, and additionally many problems on cyberspace arise. One among them is the most serious cyber attack of the information society. The cyber attacks increase each year, attack type and the intelligence is evolving, and then the cyber ecosystem is getting more complicated. In this study, we analyze the Internet last incident status and type of Internet invasion and hacking methods, and analyze the corresponding national and international organizations and associations active status.

• Journal of the Korean Society of Costume
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• v.63 no.7
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• pp.94-108
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• 2013

This study is about the armors that high navy officers of Joseon wore during the period of Japanese invasion of Korea(1592~1598). The kinds of armors that these officers wore during this period are Sueungap, cheolgap, pigap, jigap and myeongap. Sueungap, cheolgap, pigap are all described in literatures, which were released in that period and the early Joseon period. According to publications that were released during that period, Yuyeopgap was a type of an iron armor. Armors that are recorded in only literatures published in the early Joseon period include swaejagap, gyeongbeongap, dujeonggap, hwangdongdujeonggap and dudumigap. Myeongap is found only in publications that were made in the above war time. The styles of armors are largely classified into chalgap and dujeonggap. The chalgap-styled armors used gapchal as their main component. Dujeonggap-styled armors used fabrics and dujeong. The names and the manufacturing methods of the gapchal did not changed since its creation in the early Joseon period until the above wartime. But, their shapes were considerably changed between the two times. This is clearly shown in armors that were found in the moat of the Dongrae-eup fortress. Dujeonggap-styled armors that were used during the period of the Japan-Korea war were a successor to those of dujeonggap-styled armors of the early Joseon period. But the former armors were different from the latter in that they had no gapchal inside. They are well represented by Jeong Chung Sin's armor.

• Molecules and Cells
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• v.41 no.6
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• pp.591-602
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• 2018

Gastric cancer is the fifth most common type of malignancy worldwide, and the survival rate of patients with advanced-stage gastric cancer is low, even after receiving chemotherapy. Here, we validated neurotensin receptor 1 (NTSR1) as a potential therapeutic target in gastric cancer. We compared NTSR1 expression levels in sixty different gastric cancer-tissue samples and cells, as well as in other cancer cells (lung, breast, pancreatic, and colon), by assessing NTSR1 expression via semi-quantitative real-time reverse transcription polymerase chain reaction, immunocytochemistry and western blot. Following neurotensin (NT) treatment, we analyzed the expression and activity of matrix metalloproteinase-9 (MMP-9) and further determined the effects on cell migration and invasion via wound-healing and transwell assays. Our results revealed that NTSR1 mRNA levels were higher in gastric cancer tissues than non-cancerous tissues. Both of NTSR1 mRNA levels and expression were higher in gastric cancer cell lines relative to levels observed in other cancer-cell lines. Moreover, NT treatment induced MMP-9 expression and activity in all cancer cell lines, which was significantly decreased following treatment with the NTSR1 antagonist SR48692 or small-interfering RNA targeting NTSR1. Furthermore, NT-mediated metastases was confirmed by observing epithelial-mesenchymal transition markers SNAIL and E-cadherin in gastric cancer cells. NT-mediated invasion and migration of gastric cancer cells were reduced by NTSR1 depletion through the Erk signaling. These findings strongly suggested that NTR1 constitutes a potential therapeutic target for the inhibition of gastric cancer invasion and metastasis.