• Journal of Astronomy and Space Sciences
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• v.29 no.1
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• pp.51-55
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• 2012

A few high-mass X-ray binaries-consisting of an OB star plus compact companion-have been observed by Fermi and ground-based Cerenkov telescopes like High Energy Stereoscopic System (HESS) to be sources of very high energy (VHE; up to 30 TeV) ${\gamma}$-rays. This paper focuses on the prominent ${\gamma}$-ray source, LS 5039, which consists of a massive O6.5V star in a 3.9-day-period, mildly elliptical ($e{\approx}0.24$) orbit with its companion, assumed here to be an unmagnetized compact object (e.g., black hole). Using three dimensional smoothed particle hydrodynamics simulations of the Bondi-Hoyle accretion of the O-star wind onto the companion, we find that the orbital phase variation of the accretion follows very closely the simple Bondi-Hoyle-Lyttleton (BHL) rate for the local radius and wind speed. Moreover, a simple model, wherein intrinsic emission of ${\gamma}$-rays is assumed to track this accretion rate, reproduces quite well Fermi observations of the phase variation of ${\gamma}$-rays in the energy range 0.1-10 GeV. However for the VHE (0.1-30 TeV) radiation observed by the HESS Cerenkov telescope, it is important to account also for photon-photon interactions between the ${\gamma}$-rays and the stellar optical/UV radiation, which effectively attenuates much of the strong emission near periastron. When this is included, we find that this simple BHL accretion model also quite naturally fits the HESS light curve, thus making it a strong alternative to the pulsar-wind-shock models commonly invoked to explain such VHE ${\gamma}$-ray emission in massive-star binaries.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7421-7426
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• 2013

Background: Colorectal cancer is the fourth most common cancer worldwide and the second leading cause of cancer-related death. FOLFOX is the most common regimen used in the first-line chemotherapy in advanced colorectal cancer, but only half of the patients respond to this regimen and we have almost no clue in predicting resistance in such first-line application. Methods: To explore the potential molecular biomarkers predicting the resistance of FOLFOX regimen as the first-line treatment in advanced colorectal cancer, we screened microRNAs in serum samples from drug-responsive and drug-resistant patients by microarrays. Then differential microRNA expression was further validated in an independent population by reverse transcription and quantitative real-time PCR. Results: 62 microRNAs expressing differentially with fold-change >2 were screened out by microarray analysis. Among them, 5 (miR-221, miR-222, miR-122, miR-19a, miR-144) were chosen for further validation in an independent population (N=72). Our results indicated serum miR-19a to be significantly up-regulated in resistance-phase serum (p=0.009). The ROC curve analysis showed that the sensitivity of serum miR-19a to discriminate the resistant patients from the response ones was 66.7%, and the specificity was 63.9% when the AUC was 0.679. We additionally observed serum miR-19a had a complementary value for cancer embryonic antigen (CEA). Stratified analysis further revealed that serum miR-19a predicted both intrinsic and acquired drug resistance. Conclusions: Our findings confirmed aberrant expression of serum miR-19a in FOLFOX chemotherapy resistance patients, suggesting serum miR-19a could be a potential molecular biomarker for predicting and monitoring resistance to first-line FOLFOX chemotherapy regimens in advanced colorectal cancer patients.

• International Journal of Ocean System Engineering
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• v.1 no.2
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• pp.60-67
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• 2011

This paper presents an in-situ correction method to compensate for the position error of an autonomous underwater vehicle (AUV) near the sea floor. AUVs generally have an inertial navigation system assisted with auxiliary navigational sensors. Since the inertial navigation system shows drift in position without the bottom reflection of a Doppler velocity log, external acoustic positioning systems, such as an ultra short baseline (USBL), are needed to set the position without surfacing the AUV. The main concept of the correction method is as follows: when the AUV arrives near the sea floor, the vehicle moves around horizontally in a circular mode, while the USBL transceiver installed on a surface vessel measures the AUV's position. After acquiring one data set, a least-square curve fitting method is adopted to find the center of the AUV's circular motion, which is transferred to the AUV via an acoustic telemetry modem (ATM). The proposed method is robust for the outlier of USBL, and it is independent of the time delay for the data transfer of the USBL position with the ATM. The proposed method also reduces the intrinsic position error of the USBL, and is applicable to the in-situ calibration as well as the initialization of the AUVs' position. Monte Carlo simulation was conducted to verify the effectiveness of the method.

• Korean Journal of Head & Neck Oncology
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• v.27 no.1
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• pp.27-31
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• 2011

Purpose : Anterolateral thigh and radial forearm flap is the most important fasciocutaneous flap widely used for reconstruction of tongue. One important purpose of flap is replacing the volume of tongue but still there is no data about the surface area and volume to be reconstructed after glossectomy. In this paper, surface area and volume is estimated from the 3-dimensionally reconstructed MRI images to see which flap is more ideal and to give the reference value for reconstruction. Materials and Methods : With coronal MRI image, tongue including only the intrinsic muscle is delineated in every section and reconstructed 3-dimensionally and calculated the volume and surface area to be reconstructed according to the degree of glossectomy. This volume and surface area was compared with the volume of anterolateral thigh and radial forearm flap. Results : The volume and surface area to be reconstructed in hemiglossectomy was $39.0{\pm}4.0cm^3$ and $31.8{\pm}2.7cm^2$ respectively. The average thickness of anterolateral thigh flap is $9.4{\pm}2.8mm$ and that of radial forearm is $3.8{\pm}1.0mm$. Comparing the curve of tongue surface area and volume with the volume of flap, the anterolateral thigh flap has more ideal volume to replace the defect. Conclusions : The surface area and volume requested for reconstruction could be suggested and the anterolateral thigh flap has more ideal volume for reconstruction of glossectomy defect.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2962-2968
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• 2009

The photodissociation dynamics of 1,2-bromochloroethane ($C_2H_4BrCl$) was investigated near 234 nm. A two-dimensional photofragment ion-imaging technique coupled with a [2+1] resonance-enhanced multiphoton ionization scheme was utilized to obtain speed and angular distributions of the nascent Br($^2P_{3/2}$) and Br${\ast}($^2P_{1/2}$) atoms. The total translational energy distributions for the Br and Br${\ast}$ channels were well characterized by Gaussian functions with average translational energies of 100 and 84 kJ/mol, respectively. The recoil anisotropies for the Br and Br${\ast}$ channels were measured to be ${\beta}$ = 0.49 ${\pm}$ 0.05 for Br and 1.55 ${\pm}$ 0.05 for Br${\ast}$. The relative quantum yield for Br${\ast}$ was found to be ${\Phi}_{Br{\ast}}$ = 0.33 ${\pm}$ 0.03. The probability of nonadiabatic transition between A' states was estimated to be 0.46. The relevant nonadiabatic dynamics is discussed in terms of interaction between potential energy surfaces in Cs symmetry.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.9
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• pp.62-68
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• 2008

This paper describes the electrical characteristics of ZnO surge arresters associated with the variation of surrounding conditions. To investigate the deterioration behaviors of ZnO surge arresters due to lightning surges, 8/20[${\mu}s$], 2.5[kA] impulse currents were injected to the ZnO surge arrester under test. The leakage currents of ZnO surge arrester subject to power frequency AC voltage were measured in different surrounding temperature and wet conditions. As a result, it was found that the leakage current is increased and its asymmetry is pronounced as the number of injection of the impulse current and the ambient temperature increase. Also, in the wet test the outside leakage current flowing through the housing surface of the ZnO surge arrester is much larger than the intrinsic leakage current of ZnO surge arrester element. The results obtained in this work can be a lied as factors of improving the reliability and performance of monitoring system for surge arresters.

• Journal of Yeungnam Medical Science
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• v.37 no.2
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• pp.106-111
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• 2020

Background: Fever is a common cause of pediatric consultation in the emergency department. However, identifying the source of infection in many febrile infants is challenging because of insufficient presentation of signs and symptoms. Meningitis is a critical cause of fever in infants, and its diagnosis is confirmed invasively by lumbar puncture. This study aimed to evaluate potential laboratory markers for meningitis in febrile infants. Methods: We retrospectively analyzed infants aged <3 months who visited the emergency department of our hospital between May 2012 and May 2017 because of fever of unknown etiology. Clinical information and laboratory data were evaluated. Receiver operating characteristic (ROC) curves were constructed. Results: In total, 145 febrile infants aged <3 months who underwent lumbar punctures were evaluated retrospectively. The mean C-reactive protein (CRP) level was significantly higher in the meningitis group than in the non-meningitis group, whereas the mean white blood cell count or absolute neutrophil count (ANC) did not significantly differ between groups. The area under the ROC curve (AUC) for CRP was 0.779 (95% confidence interval [CI], 0.701-0.858). The AUC for the leukocyte count was 0.455 (95% CI, 0.360-0.550) and that for ANC was 0.453 (95% CI, 0.359-0.547). The CRP cut-off value of 10 mg/L was optimal for identifying possible meningitis. Conclusion: CRP has an intrinsic predictive value for meningitis in febrile infants aged <3 months. Despite its invasiveness, a lumbar puncture may be recommended to diagnose meningitis in young, febrile infants with a CRP level >10 mg/L.

• Geomechanics and Engineering
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• v.33 no.1
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• pp.11-18
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• 2023

This study explores a new energy partitioning approach to determine the fracture toughness of 3-D printed pristine/recycled high density polyethylene (HDPE) blends employing the essential work of fracture (EWF) concept. The traditional EWF approach conducts a uniaxial tensile test with double-edge notched tensile (DENT) specimens and measures the total energy defined by the area under a load-displacement curve until failure. The approach assumes that the entire total energy contributes to the fracture process only. This assumption is generally true for extruded polymers that fracture occurs in a material body. In contrast to the traditional extrusion manufacturing process, the current 3-D printing technique employs fused deposition modeling (FDM) that produces layer-by-layer structured specimens. This type of specimen tends to include separation energy even after the complete failure of specimens when the fracture test is conducted. The separation is not relevant to the fracture process, and the raw experimental data are likely to possess random variation or noise during fracture testing. Therefore, the current EWF approach may not be suitable for the fracture characterization of 3-D printed specimens. This paper proposed a new energy partitioning approach to exclude the irrelevant energy of the specimens caused by their intrinsic structural issues. The approach determined the energy partitioning location based on experimental data and observations. Results prove that the new approach provided more consistent results with a higher coefficient of correlation.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2A
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• pp.187-196
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• 2008

The punching shear strength of RC slabs is estimated analytically by the simple truss model. To avoid intrinsic difficulties in punching shear analysis of reinforced concrete slabs, the slabs were divided into three sub-structures as the punching cone and the remaining parts. The strength of the punching cone was evaluated by the stiffness of inclined strut. The stiffness of springs which control lateral displacement of the roller supports consists of the steel reinforcement which passed through the punching cone. Initial angle of struts was determined by curve fitting method of the experimental data with variable reinforcement ratio in order to compensate for uncertainties in the slab's punching shear, the simplification errors and the stiffness of the remaining sub-structures. The validity of computed punching shear strength by simple truss model was shown by comparing with experimental results. The punching shear strength, which was determined by snap-through critical load of shallow truss, can be used effectively to examine punching shear strength of RC slabs.

• Journal of the Korean Geotechnical Society
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• v.18 no.4
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• pp.295-307
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• 2002

In the Nakdong River plain a very thick clayey soils are covered widely. Since the early 1990's, some huge reclamation projects have been performed for the development of industrial and residential complexes and so on. Despite a large number of soil investigations have been carried out for the projects, the geotechnical properties have never been elucidated well, so that the settlements of the ground due to the mischaracterized properties were greatly underestimated. Therefore, it has been needed to evaluate definitely the characteristics of the clayey soils, particularly for the compressibility characteristics to help understand the settlement behavior. For the compressibility characteristics of the Pusan clays, physical index and consolidation tests were conducted on the reconstituted and undisturbed samples. Using the result of physical index, the Pusan clays could be divided into two different units, which have different depositional environments. According to the concepts of Burland (1990) and Nagaraj et. al. (1990), the intrinsic state line and field compression curve of the Pusan clays could be established. It could be found from their concepts that the Pusan clays are under the cemented and young normally consolidated state and largely consisted of two units. The cementation of the clays was as well identified by compression index ratio (Tsuchida et. al.,1991) and sensitivity (Leroueil et. al.,1983).