• 제목/요약/키워드: Intrinsic Curve

검색결과 63건 처리시간 0.03초

부산점토 재성형 시료의 압축특성에 관한 연구 (The study for compressibility of reconsititued Busan clay)

  • 홍성진;이문주;최영민;김민태;이우진
    • 한국지반공학회:학술대회논문집
    • /
    • 한국지반공학회 2009년도 세계 도시지반공학 심포지엄
    • /
    • pp.1141-1146
    • /
    • 2009
  • The compressibility of clay has been expressed e-log p' graph. In natural clay, e-log p' graph are changed by deposition condition and chemical cementation as well as Atterberg limits, whereas in reconstituted clay, it is generally known that e-log p’ curve is varied with Atterberg limits. However, e-log p' graph is possible to change according to the reconstituting methods and test conditions. In this study, consolidation tests are performed as various test condition for reconstituted Busan clay. Test results show that the relationship e/$e_L$ and log p' is almost constant with $e_L$. And the compression index obtained from slurry method sample is larger than one obtained from kneading method sample. Intrinsic compression line (ICL) of Busan clay is identical with ICL suggested by Burland.

  • PDF

The Influence of Cimetidine on the Pharmacokinetics of Diltiazem and its Main Metabolite in Rabbits

  • Park, Jun-Shik;Burm, Jin-Pil
    • Archives of Pharmacal Research
    • /
    • 제27권2호
    • /
    • pp.254-258
    • /
    • 2004
  • The purpose of this study was to investigate the pharmacokinetic alteration of diltiazem and its main metabolite, deacetyldiltiazem, after oral administration of diltiazem in rabbits with or with-out cimetidine co-administration. The area under the plasma concentration-time curve (AUC) of diltiazem was significantly elevated in rabbits pretreated with cimetidine, suggesting that the oral clearance, an index of intrinsic clearance, may be decreased by the cimetidine treatment. Consistent with the increased AUC by the treatment, peak plasma concentration ($C_{max}$) for diltiazem was also elevated. Apparent volume of distribution normalized by the bioavailability (($V_{d}$/F) of diltiazem increased sigrificantly in rabbits pretreated with cimetidine increased. Taken together with the fact that the first pass metabolism for diltiazem is the primary determinant for the oral bioavailability, these observations indicate that increases in the oral clearance and (($V_{d}$/F may be a manifestation of the decreased first pass metabolism. Consistent with the hypothesis, the AUC of deacetyldiltiazem was significantly decreased in rabbits with cimetidine treatment. Ratio of deacetyldiltiazem to total diltiazem in the plasma was significantly decreased in rabbits with cimetidine treatment. These observations suggested that the metabolism of diltiazem to deacetyldiltiazem was reduced by cimetidine treatment and that the dosage of diltiazem should be adjusted when the drug is co-administered chronically with cimetidine in a clinical setting.

Effect of Uranyl Nitrate-Induced Acute Renal Failure on the Pharmacokinetics of Sulfobromophthalein in Rats

  • Park, Gun-Hwa;Shim, Chang-Koo
    • Archives of Pharmacal Research
    • /
    • 제13권3호
    • /
    • pp.233-239
    • /
    • 1990
  • The efect of acute renal failure (ARF) on the pharmacokinetics o sulfobromophthalein (BSP) was investigated in order to elucidate if renal failure modifies the hepatic metabolism of drugs. ARF was induced by intravenous (iv) injection of uranyl nitrate (UN) to rats (5 mg/kg) five days before the experiment. Area under the plasma concentration-time curve (AUC)of BSP after portal vein (pv) injection increased by 2-fold and total body clearance ($CL_1$) decreased one half (p <0.01) in UN-induced ARF (UN-ARF) rate compared to the control rats. But the plasma disappearance of BSP after iv injection did not differ significantly between control and UN-ARF rats. Since BSP is excreted via the liver, $CL_1$ represented the approximate hepatic clearance of BSP. Therefore, the decrease in $CL_1$ represented the approximate hepatic clearance of BSP. Therefore, the decrease in $CL_1$ represents a decrease in hepatic intrinsic clearance ($CL_{int}$) for BSP since plasma free fraction ($f_p$) of BSP was not affected by UN-ARF. The content of hepatic cytoplasmic Y-protein, which catalyzes BSP-glutathione conjugation and limits the trasfer of BSP from blood to bile, increased significantly (p < 0.01), however its binding activity (BA) for BSP was decreased significantly (p <0.01) by UN-ARF. The decrease in $CL_{int}$might have some correlation with the changed characteristics of hepatic Y-protein, specifically its decreased BA for BSP.

  • PDF

광산란과 점성도법에 의한 폴리감마글루탐산 나트륨 염의 열분해 분석 (Analysis on Thermal Degradation of Poly($\gamma$-glutamic acid) Sodium Salt by means of Light Scattering and Viscometry)

  • 박일현;엄효상;권효리
    • 폴리머
    • /
    • 제33권5호
    • /
    • pp.501-508
    • /
    • 2009
  • 폴리감마글루탐산의 나트륨 염 (sodium salt of poly(${\gamma}$-glutamic acid))의 고체상과 용액상에서의 열분해 실험을 $57{\sim}120^{\circ}C$ 부근에서 실시하였고, 점성도법과 광산란법을 이용하여 분자량 감소 결과를 시간의 함수로 분석하였다. 고체상에서의 분해 결과는 사슬 절단 속도가 시간에 무관하게 일정하며, 사슬 내에서의 절단 위치 또한 무작위하다는 것을 보여주었다. 특히, 용액상에서의 시간에 따른 분해과정은 특성분해시간 $t^*$로 스케일링된 환산시간 $t/t^*$를 이용하여 분자량 또는 고유점성도를 도시할 경우 서로 다른 온도에서의 분해 과정은 하나의 표준곡선 위에 놓임을 알 수 있었다. 특히, 용액상에서의 분해곡선은 지수함수와 선형식의 합으로 표시할 수 있었으며 지수함수는 분해 초기에 뚜렷이 나타났다. 또한, 고체상 분해와 용액상 분해 모두 활성화 에너지는 $107{\sim}115$ kJ/mol로써 측정되었으며 문헌치와 좋은 일치를 보여준다.

방폭구조 ESD Detector 개발 및 본질안전 특성 분석에 관한 연구 (A Study on the Development of Explosion Proof ESD Detector and Intrinsic Safety Characteristics Analysis)

  • 변정환;최상원
    • 한국안전학회지
    • /
    • 제35권1호
    • /
    • pp.1-11
    • /
    • 2020
  • Article 325 (Prevention of Fire Explosion due to Electrostatic) of the Rule for Occupational Safety and Health Standard specifies that in order to prevent the risk of disasters caused by static electricity, fire, explosion and static electricity in the production process, However, in order to do this, it is absolutely necessary to use a pre-detection technology and a detector for antistatic discharge prediction, which is a precautionary measure by static electricity in a fire / explosion hazard place, but in Korea, And there is no technical standard for the application of the technology of the explosion proof structure of the related equipment. Research methods include domestic and overseas electrostatic discharge detection technology and literature investigation of related equipment explosion proofing technology, domestic and foreign electrostatic discharge detection device production and use situation investigation, advanced foreign technology data analysis and benchmarking. In particular, we sought to verify the results of empirical experiments using electrostatic discharge detection technology through sample purchase and analysis of related major products, development of optimization technology through prototype production, evaluation, and supplementation, and expert knowledge through expert consultation. The results of this study were developed and fabricated two prototypes of electrostatic discharge detector based on the technology / standard related to electrostatic discharge detection technology in Korea and abroad through development of electrostatic discharge detection technology and development and production of detector. In addition, based on the development of electrostatic discharge detection technology, we developed an intrinsic safety explosion proof ib class explosion proof technology applicable to the process of using and handling flammable gas and flammable liquid vapor and combustible dust. In the case of the over voltage and minimum voltage are supplied to the explosion-proof structure ESD detector, check the state of the circuit and the transient and transient currents generated by the coil and capacitor elements during the input and standby of the signal pulse voltage. Explosion-proof equipment-Part 11: Intrinsically safe explosion proof structure The comparative evaluation with the reference curve in Annex A of "i" confirms that the characteristics of the intrinsically safe explosion protection structure are met.

강우-지하수위 상관성 분석을 통한 사질토층의 수리전도도 산정 (Determination of Hydraulic Conductivities in the Sandy Soil Layer through Cross Correlation Analysis between Rainfall and Groundwater Level)

  • 박승혁;손두기;정교철
    • 지질공학
    • /
    • 제29권3호
    • /
    • pp.303-314
    • /
    • 2019
  • 얕은 대수층에서 매우 복잡한 함양과정을 거치는 지하수의 함양은 지표와 지하매질의 투수성에 의해 상당한 영향을 받는다. 투수성은 고유투수계수(intrinsic permeability)와 수리전도도(hydraulic conductivity)의 두 가지 개념으로 설명되며 이중 지표매질의 특성만으로 수리전도도를 구하려는 많은 연구가 이루어졌다. 본 연구에서는 경주지역 지하수기초조사에서 수행된 미고결퇴적물의 입도분포곡선과 강우-지하수위 교차상관분석을 토대로 회귀식을 사용하여 강우-지하수위 교차상관분석을 통한 수리전도도 산정식을 제안하고 실제현장에서 수행한 대수성 시험결과와 비교하여 그 적용성을 검토하였다. 그 결과 사질토 기반 충적층대수층에서 Zunker의 경험식에서 산정된 수리전도도와 강우-지하수위 최대 교차상관계수의 상관식이 자연로그형태로 증가하면서 결정계수 0.95 이상으로 매우 큰 상관성을 나타내었고 이 회귀식을 다른 관측공에 적용한 결과 실제 현장에서 수행한 대수성시험 결과와 평균제곱근오차가 2.83%로 나타나 강우-지하수위 모니터링 자료만으로 매우 신뢰할 만한 수리전도도를 추정할 수 있었다.

Gas Exchanges and Dehydration in Different Intensities of Conditioning in Tifton 85 Bermudagrass: Nutritional Value during Hay Storage

  • Pasqualotto, M.;Neres, M.A.;Guimaraes, V.F.;Klein, J.;Inagaki, A.M.;Ducati, C.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제28권6호
    • /
    • pp.807-815
    • /
    • 2015
  • The present study aimed at evaluating the intensity of Tifton 85 conditioning using a mower conditioner with free-swinging flail fingers and storage times on dehydration curve, fungi presence, nutritional value and in vitro digestibility of Tifton 85 bermudagrass hay dry matter (DM). The dehydration curve was determined in the whole plant for ten times until the baling. The zero time corresponded to the plant before cutting, which occurred at 11:00 and the other collections were carried out at 8:00, 10:00, 14:00, and 16:00. The experimental design was randomised blocks with two intensities of conditioning (high and low) and ten sampling times, with five replications. The high and low intensities related to adjusting the deflector plate of the free iron fingers (8 and 18 cm). In order to determine gas exchanges during Tifton 85 bermudagrass dehydration, there were evaluations of mature leaves, which were placed in the upper middle third of each branch before the cutting, at every hour for 4 hours. A portable gas analyser was used by an infrared IRGA (6400xt). The analysed variables were photosynthesis (A), stomatal conductance (gs), internal $CO_2$ concentration (Ci), transpiration (T), water use efficiency (WUE), and intrinsic water use efficiency (WUEi). In the second part of this study, the nutritional value of Tifton 85 hay was evaluated, so randomised blocks were designed in a split plot through time, with two treatments placed in the following plots: high and low intensity of cutting and five different time points as subplots: cutting (additional treatment), baling and after 30, 60, and 90 days of storage. Subsequently, fungi that were in green plants as well as hay were determined and samples were collected from the grass at the cutting period, during baling, and after 30, 60, and 90 days of storage. It was observed that Tifton 85 bermudagrass dehydration occurred within 49 hours, so this was considered the best time for drying hay. Gas exchanges were more intense before cutting, although after cutting they decreased until ceasing within 4 hours. The lowest values of acid detergent insoluble nitrogen were obtained with low conditioning intensity after 30 days of storage, 64.8 g/kg DM. The in vitro dry matter of Tifton 85 bermudagrass did not differ among the storage times or the conditioning intensities. There was no fungi present in the samples collected during the storage period up to 90 days after dehydration, with less than 30 colony forming units found on plate counting. The use of mower conditioners in different intensities of injury did not speed up the dehydration time of Tifton 85.

Growth curve estimates for wither height, hip height, and body length of Hanwoo steers (Bos taurus coreanae)

  • Park, Hu-Rak;Eum, Seung-Hoon;Roh, Seung-Hee;Sun, Du-Won;Seo, Jakyeom;Cho, Seong-Keun;Lee, Jung-Gyu;Kim, Byeong-Woo
    • 농업과학연구
    • /
    • 제44권3호
    • /
    • pp.384-391
    • /
    • 2017
  • Growth curves in Hanwoo steers were estimated by Gompertz, Von Bertalanffy, Logistic, and Brody nonlinear models using growth data collected by the Hanwoo Improvement Center from a total of 6,973 Hanwoo (Bos taurus coreanae) steers 6 to 24 months old that were born between 1996 and 2015. The data included three parameters: A, mature size of body measurement; b, growth ratio; and, k, intrinsic growth rate. Nonlinear regression equations for wither height according to Gompertz, Von Bertalanffy, Logistic, and Brody models were $Y_t=144.7e^{-0.5869e^{-0.00301t}}$, $Y_t=145.3(1-0.1816e^{-0.00284t})^3$, $Y_t=143.1(1+0.7356e^{-0.00352t})^{-1}$, and $Y_t=146.8(1+0.4700e^{-0.00249t})^1$, respectively, while those for hip height were $Y_t=144.5e^{-0.5549e^{-0.00312t}}$, $Y_t=145.0(1-0.1724e^{-0.00295t})^3$, $Y_t=143.1(1+0.6863e^{-0.00360t})^{-1}$, and $Y_t=146.2(1+0.4501e^{-0.00263t})^1$, respectively. Equations for body length $Y_t=174.1e^{-0.8342e^{-0.00289t}}$, $Y_t=175.8(1-0.2500e^{-0.00265t})^3$, $Y_t=170.0(1+1.1548e^{-0.00363t})^{-1}$, and $Y_t=180.3(1+0.6077e^{-0.00215t})^1$, respectively, for the same models. Among the four models, the Brody model resulted in the lowest mean square error, with mean square errors of 31.79, 30.57, and 42.13, respectively, for wither height, hip height, and body length. Also, an estimated birth wither height, birth hip height, and birth body length (77.98, 80.57, and 70.97 cm, respectively) were lower in the Brody model than in other models. An inflection point was not observed during the growth phase of Hanwoo steer according to the growth curves calculated using Gompertz, Von Bertalanffy, and Logistic models. Based on the results, we concluded that the regression equation using the Brody model was the most appropriate among the four growth models. To obtain more accurate parameters, however, using data from a wider production period (from birth to shipping) would be required, and the development of a suitable model for body conformation traits would be needed.

HeLa 세포의 Spheroid에 대한 방사선과 Platinum 유사체의 치사 효과 (Lethal Effects of Radiation and Platinum Analogues on Multicellular Spheroids of HeLa Cells)

  • 홍성언
    • Radiation Oncology Journal
    • /
    • 제7권2호
    • /
    • pp.149-156
    • /
    • 1989
  • HeLa 세포의 spheroid를 배 양시켜 cis-platinum과 carboplatin으로 처리한 후 그 반응을 세포의 생존분획으로 분석하였다. 체외실험 model인 spheroid를 사용하여 platinum유사체의 약효와 방사선 감수성을 평가하고 약제에 대한 단층 세포와 spheroid의 감수성 차이를 세포-생존곡선에서 규명하기 위하여 본 실험을 시행하였다. Cis-platinum 농도-곡선에서 spheroid의 $Cq=3.4{\mu}M$이고 $Co=1.2{\mu}M$이었다. 이 것은 단층세포에 비하여 Co는 큰 변화가 없으나 Cq가 증가되어 cis-platinum이 저산소층 세포보다 활동적으로 분화하는 표면세포에 주로 작용하였으며, 반대로 carboplatin의 효과는 spheroid에 대한 $(Co=15.0{\mu}M)$ 감수성이 단층세포$(Co=32.5{\mu}M)$에 비하여 크게 증가되어, spheroid의 심층 세포에 주로 작용하였다. 방사선과 carboplation의 병용효과를 세포 생존분획이 0.01 수준에서 isobologram으로 분석한 결과 상호작용으로 supra-additive 효과를 나타내었다. 따라서, carboplatin은 cis-platinum에 비하여 신장과 위장에 대한 독성작용이 적고, 방사선과 병용함으로써 향후 더욱 효과적 인 종양 치료에 중요한 역할을 할 것으로 기대한다.

  • PDF

반응표면분석법을 이용한 영구자석의 형상 및 특성에 따른 매입형 영구자석 동기기의 최적 설계 (Optimal Design of Interior Permanent Magnet Synchronous Machines Consideration of Magnet BH Characteristic with Different Rotor Type using Response Surface Methodology)

  • 임영훈;장석명
    • 전기학회논문지
    • /
    • 제62권8호
    • /
    • pp.1080-1089
    • /
    • 2013
  • Interior Permanent Magnet Synchronous Machines (IPMSMs) with rare earth magnet are widely used in electric vehicles and hybrid electric vehicles. IPMSMs having high efficiency, high torque, and a wide speed range are employed in propulsion system. And the rotor in an IPMSM is generally made of a rare earth magnet to achieve a large energy product and high torque. This paper discusses issues regarding design and performance of IPMSMs using different factors of BH magnetic characteristic. It is necessary to choose factors of magnetic material according to permanent magnet shape in rotor for high performance. Response Surface Methodology (RSM) is selected to obtain factors of magnetic material according to variety of rotor shapes. The RSM is a collection of mathematical and statistical techniques useful for the analysis of problems in which a response of interest in influenced by several variables and the objective is to optimize response. Therefore, it is necessary to analyze the torque characteristics of an IPMSM having magnet BH hysteresis curve with different rotor shape. Factors of residual flux density (Br) factor and intrinsic coercive force (Hc) are important parameters in RSM for rotor shape. The rotor shapes for IPMSMs having magnet BH characteristic were investigated using the RSM, and three shapes were analyzed in detail using FEA. The results lead to design consequence of IPMSMs in the various rare earth magnet materials.