• 복식
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• 제65권3호
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• pp.28-46
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• 2015

The aim of this research is to classify the concept expressed in the mobility of la diff${\acute{e}}$rant play, and supplement logic, which is process of the changeability of fashion style. The specific research questions are as follows: first question deals with the relationship between changeability and la diff${\acute{e}}$rant images, and how la diff${\acute{e}}$rant images are divided by each phase and how their circumduction play is proceeded. The second question is about the important features of the mobility of la diff${\acute{e}}$rant play and the method of la diff${\acute{e}}$rance play. The last topic of this study covers the supplement logic and the condition, and how supplement logic has been applied in the process of changeability of fashion style. This paper deploys a qualitative research method providing a systematic review of the previous studies. To sum it up, the mobility of la diff${\acute{e}}$rant play is the root of power, which is controlling the changeability of fashion style, and the objective of the play is to outline new la diff${\acute{e}}$rant images through spatialization of time. In addition, supplement logicis the method of la diff${\acute{e}}$rant play and the purpose of the logic is to harmonize 'ultimate la diff${\acute{e}}$rant image', which is the phenomenological construction stratum in the state of sub-conscious changeability, and 'immediate la diff${\acute{e}}$rant image', which is the structural construction level stratum in the state of external changeability. This research proves that the intrinsic attribute of changeability is contained the mobility of la diff${\acute{e}}$rant play and supplement logic.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 추계학술발표대회
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• pp.12.1-12.1
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• 2009

Nano-hydroxyapatite (N-HAp)has shown the pivotal role in producing bone-regenerative materials since it has similarity to natural bone minerals in terms of size, morphology, and the composition. Currently, the combination of biopolymers and N-HAp is recognizedas an attractive approach in generating hybrid scaffolds for bone tissueengineering. Surface engineering is an important issue since it determines whether cells can effectively adhere and proliferate on porous scaffolds. We aim to develop a synthetic approach to porous 3D scaffolds by immobilizing N-HAp on pore surfaces. The discrete nano-level anchoring of N-HAp on the scaffold pore surface is achieved using surface-repellent stable colloidal N-HAp with surface phosphate functionality. This rational surface engineering enables surface-anchored N-HAp to express its overall intrinsic bioactivity,since N-HAp is not phase-mixed with the polymers. The porous polymer scaffolds with surface-immobilized N-HAp provide more favorable environments thanconventional bulk phase-mixed polymer/N-HAp scaffolds in terms of cellular interaction and growth. In vitro biological evaluation using alkalinephosphatase activity assay supports that immobilized N-HAp on pore surfaces of polymer scaffolds contributed to the more enhanced in vitro osteogenicpotential. Besides, the scaffolds with surface-exposed N-HAp provide favorable environments for enhanced in vivo bone tissue growth, estimated by characteristic biomarkers of bone formation such as collagen. The results suggest that newly developed hybrid scaffolds with surface-immobilized N-HApmay serve as a useful 3D substrate with pore surfaces featuring excellent bonetissue-regenerative properties. Acknowledgement. This research was supported by a grant (code #: 2009K000430) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Education, Science and Technology, Korea.

• 한국과학교육학회지
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• 제33권3호
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• pp.581-596
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• 2013

The aim of this study was to identify students' views on the orientation of science and to investigate the relationship between their views and decision-making on socio-scientific issues (SSI). In this study, 27 university students attending a science course were asked to discuss four controversial issues: the Toyota recall, the green car, the global warming and swine influenza (influenza A (H1N1)). The study was comprised of two stages. At the first stage, we examined students' views on the nature of science and on the orientation of science with the open-ended questionnaire based on VNOS and VOSTS. While they held relatively similar views on the nature of science, their views on the orientation of science were distinct as pragmatic, intrinsic, communal and ethical views. At the second stage, to examine the role of their views on the orientation of science in decision-making, we selected four students who had similar views on NOS but different views on the orientation of science. The four students were selected from each group of views on the orientation of science and their decision-making processes were analyzed following grounded theory. Across SSIs, they relied upon their views on the orientation of science as the strategies for decision, though considered different perception, and causal and contextual conditions. This study indicates that understanding students' views on the orientation of science would be helpful for achieving scientific literacy for informed decision.

• The Korean Journal of Physiology and Pharmacology
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• 제24권3호
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• pp.249-257
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• 2020

The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by the expression of cholesterol-25-hydroxylase (CH25H) under inflammatory conditions. Interleukin-1β induced the apoptosis of chondrocytes in a dose- dependent manner. Furthermore, the production of 25-HC increased in the chondrocytes treated with interleukin-1β through the expression of CH25H. 25-HC decreased the viability of chondrocytes. Chondrocytes with condensed nucleus and apoptotic populations increased by 25-HC. Moreover, the activity and expression of caspase-3 were increased by the death ligand-mediated extrinsic and mitochondria-dependent intrinsic apoptotic pathways in the chondrocytes treated with 25-HC. Finally, 25-HC induced not only caspase-dependent apoptosis, but also induced proteoglycan loss in articular cartilage ex vivo cultured rat knee joints. These data indicate that 25-HC may act as a metabolic pathophysiological factor in osteoarthritis that is mediated by progressive chondrocyte death in the articular cartilage with inflammatory condition.

• Steel and Composite Structures
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• 제28권5호
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• pp.617-628
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• 2018

Steel shear wall possesses priority over many of the current lateral load-bearing systems due to reasons like higher elastic stiffness, desirable ductility and energy absorption, convenience in construction and implementation technology, and economic criteria. Besides these advantages, this system causes increase in the dimensions of other structural elements due to its high stiffness as one of its intrinsic characteristics. One of the methods for stiffness reduction is perforating the wall panel and creating openings in the wall that can also be used as windows or ducts in buildings service period. The aim of the present study is probing the appropriate geometric shape and location of opening to fulfil economic criterion plus technical and seismic design criteria. In the present research, a number of possible while reasonable opening shapes and locations are defined in various sizes for some steel shear wall specimens. The specimens are modelled in ABAQUS finite elements software and analyzed using nonlinear pushover analysis. Finally, the analyses' results are reported as force-displacement diagrams and the strength, the initial stiffness and the energy absorption are calculated for all specimens and compared together. The obtained results show that both shape and location of the openings affect the seismic parameters of the shear wall. The specimens in which the openings are further from the center and closer to the columns possess higher stiffness and strength while the specimens in which the openings are closer to the center show more considerable changes in their seismic parameters in response to increase in opening area.

• 한국언어정보학회지:언어와정보
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• 제14권2호
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• pp.71-84
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• 2010

The aim of this paper is to propose that a category P is encapsulated within a functional layer above the lexical layer, just like vP containing a lexical VP. As is well known, the category P has long been in the obscure domain of syntactic studies: Marantz (2001) and den Dikken (2003), for example, argue that P is a lexical category, but Emonds (1985), Grimshaw (1991), and Baker (2003), maintain that the category P is functional and is a closed category without its own intrinsic meaning. On the other hand, Zwart (2005) argues that it does have some meaning. Following the works of Svenonius (2003, 2006, 2007), and the spirit of Rizzi's (1997) split CP hypothesis, we elaborate and develop Svenonius' idea of split-pP analysis with detailed schematic representations of the novel examples in English, Korean, and Chinese in this paper. Unlike Svenonius, however, this paper incorporates KP into pP-Shell, which is a substantial simplification. Furthermore, Chinese Localizers that have long been considered as Postpositions are now under the category of Prepositions. This proposal renders an X-bar theoretic consistency over the categorical status of Chinese phrasal structures. In short, the present analysis accounts for inconsistency found in English complex preposition phrase (Quirk, et al, 1972, 1985), Chinese circumposition phrase (Ernst 1988, Liu, 2002) and Korean postposition phrase in a unified and consistent manner. Furthermore, by proposing a finer-grained phrasal architecture for the category P, the controversial status of the category subsides within this analysis.

• 한국인구학
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• 제24권2호
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• pp.5-45
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• 2001

인구와 환경은 생태계의 기본 요소를 구성하고 있으며, 따라서 이 둘의 연관성은 기본적인 생태학적 전제의 하나로 되어있다. 그러나 이들의 관계에 대한 연구는 매우 제한되어 있다. 최근 인구의 환경 영향에 대한 관심이 늘고 있으나, 그 논의는, 선진국에서조차, 매우 초보적인 단계에 머물러 있는 실정이다. 이는 주로 환경의 개념적 정의의 어려움, 환경자료의 부족, 이로 인한 분석적 연구모형 개발의 어려움에 기인한다. 우리나라의 경우 그 한계는 더욱 분명하다. 따라서 이 연구는 생태학적인 관념을 기초로 20세기 우리 나라가 경험한 인구변동이 환경의 파괴와 훼손에 어떻게 연관되었는지를 탐색하는데 그 의의를 두고 있다. 먼저 논의와 관련된 기본적인 이론적 전망을 조망하고, 다음 인구변동의 내용을 살피고, 그 가운데 인구성장과 도시화를 중심으로 인구의 환경적 의미를 다양하게 짚어보고 있다. 정부의 환경통계는 매우 제한되어 있고 그 내용도 커다란 한계를 가지고 있다. 따라서 이 연구에서는 정부 통계 이외에 1990년 이후의 신문보도 자료를 참고로 사용하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5127-5132
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• 2016

Objective: The aim of this study was to identify associations of internal motivation, perceived health competency, and health literacy with primary and secondary cancer prevention. Methods: A telephone survey was conducted with a sample of 2,700, 30-69 year olds, proportionally extracted from Gangwon Province, South Korea. The dependent variables were actions in primary and secondary prevention and the explanatory variables were 13 questions in three areas: internal motivation (4 items), perceived health competency (4 items), and health literacy (5 items). Result: Multiple linear regression analysis showed that internal motivation, perceived health competency, and health literacy positively impacted primary prevention after controlling for gender and age. As internal motivation, perceived health competency, and perceived literacy increased by 1 point, primary prevention scores increased by 0.11, 0.11, and 0.07 points, respectively. In addition, logistic regression results for secondary prevention showed that health literacy had a positive impact on secondary behavior. As health literacy increased by 1 point, the odds ratio of the practice of secondary prevention was 1.4 times higher. Conclusion: This study suggests that primary and secondary prevention of cancer are significantly related to intrinsic motivation factors, perceived health competency, and actual health literacy. Health literacy concepts that cover the capacity of health management in comprehensive areas need to be applied to education and promotion for improvement of primary and secondary prevention of cancer.

• 한국초지조사료학회지
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• 제34권3호
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• pp.169-173
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• 2014

The aim of present study was to improve the quality of silage using lactic acid bacteria (LAB) and chlorella as a supplement. Italian ryegrass (IRG) mediated silage was prepared with lactic acid bacteria (L. plantarum) and different concentration of chlorella. We analyzed the nutritional profiles such as crude protein (CP), acid detergent fiber (ADF) neutral detergent fiber (NDF), total digestible nutrient (TDN) and in-vitro dry matter digestibility (IVDMD), microbial counts and fermentative acids such as lactic acid, acetic acid and butyric acid in the control and experimental silage after three months. It shows increased crude protein content and also maintains the rest of nutritional values as compared with control silage. LAB inoculation with chlorella as supplementation slightly reduced the pH of the silage. In addition, it increased the fermentative acids production as compared with control silage and inhibits the undesired microbial growth especially fungi in the silage. Therefore, we suggest that LAB inoculation and chlorella supplementation to the IRG mediated silage could be improved the nutritional quality of the silage which is an intrinsic feature for the application in the preparation of animal feeds and functional foods.

• Nutrition Research and Practice
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• 제11권2호
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• pp.97-104
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• 2017

BACKGROUND/OBJECTIVE: Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS: AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP. The protective effects of AK-Ex against AAP-induced hepatotoxicity in HepG2 and HepaRG cells were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, lactate dehydrogenase (LDH) assay, flow cytometry, and Western blotting. RESULTS: AK-Ex, when administered prior to AAP, increased cell growth and decreased leakage of LDH in a dose-dependent manner in HepG2 and HepaRG cells against AAP-induced hepatotoxicity. AK-Ex increased the level of Bcl-2 and decreased the levels of Bax, Bok and Bik decreased the permeability of the mitochondrial membrane in HepG2 cells intoxicated with AAP. AK-Ex decreased the cleavage of poly (ADP-ribose) polymerase (PARP) and the activation of caspase-9, -7, and -3. CONCLUSIONS: These results demonstrate that AK-Ex downregulates apoptosis via intrinsic and extrinsic pathways against AAP-induced hepatotoxicity. We suggest that AK could be a useful preventive agent against AAP-induced apoptosis in hepatocytes.