• 제목/요약/키워드: Intravenous anesthesia

검색결과 223건 처리시간 0.027초

개에서 Remifentanil과 Propofol에 의한 완전 정맥 내 마취 시 Doxapram 투여가 심폐기능에 미치는 효과 (The Effect of Doxapram on Cardiopulmonary Function in Dogs under Total Intravenous Anesthesia with Remifentanil and Propofol)

  • 윤성호;권영삼
    • 한국임상수의학회지
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    • 제32권6호
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    • pp.491-498
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    • 2015
  • 개에서 remifentanil과 propofol을 사용한 완전 정맥내 마취에서 doxapram의 점적투여가 심폐기능에 미치는 영향에 대해 평가해 보았다. 수컷 비글견 15마리를 사용하였으며 무작위로 5마리씩 3군으로 나누었다. 모든 군에서 전 마취제로 medetomidine을 $20{\mu}g/kg$ 정맥주사 하였고 remifentanil과 propofol의 점적 투여로 1시간 30분 동안 마취하였다. 마취 시작 시, 각 그룹 별로 지정된 용량의 doxapram을 병용 투여하였다. D1 군은 doxapram 0.25 mg/kg을 투여한 후 $8.33{\mu}g/kg/min$의 속도로 점적 투여했다. D2 군은 doxapram 2 mg/kg을 투여한 후 $66.66{\mu}g/kg/min$의 속도로 점적 투여했다. 대조군은 생리 식염수를 투여하였다. 외과적 마취기를 평가하고, 혈액 가스 분석, 호흡수, 심박수, 동맥혈압을 측정하였으며 마취회복기 동안의 행동변화를 관찰 기록하였다. 외과적 마취기는 마취기 전반에 걸쳐 모든 군에서 잘 유지되었다. 대조군에 비해 D2 군에서 호흡수의 유의적인 상승이 있었으며 (p < 0.05), 동맥혈 산소 분압과 산소 포화도에서는 doxapram 처치군 모두에서 대조군에 비해 유의적인 상승을 보였다(p < 0.05). 동맥혈 이산화탄소 분압은 고농도 처치 군인 D2군에서 유의적인 감소를보였다(p < 0.05). 수축기 동맥혈압, 이완기 동맥혈압, 평균 동맥혈압은 D2군에서 유의적인 증가를 보였다. 심박수와 pH는 유의적인 변화가 관찰되지 않았다. 따라서 본 실험을 통해 개에서 remifentanil과 propofol을 사용한 완전 정맥내 마취에서 일어날 수 있는 저산소증이나 저혈압과 같은 심폐 기능 저하를 doxapram의 점적 투여가 진통 작용에 경감 없이 완화 시키는 것을 알 수 있었다.

Intravenous contrast media application using cone-beam computed tomography in a rabbit model

  • Kim, Min-Sung;Kim, Bok-Yeol;Choi, Hwa-Young;Choi, Yoon-Joo;Oh, Song-Hee;Kang, Ju-Hee;Lee, Sae-Rom;Kang, Ju-Han;Kim, Gyu-Tae;Choi, Yong-Suk;Hwang, Eui-Hwan
    • Imaging Science in Dentistry
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    • 제45권1호
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    • pp.31-39
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    • 2015
  • Purpose: This study was performed to evaluate the feasibility of visualizing soft tissue lesions and vascular structures using contrast-enhanced cone-beam computed tomography (CE-CBCT) after the intravenous administration of a contrast medium in an animal model. Materials and Methods: CBCT was performed on six rabbits after a contrast medium was administered using an injection dose of 2 mL/kg body weight and an injection rate of 1 mL/s via the ear vein or femoral vein under general anesthesia. Artificial soft tissue lesions were created through the transplantation of autologous fatty tissue into the salivary gland. Volume rendering reconstruction, maximum intensity projection, and multiplanar reconstruction images were reconstructed and evaluated in order to visualize soft tissue contrast and vascular structures. Results: The contrast enhancement of soft tissue was possible using all contrast medium injection parameters. An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning. Artificial soft tissue lesions were successfully created in the animals. The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures. Conclusion: Despite limited soft tissue resolution, the opacification of vascular structures was observed and artificial soft tissue lesions were visualized with sufficient contrast to the surrounding structures. The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

구강 내 소수술에 있어 Midazolam을 이용한 의식하진정 치료원칙 (Conscious Sedation Protocol with Midazolam in Minor Oral Surgery)

  • 김성민;김지혁;박영욱;장재현;권광준;김세정;남대우;권기열
    • 대한치과마취과학회지
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    • 제3권1호
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    • pp.19-27
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    • 2003
  • Background: Conscious sedation is a minimally depressed level of consciousness that retains the patient's ability to maintain the airway continuously and to respond appropriately to physical stimulation and verbal command at any time, produced by a pharmacologic or nonpharmacologic method or a combination thereof. In dental anesthesia, a state of sedation in which the conscious patient is rendered free of fear, apprehension, and anxiety through the use of pharmacologic agents. Midazolam is a useful drug of benzodiazepine on minor operation of dentistry. The purpose of this study is to estimate the appropriate dosage protocol of midazolam to the patient receiving intravenous sedation at the department of oral and maxillofacial surgery. Methods: Total subject was fifty-one patients and fifteen patients of this subject were decided to control group (Group I) that they were not received intravenous sedation. The experimental group was randomly subdivided into two groups and each of those groups was administrated to 0.05 mg/kg (Group II) and 0.08 mg/kg (Group III) each other. All patients of the subject were surveyed with postoperative one day questionaire to evaluate the level of sedation. Results: In view of antegrade amnesia, 1. Group II and III were statistically different compared to Group 1, respectively. 2. Group II and III were not statistically different. Conclusions: Apparent antegrade amnesia was found in both groups 0.05 mg/kg and 0.08 mg/kg intravenously administered. So we present the protocol of the department of oval and maxillofacial surgery, Kangnung National University Dental Hospital. But further studies concerning patient's age, body weight, and general condition will be carried out.

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실험적으로 전십자 인대를 단열한 개에서 TPLO의 핵의학적 평가 (Scintigraphic Evaluation of Dogs with Experimentally Transected Cranial Cruciate Ligaments Treated Using Tibial Plateau Leveling Osteotomy)

  • 이재영;김중현;이원국;강성수;배춘식;최석화
    • 한국임상수의학회지
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    • 제22권1호
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    • pp.21-25
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    • 2005
  • This study was performed to assess therapeutic effect of the tibial plateau leveling osteotomy (TPLO) in dogs with experimentally transected cranial cruciate ligaments (CrCL). Nine healthy adult Beagle dogs were transected left CrCL under general anesthesia. The dogs were assigned to TPLO and non-TPLO control groups. The TPLO procedures for correcting the CrCL rupture in the left stifle of dogs were performed under sterile conditions. Before TPLO procedures, all dogs were screened by orthopedic and radiographic examinations. Dogs were lameness free for the previous three months, and when examined at the walk and trot on a hard surface, in a straight line and on a circle. Lateral and craniocaudal radiographs were done to confirm the soundness of the both knee joint in dogs and not detectable lesions were diagnosed. The dogs were intravenously injected with a 10 mci/kg of 99mTechnetium-methylene diphosphonate (99mTc-MDP) under general anesthesia. Scintigraphs were obtained using a large field of view gamma camera equipped a parallel-hole, low-energy about 3 hours after intravenous injection of 99mTc-MDP. Before CrCL transection and 4, 8, and 12 weeks after the procedures, scintigraphy were conducted. Bone uptake of the left stifle joint increased after the procedures in all dogs. When the bone uptake from the TPLO procedure was compared with that of the control, there was a significant difference (p < 0.05). At 12 weeks after the TPLO procedure, the dogs showed normal anatomical posture and gait. It is concluded that TPLO procedure was effective in reconstruct of the stifle joint in dogs with CrCL rupture.

급성 술후 통증 조절을 위한 경막외차단 2,381예의 임상적 평가 (A Clinical Assessment of Epidural Block for Acute Postoperative Pain Control in 2,381 Cases)

  • 장문석;채병국;이혜원;임혜자;장성호
    • The Korean Journal of Pain
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    • 제8권2호
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    • pp.235-243
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    • 1995
  • A retrospective study was performed to evaluate the effects, and side effects, of epidural analgesia for postoperative pain relief of 2,381 surgical patients who received general-epidural, or epidural anesthesia only. Anesthesia records, patients charts, and pain control records were reviewed and classified according to: age, sex, body weight, department, operation site, epidural puncture site, degree of pain relief by injection mode & epidural injectate, and side effects(including nausea, vomiting, pruritus, urinary retention and respiratory depression). The results were as follows: 1) From the total of 2,381 patients, there were 1,563(66%) female patients; 1.032(43%) patients were from Obstetrics and Gynecology. 2) Lower abdomen, thorax, lower extremity and upper abdomen in the operation site; and lumbar, upper, lower thoracic in puncture site were order of decreasing frequency. Length of epidural injection for pain relief averaged $1.72{\pm}1.02$ days. 3) Ninety three percent of the patients experienced mild or no pain in the postoperative course. Analgesic quality was not affected by the kind of epidural injectate. 4) Nausea occurred in 3.2% of all patients, vomiting in 1.1%, pruritus 0.9%, urinary retention 0.6%, respiratory depression 0.08%. 5) Frequency of nausea was higher with female patients compared to male patients(p<0.05). 6) Pruritus frequency was higher with male patients than female patients(p<0.05); and more frequent with patients who received epidural injection with morphine than patients who received epidural injection without morphine(p<0.01). 7) Urinary retention was higher in female patients, and more frequent with patients who had received epidural injection with morphine than epidural injection without morphine(p<0.05). 8) There were two cases of respiratory depression. The course of treatment consisted of: cessation of epidural infusion, then administration of oxygen and intravenous naloxone. We conclude that postoperative epidural analgesia with a combination of local anesthetics and opiate is and effective method for postoperative pain relief with low incidence of side effects. However, patients should be carefully evaluated as rare but severe complications of respiratory depression may ensue.

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내측 개방 근위 경골 절골술 후 통증 조절에서 관절 주위 다중 약물 국소 주사와 내전근관 차단술의 효과 비교 (Comparison of the Effects of an Adductor Canal Block and Periarticular Multimodal Drug Local Injection on Pain after a Medial Opening High Tibial Osteotomy)

  • 김옥걸;김도훈;서승석;이인승
    • 대한정형외과학회지
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    • 제54권2호
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    • pp.120-126
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    • 2019
  • 목적: 내측 개방 근위 경골 절골술 후 통증 조절에서 관절 주위 다중 약물 국소 주사와 내전근관 차단술의 효과를 비교하고자 하였다. 대상 및 방법: 2016년 11월부터 2017년 3월까지 개방형 내측 근위 경골 절골술을 시행한 환자 60명을 대상으로 하여 후향적으로 분석하였다. 전 예에서 척추 마취를 시행하였으며, 수술 직전 선제 약물 투여 후 정맥내 자가 통증 조절 장치를 시행하였다. 30명의 환자(I군)는 관절 주위 다중 약물 국소 주사를 맞았고, 다른 30명의 환자(II군)는 내전근관 차단술을 시행 받았다. 두 그룹에 대해 수술 후 통증 수준, 추가적인 tramadol hydrochloride 주사의 빈도, 자가 통증 조절 장치 사용 총량 및 버튼을 누른 횟수 등을 비교하였다. 결과: 수술 후 2주째까지 시각통증점수(visual analogue scale)는 두 군 간에 유의한 차이를 보이지 않았다. 추가 tramadol hydrochloride 주사의 빈도는 두 군 간에 유의한 차이가 없었다. 자가 통증 조절 장치 버튼을 누르는 횟수와 평균 총 fentanyl 소비량에서도 그룹 간에 유의한 차이가 없었다. 결론: 내측 개방적 근위 경골 절골술을 시행한 환자의 급성기 통증 조절에 있어서 관절 주위 다중 약물 주입 및 내전근관 신경 차단술은 비슷한 효과를 가지는 것으로 생각된다.

상지(上肢) 외전위(外轉位)에서 시행(施行)한 쇄골상(鎖骨上) 상완신경총차단(上腕神經叢遮斷) (Supraclavicular Brachial Plexus block with Arm-Hyperabduction)

  • 임권;임화택;김동권;박오;김성열;오흥근
    • The Korean Journal of Pain
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    • 제1권2호
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    • pp.214-222
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    • 1988
  • With the arm in hyperabduction, we have carried out 525 procedures of supraclavicular brachial plexus block from Aug. 1976 to June 1980, whereas block with the arm in adduction has been customarily performed by other authors. The anesthetic procedure is as follows: 1) The patient lies in the dorsal recumbent position without a pillow under his head or shoulder. His arm is hyperabducted more than a 90 degree angle from his side, and his head is turned to the side opposite from that to be blocked. 2) An "X" is marked at a point 1 cm above the mid clavicle, immediately lateral to the edge of the anterior scalene muscle, and on the palpable portion of the subclavian artery. The area is aseptically prepared and draped. 3) A 22 gauge 3.5cm needle attached to a syringe filled with 2% lidocaine (7~8mg/kg of body weight) and epineprine(1 : 200,000) is inserted caudally toward the second portion of the artery where it crosses the first rib and parallel with the lateral border of the muscle until a paresthesia is obtained. 4) Paresthesia is usually elicited while inserting the needle tip about 1~2 em in depth. If so, the local anesthetic solution is injected after careful aspiration. 5) If no paresthesia is elicited, the needle is withdrawn and redirected in an attempt to elicit paresthesia. 6) If, after several attempts, no paresthesia is obtained, the local anesthetic solution is injected into the perivascular sheath after confirming that the artery is not punctured. 7) Immediately after starting surgery, Valium is injected for sedation by the intravenous route in almost all cases. The age distribution of the cases was from 11 to 80 years. Sex distribution was 476 males and 49 females (Table 1). Operative procedures consisted of 103 open reductions, 114 skin grafts combined with spinal anesthesia in 14, 87 debridements, 75 repairs, i.e. tendon (41), nerve(32), and artery (2), 58 corrections of abnormalities, 27 amputations above the elbow (5), below the elbow (3) and fingers (17), 20 primary closures, 18 incisions and curettages, 2 replantations of cut fingers. respectively (Table 2). Paresthesia was obtained in all cases. Onset of analgesia occured within 5 minutes, starting in the deltoid region in almost all cases. Complete anesthesia of the entire arm appeared within 10 minutes but was delayed 15 to 20 minutes in 5 cases and failed in one case. Thus, our success rate was nearly 100%. The duration of anesthesia after a single injection ranged from $3\frac{1}{2}$ to $4\frac{1}{2}$, hours in 94% of the cases. The operative time ranged from 0.5 to 4 hours in 92.4% of the cases(Table 3). Repeat blocks were carried out in 33 cases when operative times which were more than 4 hours in 22 cases and the others were completed within 4 hours (Table 4). Two patients of the 33 cases, who received microvasular surgery were injected twice with 2% lidocaine 20 ml for a total of $13\frac{1}{2}$ hours. The 157 patients who received surgery on the forearms or hands had pneumatic tourniquets (250 torrs) applied without tourniquet pain. There was no pneumothorax, hematoma or phrenic nerve paralysis in any of the unilateral and 27 bilateral blocks, but there was hoarseness in two, Horner's syndrome in 11 and shivering in 7 cases. No general seizures or other side effects were observed. By 20ml of 60% urcgratin study, we confirm ed the position of the needle tip to be in a safer position when the arm is in hyperabduction than when it is in adduction. And also that the humoral head caused some obstraction of the distal flow of the dye, indicating that less local anesthetic solution would be needed for satisfactory anesthesia. (Fig. 3,4).

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개에서 트라마돌의 정맥투여가 아이소플루란의 최소폐포농도에 미치는 영향 (Effect of Intravenous Administration of Tramadol on the Minimum Alveolar Concentration of Isoflurane in Dogs)

  • 석성훈;박세진;이승용;진소영;김영기;황재민;이희천;연성찬
    • 한국임상수의학회지
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    • 제32권4호
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    • pp.308-312
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    • 2015
  • 본 연구는 개에서 트라마돌의 정맥투여가 아이소플루란의 최소폐포농도 ($MAC_{ISO}$)에 미치는 영향을 평가하기 위하여 수행되었다. 6마리의 암컷 저먼셰퍼드견이 본 실험에 사용되었다. 실험견의 마취유도는 안면마스크를 이용하여 시행되었으며 실험하는 동안 기계적 환기장치를 이용하여 호기말 이산화탄소 분압 ($P_{ET}CO_2$)을 35-45 mmHg로 유지하였다. 개에서 마취유도 후 45분이 경과한 다음 gross purposeful movement가 감지 될 때까지 후지 발가락을 클램핑하는 방법을 사용하여 baseline $MAC_{ISO}$ ($MAC_{ISO}B$) 측정을 시작하였다. $MAC_{ISO}B$가 결정된 후, 트라마돌 3 mg/kg을 투여하였고 뒤이어 2.6 mg/kg/h으로 지속점적투여 (CRI)를 실시하였다. CRI 시작 후 20분이 경과한 다음, 트라마돌 투여 후 $MAC_{ISO}$값 ($MAC_{ISO}T$) 측정을 시작하였다. 동맥혈압과 심박수는 지속적으로 기록하였고 $MAC_{ISO}B$$MAC_{ISO}T$의 결정 후 각각 20분간 평형기간이 경과한 다음 동맥혈가스분석을 실시하였다. $MAC_{ISO}B$$MAC_{ISO}T$는 각각 $1.33{\pm}0.04%$$1.23{\pm}0.04%$로 측정되었고 $MAC_{ISO}B$는 트라마돌 투여 후 $7.5{\pm}0.2%$의 유의적인 (P < 0.05) 감소효과를 나타냈다. 트라마돌 투여 후 심박수와 동맥혈압에서는 유의적인 변화가 나타나지 않았으며 동맥혈 가스분석 결과에서도 유의적인 차이가 없었다. 이상의 결과로 보아 개에서 아이소플루란을 이용한 전신마취 시 트라마돌의 투여는 심폐기능의 억압을 일으키지 않고 $MAC_{ISO}$값을 감소시켰으므로 마취의 안정성과 마취회복의 질을 향상시키는데 유용할 것으로 사료된다.

비글견에서 Propofol/Remifentanil과 Ketamine/Remifentanil을 사용한 완전 정맥 내 마취법의 비교 (Comparison between Propofol/Remifentanil and Ketamine/Remifentanil for TIVA in Beagle Dogs)

  • 최우식;장환수;박재순;윤성호;권영삼;장광호
    • 한국임상수의학회지
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    • 제28권5호
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    • pp.479-485
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    • 2011
  • 비글견에서 remifentanil/ketamine 점적 투여 병용마취법과 remifentanil/propofol 점적 투여 병용마취법이 심폐기능에 미치는 영향에 대하여 비교평가하였다. 14 마리의 비글견을 이용하였다. 실험견은 acepromazine (0.1 mg/kg, 피하)과 medetomidine (20 ${\mu}g$/kg, 정맥내)으로 전처치하고, Group P는 정맥 내 propofol 1 mg/kg, Group K는 정맥 내 ketamine 5 mg/kg으로 마취 유도 하고, 이 후 실험군별로 고정된 용량의 remifentanil (0.5 ${\mu}g$/kg/min)과 ketamine 0.1 mg/kg/min 또는 propofol 0.3 mg/kg/min을 3 시간 동안 투여하였다 (Group K와 Group P). 동맥혈압, 심박수, 호흡 수, 혈액가스분석과 마취회복기 동안의 행동변화를 측정하였다. 또한 toe-web clamping 검사를 통해 마취 깊이를 평가하였다. 외과적 마취기는 두 군 모두에서 전 시간 동안 유지가 되었다. Group K의 수축기 동맥혈압, 평균 동맥혈압, 동맥산소 분압, 동맥 산소 포화도는 Group P에 비해 정상 범위 내에서 현저히 높았으며 Group K의 이산화탄소 분압은 Group P에 비해 현저히 낮았다. 그러나 이완기 동맥혈압, 심박수, 호흡수에서는 현저한 차이가 없었다. 점적투여 중단시점부터 발관까지의 평균시간은 Group K에서 현저히 감소되었지만, 평균 sitting time은 Group P에서 현저히 감소되었다. 평균 head-up time과 평균 walking time은 현저한 차이가 없었다. Group K에서는 약간의 근강직, 머리 흔듬, 혀로 핥는 동작이 회복기에 관찰되었다. 결론적으로, Group K가 Group P보다 심폐 기능에서 더 좋았다. 즉, remifentanil/ketamine을 이용한 점적투여 병용마취법이 remifentanil/propofol을 이용한 점적투여 병용마취법 보다 3 시간의 마취 유지에서 보다 나은 방법으로 판단되었다.

흉터성 눈썹소실환자에 실시한 단일모 이식술 (Single Hair Transplantation for Cicatrical Eyebrow Alopecia)

  • 최원석;석정훈;김태범;양완석
    • Archives of Plastic Surgery
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    • 제34권5호
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    • pp.647-652
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    • 2007
  • Purpose: Single hair transplantation for eyebrow loss has been considered as a good method of achieving natural appearance of eyebrow. To date, however, no study has reported the survival rate following single hair transplantation for cicatricial eyebrow alopecia. Methods: We performed single hair transplantation using Choi hair transplanter for 49 cases of scarring eyebrow loss from March 2003 to March 2006. Of these cases, 33 could be under a follow-up postoperatively for more than seven months. These 33 cases comprised 20 men and 13 women. Mean follow-up period was 12 months (7-36 months). In 17 patients(51.5%), 100 to 200 hairs were unilaterally transplanted. Results: Following initial hair transplantation, the surgical outcome was excellent in 11 cases(33.3%), good in 12 cases(36.4%), fair or poor in the remaining ten cases(30.3%). All procedures were done under intravenous sedation and local or regional block anesthesia. It took about one and a half hours for us to transplant 200 hairs. The shape of eyebrow was aesthetically acceptable with a good direction and an ideal inclination of hairs. No patients developed notable complications, while 30 percent had a low survival rate. Conclusion: Single hair transplantation using Choi hair transplanter is a safe, effective surgical method for scarring eyebrow loss.