• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2001년도 춘계학술발표회요약집
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• pp.444.1-444
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• 2001

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4459-4459
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• 2013

• 한국전자현미경학회:학술대회논문집
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• 한국현미경학회 1992년도 제23회 학술대회 연제 초록
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• pp.23-23
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• 1992

• Korean Circulation Journal
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• 제54권2호
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• pp.110-112
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• 2024

• The Korean journal of internal medicine
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• 제39권1호
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• pp.198-199
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• 2024

• Archives of Pharmacal Research
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• 제10권1호
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• pp.42-49
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• 1987

This study is to evaluate the potential use of aclarubicin-loaded gelatin microspheres as an intravascular biodegradable drug delivery system for the regional cancer therapy. The diameter of the microspheres prepared by water in oil emulsion polymerization could be controlled by adjusting the stirring rate in the range of 10-50 $\mu$m : D(in $\mu$m) = -73.8 log (rpm) + 262.7. The addition of proteolytic enzyme increased the in vitro aclarubicin release but it did not change the amount of the initial burst release which reached about 45%. Microspheres injected intravenously into the mouse tail vein embolized only to the lung when observed by fluorescence microscopy. From histological examination following injection of gelatin microspheres into mouse femoral muscle, mild inflammation was observed from the appearance of neutrophils after 2 days and rapid repair process was confirmed thereafter. Biodegradation process of gelatin microspheres lodged on the pulmonary capillary bed was followed up by microscopic observation; degradation was taking place by about 36 hrs, followed by severe damage on the spheerical shape and microspheres was no longer found 10 days after injection.

• Journal of Acupuncture Research
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• 제18권3호
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• pp.23-34
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• 2001

Objective : The purpose of this study was to investigate the effect of Intravascular Laser Irradiation of Blood(ILIB) by the live blood analysis. Methods : We had analysed the changing forms of the live blood samples with Ultra Darkfield Microscope before and after Intravascular Laser Irradiation of Blood. Results and Conclusion : 1. Nomal Erythrocytes were increased significantly after ILIB by the live blood analysis. 2. Poikilocytes were decreased significantly after ILIB by the live blood analysis. 3. Target Cells were decreased significantly after ILIB by the live blood analysis. 4. Somatid was improved significantly after ILIB by the live blood analysis. 5. Erythrocyte Aggregtion was improved significantly after ILIB by the live blood analysis.

• 대한의생명과학회지
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• 제11권1호
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• pp.23-29
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• 2005

Molecular imaging with targeted contrast agents enables tissues to be distinguished by detecting specific cell-surface receptors. In the present study, a ligand-targeted acoustic nanoparticle system is used to identify angioplasty-induced expression of tissue factor by smooth muscle cell within carotid arteries. Pig carotid arteries were overstretched with balloon catheters, treated with tissue factor-targeted or a control nanoparticle system, and imaged with intravascular ultrasound before and after treatment. Tissue factor-targeted emulsion bound and increased the echogenicity and gray-scale levels of overstretched smooth muscle cell within the tunica media, versus no change in contralateral control arteries. Expression of stretch-induced tissue factor in carotid artery media was confirmed by immunohistochemistry. The potential for abnormal thrombogenicity of balloon-injured arteries, as reflected by smooth muscle expression of tissue factor, was imaged using a novel, targeted, nanoparticulate ultrasonic contrast agent.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.79-83
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• 1997

A new computation algorithm to detect the intimal and adventitial contours from the intravascular images was developed. An image processing on gray level image was used. It uses arrays of pixels in each radial lines on the images. A Low-Pass filters was adopted at first step for one dimensional image processing. Some other calculations techniques were developed to increase the accuracy of automatically detected contours. The program implemented in C++ as a window95-base application.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1250-1253
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• 1992

A patient with intravascular hemolysis due to residual shunt and right ventricular outflow track obstruction after total correction of TOF was presented. The patient was 29 years old female. She underwented VSD closure with dacron patch, infundibulectomy, pulmonic valvotomy and direct closure of PFO. 8 months after the operation, severe intravascular hemolysis and hemolytic anemia appeared. Conservative therapies were not effective, her general condition and laboratory finding got worse gradually. She underwent reoperation, the shunt was closed and right ventricular outflow tract obstruction was corrected by pulmonary valvotomy, infudibulectomy and transannular patch. After operation, hemolysis disappeared dramatically. Severe hemolysis may induce renal failure and necessitate transfusion frequently. If hemolytic anemia is not corrected by conservative treatment, early reoperation is required.