• 지구물리와물리탐사
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• 제15권1호
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• pp.8-15
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• 2012

원주 KS31 광대역 지진관측소 하부의 S파 속도구조를 구명하기 위해서, 2002 ~ 2009년 사이에 기록된 규모 Mw 5.5 이상의 297개 원거리 지진 이벤트 자료로부터 구한 수신함수와 표면파 분산곡선의 복합역산 및 $H-{\kappa}$ 영역에서의 중합법을 적용하였다. 분석 결과는 이 관측소 반경 수십 km 이내의 모호면 평균 깊이가 $32.4{\pm}0.5\;km$로 거의 평탄하게 놓여 있음을 지시한다. 이 지역 지각의 평균 S파 속도는 3.69 km/s이고, P파와 S파 속도비, $V_p/V_s$가 $1.72{\pm}0.04$로 나타나서 전형적인 육지지각의 특성을 보인다. 수신함수 1 s에 나타난 음 위상은 KS31 관측소 하부의 상부지각 10 ~ 18 km 깊이에 S파 저속도층이 존재함을 지시한다.

• Journal of Preventive Medicine and Public Health
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• 제40권4호
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• pp.305-312
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• 2007

Objectives : To estimate the awareness, treatment and control rate, as well as to identify the awareness-related factors for hypertension. Methods : The study participants were 482 adults (men 206, women 276), aged 45 or over, diagnosed with hypertension and living in Chuncheon. The awareness rate was defined as the proportion of persons among those with hypertension who had previously been diagnosed by a physician. The treatment rate was defined as the proportion of persons who had used anti-hypertensive medication, among those who were aware of their hypertension. The control rate was defined as the proportion of persons who kept blood pressure normal, among those who had been treated for their hypertension. Multivariable logistic regression analysis was carried out for the awareness-related factors using SAS VER 8.1. Results : The awareness, treatment, and control rate were 55,8% (53.4% for men; 57.6% for women), 89.6% (87,2% for men; 91.2% for women), and 34.4% (28.1 % for men; 38.6% for women), respectively. The awareness-related factors included a family history of hypertension (odds ratio[OR], 5.63; 95% confidence interval[95% CI]=1.53-20.72), smoking([Ex; OR 0.38, 95% CI= 0.15-0.96)], [Current; OR 0.28, 95% CI=0.10-0.80]), and alcohol intake ([Ex; OR 3.22, 95% CI 1.03-10.09],[Current; OR 3.36, 95% CI=1.30-8.71]) for men, and education(OR 2.23, 95% CI=1.10-4.53), body mass index(OR 2.72, 95% CI=1.13-6.53), and self-rated health(OR 2.38, 95% CI=1.07-5.30) for women. Conclusions : The awareness rate of hypertension among the middle aged and elderly in Chuncheon was 55.8%. The related factors of awareness were gender specific. Further studies are needed to elucidate the putative reasons for these gender differences.

• Journal of Preventive Medicine and Public Health
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• 제45권6호
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• pp.394-401
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• 2012

Objectives: Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD). Methods: Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model. Results: Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 $kg/m^2$), lean subjects with diabetes (BMI <21 $kg/m^2$) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ${\geq}25kg/m^2$) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension. Conclusions: This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.

• Tuberculosis and Respiratory Diseases
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• 제63권1호
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• pp.24-30
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• 2007

연구배경: 폐렴 환자 중 약 40%에서 흉막삼출이 동반되고 이 가운데 약 10%에서 배액이 필요한 합병부폐렴삼출 또는 농흉으로 진행된다. 저자들은 합병부폐렴삼출 및 농흉 환자에서 치료성적과 예후인자에 대해 알아보고자 하였다. 방 법: 2001년 9월부터 2005년 12월까지 합병부폐렴삼출 및 농흉으로 치료받았던 115명의 환자를 대상으로 후향적 연구를 시행하였다. 결 과: 대상환자 중 101예(87.8%)에서 치료성공을 보였는데 다변량분석에서 흉막액 LDH 수치(OR 7.37;95% CI, 1.63-33.37; p=0.009)가 치료성공 및 실패에 중요한 예후인자로 나타났다. 해열기간과 유의한 상관관계를 보인 인자로는 흉막액의 농성여부(r=0.236;p=0.01)와 섬유소용해물질 사용빈도(r=0.257; p=0.01)가 확인되었고 입원기간과 유의한 상관관계를 보인인자는 없었다. 결 론: 흉막액 LDH 수치가 합병부폐렴삼출 및 농흉에서 치료성적과 연관된 예후인자로 생각된다.

• Journal of Gastric Cancer
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• 제19권4호
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• pp.427-437
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• 2019

Purpose: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods: The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as microsatellite stable (MSS). Results: Overall, 1,156 tumors were included in the analysis, with 85 (7.4%) classified as MSI-H compared with MSS tumors. For MSI-H tumors, there was a significant correlation with the female sex, older age, tumor location in the lower gastric body, intestinal histology, lymphovascular invasion (LVI), and submucosal invasion (P<0.05). There was also a trend toward an association with lymph node (LN) metastasis (P=0.056). In mucosal gastric cancer, there was no significant difference in MSI status in tumors with LN metastasis or tumors with LVI. In submucosal gastric cancer, LVI was more frequently observed in MSI-H than in MSS tumors (38.9% vs. 25.0%, P=0.027), but there was no difference in the presence of LN metastases. The prognosis of MSI-H tumors was similar to that of MSS tumors (log-rank test, P=0.797, the hazard ratio for MSI-H was adjusted by age, sex, pT stage, and the number of metastatic LNs, 0.932; 95% confidence interval, 0.423-2.054; P=0.861). Conclusions: MSI status was not useful in predicting prognosis in early gastric cancer. However, the frequent presence of LVI in early MSI-H gastric cancer may help guide the appropriate treatment for patients, such as endoscopic treatment or limited LN surgical dissection.

• Journal of Gastric Cancer
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• 제19권4호
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• pp.408-416
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• 2019

Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. Materials and Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed. Results: There were no significant differences in the objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control rate (72.73% vs. 73.81%, P>0.05), progression-free survival (hazard ratio [HR], 1.119; 95% confidence interval [CI], 0.739-1.741; P=0.586), and overall survival (OS; HR, 0.855; 95% CI, 0.481-1.511; P=0.588) between CAPOX and SOX. A higher number of stage IV patients showed TP positivity, while DPD-positive patients predominantly showed intestinal type of gastric cancer. In TP-positive patients, the ORRs associated with CAPOX and SOX treatments were 57.14% and 38.10%, respectively; OS was better with CAPOX than with SOX (HR, 0.447; 95% CI, 0.179-0.978; P=0.046). Among DPD-positive patients, the SOX treatment-associated ORR (60.87%) was significantly higher than the CAPOX treatment-associated ORR (43.48%). Furthermore, SOX treatment resulted in better OS than did CAPOX treatment (HR, 2.020; 95% CI, 1.019-4.837; P=0.049). Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer.

• 한국작물학회지
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• 제26권1호
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• pp.96-102
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• 1981

본 실험은 홍화에 대한 파종기 7수준(3월 17일부터 5월 16일까지 10일 간격)과 질소 비료 5개 수준(무배비, 0.5배비, 표준비, 1.5배비 및 2배비)으로 각각 파종하여 알맞는 파종 적기 및 시비량 수준에 따른 형질간의 변이를 구명하기 위하여 상지대학 농학과 실습 포장에서 실시하였다. 얻어진 결과를 요약하면 다음과 같다. 1. 발아율은 파종기가 늦어짐에 따라 감소되고 발아세는 파종기가 늦어질 수록 증가하였다. 발아 최감기는 위의 결과와 반대로 반종기가 늦어질수록 단축되였다. 발아 소요 기간도 파종기가 늦어갈 수록 단축되었다. 2.초장, 분지수, 치경에서도 파종기가 늦어질 수록 감소되는 경향을 보여주었다. 또한 질소 시비량이 증가할 수록 초장 및 분지수는 증가되는 경향을 보였다. 3. 꼬투리와 1,000입중도 파종기가 지연될수록 감소되었고 1,000입중은 파종기가 이를 수록 무거워지는 경향을 보였다. 또한 질소 시비량이 증가함에 따라 꼬뚜리수와 수량에서토 현저한 증가를 보여 주었다. 4. 파종기 차이에 따른 등황색 및 등홍색 꽃의 중량은 4월 상순 파종구가 가장 무거웠다. 그러나 질소 시비량의 증가는 개화에 영향을 주지 않는 것으로 나타나고 있었다. 5. 본 실험의 결과로서 파종 적기는 4월 상순이라고 믿어졌고 홍화 재배에서는 다비의 효과가 있는것으로 나타나고 있었다.

• 자원환경지질
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• 제44권6호
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• pp.513-523
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• 2011

이 연구에서는 최근에 발표되고 국제기구에 의해 공인된 protocol에 따라 인공 지열 저류층 생성 기술(EGS)을 통한 우리나라 지열발전의 잠재량을 평가하였다. 잠재량 추정에 필요한 입력 자료인 암석 밀도, 비열 및 열전도도는 1,516개 암반 시료의 측정값을 이용했으며, 열생산율은 180개 자료, 지열류량은 352개 자료, 그리고 지표면 온도는 54개 자료를 사용하였다. 내륙을 34,742개의 $1'{\times}1'$ 크기 격자로 나누어 3-10 km 깊이 범위에 걸쳐 1 km 깊이 구간별로 온도 분포를 계산하고 이로부터 열에너지 부존량을 계산하였다. 지하 3-10 km 범위의 이론적 잠재량은 6,975 GW로 계산되었고 이는 2010년 우리나라 총 발전용량인 76 GW의 약 92배에 달한다. 기술적 잠재량은 3-6.5 km 깊이, 개발행위가 가능한 지역만을 고려하고 또한 암반으로부터의 열 회수율(0.14)과 발전시설의 온도 특성까지 포함해서 산출되었다. 온도하강요소 $10^{\circ}C$를 고려할 때 총 기술적 잠재량은 19.6 GW로 나타나고 있다. 만약 온도하강요소를 경제적 잠재량에 포함시킬 수 있도록 제외한다면 기술적 잠재량은 56 GW로 늘어난다.

• Applied Biological Chemistry
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• 제28권3호
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• pp.182-186
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• 1985

본실험은 중부지방(中部地方)의 땅콩 파종적기(播種適期)를 구명(究明)하고자 초형별(草型別)로 여주재래종, 수원15호 및 Wasedairu의 3품종을 5월 5일 부터 7월 4일 까지 10일 간격으로 파종하여 재배하였다. 땅콩의 조지방(粗脂肪)은 평균 46.05%로 가장 많고, 다음은 조단백질(粗蛋白)으로 평균 32.26%였다. 땅콩의 100입중(粒重)은 5월 5일부터 6월 4일 파종까지는 서로 비슷한 중량(重量)이였으며, 그중 5월 15일(평균 68.3g) 파종때가 가장 높았다. 또 품종간에는 Wasedairu, 수원15호, 여주재래종의 순(順)으로 나타났다. 땅콩의 조지방(粗脂肪)함량은 5월 15일 또는 5월 25일을 정점(頂點)으로 증가하다가 그후는 감소하는 경향을 보였으며, 품종간에는 서로 비슷한 함량이었다. 땅콩의 지방산(脂肪酸)은 oleic acid와 linoleic acid가 $80{\sim}85%$로 대부분을 차지하였고, palmitic acid는 $10{\sim}15%$, stearic 및 arachidic acid는 각각 $1{\sim}5%$를 함유하였다. 또 땅콩은 파종기(播種期)가 늦어질수록 미성숙종실(未成熟種實)이 되어 지방산조성비(脂肪酸組成比)의 증감변화(增減變化)가 현저하였다.

• Journal of Chest Surgery
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• 제47권3호
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• pp.255-261
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• 2014

Background: To determine the predictors of clinical outcomes following surgical descending thoracic aortic (DTA) repair. Methods: We identified 103 patients (23 females; mean age, $64.1{\pm}12.3$ years) who underwent DTA replacement from 1999 to 2011 using either deep hypothermic circulatory arrest (44%) or partial cardiopulmonary bypass (CPB, 56%). Results: The early mortality rate was 4.9% (n=5). Early major complications occurred in 21 patients (20.3%), which included newly required hemodialysis (9.7%), low cardiac output syndrome (6.8%), pneumonia (7.8%), stroke (6.8%), and multi-organ failure (3.9%). None experienced paraplegia. During a median follow-up of 56.3 months (inter-quartile range, 23.1 to 85.1 months), there were 17 late deaths and one aortic reoperation. Overall survival at 5 and 10 years was $80.9%{\pm}4.3%$ and $71.7%{\pm}5.9%$, respectively. Reoperation-free survival at 5 and 10 years was $77.3%{\pm}4.8%$ and $70.2%{\pm}5.8%$. Multivariable analysis revealed that age (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.05 to 1.15; p<0.001) and left ventricle (LV) function (HR, 0.88; 95% CI, 0.82 to 0.96; p<0.003) were significant and independent predictors of long-term mortality. CPB strategy, however, was not significantly related to mortality (p=0.49). Conclusion: Surgical DTA repair was practicable in terms of acceptable perioperative mortality/morbidity as well as favorable long-term survival. Age and LV function were risk factors for long-term mortality, irrespective of the CPB strategy.