• International Journal of Advanced Culture Technology
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• 제7권4호
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• pp.156-162
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• 2019

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by progressive joint deterioration; Furthermore, RA can also affect body tissues, including the skin, eyes, lungs, heart and blood vessels. The early stages of RA can be difficult to diagnose because the signs and symptoms mimic those of many other diseases. It is not known exactly what triggers the onset of RA and how to cure the disease. But recent discoveries indicate that remission of symptoms is more likely when treatment begins early with strong medications known as disease-modifying anti-rheumatic drugs (DMARDs). Tumor necrosis factor (TNF) inhibitors are typical examples of biotherapies that have been developed for RA. The substances may occur naturally in the body or may be made in the laboratory. Other biological therapies care biological response modifiers (BRMs)such as monoclonal antibodies, interferon, interleukin-2 (IL-2) and a protein binder using repeat units. These substances play significant anti-inflammatory roles. Proteins with recurrent, conserved amino acid stretches mediate interactions among proteins for essential biological functions; for example, ankyrin (ANK), Heat repeat protein (HEAT), armadillo repeat protein (ARM) and tetratricopeptide repeats (TPR). Here, we describe Leucine rich repeats (LRR) that ideally fold together to form a solenoid protein domain and is more applicable to our current study than the previously mentioned examples. Although BRMs have limitations in terms of immunogenicity and effector functions, among other factors, in the context therapeutic use and for proteomics research, We has become clear that repeat-unit-derived binding proteins will increasingly be used in biotechnology and medicine.

• 시큐리티연구
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• 제29호
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• pp.7-34
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• 2011

우리나라의 경우 IT관련 기술뿐 아니라 반도체, 휴대폰, LCD, 자동차, 조선 등 첨단 분야에서 최고 수준의 기술력을 확보하여 세계시장을 주도함으로서 기술유출 시도가 다각적으로 대폭 증가하고 있는 것이 현실이다. 최근에는 산업스파이에 의한 불법적 기술유출뿐만 아니라 기술이전, 공동연구, 인수합병 등 정상적 기업 활동 과정에서도 기술이 유출되고 있다. 우리나라의 쌍용자동차와 중국의 상하이자동차 간의 M&A(인수 합병) 시 실제로 기술유출 문제가 발생했다. 이처럼 국가핵심기술의 유출을 목적으로 한 국내기업의 해외 합병 등과 같이 합법적이지만 국가핵심기술의 유출이 우려되는 외국인 투자가 증가하고 있지만 규제를 다루는 법들은 다양한 법으로 산재되어 있어 효과적 규율이 어려운 상황이다. 그래서 본 논문은 해외기업이 국가핵심기술을 보유한 국내기업을 대상으로 기술유출을 목적으로 한 적대적 M&A를 통해 인수하거나 합작투자로 핵심기술을 유출하는 경우에 이를 효과적으로 규율할 수 있는지 관련 법령을 살펴보고, 개선안 등 보완점을 모색해 보고자 하는 것이다.

• 한국운동역학회지
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• 제31권2호
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• pp.95-103
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• 2021

Objective: The aim of this study was to investigate the differences in spatiotemporal gait performance, function, and pain of lower-extremity according to foot morphological characteristics. Method: This case-control study recruited 42 adults and they were classified into 3 groups according to foot morphology using navicular-drop test: pronated (≥ 10 mm), normal (5~9 mm), and supinated (≤ 4 mm) feet. Spatiotemporal gait analysis and questionnaires including Foot and Ankle Ability Measure activities of daily living / Sports, Western Ontario and McMasters Universities Osteoarthritis Index, Lower Extremity Functional Scale, International Physical Activity Questionnaire, and Tegner activity score were conducted. One-way analysis of variance was used for statistical analysis. Results: The pronated feet group showed longer loading response and double limb support in both feet and increased pre-swing phase in non-dominant feet. The supinated feet group demonstrated a longer swing phase in non-dominant feet and single limb support in dominant feet. However, there was no significant group difference in function and pain of knee joint and lower-extremity between groups. Conclusion: Our results indicated that abnormal spatiotemporal gait performance according to foot morphology. Although there was no difference in lower extremity dysfunction and pain according to the difference in foot morphology, they have the possibility of symptom occurs as a result of continuous participation in activities of daily living and sports. Therefore, individuals with pronated or supinated foot should be supplemented by utilizing an orthosis or training to restore normal gait performance.

• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.110-119
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• 2021

The Coronavirus or COVID-19 is contagiousness virus that infected almost every single part of the world. This pandemic forced a major country did lockdown and stay at a home policy to reduce virus spread and the number of victims. Interactions between humans and robots form a popular subject of research worldwide. In medical robotics, the primary challenge is to implement natural interactions between robots and human users. Human communication consists of dynamic processes that involve joint attention and attracting each other. Coordinated care involves sharing among agents of behaviours, events, interests, and contexts in the world from time to time. The robotics arm is an expensive and complicated system because robot simulators are widely used instead of for rehabilitation purposes in medicine. Interaction in natural ways is necessary for disabled persons to work with the robot simulator. This article proposes a low-cost rehabilitation system by building an arm gesture tracking system based on a depth camera that can capture and interpret human gestures and use them as interactive commands for a robot simulator to perform specific tasks on the 3D block. The results show that the proposed system can help patients control the rotation and movement of the 3D arm using their hands. The pilot testing with healthy subjects yielded encouraging results. They could synchronize their actions with a 3D robotic arm to perform several repetitive tasks and exerting 19920 J of energy (kg.m².S^-2). The average of consumed energy mentioned before is in medium scale. Therefore, we relate this energy with rehabilitation performance as an initial stage and can be improved further with extra repetitive exercise to speed up the recovery process.

• Imaging Science in Dentistry
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• 제50권1호
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• pp.45-52
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• 2020

Purpose: This study was conducted to develop an evidence-based clinical imaging diagnostic guideline for implant planning, taking into account efficacy, benefits, and risks. Materials and Methods: The guideline development process employed the adaptation methodology used for Korean clinical imaging guidelines(K-CIG). Core databases(Ovid-Medline, Ovid-Embase, National Guideline Clearinghouse, Guideline International Network) and domestic databases (KoreaMed, KMbase, and KoMGI) were searched for guidelines. The retrieved articles were analyzed by 2 reviewers, and articles were selected using well-established inclusion criteria. Results: The search identified 294 articles, of which 3 were selected as relevant guidelines. Based on those 3 guidelines, 3 recommendations for implant planning were derived. Conclusion: We recommend radiography or cone-beam computed tomography (CBCT) scanning for individual patients judged to require a cross-sectional image after reading of a panoramic X-ray image and a conventional intraoral radiological image. Various steps should be taken to raise awareness of these recommendations among clinicians and the public, and K-CIG should be regularly reviewed and revised.

• International Journal of Railway
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• 제2권2호
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• pp.50-59
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• 2009

Numerous train operating companies provide training by means of driving simulators. A detailed analysis in the course of the rail research project 2TRAIN has shown that the simulation technology, the purposes of training and the overall concept of simulator-based training are rather diverse (Schmitz & Maag, 2008). A joint factor however are weak assessment capabilities and the fact that the simulator training is often not embedded into the overall competence management. This fact hinders an optimal use of the simulators. Therefore, 2TRAIN aims at the development of enhanced training and assessment tools. Taking into account that several simulators are already in use, the focus lays on the extension of existing simulation technology instead of developing entirely new systems. This extension comprises (1) a common data simulation interface (CDSI), (2) a rule-based expert system (ExSys), (3) a virtual instructor (VI), and (4) an _assessment database (AssDB). The foundation of this technical development is an assessment concept (PERMA concept) that is based on performance markers. The first part of the paper presents this assessment concept and a process model for the two major steps of driver performance assessment, i.e. (1) the specification of exercise and assessment and (2) the assessment algorithm and execution of the assessment. The second part describes the rationale and the functionalities of the simulator add-on tools. Finally, recommendations for further technical improvement and appropriate usage are given. based on the results of a pilot study.

• 유통과학연구
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• 제16권12호
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• pp.13-21
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• 2018

Purpose - Because it is not possible to assess the quality of service products before experiencing them, one feature of a service product is quality uncertainty; hence consumers may react sensitively to pricing. It is necessary to investigate how different pricing strategies affect consumer purchase intention depending on the level of service quality uncertainty. Research design, data, and methodology - The authors have investigated the potential impact of the level of service quality uncertainty, price discount rate and presentation method on consumer purchase intention. A play was selected as an experimental stimulus, and Vietnamese consumers were surveyed to verify the hypotheses. Results - When uncertainty regarding service quality is low, consumer purchase intention is higher when the price discount rate is high or when the price is low. When uncertainty regarding service quality is high, if the normal price, discount rate, and discounted price are presented simultaneously, consumer purchase intention is higher when the price discount rate is low, but when only the discounted price is presented, purchase intention is higher when the price discount rate is high. Conclusions - The results of this study can provide valuable practical implications for pricing for service products with quality uncertainty.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.383_384
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• 2009

After the 1970s, the importance of underground transmission systems increased and the construction rate of underground transmission lines also showed increasing trends each year, especially in metropolitan areas. Accordingly the social ripple effects are very large and wide when the fault occurs in underground power system, and the amount of time and money spent to restore the system also increases. So we must ensure stable operation and long-term reliability of the facilities. In Korea's case, long-term reliability tests for EHV power cables and accessories progressed poorly because equipment was not compatible for long-term reliability tests. Therefore we planned to construct a long-term reliability test field for EHV underground cables in order to ensure international quality reliability and optimal power cable operation techniques. The Gochang Underground Cable Test Field is under construction, funded by the Korean government, the govenment's union investment department, KEPCO, KERI and three private cable corporations. This project began in March, 2005 and will be completed by February, 2010. It is designed to promote joint research by incorporating several types of test equipment, construction of operating facilities, and being an internationally certified authority.

• Geomechanics and Engineering
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• 제16권1호
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• pp.49-58
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• 2018

Open-mode cracks could be commonly observed in layered rocks. A concept model is firstly used to explore the mechanism of the vertical cracks (VCs) in the top layer. Then the crack behaviour of the two-layer model is simulated based on a cohesive zone model (CZM) for layer interfaces and a plastic-damage model for rocks. The model indicates that the tensile stress normal to the VCs changes to compression if the crack spacing to layer thickness ratio is lower than a threshold. The results indicate that there is a threshold for interfacial shear strength that controls the crack patterns of the layered system. If the shear strength is lower than the threshold, the top layer is meshed by the VCs and interfacial cracks (ICs). When the shear strength is higher than the threshold, the top layer is meshed by the VCs and parallel cracks (PCs). If the shear strength is comparative to the threshold, a combining pattern of VCs, PCs and ICs for the top layer can be formed. The evolutions of stress distribution in the crack-bound block indicate that the ICs and PCs can reduce the load transferred for the substrate layer, and thus leads to a crack saturation state.

• 유통과학연구
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• 제18권5호
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• pp.71-81
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• 2020

Purpose: This case study illustrates the successful entry of Saudi Aramco in the Korean market and how it grows to become one of the world's largest integrated energy enterprises. Research design, data and methodology: This case investigates diverse secondary sources to examine the entry strategy of Aramco in Korea, such as several interviews including public and anonymous dialogues, periodicals, dispatches (i.e. news articles and magazines), annual reports, industrial reports, and others. Results: The main concern for the international strategic approaching of Saudi Aramco is to enter into Korean market by joint venture with SsangYong Oil (today's S-Oil Corporation) in 1991 and finally, ending by Acquisition of S-Oil in 2015. This acquisition of local No.3 company, S-Oil, in Korea is the successful case in Asian Markets overcoming liability of foreignness. Moreover, Saudi Aramco's global distribution strategy through localization in the Korean market is appropriate given the market conditions, timing, effectiveness, and efficiency by sharing their resources and collaborating. Conclusions: It would be valuable, unique, and real story to analyze global leading company's entry and globalization strategy in overseas market. In addition, this study provides decision-makers with a significant and more strategic implication for the overseas expansion of businesses.