• 대한한방종양학회지
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• 제9권1호
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• pp.1-14
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• 2003

Objective : Ikiyangeumhaedoc-tang(IYHT) has an effect of nourishing Yin(陰) and Jin(津), and has been used to cancer patient effectively. In order to prove the anticancer's and antimetastic effect of IYHT experimentally, studies were done. Methods : We evaluated the cytotoxic activity on HT-1080 cells as well as inhibitory effect on activity of DNA topoisomerase Ⅰ, cell adhesion, cell invasion and proliferation of HUVEC cells induced by bFGF and measured the expression of mRNA(uPA, MMP2, TIMP2), p-ERK protein, recovery effect of gap junctional intercellular communication by $H_{2}O_2$ and survival time of ICR mice bearing sacoma-180. Results : IYHT showed the inhibitory effect on DNA topoisomerase Ⅰ in the concentration of $100{\mu}g/ml,\;500{\mu}g/ml$ and the dosage-dependent inhibitory effect on the adhesion of HT-1080. The concentration of 1mg/ml of IYHT inhibited 15% of adhesion compared with control. IYHT decreased the expression of uPA, but not in MMP2, TIMP2 by RT-PCR and inhibited the expression of p-ERK effectively in the concentration of more than $500{\mu}g/ml.$ IYHT recovered the inhibited gap junctional intercellular communication by $H_{2}O_2$ to the level of 60% of normal control in the concentration of $400{\mu}g/ml$ but, did not extended the mean survival time of sarcoma 180-bearing mouse. Conclusions : It was concluded that IYHT could be applied usefully for prevention and treatment of human cancer, And also experimental study for the evaluation of molecular biological study and antimetastatic research would be recommended in the near future.

• 대한치과보철학회지
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• 제42권5호
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• pp.489-500
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• 2004

Statement of problem: The use of zirconia prostheses fabricated with CAD/CAM system is on an increasing trend in dentistry. However, evaluation of the fit related to internal relief and marginal reproducibility of zirconia has not been reported. Purpose : This study was to evaluate the fit related to internal relief and marginal reproducibility of zirconia core fabricated with CAD/CAM system. Materials and methods: The evaluation was based on 30 zirconia cores and 5 IPS-Empress2 cores. Zirconia cores were fabricated in different conditions of internal relief(0, 10, 20, 30, 40 and $50{\mu}m$), and IPS-Empress2 cores were fabricated in accordance with the manufacturer's instructions. Before cementation, the marginal discrepancies or cores were measured on metal die. And then, each core was cemented to stone die, embedded in an acrylic resin and sectioned in two planes(mesiodistally and labiopalatally). The internal gaps were measured at the margin and axial surface. Measurements for the marginal discrepancies, the internal marginal gaps and the internal axial gaps were performed under a measuring microscope(Compact measuring microscope STM5; Olympus, Japan) at a magnification of ${\times}100$. In addition, the marginal conagurations of metal die, zirconia core and IPS-Empress2 core were examined with SEM(S-2700, Hitachi, Japan). Results : Within the limits of this study the results were as follows. 1. Compared with IPS-Empress2 cores, the marginal discrepancies of zirconia cores had no significant differences. the internal marginal gaps were statistically smaller and the internal axial gaps were statistically larger in each condition of internal relief. 2. The marginal discrepancies and the internal marginal gaps of zirconia cores had no significant differences related to the conditions of internal relief(P>0.05). 3. The internal axial gaps of zirconia cores with $0{\sim}20{\mu}$m for internal relief were significantly larger than that with $50{\mu}m$ (P<(0.0001). 4. SEM micrographs showed favorable marginal reproducibility of zirconia core and smooth texture on the milling surface. Conclusion: The marginal discrepancy and the internal gaps of zirconia core were clinically acceptable and the milling surface was showed smooth texture. For fabrication of the durable esthetic restoration, further investigations on complex design of core, milling accuracy, compatability of enamel porcelain and porcelain firing seems to be needed.

• 한국도서관정보학회지
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• 제30권4호
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• pp.351-370
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• 1999

This paper aims to study on bibliographic reference forms, especially focused on the forms of korean sources. Although bibliographic reference is one of the critical elements in academic works, it seems every work has it's own forms in Korea. The fact that the bibliographic reference forms in korean works are made up by option causes the present state of diversity which makes difficulty in bibliographic control. The results of this search into internal academic journals show the diversity in the entry of title and significant gap of bibliographic reference forms among disciplines.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.3473-3478
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• 2007

A dual side cooling annular fuel having internal and external coolant channels has many advantages basically due to low fuel temperature and high DNBR margin, which can make a significant increase of core power density possible. So recently a 12x12 square annular fuel array was proposed for the fuel assembly to be reloaded without structural interference with operating reactors of OPR-1000s. Even through the inherent potential of the annular fuel on the high power density, it may be seriously eroded in the case of a severe unbalanced mass flux split to the internal and external channels in standpoint of DNB. Mass flux split is determined pressure drop characteristics between inner and outer channels. The spacer grids binding fuel array influence greatly the pressure drop in outer channels and the mass flux split. As an important factor of DNB behavior, the enthalpy differences at both channel exits were evaluated using the mass flux splits.

• 한국전기전자재료학회논문지
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• 제11권11호
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• pp.963-968
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• 1998

The stress distribution in multilayer piezoelectric ceramic actuators was investigated by Finite element analysis. The y direction stress was concentrated at electrode tip. The y direction maximum stress was decreased to 4.9$\times10^ 7 N/m^2$ with internal electrode gap(a) until 0.4 mm and was not much difference with external electrode thickness(c). The stress distribution with internal layers was almost same and the stress distribution of load condition was higher than that of no load condition The y direction maximum stress increased with the number of layer and saturated at 260 layers. In the case of defective actuator, the stress distribution was disconnected around the defect and larger than that of normal actuator.

• Tuberculosis and Respiratory Diseases
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• 제80권3호
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• pp.241-246
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• 2017

Chronic obstructive pulmonary disease (COPD) is an ambulatory care-sensitive condition, and effective treatment of outpatients can prevent worsening of the illness and hospitalization. Current COPD guidelines provide appropriate guidance for the diagnosis and treatment of patients with COPD. In fact, it has been shown that when appropriate guidance and treatment are performed, the morbidity and mortality rates of COPD patients are reduced. However, there is a gap between the clinical guidelines and the actual clinical treatment. Therefore, the Health Insurance Review and Assessment Service (HIRA) conducted an evaluation of the adequacy of COPD diagnosis and treatment using the Claims Database of HIRA. This review provides a summary of the COPD adequacy assessment results reported by the HIRA and some brief comments on the results.

• 에너지공학
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• 제23권4호
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• pp.183-188
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• 2014

Solenoid operated electromagnetic control valve (ECV) using in an external variable displacement swash plate type compressor is widely used for air conditioning control system because of its low energy consumption and high efficient characteristics. ECV controls the entire vehicle air conditioning system by means of a pulse width modulation (PWM) system that supplied from an external controller. Different pressure ports located within ECV has important functions to control the air/refrigerant flow through its internal passages. The flow paths are preciously maintained with acceptable ranges of leakage (gap) between the parts inside it which is followed by effective design and critical dimensioning of its internal features. Therefore, it saves energy losses from the solenoid operation as well as ensures the balance of forces within it. The research paper highlights analysis of the leakages (at different pressure ports) and dimensioning tolerance factors that affects the ECV performance.

• Investigative Magnetic Resonance Imaging
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• 제21권1호
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• pp.61-64
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• 2017

A characteristic imaging finding in cases of methanol intoxication is putaminal necrosis, but its presence is usually not suspected due to its rarity. Methanol intoxication generally produces serious neurological symptoms that include visual disturbances and diminished consciousness, characteristically with metabolic acidosis. We reported the case of a 59-year-old man who was admitted to the hospital with diminished consciousness. Acute methanol intoxication was determined as the cause. Laboratory tests revealed high anion gap metabolic acidosis. Diffusion-weighted MRI indicated diffuse symmetric diffusion restriction lesions in the subcortical white matter of both cerebral hemispheres.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2002년도 제25회 KOSCI SYMPOSIUM 논문집
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• pp.223-229
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• 2002

Spark plug ionization signal could be useful in an internal combustion engine as a feedback signal for combustion diagnostics such as misfire detection, knocking detection and lambda control, but the signal has high level of cyclic fluctuation in an internal combustion engine due to residual gas, pressure, temperature, mixture composition in the spark gap. Because of this reason it is very difficult to apply ion signal to commercial engine control. In this Study, a correlation between A/F and spark plug ionization signal was studied in a constant volume chamber. Constant volume chamber with gas phase fuel(Propane) has homogeneous fuel composition , no mixture flow, same pressure and temperature on each test. The results show that mean chemi-ion signal has the highest correlation with A/F and intial pressure change has on effect on the thermal-ion signal and not on chemi-ion signal.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1998년도 춘계학술대회 논문집
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• pp.307-310
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• 1998

Finite element analysis was investigated on the stress distribution at the 2-D model of piezoelectric ceramic actuators. The y direction maximum stress decreased with a(internal electrode gap) size until 0.4 mm and is not much difference with c(external electrode thickness) size. The stress distribution with internal layers is almost same, and the stress distribution of load condition is higher than that of no load condition. The y direction maximum stress increased exponentially with the number of layer and saturated at 260 layers. In the case of defective actuator, the stress distribution is smaller than that of normal actuator.