• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3618-3624
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• 2012

Photodissociation dynamics of propiolic acid ($HC{\equiv}C-COOH$) at 212 nm in the gas phase was investigated by measuring rotationally resolved laser-induced fluorescence spectra of OH ($^2{\Pi}$) radicals exclusively produced in the ground electronic state. From the spectra, internal energies of OH and total translational energy of products were determined. The electronic transition at 212 nm responsible for OH dissociation was assigned as the ${\pi}_{C{\equiv}C}{\rightarrow}{\pi}^*{_{C=O}}$ transition by time-dependent density functional theory calculations. Potential energy surfaces of both the ground and electronically excited states were obtained employing quantum chemical calculations. It was suggested that the dissociation of OH from propiolic acid excited at 212 nm should take place along the $S_1/T_1$ potential energy surfaces after internal conversion and/or intersystem crossing from the initially populated $S_2$ state based upon the potential energy calculations and model calculations for energy partitioning of the available energy among products.

• The Korean journal of helicobacter and upper gastrointestinal research
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• v.18 no.3
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• pp.162-167
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• 2018

Cancer specimens obtained via surgical resection or biopsy are generally used to understand tumor-associated alterations; however, those approaches cannot always be performed because of their invasive nature, and they may fail to reflect current tumor dynamics and drug sensitivity, which may change during the therapeutic process. Therefore, many research groups have focused on developing a non-invasive biomarker with the ability to monitor tumor dynamics. Circulating tumor cells (CTCs) are metastatic cells released from the primary tumor into the bloodstream. Hematogenous spreading of CTCs is a crucial step in the metastatic cascade, which leads to the formation of overt metastases. CTCs have attracted considerable attention because of their easy accessibility and their superiority over conventional tumor markers. Detecting CTCs is considered a valuable modality to determine prognosis and monitor response to systemic therapies in patients with gastric cancer. Moreover, molecular analyses of CTCs may provide important biological information for individual patients with cancer, which may lead to the development of personalized cancer treatment. In this article, we review potential roles and clinical applications of CTCs in patients with gastric cancer.

• Nuclear Engineering and Technology
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• v.51 no.6
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• pp.1540-1553
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• 2019

A nuclear power plant (NPP) is a highly complex system-of-systems as manifested through its internal systems interdependence. The negative impact of such interdependence was demonstrated through the 2011 Fukushima Daiichi nuclear disaster. As such, there is a critical need for new strategies to overcome the limitations of current risk assessment techniques (e.g. the use of static event and fault tree schemes), particularly through simulation of the nonlinear dynamic feedback mechanisms between the different NPP systems/components. As the first and key step towards developing an integrated NPP dynamic probabilistic risk assessment platform that can account for such feedback mechanisms, the current study adopts a system dynamics simulation approach to model the thermal dynamic processes in: the reactor core; the secondary coolant system; and the pressurized water reactor. The reactor core and secondary coolant system parameters used to develop system dynamics models are based on those of the Palo Verde Nuclear Generating Station. These three system dynamics models are subsequently validated, using results from published work, under different system perturbations including the change in reactivity, the steam valve coefficient, the primary coolant flow, and others. Moving forward, the developed system dynamics models can be integrated with other interacting processes within a NPP to form the basis of a dynamic system-level (systemic) risk assessment tool.

• KEPCO Journal on Electric Power and Energy
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• v.2 no.3
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• pp.461-467
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• 2016

In order to install the floating transport type wind-turbine foundation, water pumping is used to sink the foundation. During this process, its mass and center of gravity, and buoyancy center become continuously changed so that the dynamic stability of the floating foundation become unstable. Dynamic stability analysis of the floating foundation is a complex problem since it should take into account not only the environmental wave, wind, and current loads but also its weight change effect simultaneously considering six-degree-of-freedom motion. In this study, advanced numerical method based on the coupled computational fluid dynamics (CFD) and multi-body dynamics (MBD) approach has been applied to the dynamic stability analysis of the floating foundation. The sloshing effect of foundation internal water is also considered and the floating dynamic characteristics are numerically investigated in detail.

• The Korean Journal of Nuclear Medicine
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• v.25 no.1
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• pp.53-60
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• 1991

Extracorporeal shock wave lithotripsy (ESWL) with adjunctive oral litholytic therapy has proven to be a useful treatment in selected patients with gallbladder stones. To study the effect of ESWL on gallbladder dynamics, $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy was done for 25 patients with symptomatic gallstones and 10 normal controls. Of these 25 patients, 15 were treated with ESWL and adjunctive oral litholytic agents (ESWL group) and 10 were treated only with oral litholytic agents (UDCA group). After overnight fast and gallbladder visualization on a routine hepatobiliary scintigraphy with 7mCi of $^{99m}Tc-DISIDA$, subjects were given fatty meal and imaged with a gamma camera interfaced to a computer (1 frame/minute for 70 minutes). A gallbladder time-activity curve was generated and latent period (LP), ejection period (EP), ejection fraction (EF) and ejection rate (ER) were calculated. ESWL group were studied before, 1day after and 2weeks after ESWL, and WDCA group were studied before and 2weeks after starting oral medication. Mean basal EF was significantly reduced in patients but other parameters were not reduced. In ESWL group, mean EF and mean ER at lday after ESWL were reduced. In 3 of them, gallbladder was not visualized at all. Two weeks after ESWL, however, all parameters were recoverd to basal level. In UDCA group, all parameters were not changed significantly during medication. We can conclude that ESWL has such immediate adverse effect on gallbladder dynamics as reducing contractility and nonvisualization of gallbladder but it has no long-term effect.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.305-310
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• 2005

Internal motion of the protein has been described in many papers with C$_{\alpha}$ correlation coefficients to find motional correlation and functional characteristics. To describe the secondary structural motion and stability in protein, we have studied molecular dynamics (MD) simulations on FADD Death Domain and FADD Death Effector Domain which have a similar structure but have different functional characteristics. After 10ns MD simulations, the inter-helical motional correlations and the hydrogen bond ratios were compared between the two domains. From these data we could distinctly compare the internal motions of them and could explain the differences in experimental thermodynamic melting behaviors at molecular level.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1666-1671
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• 2003

Exact dynamic stiffness model for a uniform straight pipeline conveying unsteady fluid is formulated from a set of fully coupled pipe-dynamic equations of motion, in which the fluid pressure and velocity of internal flow as well as the transverse and axial displacements of the pipeline are all treated as dependent variables. The accuracy of the dynamic stiffness model formulated herein is first verified by comparing its solutions with those obtained by the conventional finite element model. The spectral element analysis based on the present dynamic stiffness model is then conducted to investigate the effects of fluid parameters on the dynamics and stability of an example pipeline problem.

• Journal of ILASS-Korea
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• v.6 no.2
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• pp.9-15
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• 2001

The internal flow characteristics of a gasoline direct injector have been studied to improve fuel economy and reduce exhaust emissions. Computational Fluid Dynamics (CFD) is used to examine the internal flow of the GDI with the purpose of designing the optimum geometry of the injector. This study tests orifice length, cone angle, swirl angle, orifice diameter and needle lift. The results show that optimum sizes of the orifice length, cone angle, swirl angle, orifice diameter and needle lift are 0.8mm, $140^{\circ},\;120^{\circ},\;80mm\;and\;70{\mu}m$, respectively. The size of the lift does not affect the formation of the air core signficantly near the tip of the needle compared to the ball-type needle. The vena contracta phenomenon near the orifice inlet can be released by smoothing the edge.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.959-963
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• 2006

A three-dimensional elastic blood vessel model with internal diameter variation is considered to investigate internal flow characteristics and effects of structural deformation. Also, computational analyses for both the rigid model and the fully-coupled FSI model have been conducted in order to compare the shear stress, pressure distribution, and flow velocity in detail. A 70% narrowing area of asymmetric blood vessel model was especially investigated to show the versatility of fluid-structure interaction phenomenon. The results reveal that effect of fluid-structure interaction is very important to accurately investigate the flow characteristics of the blood vessel.

• Proceedings of the KIEE Conference
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• 2001.07d
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• pp.2166-2168
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• 2001

Reactor Noise is defined as the fluctuations of measured instrumentation signals during full-power operation of reactor which have informations on reactor system dynamics such as neutron kinetics. The Reactor internal structures which consist of many complex components are subjected to flow-induced vibration due to high temperature and pressure in reactor coolant system. The above flow-induced vibration causes degradation of structural integrity of the reactor and may result in loosing mechanical binding component which might impact other equipment and component or cause flow blockage. It is important to analyze reactor noise signal for the early detection of potential problem or failure in order to diagnosis reactor integrity in the point of view of safety and plant economics. Detailed design of hardware diagnostic system reactor internal structures using neutron noise(RIDS).