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Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach

  • Tae-Han Kim;In-Ho Kim;Seung Joo Kang;Miyoung Choi;Baek-Hui Kim;Bang Wool Eom;Bum Jun Kim;Byung-Hoon Min;Chang In Choi;Cheol Min Shin;Chung Hyun Tae;Chung sik Gong;Dong Jin Kim;Arthur Eung-Hyuck Cho;Eun Jeong Gong;Geum Jong Song;Hyeon-Su Im;Hye Seong Ahn;Hyun Lim;Hyung-Don Kim;Jae-Joon Kim;Jeong Il Yu;Jeong Won Lee;Ji Yeon Park;Jwa Hoon Kim;Kyoung Doo Song;Minkyu Jung;Mi Ran Jung;Sang-Yong Son;Shin-Hoo Park;Soo Jin Kim;Sung Hak Lee;Tae-Yong Kim;Woo Kyun Bae;Woong Sub Koom;Yeseob Jee;Yoo Min Kim;Yoonjin Kwak;Young Suk Park;Hye Sook Han;Su Youn Nam;Seong-Ho Kong;The Development Working Group for the Korean Practice Guidelines for Gastric Cancer 2022 Task Force Team
    • Journal of Gastric Cancer
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    • v.23 no.1
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    • pp.3-106
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    • 2023
  • Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology and guideline development methodology. Total of 33 key questions were updated or proposed after a collaborative review by the working group and 40 statements were developed according to the systematic review using the MEDLINE, Embase, Cochrane Library and KoreaMed database. The level of evidence and the grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. Evidence level, benefit, harm, and clinical applicability was considered as the significant factors for recommendation. The working group reviewed recommendations and discussed for consensus. In the earlier part, general consideration discusses screening, diagnosis and staging of endoscopy, pathology, radiology, and nuclear medicine. Flowchart is depicted with statements which is supported by meta-analysis and references. Since clinical trial and systematic review was not suitable for postoperative oncologic and nutritional follow-up, working group agreed to conduct a nationwide survey investigating the clinical practice of all tertiary or general hospitals in Korea. The purpose of this survey was to provide baseline information on follow up. Herein we present a multidisciplinary-evidence based gastric cancer guideline.

Making Cache-Conscious CCMR-trees for Main Memory Indexing (주기억 데이타베이스 인덱싱을 위한 CCMR-트리)

  • 윤석우;김경창
    • Journal of KIISE:Databases
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    • v.30 no.6
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    • pp.651-665
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    • 2003
  • To reduce cache misses emerges as the most important issue in today's situation of main memory databases, in which CPU speeds have been increasing at 60% per year, and memory speeds at 10% per year. Recent researches have demonstrated that cache-conscious index structure such as the CR-tree outperforms the R-tree variants. Its search performance can be poor than the original R-tree, however, since it uses a lossy compression scheme. In this paper, we propose alternatively a cache-conscious version of the R-tree, which we call MR-tree. The MR-tree propagates node splits upward only if one of the internal nodes on the insertion path has empty room. Thus, the internal nodes of the MR-tree are almost 100% full. In case there is no empty room on the insertion path, a newly-created leaf simply becomes a child of the split leaf. The height of the MR-tree increases according to the sequence of inserting objects. Thus, the HeightBalance algorithm is executed when unbalanced heights of child nodes are detected. Additionally, we also propose the CCMR-tree in order to build a more cache-conscious MR-tree. Our experimental and analytical study shows that the two-dimensional MR-tree performs search up to 2.4times faster than the ordinary R-tree while maintaining slightly better update performance and using similar memory space.

Cache Sensitive T-tree Main Memory Index for Range Query Search (범위질의 검색을 위한 캐시적응 T-트리 주기억장치 색인구조)

  • Choi, Sang-Jun;Lee, Jong-Hak
    • Journal of Korea Multimedia Society
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    • v.12 no.10
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    • pp.1374-1385
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    • 2009
  • Recently, advances in speed of the CPU have for out-paced advances in memory speed. Main-memory access is increasingly a performance bottleneck for main-memory database systems. To reduce memory access speed, cache memory have incorporated in the memory subsystem. However cache memories can reduce the memory speed only when the requested data is found in the cache. We propose a new cache sensitive T-tree index structure called as $CST^*$-tree for range query search. The $CST^*$-tree reduces the number of cache miss occurrences by loading the reduced internal nodes that do not have index entries. And it supports the sequential access of index entries for range query by connecting adjacent terminal nodes and internal index nodes. For performance evaluation, we have developed a cost model, and compared our $CST^*$-tree with existing CST-tree, that is the conventional cache sensitive T-tree, and $T^*$-tree, that is conventional the range query search T -tree, by using the cost model. The results indicate that cache miss occurrence of $CST^*$-tree is decreased by 20~30% over that of CST-tree in a single value search, and it is decreased by 10~20% over that of $T^*$-tree in a range query search.

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Oriental Medical Treatment Pattern of Korean Patients with Dizziness or Vertigo (한국인 어지럼증 환자의 최근 4년간 한방 진료 양태)

  • Kim, Jae-Yeong;Jeong, Seon-Yeong;Park, Sam-Min;Hwang, Dong-Gyu;Kho, Young Tak
    • Journal of Oriental Neuropsychiatry
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    • v.26 no.3
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    • pp.225-234
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    • 2015
  • Objectives: We aimed to evaluate the use of Korean medicine in patients with dizziness or vertigo, since such study has not been performed previously. Methods: In the current study, we included 3 diagnoses i.e., Disorders of vestibular function (H81), Vertiginous syndromes in diseases classified elsewhere (H82), and Dizziness and giddiness (R42) from the Health Insurance Review and Assessment Service (HIRAS) database for 4 years. We analyzed the database and compared treatment with Korean vs. Western medicine. Results: 1. Korean medical visits and cost have been increasing for 4 years, except 2011. Western medical visits are 11.9 times higher than Korean medical visits. 2. The number of women who received Korean medicine was 2.6 times higher than that of men. 3. Among all ages, the 70~79 years group were the most frequent users of Korean medicine. The older age was correlated with more patients' visits. 4. The comparative number of visits by patient care type for 4 years indicated that outpatients had more visits than hospitalization. Furthermore, outpatient visits have been increasing for 4 years. 5. The comparative number of visits by hospital type for 4 years indicated that visits to the Korean medical clinic were the highest. In primary care, patients used more Korean medicine than Western medicine. In tertiary care, patients used more Western medicine than Korean medicine. 6. Korean medical cost per patient by patient care type for 4 years was a total 89,000 won, hospitalization 449,000 won and outpatient 83,000 won. Costs of all patient care types have been increasing. 7. Korean medical cost per patient by hospital type for 4 years was 156,000 won for Korean medical hospital, 83,000 won for local clinic and 127,000 won for miscellaneous facilities. Costs of all types have been increasing. Conclusions: This study provided objective information about epidemiologic characteristics of Korean medicine in patients with dizziness or vertigo. Furthermore, it provides an understanding of the recent status and forms the basis for further expansion of demand for Korean medicine among patients with dizziness or vertigo.

Multilevel Analysis of Factors Related to Cost and Length of Stay in Acute Myocardial Infarction Patients with Coronary Stenting: Based on Korean National Health Insurance Service's Customized Database in 2010 and 2015 (관상동맥 스텐트를 삽입한 급성 심근경색 환자의 진료비 및 재원일수 관련 요인에 대한 다수준분석: 2010년과 2015년 국민건강보험공단 맞춤형 데이터베이스 자료를 바탕으로)

  • Choi, Boyoung;Lee, Hae-Jong
    • Health Policy and Management
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    • v.30 no.3
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    • pp.418-429
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    • 2020
  • Background: This study aims to analyze the cost and the length of stay (LOS) of acute myocardial infarction (AMI) patients with coronary artery stenting according to the characteristics of individuals and institutions. Methods: The data was collected from Korean National Health Insurance Service's customized database in 2010 and 2015. Chi-square test, t-test, analysis of variance, and multilevel analysis were performed. Results: The intraclass correlation coefficients for cost were 7.02% in 2010, 5.61% in 2015 and for LOS were 3.17%, 1.40%, respectively. The average costs were 9,067,000 won in 2010 and 9,889,000 won in 2015 (p<0.0001). However, the cost in 2015 was lower than the cost applying increased fee. The costs increased in aged 50-59 years, 60-69 years, and aged ≥70 years versus in aged under 49 years. The cost was higher in Charlson comorbidity index (CCI) 3 to 4 and ≥5 than in CCI 0. The costs were lower in male, medical aid recipients, metropolises, and local hospitals in other regions in 2010. LOS decreased from 8.1 days in 2010 to 7.4 days in 2015. It decreased in male, high income group, and the group of admission via emergency room. However, it increased in higher ages and medical aid recipients, and it also increased when CCI rose. The Internal Herfindahl Index was related to LOS in 2010. Conclusion: The variation of hospital level was small compared to the patient level. Therefore, it is important to implement applicable policies at the patient level in order to reduce cost and LOS of AMI patients.

Parallel Multithreaded Processing for Data Set Summarization on Multicore CPUs

  • Ordonez, Carlos;Navas, Mario;Garcia-Alvarado, Carlos
    • Journal of Computing Science and Engineering
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    • v.5 no.2
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    • pp.111-120
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    • 2011
  • Data mining algorithms should exploit new hardware technologies to accelerate computations. Such goal is difficult to achieve in database management system (DBMS) due to its complex internal subsystems and because data mining numeric computations of large data sets are difficult to optimize. This paper explores taking advantage of existing multithreaded capabilities of multicore CPUs as well as caching in RAM memory to efficiently compute summaries of a large data set, a fundamental data mining problem. We introduce parallel algorithms working on multiple threads, which overcome the row aggregation processing bottleneck of accessing secondary storage, while maintaining linear time complexity with respect to data set size. Our proposal is based on a combination of table scans and parallel multithreaded processing among multiple cores in the CPU. We introduce several database-style and hardware-level optimizations: caching row blocks of the input table, managing available RAM memory, interleaving I/O and CPU processing, as well as tuning the number of working threads. We experimentally benchmark our algorithms with large data sets on a DBMS running on a computer with a multicore CPU. We show that our algorithms outperform existing DBMS mechanisms in computing aggregations of multidimensional data summaries, especially as dimensionality grows. Furthermore, we show that local memory allocation (RAM block size) does not have a significant impact when the thread management algorithm distributes the workload among a fixed number of threads. Our proposal is unique in the sense that we do not modify or require access to the DBMS source code, but instead, we extend the DBMS with analytic functionality by developing User-Defined Functions.

Vitamin B6 Content of Vegetables and Fruits Cultivated in Korea (국내 채소류와 과일류의 비타민 B6 함량)

  • Choi, So-Ra;Song, Young-Eun;Han, Hyun-Ah;Lee, Song-Yee;Shin, So-Hee;Park, Jin-Ju
    • The Korean Journal of Food And Nutrition
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    • v.32 no.6
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    • pp.745-752
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    • 2019
  • The purpose of this study was to determine the difference in vitamin B6 content according to the varieties, regions, and harvest times of vegetables and fruits in Korea using high performance liquid chromatography. We verified the accuracy of the analytical method with standard reference material 1849a and achieved reliability for internal analysis quality control with a mixture of cereal, whole wheat, and flour. As a result of the analysis, vitamin B6 contents (㎍/100 g) were 6.9~86.5 in peppers, 5.1~17.2 in paprika, 4.4~5.0 in strawberries, 4.0~52.9 in tomatoes, 7.7~7.8 in Chinese cabbage, 17.3~23.3 in radishes, 13.4~37.6 in apples, 2.3~12.7 in peaches, and 3.7~12.7 in grapes. In general, the difference in vitamin B6 content showed by varieties, harvest times, and regions. Peppers showed the most difference as 79.6 ㎍/100 g among the varieties, and apples showed a difference as 22.8 ㎍/100 g by regions. According to the harvest times in grape 'Mihwang', there was a difference of 7.5 ㎍/100 g. We will collect an amount of nutritional data on various food materials, and continue to build a reliable and integrated nutritional database. And then the database will be used in the 10th revision of the Korean Food Composition Table.

Development and Evaluation of Korean Ambulatory Patient Groups (한국형 외래환자분류체계의 개발과 평가)

  • Park, Ha-Young;Kang, Gil-Won;Koh, Young
    • Health Policy and Management
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    • v.16 no.1
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    • pp.17-40
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    • 2006
  • With the prospect of rapidly growing health insurance expenditures, particularly spending for ambulatory care, the introduction of a case-based payment method is discussed as an alternative to the current fee-for-service based method. A system to measure case mixes of providers is a core component of such payment systems. The objective of this study were to develop a classification system for ambulatory care, Korean Ambulatory Patient Group (KAPG) based on the U.S. APG version 2.0 and to evaluate the classification accuracy of the system. A database of 64,258,386 records was constructed from insurance claims submitted to the Health Insurance Review Agency (HIRA) during three months from August 2002. A total of 41,347,307 records with a single visit was used for the development and 7% random sample of the database was used for the evaluation. Additional groups were defined to include both physician and hospital fees in the classification, age splits were added to classify the entire population as well as the population older than 65, and the definition of medical groups used by the HIRA was adopted. The variance reduction in charges achieved by KAPGs was computed to evaluate the accuracy of classification. A total of 474 KAPGs was defined compare to 290 groups in the U.S. APG. The variance reduction for charges of all visits ranged from 20% to 37% depending on the type of provider, and ranged from 22% to 42% for non-outliers, that were better than those achieved by the system currently used by the .HIRA for its internal review purpose. Although further study is required to improve the classification for complicated care in larger hospitals, the results indicated that KAPGs could be used for better management of costs for ambulatory care.

Isolation and Identification of Yeasts from Wild Flowers of Daejeon City and Chungcheongnam-do in Korea (대전과 충남 지역에서 채취한 야생화로부터 효모의 분리 및 동정)

  • Min, Jin-Hong;Hyun, Se-Hee;Kang, Min-Gu;Lee, Hyang-Beom;Kim, Chang-Mu;Kim, Ha-Kun;Lee, Jong-Soo
    • The Korean Journal of Mycology
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    • v.40 no.3
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    • pp.141-144
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    • 2012
  • Total 50 species, 80 strains: Eighty strains of yeasts were isolated from wild flowers of Daejeon city and its surroundings in Korea. Isolated yeasts were identified by comparison of their PCR-amplified 18s rDNA V3 region or internal transcribed spacer-2 (ITS-2) genes with BLAST database. Among them, 32 species, 54 strains of yeasts were isolated and identified from wild flowers of Daejeon city, and Cryptococcus species were dominant yeasts. Furthermore, 18 species, 26 strains of yeasts were isolated and identified from wild flowers of Geumsan-gun and Nonsan-gun, Chungcheongnam-do in Korea, and also Candida species and Pseudozyma species were dominant yeasts.

Korea Emissions Inventory Processing Using the US EPA's SMOKE System

  • Kim, Soon-Tae;Moon, Nan-Kyoung;Byun, Dae-Won W.
    • Asian Journal of Atmospheric Environment
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    • v.2 no.1
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    • pp.34-46
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    • 2008
  • Emissions inputs for use in air quality modeling of Korea were generated with the emissions inventory data from the National Institute of Environmental Research (NIER), maintained under the Clean Air Policy Support System (CAPSS) database. Source Classification Codes (SCC) in the Korea emissions inventory were adapted to use with the U.S. EPA's Sparse Matrix Operator Kernel Emissions (SMOKE) by finding the best-matching SMOKE default SCCs for the chemical speciation and temporal allocation. A set of 19 surrogate spatial allocation factors for South Korea were developed utilizing the Multi-scale Integrated Modeling System (MIMS) Spatial Allocator and Korean GIS databases. The mobile and area source emissions data, after temporal allocation, show typical sinusoidal diurnal variations with high peaks during daytime, while point source emissions show weak diurnal variations. The model-ready emissions are speciated for the carbon bond version 4 (CB-4) chemical mechanism. Volatile organic carbon (VOC) emissions from painting related industries in area source category significantly contribute to TOL (Toluene) and XYL (Xylene) emissions. ETH (Ethylene) emissions are largely contributed from point industrial incineration facilities and various mobile sources. On the other hand, a large portion of OLE (Olefin) emissions are speciated from mobile sources in addition to those contributed by the polypropylene industry in point source. It was found that FORM (Formaldehyde) is mostly emitted from petroleum industry and heavy duty diesel vehicles. Chemical speciation of PM2.5 emissions shows that PEC (primary fine elemental carbon) and POA (primary fine organic aerosol) are the most abundant species from diesel and gasoline vehicles. To reduce uncertainties in processing the Korea emission inventory due to the mapping of Korean SCCs to those of U.S., it would be practical to develop and use domestic source profiles for the top 10 SCCs for area and point sources and top 5 SCCs for on-road mobile sources when VOC emissions from the sources are more than 90% of the total.