• Journal of The Association for Neo Medicine
• /
• v.1 no.1
• /
• pp.57-89
• /
• 1996

A Typification of diagnosis and treatment(DT) model must be done in order to generalize the objective stage to the result of treatment to internal disease in connection with the type of viscera and bowel symptom. We could find 108 DT models in internal disease from the combination of 18 types of viscera and bowel and 6 types of DT treatment processes. Thus, the typification of 108 models of DT can be viewed as a modeling processes of utilizing DT knowledge at each stage. We argue that objectivity in diagnosis and treatment of internal disease can be obtained practically from typification of DT model.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2010.11a
• /
• pp.213-216
• /
• 2010

A typical unsteady internal ballistic analysis model was proposed to take account of the erosive burning for a solid rocket motor. The variance of local velocity and pressure along grain surface are analyzed by using the continuity and momentum equation. The model introduced in this study showed good agreements with the results of previous internal ballistics program. It was investigated that the change of combustion pressure, gas velocity and regrestion rate along the grain axis.

• Proceeding of EDISON Challenge
• /
• 2016.03a
• /
• pp.222-227
• /
• 2016

In this paper, the optimized design for bow structure was investigated by using EDISON software. Considering the mechanism of the bow, non-linear FEM analysis was essential. The factors of the design are height, width, number of holes and taper value. High performance of the internal energy and lowest mass were main issues. The limit of the von-mises stress was yield strength for the material. Material was chosen by considering typical bow material, Aluminum. Using Taguchi method($L_9$), 9 models were selected and contribution rate was calculated for each factors. Following the contribution rate, 3 factors were fixed and optimized model was predicted. After making optimized model for FEM analysis, the value of internal-energy, mass for FEM model were compared with predicted value, calculated the percentage error and figure out the reliability of Taguchi method.

• Journal of Biomedical Engineering Research
• /
• v.25 no.4
• /
• pp.283-288
• /
• 2004

The finite element modeling of small female occupant for crash simulation is presented in this paper subsequently to the part I of articulated rigid body model. The limbs and internal components are additionally modeled by joining them to the articulated rigid body model for predicting the crash injuries such as bone fractures and joint dislocations. The behavioral characteristics of each limbs and internal components were validated against available cadaveric test results. Accordingly, the human model proposed in this paper could be utilized for the investigation of impact injury mechanism and further complement the lacking biofidelity of current crash dummy.

• Journal of the Korean Society for Precision Engineering
• /
• v.25 no.3
• /
• pp.157-164
• /
• 2008

While developing physical prototype from CAD model, rapid prototyping mainly focuses on two key points reducing time and material consumption. So, we have to change from a traditional solid model to building a hollowed prototype. In this paper, a new method is presented to hollow out solid objects with uniform wall thickness to increase RP efficiency. To achieve uniform wall thickness, it is necessary to generate internal contour by slicing the offset model of an STL model. Due to many difficulties in this method, this paper proposes a new algorithm that computes internal contours computing offset model which is generated from external contour using wall thickness. Proposed method can easily compute the internal contour by slicing the offset surface defined by the sum of circle swept volumes of external contours without actual offset and the circle wept volumes. Internal contour existences are confirmed by using the external point. Presented algorithm uses the 2D geometric algorithm allowing RP implementation more efficient. Various examples have been tested with implementation of the algorithm, and some examples are presented for illustration.

• Transactions of the Korean hydrogen and new energy society
• /
• v.24 no.5
• /
• pp.401-412
• /
• 2013

The paper is to study on the simulation of the micro/macroscale thermo-electrochemical model of a single cell of anode-supported SOFC with direct internal reforming. The coupled heat and mass transport, electrochemical and reforming reactions, and fluid flow were simultaneously simulated based on mass, energy, charge conservation. The micro/macroscale model first calculates the detailed electrochemical and direct internal reforming processes in porous electrodes based on the comprehensive microscale model and then solve the macroscale processes such as heat and mass transport, and fluid flow in SOFCs with assumption of fully-developed flow in gas channel. The simulation results evaluate the overall performance by analyzing distributions of mole fraction, current density, temperature and microstructural design in co/counter flow configurations.

• The Journal of Korean Medicine
• /
• v.34 no.1
• /
• pp.1-14
• /
• 2013

Objectives: This study was designed to investigate the anti-obesity, anti-diabetic and anti-inflammatory effects of Platycodi radix on obese type 2 diabetes mouse model. Methods: Obese type 2 diabetes mouse model was induced by Surwit's high fat, high sucrose diet for 8 weeks. Models were divided into 4 groups of normal diet (ND, n=10), high fat and high sucrose diet (HFD, n=10), high fat and high sucrose diet with Platycodi radix (PR, n=10), and high fat and high sucrose diet with Metformin (Met, n=10). Body weights were measured every week. After 7 weeks fasting, blood sugar and oral glucose tolerance tests were conducted. After 8 weeks blood samples were taken from mouse hearts and analyzed biochemically. Lipid profile, fructosamine, leptin and weight of epididymal fat pad and liver were measured. Adipose tissue macrophage percentage was analyzed by fluorescence-activated cell sorting (FACS). Results: Compared with the HFD group, body weight, glucose level, fructosamine, weight of epididymal fat pad and adipose tissue macrophage percentage decreased in the PR group. Conclusions: These results suggest that Platycodi Radix has anti-obesity, anti-diabetic, and anti-inflammatory effects on obese type 2 diabetes mouse model.

• Ocean and Polar Research
• /
• v.36 no.1
• /
• pp.1-12
• /
• 2014

This study investigates spatial and temporal variations in the generation and propagation of internal tides around the Korea Strait using a three-dimensional high resolution model (Regional Ocean Modeling System; ROMS). The model results were verified through comparison with in-situ current measurements from an array of 12 acoustic Doppler current profilers (ADCPs) deployed in the Korea Strait. Fluxes and distributions of internal tidal energy were calculated using simulation results gathered in February and August. Our analyses reveal that energetic semidiurnal internal tides are generated in a region around the Korea Strait shelf break ($35.5^{\circ}N$, $130^{\circ}{\sim}130.5^{\circ}E$), where the strong cross-slope semidiurnal barotropic tidal currents interact with a sudden topographical change. The semidiurnal internal tidal energy generated in summer displays values about twice as large as values in winter. Propagation of semidiurnal internal tides also reveals seasonal variability. In February, most of the semidiurnal internal tides propagate only into the open basin of the East Sea due to weak stratification in the Korea Strait, which inhibits their southwestward propagation. In August, they propagate southwestward to $35.2^{\circ}N$ along the western channel of the Korea Strait because of strong stratification. In addition, semidiurnal internal tides generated in a region west of Tsushima Island are found to propagate to the coast of Busan. This can be explained by the intensified stratification due to the strong intrusion of bottom cold water in the western channel of the Korea Strait during summer.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.3
• /
• pp.1059-1063
• /
• 2012

Objective: Angiogenesis represents a key element in the pathogenesis of malignancy. There are no robust data on prognostic factors for overall survival (OS) in patients with metastatic colorectal cancer treated with vascular endothelial growth factor (VEGF)-targeted therapy. The present study was conducted to establish a prognostic model for patients using an oxaliplatin-based or irinotecan-based chemotherapy plus bevacizumab in metastatic colorectal cancer. Methods: Baseline characteristics and outcomes on 170 patients treated with FOLFIRI or XELOX plus anti-VEGF therapy-naive metastatic colorectal cancer were collected from three Turkey cancer centers. Cox proportional hazards regression was used to identify independent prognostic factors for OS. Results: The median OS for the whole cohort was 19 months (95% CI, 14.3 to 23.6 months). Three of the seven adverse prognostic factors according to the Anatolian Society of Medical Oncology (ASMO) were independent predictors of short survival: serum lactate dehydrogenase (LDH) greater than the upper limit of normal (ULN; p<0.001); neutrophils greater than the ULN (p<0.0014); and progression free survival (PFS) less than 6 months (p =0.001). Conclusion: Serum LDH and neutrophil levels were the main prognostic factors in predicting survival, followed by PFS. This model validates incorporation of components of the ASMO model into patient care and clinical trials that use VEGF-targeting agents.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.10 no.4
• /
• pp.105-117
• /
• 2010

The topographical depressions in urban areas, the lack in drainage capability, sewage backward flow, road drainage, etc. cause internal inundation, and the increase in rainfall resulting from recent climate change, the rapid urbanization accompanied by economic development and population growth, and the increase in an impervious area in urban areas deteriorate the risk of internal inundation in the urban areas. In this study, the vulnerability of internal inundation in urban areas is analyzed and SWMM model is applied into Oncheoncheon watershed, which represents urban river of Busan, as a target basin. Based on the results, the representative storm sewers in individual sub-catchments is selected and the risk of vulnerability to internal inundation due to rainfall in urban streams is analyzed. In order to analyze the risk and vulnerability of internal inundation, capacity is applied as an index indicating the volume of a storm sewer in the SWMM model, and the risk of internal inundation is into 4 steps. For the analysis on the risk of internal inundation, simulation results by using a SMMM model are compared with the actual inundation areas resulting from localized heavy rain on July 7, 2009 at Busan and comparison results are analyzed to prove the validity of the designed model. Accordingly, probabilistic rainfall at Busan was input to the model for each frequency (10, 20, 50, 100 years) and duration (6, 12, 18, 24hr) at Busan. In this study, it suggests that the findings can be used to preliminarily alarm the possibility of internal inundation and selecting the vulnerable zones in urban areas.