• Title/Summary/Keyword: Interdisciplinary

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Small Animal PET Imaging Study of 68Ga-BAPEN (68Ga-BAPEN 소동물 PET영상 연구)

  • Kim, Ji-Who;Lee, Jae-Sung;Yang, Bo-Yeun;Kim, Su-Jin;Kim, Joong-Hyun;Jeong, Jae-Min;Lee, Dong-Soo
    • Progress in Medical Physics
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    • v.22 no.4
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    • pp.172-177
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    • 2011
  • The purpose of this study was to analyze $^{68}Ga$-BAPEN dynamic PET image in rat myocardium to evaluate potential of this radiotracer as a perfusion imaging agent. Animal PET/CT scan was done in 9 rats during 120 minutes. Especially we synthesized $^{68}Ga$-BAPEN with kit which is simple and low cost method. PET images showed the in vivo dynamic distribution of $^{68}Ga$-BAPEN in the chest region of rats. Initially $^{68}Ga$-BAPEN PET images showed aorta and liver activities and a few minutes later, $^{68}Ga$-BAPEN moved to myocardium. Regions of interest were drawn on myocardium, liver, lung and blood pool. Time-activity curves showed significant uptake of $^{68}Ga$-BAPEN in myocardium. The contrast ratios of myocardial to blood pool, lung and liver at 60 minutes after injection were 1.66, 2.82 and 0.60. To estimate accurate kinetic parameters, 60 minutes after injection was required to PET scan as myocardium image contrast ratios reached to constant values. As a result, $^{68}Ga$-BAPEN would be suitable radiotracer for PET which can applied to diagnosis of myocardial perfusion diseases after further preclinical and clinical investigations.

Analysis and Improvement of System Efficiency for the Moving-actuator type Bi-Ventricular Assist Device ($AnyHeart^{TM}$) (한국형 양심실 보조 인공 심장의 효율 분석 및 개선에 관한 연구)

  • Chung, J.H.;Nam, K.W.;Choi, S.W.;Lee, J.J.;Park, C.Y.;Kim, W.E.;Choi, J.S.;Min, B.G.
    • Journal of Biomedical Engineering Research
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    • v.22 no.5
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    • pp.449-458
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    • 2001
  • This is a test report of system efficiency for the moving-actuator type Bi-ventricular assist device (AnyHear $t^{MT}$ ) Seoul National University). $AnyHeart^{TM}$), as an energy converter. utilities a brushless DC motor(S/M 566-26A. Sierracin/ Magnedyne, Carlsbad, CA. U.S.A.) generating their pendulous motion in the epicyclic gear train. It is necessary to know about the overall efficiency of the system. The system is subdivided into three parts: motor part, actuator part and blood sac part (including valves, etc.) according to system mechanism. The motor was operated with a variable range of torque. angular speed and width of voltage Pulse In this report. $AnyHeart^{TM}$ is focused on the efficiency of the motor and actuator parts. 4 $\ell/min$ pump output. which is normal condition of $AnyHeart^{TM}$ system, the total system efficiency is 8%, which is composed of 50%, 85% and 17% efficiency (motor Part, actuator Part and blood sac Part) respectively. In the analyzed result. applied input voltage on normal condition of $AnyHeart^{TM}$ is determined. Also speed Profile with considering filling state of blood sac is Provided. In the test of the in vitro mock circulation. some experimental results are Provided to demonstrate the effectiveness of the Presented approach.

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Analysis of Survey of Interdisciplinary Unification of Biomedical Laboratory Science (임상병리학과 학제단일화에 대한 설문조사 분석)

  • Kim, Hong Sung;Kang, Ji-Hyuk;Yang, Man-Gil;Park, Chang-Eun;Shin, Kyung-A;Kwon, Pil Seung
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.3
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    • pp.289-296
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    • 2018
  • Opinions regarding interdisciplinary unification of medical laboratory science were analyzed by an online questionnaire distributed to 255 professors and 4,000 hospital practitioners in January of 2018. The recovery rate was 79 (30.9%) for professors and 1,368 (34.2%) for hospital practitioners. In the perception survey on the duality of interdisciplinary, both the professors and the hospital practitioners reported that they felt interdisciplinary integration is necessary. The prerequisite of four-year integration was the establishment of institute of accreditation and standardization of curriculum, and the requirements for the four-year integration were considered important for adjustment of student quota and standardization of curriculum. In the four-year integrated approach, the opinion that only universities that passed the accreditation evaluation should operate a four-year system was highest among professors and hospital practitioners. The optimum capacity of university students was less than 40 in cases of 4-year integration. In conclusion, the above results suggest that the professors and hospital practitioners realize 4-year interdisciplinary integration is necessary to produce a competent medical technologist, and the institute of accreditation, standardization of curriculum, and student quota adjustment should be presupposed for 4-year integration.

Analyzing the effect of Interdisciplinary Course of Design, Business and Literature : Focusing on Human Relations, Resource & Information Use and Communication competency (학제간 융합수업의 핵심역량 향상 효과 분석 -대인관계, 자원·정보·기술의 활용, 의사소통 역량을 중심으로-)

  • Yi, San-Bsun;Kim, Dong-Min;Seo, Seong-Eun;Park, Kyung-Moon
    • 대한공업교육학회지
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    • v.41 no.2
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    • pp.151-171
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    • 2016
  • The purpose of this study is to verify the effect of Interdisciplinary course for improving the competency of collegiate Interpersonal & Cooperative Skills, Resources-Information-Technology Processing & Application and Communication. The course proved to be effective based on the result for examination of difference between the experimental group of 43 students who took the interdisciplinary course and the control group of 44 students who did not take that course of the second semester of H university in 2015. The study applied the method of Paired-sample T-Test to investigate the difference of Interpersonal & Cooperative Skills, Resources-Information-Technology Processing & Application and Communication and their sub-skills between the two participant groups. As a result, Interdisciplinary course had an effect on improvement of Interpersonal & Cooperative Skills and it's sub skills; however, it had no effect on improvement of Resources-Information-Technology Processing & Application and Communication competency and their sub-skills. The results provide theoretical and practical implications for the interdisciplinary course and core competence of college students. They suggest that interdisciplinary course design should be more careful to improve students' competency on Resources-Information-Technology Processing & Application and Communication competency than before.

Educational Effects of Interdisciplinary Creativity Promotion Program Based on Movie-Assisted Flipped Learning of creativity and STEAM literacy indexes in College Students (영화를 활용한 플립러닝 기반의 학제 간 융합 창의성 증진 프로그램이 대학생의 창의성과 융합인재소양에 미치는 효과)

  • Kim, Byung-Man;Youn, Jeong-Jin;Kim, Seoung-Won
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.7 no.7
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    • pp.37-47
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    • 2017
  • The purpose of this study is to investigate how flip learning based interdisciplinary fusion creativity promotion program using movie is effective for university students creativity and fusion talent literacy. To do this, we conducted a total of 15 sessions for a total of 89 students from 44 college students and 45 non - attendance college students who attended the "Creative Fusion Creative Encounters with Film" course at Busan Metropolitan City. The collected data were analyzed by independent sample t-test using SPSS 23.0 program. The results of this study are as follows. First, flip learning based interdisciplinary fusion creativity enhancement program using movie was significant in the order of patience / attachment, humor, self - confidence, imagination, openness, independence, and curiosity in the creativity sub - domain of college students. Second, flip learning - based interdisciplinary convergence creativity enhancement programs using movies were found to have a significant effect in the order of convergence, care, communication, and creativity in the sub - areas of university students' literacy achievement. The findings of the study proved the educational effects of the interdisciplinary creativity promotion program that was based on movie-assisted flipped learning, and this study is expected to suggest some of the right directions for education-based interdisciplinary research and to give some suggestions on that.

Effects of Liquid Fertilizer of Application from Rendered Livestock Carcass Residues on Maize Cultivation (랜더링 처리된 가축사체 잔류물로 제조한 액비 시용이 옥수수 재배에 미치는 효과)

  • Jae-Hyuk Park;Se-Won Kang;Jin-Ju Yun;Han-Na Cho;Seung-Gyu Lee;So-Hui Kim;Seong-Woo Choi;Ju-Sik Cho
    • Korean Journal of Environmental Agriculture
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    • v.41 no.4
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    • pp.236-244
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    • 2022
  • BACKGROUND: Liquid fertilizers can provide nutrients to crops effectively and quickly. Amino acid liquid fertilizers produced by decomposing the residues of rendered livestock carcasses are expected to be effective in improving the productivity and quality of crops. METHODS AND RESULTS: The treatment conditions for maize cultivation were control (Cn), inorganic fertilizer (IF), inorganic fertilizer and rendering residue liquid fertilizer (IF+RALF), compost (CP), compost and rendering residue liquid fertilizer (CP+RALF). Crop productivity, sugar content, and nutrient uptake were investigated after maize harvest in the field applied with liquid fertilizers. Maize yields ranged from 87.6-158 g/plant, and the yield increased by 7.9% and 12.9% in IF+RALF IF+RALF and CP+RALF than in IF and CP, respectively. The maize sugar content increased in the range of 0.1-0.5 brix % by rendering residue liquid fertilizer (RALF) fertilization, and the sugar content was the highest in CP+RALF. There was no significant change in soil chemical properties of the soil due to liquid fertilizer treatment. CONCLUSION(S): RALF increased yield and sugar content in maize cultivation, and fertilization with organic fertilizers was more effective for maize cultivation than inorganic fertilizers. Residues of rendered livestock carcass can be recycled as amino acid fertilizers, which can be effectively used for crop production and quality improvement.

Retrieving Protein Domain Encoding DNA Sequences Automatically Through Database Cross-referencing

  • Choi, Yoon-Sup;Yang, Jae-Seong;Ryu, Sung-Ho;Kim, Sang-Uk
    • Bioinformatics and Biosystems
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    • v.1 no.2
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    • pp.95-98
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    • 2006
  • Recent proteomic studies of protein domains require high-throughput and systematic approaches. Since most experiments using protein domains, the modules of protein-protein interactions, require gene cloning, the first experimental step should be retrieving DNA sequences of domain encoding regions from databases. For a large scale proteomic research, however, it is a laborious task to extract a large number of domain sequences manually from several inter-linked databases. We present a new methodology to retrieve DNA sequences of domain encoding regions through automatic database cross-referencing. To extract protein domain encoding regions, it traverses several inter-connected database with validation process. And we applied this method to retrieve all the EGF domain encoding DNA sequences of homo sapiens. This new algorithm was implemented using Python library PAMIE, which enables to cross-reference across distinct databases automatically.

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Development of Text-to-Speech System for PC (PC용 Text-to-Speech 시스템 개발)

  • Choi Muyeol;Hwang Cholgyu;Kim Soontae;Kim Junggon;Yi Sopae;Jang Seokbok;Pyo Kyungnan;Ahn Hyesun;Kim Hyung Soon
    • Proceedings of the Acoustical Society of Korea Conference
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    • autumn
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    • pp.41-44
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    • 1999
  • 본 논문에서는 PC 응용을 위한 고음질의 한국어 text-to-speech(TTS) 합성 시스템을 개발하였다. 개발된 시스템의 합성방식으로는 음의 고저 조절, 인접음 사이의 연결 처리 및 음색제어 등에서 기존의 PSOLA 방식에 비해 장점을 가지는 정현파 모델 기반의 방식을 채택하였고, 자연스러운 운율 모델링을 위하여 통계적 기법중의 하나인 Classification and regression tree(CART) 방법을 사용하였다. 또한 음소 경계의 불연속성 문제를 줄이기 위한 합성단위로 초성-중성 및 종성 단위를 사용하였고, 다양한 음색표현이 가능하도록 음색제어 기능을 갖추었다. 그리고, 표준 Speech Application Program Interface(SAPI)를 준용한 TTS engine 형태로 구현함으로써 PC 상에서의 응용 프로그램 개발 편의성을 높였다. 합성음의 청취평가 결과 음질의 우수성 및 음색제어 기능의 유효성을 확인할 수 있었다.

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From proteomics toward systems biology: integration of different types of proteomics data into network models

  • Rho, Sang-Chul;You, Sung-Yong;Kim, Yong-Soo;Hwang, Dae-Hee
    • BMB Reports
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    • v.41 no.3
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    • pp.184-193
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    • 2008
  • Living organisms are comprised of various systems at different levels, i.e., organs, tissues, and cells. Each system carries out its diverse functions in response to environmental and genetic perturbations, by utilizing biological networks, in which nodal components, such as, DNA, mRNAs, proteins, and metabolites, closely interact with each other. Systems biology investigates such systems by producing comprehensive global data that represent different levels of biological information, i.e., at the DNA, mRNA, protein, or metabolite levels, and by integrating this data into network models that generate coherent hypotheses for given biological situations. This review presents a systems biology framework, called the 'Integrative Proteomics Data Analysis Pipeline' (IPDAP), which generates mechanistic hypotheses from network models reconstructed by integrating diverse types of proteomic data generated by mass spectrometry-based proteomic analyses. The devised framework includes a serial set of computational and network analysis tools. Here, we demonstrate its functionalities by applying these tools to several conceptual examples.