• Genomics & Informatics
• /
• v.17 no.3
• /
• pp.24.1-24.8
• /
• 2019

Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies.

• Journal of the HCI Society of Korea
• /
• v.6 no.1
• /
• pp.17-20
• /
• 2011

The contingency theory of leadership was proposed by F. Fiedler. In his theory, he divided the group into Task oriented and Relationship-oriented people based on work-style by LPC(Least Preffered Co-workers) test. This survey searches significance of interaction usage depending on which group has more aggressive interaction on the address list with mobile phones focusing on the differences between mainfunctions (name, cell phone, group name) and sub-functions (birthday, Photo, E-mail). Itis the hypothesis that the relationship-oriented group has more interaction than the task-oriented group which was identified through the analyzed usage of the address list. Results show that the contingency theory was not appropriately related with the research. Interaction usage by the following task based on Fiedler's contingency theory of leadership isn't related much. However, by discovering the interesting patterns by the test, this research is able to guide human-centered address design directions.

• The Bulletin of The Korean Astronomical Society
• /
• v.39 no.2
• /
• pp.49-49
• /
• 2014

Blue Compact Dwarf galaxies (BCDs) are low-mass galaxies with recently enhanced star formation activity. Since the discovery of old stellar population in the BCDs, a number of hypotheses have been suggested as the origin of the current active star formation. One theory is tidal interactions such as fly-by and merger. In this study we test this hypothesis using a pair of BCDs, ESO 435-IG20 and ESO 435-IG16 that are separate by only ~80 kpc in projection at a similar redshift (at a ~9 Mpc distance). In the HIPASS survey, intergalactic atomic hydrogen envelope has been found to be covering both galaxies, making the pair a good candidate for the case where the star formation has been triggered by tidal interaction. We probe the gas morphology and kinematics of the BCD pair using ATCA HI data in order to find the evidence of tidal interaction. We also estimate star formation rates in the pair based on Ha emission and UV continuum, and compare with other dwarf galaxies to investigate how responsible the tidal interaction is for the enhanced star formation in this case.

• Biomedical Science Letters
• /
• v.17 no.2
• /
• pp.167-171
• /
• 2011

[ ${\alpha}$ ]synuclein (${\alpha}$-syn) is implicated in the pathogenesis of Parkinson's disease (PD) and other related diseases. We have previously reported that ${\alpha}$-syn binds to the cell membranes in a transient and reversible manner. However, little is known about the physiologic function and/or consequence of this association. Here, we examined whether chemically induced perturbations to the cellular membranes enhance the binding of ${\alpha}$-syn, based on hypothesis that ${\alpha}$-syn may play a role in maintenance of membrane integrity or repair. We induced membrane perturbations or alterations in ${\alpha}$-syn-overexpressing human neuroblastoma cells (SH-SY5Y) by treating the cells with hydrogen peroxide ($H_2O_2$) or oleic acid. In addition, membranes fractionated from these cells were perturbed by treating them with proteinase K or chloroform. Dynamic interaction of ${\alpha}$-syn to the membranes was analyzed by the chemical cross-linking assay that we developed in the previous study. We found that membrane interaction of ${\alpha}$-syn was increased upon treatment with membrane-perturbing reagents in a dose and time dependent manner. These results suggest that perturbations in the cellular membranes cause increased binding of ${\alpha}$-syn, and this may have significant implication in the physiological function of ${\alpha}$-syn in cells.

• Journal of Korea Society of Industrial Information Systems
• /
• v.18 no.5
• /
• pp.93-105
• /
• 2013

This paper mainly focuses on comparison analysis of the quality factors targeted at one shopping mall web site in Korea and China. There are a total of 14 hypothesis, and we use the SAS 9.2 statistical package tool. The survey to verify those hypothesis is filled out by 519 voluntary participants. The following describes the results that are found. The shopping mall web site of two countries shows a difference in terms of design, communication, community, commercialization, security, customer satisfaction, repurchase intention, contents, e-commerce, customer loyalty, interaction, technology, reliability, and size. Therefore, we suggest how to implement more effective shopping mall websites based on those 14 factors.

• Research in Community and Public Health Nursing
• /
• v.13 no.2
• /
• pp.216-229
• /
• 2002

Objectives: This study was conducted to investigate the effects of a self growth program through MBTI on interpersonal relationships, and the career identity of nursing college students. Methods: A randomized controlled pre-post test experimental design was used for this study. The 24 nursing students were randomly assigned into two groups: 12 for the experimental group, and 12 for the control group. The subjects were junior nursing students, who were randomly selected from an undergraduate nursing program at K university located in Daegu, Korea. The data was collected from March 18 to April 1, 2002. The MBTI self growth program used in this study was based on the one developed by Shim and Kim (1997). The 12 experimental group students received the group self growth program through MBTI for 15 hours, while the 12 control group students received no treatment, except a series of tests. The Korean version MBTI test used in this study was developed and verified for reliability and validity by Kim and Sim (1990). Change in inter-personal relationships was measured using the Relationship Change Scale developed by Schlein and Guerney (1971), and modified by Lee and Mun (1982). Career identity was measured using the My Vocational Situation developed by Holland. Daiger and Power (1980), and revised by Kim (1997). The data were analyzed with the SPSS Win 10.0 program, through which the 2 test, t-test, and Repeated measures ANOVA were examined. Results: 1) The first hypothesis, 'the experimental group that received the self growth program through MBTI will obtain a higher interpersonal relationship score than the control group', was supported (F=5.295. p=.031. Interaction: p=.000). 2) The second hypothesis, 'the experimental group that received the self growth program through MBTI will obtain a higher career identity score than the control group', was supported (F=28.575, p=.000, Interaction: p=.000). Conclusion: The results showed that the ready planned self growth program through MBTI had positive effects on improving the interpersonal relationships, and the career identity of nursing college students.

• The Journal of Industrial Distribution & Business
• /
• v.9 no.5
• /
• pp.47-62
• /
• 2018

Purpose - Based on preceding studies, this thesis focuses on the finding of the definition and category of mobile tourism application and deriving out its characteristics. And after looking for how they make influences on continuous intention to use, we make empirical study with TAM model. Research design, data, and methodology - There are many Chinese tourist who visit Korea with user's constant intention to use of tourism application. This study is to find out the definition and category of mobile tourism application through research of preceding study and to fomulate the research model and hypothesis that how tourism application attributes (convenience, interaction, accessibility, local basis, security) affect constant intention to use of mobile tourism application. In order to verify a hypothesis, we conducted a survey for Chinese users of tourism application. In empirical study, we analyzed a structure model for frequency analysis, reliability analysis, exploratory factor analysis, validity analysis through IBM SPSS Statistics 21.0 and IBM SPSS AMOS 21.0 Results - Among tourism applications, convenience, interaction, accessibility and local basis have positive effects on both perceived usefulness and perceived easiness respectively. But security does not. Also perceived easiness has a positive effect on perceived usefulness. Finally, perceived usefulness and perceived easiness have positive effect on constant intent to use. Conclusions - Tourism application enterprises should put emphasis on design such as menu or function in order to simplify the operation of new services for new customers. Therefore, comfortable user interface and development of useful function can improve tourism application. Consequently, it leads to the promotion of tourism application. Also, when users perceive tourism application as a useful media which is easy, comfortable and useful content, the degree of constant intention to use becomes increased. It is important to provide plentiful and useful contents for customers and to develop user interface such as easy operation because these factors have positive effects on constant demand and use of tourism application.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.9 no.5
• /
• pp.539-547
• /
• 1985

The low-cycle fatigue crack growth behavior of SUS 304 Stainless steel was investigated at 650.deg. C by the nonlinear fracture mechanics. Crack Propagation can be separated in to cycle-dependent and time-dependent, the former is correlated with .DELTA. $J_{f}$ , J-intergral range and the latter is correlated with J', modified J integral. Transition from cycle-dependent to time-dependent crack growth was successfully predicted using the .betha. hypothesis, which was proposed by the authors on the basis of an analysis on the interaction of elastic and creep strain. To investigate the reliability of .betha.-hypothesis, experimenting by the change of stress-level, stress rate and frequency, following conclusions were obtained. (1) High temperature fatigue crack propagation was separated into cycle-dependent and time-dependent. (2) Transition of crack propagation was predicted by .DELTA. $J_{c}$/.DELTA.$_{f}$ or .betha. (3) Lower limit in cycle-dependent crack propagation was obtained..

• Journal of Distribution Science
• /
• v.14 no.10
• /
• pp.117-126
• /
• 2016

Purpose - Color is perceived to have an effect on humans' cognition and behavior because of its association with specific concepts. Since there are few studies linking color and price presentation, we investigated a constrained condition of consumers' regulatory focus and involvement. Research design, data, and methodology - We performed a 2 (color: red vs. black) × 2 (regulatory focus: prevention vs. promotion) × 2 (involvement: high vs. low) test of our hypothesis. The target product was a portable data storage device (USB) and data from 165 respondents were analyzed. Each condition had two stages. In the first, product information and price were presented. After reviewing the product information, respondents evaluated price attractiveness. In the second stage, respondents filled out regulatory focus and involvement questionnaires. The main variables were color, regulatory focus, and involvement. Therefore, we ran a three-way ANOVA (Analysis of Variance) to test our hypothesis. Results - When the price was red (vs. black), consumers perceived the red price as more attractive than the black price. However, this effect varied by situation. Specifically, in the low involvement condition among prevention-focused consumers, when the price was in red, price attractiveness was higher than when the price was in black. However, for promotion-focused consumers, there was no difference in the price color effect. In the high involvement condition, promotion-focused consumers showed stronger price attractiveness for the red price than the black price. However, the effect of price color diminished for prevention-focused consumers. That is, prevention-focused consumers did not reveal a different price perception between red versus black in the high involvement condition. Conclusions - This research contributes by academically linking the effects of color to price attractiveness, and focusing on the interaction of regulatory focus and involvement. When involvement is low, the effect of red disappeared for promotion-focused consumers, whereas the same happened for prevention-focused consumers under the condition of high involvement.

• Journal of Digital Convergence
• /
• v.13 no.1
• /
• pp.163-176
• /
• 2015

The purpose of this research is to find out the service quality dimensions and detailed elements of a call center, and to study what relationship the service quality dimensions have with service recovery and customer royalty. This research set up the hypothesis and the research model to verify the relationship between the call center service quality and the service quality customer royalty for 139 people surveyed who experienced dissatisfactions. The result of the hypothesis verification shows that it has an influence on the counselors' service quality and service recovery processes of 3 call centers. The service recovery has en influence on the customer royalty. The result quality as a result remained for a customer after counseling can be called the ultimate purpose of using the call center for a customer, and the research shows that it has the largest influence on the service recovery of 3 dimensions of the call center service quality. In the relationship between the service recovery and the customer royalty, the service recovery has a meaningful influence on the customer royalty.