• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1175-1179
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• 2015

Background: Expression of matrix metalloproteinases (MMPs) is up-regulated in human cancers. The aim of present study was to investigate the role of MMP-9 C-1562T polymorphism and its interaction with MMP-2 C-735T polymorphism in susceptibility to breast cancer in a population from Western Iran with Kurdish ethnic background. Materials and Methods: The study sample of 205 individuals consisted of 101 breast cancer patients and 104 healthy subjects. MMP-9 C-1562T and MMP-2 C-735T variants were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Among 67.4% of studied patients the breast cancer developed in the third and forth decades of the life. The frequency of MMP-9 T allele was 17.3% in patients and 10.1% in controls. The presence of T allele significantly increased the risk of breast cancer by 1.87-fold [OR=1.87 (95% CI 1.05-3.33, p=0.035)]. The frequency of MMP-9 CT+TT genotype tended to be higher in those patients with a family history of cancer in first degree-relatives (36.8%) than those without a family history (28.3%, p=0.37). We observed an interaction between the MMP-9 -1562 T allele with MMP-2 -735 C allele that significantly increased the risk of breast cancer [OR=1.42 (95% CI 1.02-1.98, p=0.036)]. Conclusions: The present study demonstrated that MMP-9 C-1562T polymorphism alone and in combination with MMP-2 C-735T polymorphism increased the risk of breast cancer that might be a useful biomarker in identifying women at risk of developing breast cancer. Also, this study revealed that in most women from Western Iran breast cancer presents in third and fourth decades of life.

• International Journal of Computer Science & Network Security
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• 제21권4호
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• pp.178-185
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• 2021

The emergence of social networks has led to the flourishing of a new golden era of branding, which is a challenge for companies due to the need for creative positioning of companies with an emphasis on building trust and loyalty to the brand. Consumers are becoming more demanding and due to a wide range of products in different markets, make demands that are more stringent on companies. The goal of this article was to study the main trends of branding and advertising on social networks to develop a new approach to brand promotion. Methodology. The quantitative and qualitative research design was used to determine the main trends in branding and advertising on social networks. The methodology included the following methods: 1) analysis of the relationship between brand value and brand content strategy, 2) content analysis of the content of companies in social networks on the example of 10 world-famous brands with the highest value. The results allowed forming the criteria of effective content and communication: simplicity of content and simplicity of communication, lack of direct advertising of products, emphasis on global socio-economic problems and social orientation, unobtrusive communication, content creativity, indirect information about the product or work, the history of the company's development through various tools. The main content strategies of brands are defined: storytelling strategy; strategy of informing about the history of the company's development; entertainment and information strategy; strategy of joint interaction with the audience through the involvement of wellknown influencers or users of products. The theoretical and practical value of the results is confirmed by the conceptualization of the main content strategies of world-famous brands, which are pioneers in new ways to build relationships with users through social networks. The research proposes to use a customer-oriented approach to brand promotion. This means studying consumer behavior and predicting possible changes in behavior, which determines the level of interaction with the brand, the content strategy of the brand, and its effectiveness.

• 대한한의학원전학회지
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• 제37권1호
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• pp.1-24
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• 2024

Objectives : The objective of this study is to compare the properties of Mahuang and Shigao based on their similar effects and how they are manifested in formulas that include these medicinals. Methods : Descriptions of Mahuang and Shigao as written in the Shennongbencaojing, Mingyibielu, Bencaogangmu, Benjingshuzheng were analyzed to determine their similar traits. Formulas in which these medicinals were both used for their similar effects were analyzed. Results & Conclusions : Mahuang and Shigao, through their interaction, both communicate fluids, relieve stagnation, and draw out heat or Yang qi from the Yin part. These similarities influence each other, which is related to their common meridian tropism, the Lung Channel, to diffuse, purify and descend. The ten formulas that include the two medicinals were similar in that Yin and Yang were interactive. Of these, those that relieved stagnation were Maxingganshitang and Daqinglongtang. Those which communicated fluids and relieved stagnation were Yuebitang, Yuebijiabanxiatang, Yuebijiashutang, Xiaoqinglongjiashigaotang, Houpumahuangtang, and Wengetang. Those that drew out heat or Yang qi from the Yin part through interaction between Yin and Yang were Guizhieryuebiyitang and Mahuangshengmatang. Previous studies stated that Mahuang and Shigao are different and using both medicinals in the same formula would repress each other or balance each other out-this study focused on their common properties which resulted in the above-mentioned findings.

• Clinical and Experimental Pediatrics
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• 제63권9호
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• pp.368-372
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• 2020

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication. Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children. Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2-10 years without ASD, while the cases were women with a child aged 2-10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level. Results: In the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child's birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11-4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76-9.21; P=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91-27.30; P=0.065). Conclusion: After the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.

• 폴리머
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• 제28권6호
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• pp.455-459
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• 2004

폴리(에틸렌 옥사이드) (PEO)를 기초로 한 전해질의 이온 전도도는 같은 조성인데도 불구하고 보고 된 값은 연구자에 따라 수천 배의 차이가 난다. 한편 세라믹 입자를 충전하면 열적 취급에 따라서 이온전도성이 수천 배 변할 수 있음이 보고되고, 그 원인이 세라믹 입자-PEO 고분자의 상호작용 때문인 것으로 논의되었다. 본 연구에서는 세라믹 입자가 충전되지 않은 PEO$_{10}$LiClO$_4$ 고분자 전해질에 대해서 여러 가지 열적 조건에 따른 이온 전도도의 변화 양상을 조사하고, 이온 전도도 값이 열적 이력에 따라 같은 시료에서도 수백 배 정도 차이가 날 수 있음을 보였다. 이는 PEO의 재결정화 과정이 너무 느리기 때문인 것으로 분석하였다. 따라서 본 연구 결과는 세라믹 충전제 효과가 전도도 이완 현상의 주원인이 아니라는 것을 나타낸다.다.

• 기록학연구
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• 제79호
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• pp.443-469
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• 2024

본 연구는 다양한 기관에서 생산하고 있는 구술 기록과 구술 기록 생산과정에 공론장 형성 기능이 있으며, 이것이 구술 기록의 공공성이라는 점을 드러내려는 데에 목적이 있다. 연구는 이를 위해 공론장과 공공성을 논의하고 분석한 철학, 사회학, 정치학 분야 선행연구를 살펴보면서 공론장의 기능과 공공성의 의미를 규정하고, 그것이 구술 기록의 일반적인 특성과 어떤 연관성이 있는지 확인했다. 본 연구는 이와 같은 논의의 구체성을 확보하기 위해 문화체육관광부에서 주관하고 (협)아카이빙네트워크연구원이 수행했던 ｢2021년 디지털 생활사 아카이빙 사업｣의 성과를 분석하였다. 결과적으로 사업에 참여했던 시민 면담자들의 구술 기획과 구술 기록, 구술 기록 해설로부터 공공성을 강화하는 데 기여할 수 있는 요소를 다수 찾아낼 수 있었다.

• 의학교육논단
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• 제19권2호
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• pp.83-89
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• 2017

The aim of this study is to examine the effect of recorded video monitoring on students' self-reflection after completing their clinical performance examination. Taking into account the particular cases involved in the examination, the present study utilized history-taking, physical examination, and patient education as bases for evaluating information-establishment ability, and asking, listening, understanding, explaining, and connectedness as the bases for evaluating patient-physician interaction ability. Student self-monitoring through recorded video feedback was carried out three days after completion of their clinical performance examination. Students self-evaluated their performance with a 10-point scale before and after self-monitoring. The results of this study show that students have a general tendency to lower their own self-evaluation scores after self-monitoring. Although there was not a statistically significant change of interrelationship in the information-establishment ability evaluation, there was a meaningful change of interrelationship in the patient-physician interaction ability evaluation after self-monitoring; specifically, in the case of acute lower abdominal pain, a high correlation was found (r=0.31, p=0.02) between the evaluation scores of standardized patients and students related to patient-physician interaction ability. This implies that self-monitoring enables the students to acquire a reflective viewpoint from which to evaluate their own performance. Therefore, it can be said that self-monitoring through recorded video feedback is a valuable method for students to use in reviewing their performance in patient-physician interactions.

• Structural Engineering and Mechanics
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• 제56권1호
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• pp.27-47
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• 2015

In this study, the accuracy and reliability of fully nonlinear method against equivalent linear method for dynamic analysis of soil-structure interaction is investigated comparing the predicted results of both numerical procedures with the results of experimental shaking table tests. An enhanced numerical soil-structure model has been developed which treats the behaviour of the soil and the structure with equal rigour. The soil-structural model comprises a 15 storey structural model resting on a soft soil inside a laminar soil container. The structural model was analysed under three different conditions: (i) fixed base model performing conventional time history dynamic analysis, (ii) flexible base model (considering full soil-structure interaction) conducting equivalent linear dynamic analysis, and (iii) flexible base model performing fully nonlinear dynamic analysis. The results of the above mentioned three cases in terms of lateral storey deflections and inter-storey drifts are determined and compared with the experimental results of shaking table tests. Comparing the experimental results with the numerical analysis predictions, it is noted that equivalent linear method of dynamic analysis underestimates the inelastic seismic response of mid-rise moment resisting building frames resting on soft soils in comparison to the fully nonlinear dynamic analysis method. Thus, inelastic design procedure, using equivalent linear method, cannot adequately guarantee the structural safety for mid-rise building frames resting on soft soils. However, results obtained from the fully nonlinear method of analysis fit the experimental results reasonably well. Therefore, this method is recommended to be used by practicing engineers.

• 복식
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• 제65권8호
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• pp.110-124
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• 2015

This study examined a phenomenon of exaggerated hairstyle in the history of Western custom through publications related with Western costume and research papers. By adopting the criteria of Delong, M. R. to analyze visual forms shown by interaction between human body and costume worn over the body, it analyzed the formative characteristics by the interaction between hairstyle and costume. In addition, it inferred the aesthetic characteristics through content analysis of examined phenomenon focusing on socio-cultural background and costume socio-psychological precedent studies. Formative characteristics of exaggerated hairstyle applied by analysis criteria of Delong, M. R. were in pursuit of the emphasis style. This was clearly and intensively recognized by forming spaces for mostly closure style, part style, three dimensional style, determinate style, and space separation style. Regarding the interaction between hair and ornamentations, 'precedence of ornamentation' was pursued as ornamentations were recognized earlier than the hair itself. It means associative meanings of the surface effect were accompanied by emotions of 'intensiveness' and the pursuit of the attractive style. As for the interaction between hairstyle and costume, there were many cases of pursuing 'continuity' mutually and visually by connecting the hairstyle and the costume. Aesthetic characteristics of exaggerated hairstyle were inferred as 1) the expression of the sprite of the age(i.e. art, culture, politics, society, ideology, religion), 2) symbols of wealth, class, authority, and excellence, 3) pursuit of addicted desire to ornament, and 4) harmony through continuity with costume. This study verified that hairstyle was connected as a part of costume, or formed as a way to express deeper human psychology beyond just a part of a costume. It was also confirmed that hairstyle was an expressive method to express the spirit of the age, such as art, culture, society, religion, ideology.

• Nuclear Engineering and Technology
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• 제48권1호
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• pp.246-258
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• 2016

The shield building of AP1000 was designed to protect the steel containment vessel of the nuclear reactor. Therefore, the safety and integrity must be ensured during the plant life in any conditions such as an earthquake. The aim of this paper is to study the effect of water in the water tank on the response of the AP1000 shield building when subjected to three-dimensional seismic ground acceleration. The smoothed particle hydrodynamics method (SPH) and finite element method (FEM) coupling method is used to numerically simulate the fluid and structure interaction (FSI) between water in the water tank and the AP1000 shield building. Then the grid convergence of FEM and SPH for the AP1000 shield building is analyzed. Next the modal analysis of the AP1000 shield building with various water levels (WLs) in the water tank is taken. Meanwhile, the pressure due to sloshing and oscillation of the water in the gravity drain water tank is studied. The influences of the height of water in the water tank on the time history of acceleration of the AP1000 shield building are discussed, as well as the distributions of amplification, acceleration, displacement, and stresses of the AP1000 shield building. Research on the relationship between the WLs in the water tank and the response spectrums of the structure are also taken. The results show that the high WL in the water tank can limit the vibration of the AP1000 shield building and can more efficiently dissipate the kinetic energy of the AP1000 shield building by fluid-structure interaction.