• Title/Summary/Keyword: Interaction Function

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Graph-based modeling for protein function prediction (단백질 기능 예측을 위한 그래프 기반 모델링)

  • Hwang Doosung;Jung Jae-Young
    • The KIPS Transactions:PartB
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    • v.12B no.2 s.98
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    • pp.209-214
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    • 2005
  • The use of protein interaction data is highly reliable for predicting functions to proteins without function in proteomics study. The computational studies on protein function prediction are mostly based on the concept of guilt-by-association and utilize large-scale interaction map from revealed protein-protein interaction data. This study compares graph-based approaches such as neighbor-counting and $\chi^2-statistics$ methods using protein-protein interaction data and proposes an approach that is effective in analyzing large-scale protein interaction data. The proposed approach is also based protein interaction map but sequence similarity and heuristic knowledge to make prediction results more reliable. The test result of the proposed approach is given for KDD Cup 2001 competition data along with those of neighbor-counting and $\chi^2-statistics$ methods.

Analytical Formulation for the Everett Function

  • Hong, Sun-Ki;Kim, Hong-Kyu;Jung, Hyun-Kyo
    • Journal of Magnetics
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    • v.2 no.3
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    • pp.105-109
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    • 1997
  • The Preisach model neds a density function or Everett function for the hysterisis operator to simulate the hysteresis phenomena. To obtain the function, many experimental data for the first order transition curves are required. However, it needs so much efforts to measure the curves, especially for the hard magnetic materials. By the way, it is well known that the density function has the Gaussian distribution for the interaction axis on the Preisach plane. In this paper, we propose a simple technique to determine the distribution function or Everett function analytically. The initial magnetization curve is used for the distribution of the Everett function for the coercivity axis. A major, minor loop and the initial curve are used to get the Everett function for the interaction axis using the Gaussian distribution function and acceptable results were obtained.

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Modular neural network in prediction of protein function (단위 신경망을 이용한 단백질 기능 예측)

  • Hwang Doo-Sung
    • The KIPS Transactions:PartB
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    • v.13B no.1 s.104
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    • pp.1-6
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    • 2006
  • The prediction of protein function basically make use of a protein-protein interaction map based on the concept of guilt-by-association. The method however cannot determine the functions of proteins in case that the target protein does not interact with proteins with known functions directly. This paper studies protein function prediction considering the given problem as a K-class classification problem and proposes a predictive approach utilizing a modular neural network. The proposed method uses interaction data and protein related attributes as well. The experimental results demonstrate that the proposed approach can predict the functional roles of Yeast proteins whose interaction knowledge is not known and shows better performance than the graph-based models that use protein interaction data.

Computing Method for The Number of The Interaction Strength Based on Software Whitebox Testing (소프트웨어 화이트박스 테스트의 교호 강도 수 기반 테스트 방법)

  • Choi, Hyeong-Seob;Park, Hong-Seong
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.46 no.5
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    • pp.29-36
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    • 2009
  • Cost and Time for software test is gradually increasing as the software complexity increases. To cope with this problem, it is very important to reduce the number of test cases used in the software test. The interaction strength number is especially important in decision of the number of test cases for the unit test, where the interaction strength number means the number of arguments which affect the results of a function by the analysis of their combination used in source code of the function. This paper proposes the algorithm that computes the number of the interaction strength, where analyzes the patterns used in the source code of a function and increase its number when the pattern matches one of the specified patterns. The proposed algorithm is validated by some experiments finding coverage and the number of fault detection.

An Effect of Parent-Child Interactions on Children's Academic Performance: the Mediating Effect of Children's Executive Function Difficulty (부모-아동 상호작용이 아동의 학업수행에 미치는 영향: 아동의 집행기능 곤란의 매개효과)

  • Choi, Hyesun
    • Journal of Korean Home Economics Education Association
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    • v.33 no.1
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    • pp.81-99
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    • 2021
  • The purpose of this study was to examine the effect of parent-child interactions on children's academic performance focusing on the mediating effect of children's executive function difficulty. The data for this study were drawn from the Panel Study on Korean Children(PSKC). The participants were 559 children of elementary school and their families from 8th wave(1st graders), 9th wave(2nd graders), and 10th wave(3rd graders) of PSKC. The data were analyzed with structural equation modeling. The results of this study were as follows. First, mother-child interaction and father-child interaction didn't have a significant direct effect on children's academic performance. Second, mother-child interaction had a significant positive indirect influences on academic performance through children's executive function difficulty. The results of this study indicated that mother-child interaction and children's executive function difficulty are important for children's academic performance.

Calculation of Interaction Parameters in Mixed Layer Minerals and their Application (층상형 혼합광물의 상호작용계수의 계산 및 응용)

  • 이성근;김수진
    • Journal of the Mineralogical Society of Korea
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    • v.10 no.2
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    • pp.97-104
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    • 1997
  • Based on the method of determination for relative stability of each phase from the difference among the interaction parameters of the phases consisting the mixed layer, the types of interactions between layers were specified and interaction parameter between layers in ordered domain was analytically derived as a function parameter between layers in ordered domain was analytically derived as a function of not only temperature and mole fraction of layers but also ordering parameter. Interaction parameter between the different layers in ordered phase, L is as follows:{{{{ {L }_{1 } (X,Q,T)= { C} over { Q} -4(1-2Q) { L}^{2 } - { RT} over {2} ln { 1} over {2 } - { 2RT} over { { X}_{ s} } ln { { 4QX}`_{s } ^{2 } } over {(1- { X}_{s }- { QX}_{s })( { X}_{s }- {QX }_{s } ) } }}}}L2 is the interaction parameter between ordered and disordered phase in domain and is the mole fraction of the domain which represent the infinite length of mixed layer mineral and Q and C are the reaction progress parameter and arbitrary constant, respectively. This equation was used for the I/S mixed layer clay minerals to infer the relative stability of R1 type I/S mixed layer in the temperature range from 373K to 450K. The result of calculation suggest that, owing to the decrease in interaction parameter with increasing temperature. The interaction parameter decreases more rapidly with decreasing mole fraction of smectite in domain, which is consistent with the fact that the probability of finding the series smectite layer is lo in the domain with small mole fraction of smectite layers in natural system.

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A New Function of Skp1 in the Mitotic Exit of Budding Yeast Saccharomyces cerevisiae

  • Kim, Na-Mil;Yoon, Ha-Young;Lee, Eun-Hwa;Song, Ki-Won
    • Journal of Microbiology
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    • v.44 no.6
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    • pp.641-648
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    • 2006
  • We previously reported that Skp1, a component of the Skp1-Cullin-F-box protein (SCF) complex essential for the timely degradation of cell cycle proteins by ubiquitination, physically interacts with Bfa1, which is a key negative regulator of the mitotic exit network (MEN) in response to diverse checkpoint-activating stresses in budding yeast. In this study, we initially investigated whether the interaction of Skp1 and Bfa1 is involved in the regulation of the Bfa1 protein level during the cell cycle, especially by mediating its degradation. However, the profile of the Bfa1 protein did not change during the cell cycle in skp1-11, which is a SKP1 mutant allele in which the function of Skp1 as a part of SCF is completely impaired, thus indicating that Skp1 does not affect the degradation of Bfa1. On the other hand, we found that the skp1-12 mutant allele, previously reported to block G2-M transition, showed defects in mitotic exit and cytokinesis. The skp1-12 mutant allele also revealed a specific genetic interaction with ${\Delta}bfa1$. Bfa1 interacted with Skp1 via its 184 C-terminal residues (Bfa1-D8) that are responsible for its function in mitotic exit. In addition, the interaction between Bfa1 and the Skp1-12 mutant protein was stronger than that of Bfa1 and the wild type Skp1. We suggest a novel function of Skp1 in mitotic exit and cytokinesis, independent of its function as a part of the SCF complex. The interaction of Skp1 and Bfa1 may contribute to the function of Skp1 in the mitotic exit.

Relationship between Maternal Conversational Function and Question Type and Early Language Development (어머니가 사용한 담화기능 및 질문유형과 영아의 언어발달과의 관계)

  • Lee Kwee-Ock
    • The Korean Journal of Community Living Science
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    • v.17 no.3
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    • pp.3-14
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    • 2006
  • The purpose of this study was to investigate the relationship between conversational function and question type in mothers' utterances and their infant's language development. The subjects were 20 infants from 1;07 to 1;11 years of age in Yanji, China. Each child's spontaneous natural speech during interaction with his/her mother was videotaped for about 30 minutes. The children and their mother's spontaneous utterances were transcribed and coded for the number of type and token of word, grammatical morpheme conversational function and type of question in mother's language input to her child. The result showed that mothers used questions as the most frequent conversational function with their infants. The number of questions in conversational function in mothers' utterances positively correlated with the type of word, type of morpheme and grammatical morpheme in infants' utterance. However, there was no correlation between mothers' language input and infant early language development.

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Nonlinear analysis of interaction between flexible pile group and soil

  • Liu, Jie;Li, Q.S.;Wu, Zhe
    • Structural Engineering and Mechanics
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    • v.20 no.5
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    • pp.575-587
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    • 2005
  • Using the nonlinear load transfer function for pile side soil and the linear load transfer function for pile end soil, a combined approach of the incremental load transfer matrix method and the approximate differential equation solution method is presented for the nonlinear analysis of interaction between flexible pile group and soil. The proposed method provides an effective approach for the solution of the nonlinear interaction between flexible pile group under rigid platform and surrounding soil. To verify the accuracy of the proposed method, a static load test for a nine-pile group under a rigid platform is carried out. The finite element analysis is also conducted for comparison purposes. It is found that the results from the proposed method match very well with those from the experimental test and are better in comparison with the finite element method.