• IMMUNE NETWORK
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• v.5 no.1
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• pp.11-15
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• 2005

Background: Throughtout the last three decades, the therapy of leukemias and lymphoma has set the stage for curative cancer therapy in systemic malignant disease. This was the result of an integrated work of basic reaserch and clinical investigators leading to more aggressive albeit tolerable protocol of chemotherapy and radiotherapy. High dose therapy marks the most elaborated strategies in this field today. However, intensification of conventional therapeutic modalities as mentioned has to be based on new approaches and the exploration of new antineoplastic mechanisms. This insight has resulted in immune therapy of cancer. Among the cells of the immune system, natural killer (NK) cells and T cells are of major interest for the development of therapeutic strategies. Methods: Cytotoxicity to target cells was measured by LDH release method, Characterization of activated lymphocyte was measured by Flow cytometry analysis. Anti-CD3, 16, 56 monoclonal antibody and IL-2 were used for the activation of NK and T cell. The analysis of effect of activated lymphocyte, in vivo, were used by Balb/c nude mouse. Results and Conclusion: Cytotoxicity to K562 cells was significantly higher in the mixture group of NK and T cells than that of a group of activating T cells. The survivors and the rate of reduction of size of tumor craft of nude mouse group treatment with activated lymphocyte was higher than that of the group without treatment with activated lymphocyte. Therefore, this results are suggested that the activated lymphocytes by anti-CD3, CD16 and CD56 can reduce the malignancy effect of lymphoma.

• Journal of Korean Society of Transportation
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• v.5 no.2
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• pp.55-72
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• 1987

The work analyzes the existing situation and defines special problems concerning traffic accidents in the two countries. The report is divided into three parts: 1) Using the global approach of SMEED, the data were evaluated using multiple regression analysis, and homogeneous groups of countries were defined by cluster analysis. In the global approach, the linear model is better than SMEED's non-linear model in explaining the number of fatalities. Among the different groups of countries, the linear approach was found to be better suited for industrialized countries and the non-linear approach better for the developing countries. T도 comparison of traffic fatality data for the Federal Republic the developing countries. The comparison of traffic fatality data for the Federal Republic of Germany and the Republic of Korea showed different regression equations during the same time period. 2) The BOX/JENKINS time series analysis on a monthly basis points out clearly similar seasonal patterns for the two countries over the years studied. The decrease in traffic accidents following the intensification of the safety belt requirement was proved in the ARIMA model. It amounts to 7 to 8 percent fewer personal injury accidents and fatal accidents. The identified increase in safety in the Federal Republic of Germany since the 1970s is mainly due to the reduction of accident severity in residential areas. 3) Speeds and headways on motorways in th3e two countries were also compared. The measurements point out that German road users drive faster, take more risks, and accept shorter time gaps than Korean road users. However, the accident statistics show accident rates for Korea that are several times higher than those in the Federal Republic of Germany.

• Journal of the Korean earth science society
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• v.38 no.7
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• pp.469-480
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• 2017

Controversy has surrounded the potential impacts of phytoplankton on the tropical climate, since climate models produce diverse behaviors in terms of the equatorial mean state and El $Ni{\tilde{n}}o$-Southern Oscillation (ENSO) amplitude. We explored biophysical impacts on the tropical ocean temperature using an ocean general circulation model coupled to a biogeochemistry model in which chlorophyll can modify solar attenuation and in turn feed back to ocean physics. Compared with a control model run excluding biophysical processes, our model with biogeochemistry showed that subsurface chlorophyll concentrations led to an increase in sea surface temperature (particularly in the western Pacific) via horizontal accumulation of heat contents. In the central Pacific, however, a mild cold anomaly appeared, accompanying the strengthened westward currents. The magnitude and skewness of ENSO were also modulated by biophysical feedbacks resulting from the chlorophyll affecting El $Ni{\tilde{n}}o$ and La $Ni{\tilde{n}}a$ in an asymmetric way. That is, El $Ni{\tilde{n}}o$ conditions were intensified by the higher contribution of the second baroclinic mode to sea surface temperature anomalies, whereas La $Ni{\tilde{n}}a$ conditions were slightly weakened by the absorption of shortwave radiation by phytoplankton. In our model experiments, the intensification of El $Ni{\tilde{n}}o$ was more dominant than the dampening of La $Ni{\tilde{n}}a$, resulting in the amplification of ENSO and higher skewness.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.1
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• pp.1-18
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• 2013

The elements that determine the success of development projects on goats and the prerequisites for ensuring this are discussed in the context of the bewildering diversity of goat genetic resources, production systems, multifunctionality, and opportunities for responding to constraints for productivity enhancement. Key determinants for the success of pro-poor projects are the imperatives of realistic project design, resolution of priorities and positive impacts to increase investments and spur agricultural growth, and appropriate policy. Throughout the developing world, there exist 97% of the total world population of 921 million goats across all agroecological zones (AEZs), including 570 breeds and 64% share of the breeds. They occupy a very important biological and socioeconomic niche in farming systems making significant multifunctional contributions especially to food, nutrition and financial security, stability of farm households, and survival of the poor in the rural areas. Definitions are given of successful and failed projects. The analyses highlighted in successful projects the value of strong participatory efforts with farmers and climate change. Climate change effects on goats are inevitable and are mediated through heat stress, type of AEZ, water availability, quantity and quality of the available feed resources and type of production system. Within the prevailing production systems, improved integrated tree crops - ruminant systems are underestimated and are an important pathway to enhance C sequestration. Key development strategies and opportunities for research and development (R and D) are enormous, and include inter alia defining a policy framework, resolution of priority constraints using systems perspectives and community-based participatory activities, application of yield-enhancing technologies, intensification, scaling up, and impacts. The priority for development concerns the rainfed areas with large concentrations of ruminants in which goats, with a capacity to cope with heat tolerance, can be the entry point for development. Networks and networking are very important for the diffusion of information and can add value to R and D. Well formulated projects with clear priority setting and participatory R and D ensure success and the realisation of food security, improved livelihoods and self-reliance in the future.

• Convergence Security Journal
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• v.13 no.5
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• pp.129-135
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• 2013

The revised security industry law revised 17 provisions among 31 provisions in order to root out the violent event. The main contents of the revised security industry law is the intensitfication of the required condition of permission, intensitfication of the obligation, management strengthening of the public resentment of group field, official, reason of expansion of the expenses instructor and guard, dress and equipment, vehicle, intensitfication of the managing director, intensitfication of the punishment, and etc. However, there is the problem including the putting under an obligation of the arrangement new appointment education, cause provider punishment of the service company violence, awareness of the police to the security company, excessive regulation, intensification of punishment problem, supervision power intensitfication of the revised security industry law is excessive the police, and etc. The individual responsibility education completion method and public resentment of group field in addition to is thought in order to solve this that exclusion of the prior education obligation, revision of the security industry law, burden on tax payers of the extra charge, punishment of the violence request contract trader, introduction of the guard qualification certificate system, and etc. are needed.

• Journal of the Korean institute of surface engineering
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• v.43 no.6
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• pp.297-303
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• 2010

The effect of solution acidity and organic additives, polyethylene glycol (PEG), on the trivalent chromium electroplating was systematically investigated in the view point of electroreduction of trivalent chromium ions and solution stability. It was found that solution acidity controlled at pH 2.5 showed the widest current range for bright electrodeposits in the presence of PEG additives, which reduced the local current intensification at high current densities. Through complex interaction between PEG additives and hydrogen ion, that is, solution acidity, electrode potential was moved in the negative direction in the bulk solution, while it shifted in the positive when electric potential was scanned. In conjunction with electrochemical quartz crystal microbalance (EQCM), it was found that PEG additives had a role in promoting the electron transfer to trivalent chromium ion complexes in bulk solution and their adsorption at the electrode surface as well as interfering with hydrogen ion reduction process below pH 2.5. The PEG additives developed the nodular morphology during electroreduction of trivalent chromium ions with the increase of solution acidity and enhanced its current efficiency by maintaining the consumption of complexant, formic acid, at low speed.

• The Journal of Information Technology
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• v.6 no.3
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• pp.169-188
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• 2003

Roadmap of cyber trade offers members the opportunity to interact electronically with like-mined individuals and to both create and buyer relevant to a topic of interest. Roadmap of cyber trade was conduct on the economic effect of electronic commerce according to the method of constructing the Internet. Firms using cyber trade have difficulty enjoying a uniformly identical effect. That is, since the improvement effect of the intrafirm business method, unnecessary repeated manual paperwork and the use effect of being able to maintain the close relationship with to the parties to trades in the process of prompt receipt and delivery of documents are long-term and indirect effects, they have some limitation in that they can not be measured as coefficients but only as scales. In terms of business management, the intensification of corporate competitiveness improved by $10.00\%$ in case of less than 10 times and by $11.53\%$ in case of 50 to less than 50 times. And it was found that the effect of profit increase as the number of inquiries was large. That is, it was found that the effect of profit increase was $10.88\%$ when the number of inquiries was less than 10 times but it increased to $14.00\%$ in case of 50$\∼$less than 100 times. Therefore, to revitalize cyber trade, it is thought that government, the academic community and the business world all need to make much research into and sustained investment in cyber trade.

• Ocean and Polar Research
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• v.33 no.4
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• pp.409-419
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• 2011

Semi-diurnal internal tides and near-inertial waves are investigated using moored current meter measurements at four sites along the shelf break of the East China Sea during August 1987 and May-June 1988. Each mooring is equipped with four current meters spanning from near surface to near bottom. Spectral analyses of all current data reveal dominant spectra at the semi-diurnal frequency band, where the upper and lower current measurements show out-of-phase relationship between them with significant coherences. These are consistent with typical characteristics of the first-mode semi-diurnal internal tide. Strong intensification of the near-bottom baroclinic currents is observed only at one site, where the ratio of the bottom slope to the slope of the internal-wave characteristics at the semi-diurnal frequency is close to unity. An energetic near-inertial wave event is observed during the first half of May-June 1988 observation at two mooring sites. Rotary spectra reveal that the most dominant signal is clockwise rotating motion at the near-inertial frequency band. Upward phase and downward energy propagations, shown in time-depth contour plots of near-inertial bandpass filtered currents, are confirmed by cross correlations between the upper- and lower-layer current measurements. The upward-propagating phase speed is estimated to be about 0.13 cm $s^{-1}$ at both sites. Significant coherences and in-phase relationships of near-inertial currents at the same or similar depths between the two sites are observed in spite of their long distance of about 110 km.

• Korean Journal of Remote Sensing
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• v.30 no.4
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• pp.465-480
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• 2014

In this study, we analyzed the spatio-temporal variations of satellite imagery for the two heavy rainfall cases (21 September, 2010, 9 August, 2011) occurred in the Korean Peninsula. In general, the possibility of strong convection can be increased when the region with plenty of moisture at the lower layer overlapped with the boundary between dark and bright area in the water vapor imagery. And the merging of convective cells caused by the difference in the moving velocities of two cells resulted in the intensification of convective activity and rainfall intensity. The rainfall intensity is more closely linked with the minimum cloud top temperature than the mean cloud top temperature. Also the spatio-temporal variations of rainfall intensity are impacted by the existence of merging processes. The merging can be predicted by the animation of satellite imagery but earlier detection of convective cells is almost impossible by using the infrared and water vapor imagery.

• BMB Reports
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• v.53 no.9
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• pp.484-489
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• 2020

Epilepsy is a neurological disorder characterized by unpredictable seizures, which are bursts of electrical activity that temporarily affect the brain. Cereblon (CRBN), a DCAFs (DDB1 and CUL4-associated factors), is a well-established protein associated with human mental retardation. Being a substrate receptor of the cullin-RING E3 ubiquitin ligase (CRL) 4 complex, CRBN mediates ubiquitination of several substrates and conducts multiple biological processes. In the central nervous system, the large-conductance Ca²⁺-activated K⁺ (BK_Ca) channel, which is the substrate of CRBN, is an important regulator of epilepsy. Despite the functional role and importance of CRBN in the brain, direct injection of pentylenetetrazole (PTZ) to induce seizures in CRBN knock-out mice has not been challenged. In this study, we investigated the effect of PTZ in CRBN knock-out mice. Here, we demonstrate that, compared with WT mice, CRBN knock-out mice do not show the intensification of seizures by PTZ induction. Moreover, electroencephalography recordings were also performed in the brains of both WT and CRBN knockout mice to identify the absence of significant differences in the pattern of seizure activities. Consistently, immunoblot analysis for validating the protein level of the CRL4 complex containing CRBN (CRL4^Crbn) in the mouse brain was carried out. Taken together, we found that the deficiency of CRBN does not affect PTZ-induced seizure.