• 대한약침학회지
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• 제19권3호
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• pp.259-263
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• 2016

Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Gefitinib is a targeted molecular therapeutic drug used to treat patients with non-small-cell lung cancer (NSCLC). Korean herbal medicines may also have therapeutic efficacy against lung cancer, reduce the side effects associated with chemotherapy, and improve patient quality of life (QOL). This case report describes the effects of a Korean herbal medicine regimen combined with gefitinib in a patient with NSCLC and bone metastasis. The Korean herbal medicine regimen included woohwanggeosa-dan, hwanggibujeong-dan and geonchilgyebok-jeong. The computed tomography (CT) findings showed that following combination treatment, the size of the tumor was markedly decreased without serious adverse events. Moreover, the Eastern Cooperative Oncology Group (ECOG) performance status was improved and cancer-related pain was decreased. These results suggest that a combination of Korean herbal medicines and gefitinib may be an effective therapeutic option for patients with advanced NSCLC and bone metastasis. Further studies are needed to examine the mechanism and the clinical efficacy of Korean herbal medicines against NSCLC.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.635-645
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• 2019

비특이적 만성 목통증은 흔한 질환이며, 흔히 통증, 피로감, 관절가동범위 및 손기능의 감소를 동반한다. 만성 목통증에 의한 증상을 중재하기 위하여 다양한 약물 중재가 사용되고 있지만, 부작용이 적고 적용이 용이한 운동중재 및 대체의학 중재가 요구되고 있다. 본 연구는 비특이적 만성 목통증 노인환자의 라이프케어를 위하여 소금팩과 목운동이 통증, 관절가동범위와 손기능과 같은 운동기능에 미치는 효과를 규명하였다. 16명의 비특이적 만성 목통증 노인환자가 동원되었고, 중재군(8명)과 대조군(8명)으로 무작위 배정되었다. 모든 대상자는 1주일간 30분(일), 5회(주)의 자가 목운동을 수행하였고, 중재군의 대상자는 회당 20분 소금온열팩 중재를 추가적으로 받았다. Visual analogue scale (VAS)와 algometer를 이용한 pain pressure threshold (PPT) 측정을 통해 통증을 평가하였다. 어깨와 손 기능을 평가하기 위하여 어깨 관절의 가동범위 및 악력을 측정하였다. 모든 결과 측정에서 중재군은 유의한 개선을 보였으며(p<.05), 반면 대조군의 피험자는 중재 후 유의한 변화를 보이지 않았다(p>.05). 또한, 중재군은 사후 측정에서 대조군에 비교하여 VAS와 PPT에서 유의한 차이를 나타냈다(p<.05). 따라서 우리의 결과는 소금팩과 목운동이 만성 목통증 노인환자의 통증, 관절가동범위 그리고 손기능 개선에 효과적임을 증명하였다. 또한 소금팩은 목운동의 효과를 증가시키는 중재가 될 수 있음을 확인하였다.

• 수면정신생리
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• 제26권1호
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• pp.44-48
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• 2019

목 적 : 불면증은 대표적인 수면 질환이다. 최근 연구에 의하면 인지적 신체적 각성이 불면증을 야기하는 주요 역할을 한다. 아울러 대뇌 피질의 과각성으로 인한 정보처리과정 장애가 정상적인 입면과 수면의 연속성을 방해한다는 연구 결과도 있다. 뉴로피드백은 행동치료의 한 방식으로 피검자의 뇌파에 영향을 미쳐서 대뇌 과각성을 감소 시킬 수 있다. 이에 본 연구에서는 불면증 환자에서 뉴로피드백 치료가 뇌파 특성에 미치는 영향을 분석하고자 한다. 방 법 : 본 연구는 불면증 진단기준을 만족하는 피검자 13명과 성별 및 연령이 매칭된 대조군 14명을 대상으로 진행하였다. 뉴로피드백 치료와 Sham 치료를 무작위로 각각 30분씩 시행하였다. 각각의 치료 세션 중 뇌파를 측정하고 스펙트럼 분석을 시행하여, 뉴로피드백 치료가 뇌파 스펙트럼에 미치는 영향을 비교 분석하였다. 결 과 : 불면증 환자에서 치료적인 1회기 뉴로피드백을 한 경우, Sham 치료를 한 경우에 비해서 세타 및 시그마 파워($13.9{\pm}2.6$ vs. $12.2{\pm}3.8$ and $3.6{\pm}0.9$ vs. $3.2{\pm}1.0$ in %, respectively ; p < 0.05)가 통계적으로 유의한 수준으로 증가하였다. 그 외 뇌파상으로 통계적으로 유의미한 변화는 없었다. 결 론 : 본 연구는 국내 최초로 불면증 환자에서 1회기 뇌파 뉴로피드백을 통해 입면에 도움이 되는 세타파의 비율이 증가하는 것을 확인하였으며, 이는 입면주기를 앞당길 수 있는 새로운 방법에 대한 제안을 줄 수 있다. 불면증 자체의 치료 반응을 평가하지 못한 제한점은 있으며, 향후 불면증상의 변화까지 평가할 수 있는 후속 연구가 이어져야 한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제31권4호
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• pp.306-311
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• 2005

Despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with oral squamous cell carcinoma has not significantly improved over the past several decades. Gene therapy is currently under investigation and shows us new possibility of cancer curing method. This experiment was undergone to find out the cell growth inhibition effect and evidence of apoptosis by HCCS-1(human cervical cancer suppressor-1), one of the candidates of tumor suppressor gene, transducted to human oral cancer cell line. To determine the efficiency of the adenovirus as a gene delivery vector cell line was transducted with LacZ gene and analysed with X-gal staining. Northern blot was performed to confirm the transfection with HSCC-1 gene and cell viability was assessed by cell cytotoxicity assay using cell count kit(CCK). To show the evidence of apoptosis, DNA fragmentation assay and flow cytometry(FACS) were performed. We had successfully construct the recombinant HSCC-1 adenovirus(Ad5CMV-HCCS-1), and importation efficiency was 20% at 2 MOI(multiplicity of infection), 80% at 20 MOI. Northern blot analysis showed that a single 0.6kb mRNA transcript was expressed in Ad5CMV-HCCS-1 transducted cell lines. As a result of CCK, when comparing to control subjects, transducted group showed 50% growth inhibition. In DNA fragmentation assay, according to increasing of MOI, DNA volume was diminished. In FACS analysis, DNA distribution showed fragmentation. This results imply that HCCS-1gene has growth inhibition effect in human oral cancer cell lines through apoptosis induction.

• 대한예방한의학회지
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• 제17권3호
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• pp.1-18
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• 2013

Objectives: Korea has a dual medical system where traditional Korean Medicine (KM) and Western Medicine (WM) exist au equal terms with exclusive practice boundaries. The aim of this study was to identify complementary and substitute relationships between KM and WM in Korea. Methods: The data of 19,413 respondents were collected from the 2009 Korea Health Panel dataset. General characteristics and the medical utilization of respondents were analyzed descriptively. the Univariable Analysis was used to compare the factors that affected KM and WM utilization, and the Multivariable Analysis was applied to identify complementary or substitute relationships between the respondents' choices for KM and WM. The data were analyzed by the seven disease groups; diseases of nervous system, circulatory system, respiratory system, digestive system, skin and subcutaneous tissue, musculoskeletal system, and connective tissue, injury, poisoning and others. Results: 13.6% and 76.9% of respondents used KM and WM respectively last 12 mouths. 12.7% used both, and 0.9% used KM only. In overall, respondents who visited KM institutions used also WM. However, according to the analysis of choices of medical institutions, non-pharmacological KM treatment and WM has been used as a substitute for another in the diseases of the skin and subcutaneous tissue, diseases of the musculoskeletal system, and connective tissue, injury, poisoning and others. Conclusions: Despite some exceptional disease areas, Korean people use KM complementarily to WM, and this result can rationalize the recent Korean government policies encouraging the cooperation of KM and WM. This study can he used for the future policies development for KM service delivery.

• 대한한의학방제학회지
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• 제31권4호
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• pp.361-371
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• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• 융합정보논문지
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• 제9권3호
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• pp.104-111
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• 2019

본 연구의 목적은 대체의학기술인 SUKI(Superficial Using Ki energy Instrument) 점압법을 활용한 특정근육(상부승모근 trigger point) 부분을 자극하여 스트레스를 받은 뇌파의 변화를 알아보고자 실시하였다. 연구방법은 스트레스에 의해 승모근통증을 호소하는 12명의 남녀 대학생을 대상으로 실시하였다. 상부승모근 통증유발점에 SUKI를 사용하기 전후의 특정영역의 뇌파를 측정하였다. SUKI자극시간은 3min 자극한 후 각 부위별로 비교하였으며(FP2, F3, F4, FP1, T3, T4, P3, P4), 실험기간은 총 5회 실시하였다. QEEG-S 뇌파측정기를 이용하였고, 데이터 수집을 위해 Telescan(LXE 5208) 프로그램을 사용하였다. 자료분석은 SPSS 22.0 version을 사용하였고, 점압법 전후 차이를 비교하기 위하여 대응표본 t-검정(paired t-test)을 실시하였으며, 통계학적인 유의수준은 p<.05로 설정하였다. 연구결과는 다음과 같다. FP2, F3, F4(*p<0.049, *p<0.042, *p<0.019)는 뇌파는 유의하게 나타났고, FP1, T3, T4, P3, P4는 유의하지 않았다. 따라서 SUKI 대체의학기술에 의한 뇌스트레스 감소 효과가 있었다. 추후 SUKI 대체 의학의 지속적인 연구가 요청된다.

• The Journal of Korean Physical Therapy
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• 제34권5호
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• pp.255-266
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• 2022

Purpose: This study sought to study the effects of cross-legged sitting posture on joint motion. It also examined the correlation between the changes in the joint range of motion, musculoskeletal symptoms, and facial asymmetry. Methods: The Acumar Digital Inclinometer (Lafayette Instrument Company, USA) was used to measure the range of motion (ROM). We measured the flexion and extension of the cervical, thoracic, and lumbar spine using a dual inclinometer, and measured the ROM of the shoulder and hip joint with a single inclinometer. The Likert scale questionnaire was used to investigate musculoskeletal symptoms and facial asymmetry. Results: The data analysis was performed using the Jamovi version 1.6.23 statistical software. After confirming the normality of the ROM with descriptive statistics, it was compared with the normal ROM through a one-sample t-test. Correlation matrix analysis was performed to confirm the association between facial asymmetry and musculoskeletal symptoms. The result of the one-sample t-test showed a significant increase in the thoracic spine extension and right and left hip external rotation (p<0.001^***), while most other joints were restricted. As per the frequency analysis, facial asymmetry was found to be 81.70%. Conclusion: The independent variable, namely cross-legged sitting posture led to an increase in ROM. The study also suggests that facial asymmetry and musculoskeletal symptoms could occur. Therefore, to prevent the increase and limitation of ROM and to prevent the occurrence of facial asymmetry and musculoskeletal symptoms, it is suggested that the usual cross-legged sitting posture should be avoided.

• 대한한의학회지
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• 제38권2호
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• pp.61-72
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• 2017

Objectives: The effects of Gamiondam-tang (GMODT) co-administration within 5min on the pharmacokinetics (PK) of tamoxifen were observed as a process of the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT to achieve synergic pharmacodynamics and reduce toxicity on the breast cancer. Methods: After 50mg/kg of tamoxifen treatment, GMODT 100mg/kg was administered within 5min. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats using noncompartmental pharmacokinetics data analyzer programs. Results: Co-administration with GMODT induced increased trends of plasma tamoxifen concentrations to 1hr after end of administration, and then showed decreased trends of plasma tamoxifen concentrations, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5hr after end of co-administration with GMODT and also related significant (p<0.05) decreases of $AUC_{0-inf}$ and $MRT_{inf}$ as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 10 mg/kg and GMODT 100 mg/kg within 5 min, in this experiment. Conclusion: Based on the results of the present study, it is considered that single co-administration GMODT within 5min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen, can be influenced on the toxicity or pharmacodynamic of tamoxifen.

• 대한예방한의학회지
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• 제21권2호
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• pp.127-137
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• 2017

Objectives : In our previous study, single co-administration GMODT within 5 min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Therefore, the object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of GMODT with 2.5 hr-intervals. Methods : After 50 mg/kg of tamoxifen treatment, GMODT 100 mg/kg was administered with 2.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats. Results : Two-half hr-interval co-administration with GMODT induced variable changes on the plasma tamoxifen concentrations as compared with tamoxifen single treated rats, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 (199.61%) and 1 hr (101.06%) after end of co-administration with GMODT, and also related significant (p<0.05) decreases of $t_{1/2}$ (-39.54%) and $MRT_{inf}$ (-43.94%) as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 50 mg/kg and GMODT 100 mg/kg with 2.5 hr-intervals, in this experiment. Conclusions : According to the results, GMODT critically decreased on the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Hence, the co-administration of GMODT and tamoxifen should be avoided in the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT on the breast cancer.