• Journal of The Korean Society of Integrative Medicine
• /
• v.1 no.3
• /
• pp.9-17
• /
• 2013

Purpose : The purpose of this study was to analyze the effects of transverse abdominal exercise on the change of chronic low back pain and lumbar muscle strength. Method : 18 chronic lumbago patients were transverse abdominal exercise for 3weeks. Result : 1. The strength of the lumbar extensor and flexor of the male subjects was increased significantly after abdominal exercise(p<0.05). 2. The strength of the lumbar extensor and flexor of the female subjects was increased significantly after abdominal exercise(p<0.05). 3. The study can confirm significant relationship between the lumbar muscle strength and lumbar pain before and after the exercise Conclusion : The study of could find the increase of the ability of the lumbar extensor and flexor of both male and female subjects suffering from chronic low back and pain using three-week transverse abdominal exercise. The study confirmed the general decrease of pain after the experiment.

• Journal of The Korean Society of Integrative Medicine
• /
• v.5 no.3
• /
• pp.49-55
• /
• 2017

Purpose: The purpose of this study was to investigate effect of open kinetic chain exercise on the motor function of the lower limb in middle school soccer players. Method: The subjects consisted of 14 soccer players who attend middle school in Gwangju. All subjects received open kinetic chain exercise for 3 weeks. The muscle strength of the ankle was measured by a commander muscle tester. Postural control ability was measured using a hopping test. All measurements for each subject were conducted pre-intervention and 3 weeks post-intervention. Result: There were significant differences post-intervention in the muscle strength and-the postural control ability of the open kinetic chain exercise group(p<.05). Conclusion: Open kinetic chain exercise had a significant positive effect on the motor function of the lower limb in soccer players. Therefore, open kinetic chain exercise may prevent and resolve injury with careful management while soccer players are training or playing games. It could be helpful to extend the lives of athletes and improve their records.

• Journal of The Korean Society of Integrative Medicine
• /
• v.5 no.2
• /
• pp.1-10
• /
• 2017

Purpose : This study was aimed at investgating the effect of short foot exercise(SFE) using an imagery technique on chronic ankle instability(CAI). Methods : Twenty subjects with chronic ankle instability were selected by using the Cumberland ankle instability tool. They were randomly assigned to one of two groups(10 in each group) : namely the short foot exercise group and imagery technique group. The short foot exercise group performed short foot exercise for 6 weeks(3 times a week, 15 min per session). The imagery technique group performed short foot exercise(3 times a week, 15 min per session) and the imagery technique(3 times a week, 5 min per session) for 6 weeks. We measured chronic ankle instability, balance and threshold of vibration sensation before and after exercise by using the Cumberland ankle instability tool, Biodex Balance System and VSA-II, respectively. Results : We found statistically significant differences in cumberland ankle instability tool, balance and threshold of vibration sensation between the groups(p<.05). Conclusion : We confirmed the effect of short foot exercise using an imagery technique. Thus, we thought these results could be used as basic data and reference for musculoskeletal therapy or intervention using an imagery technique.

• Journal of Korean Traditional Oncology
• /
• v.21 no.2
• /
• pp.63-74
• /
• 2016

Objective : The purpose of this study is to report the effects of radio-frequency hyperthermia cancer treatment in conjunction with Sorafenib on hepatocellular carcinoma patient. Method : The patient was diagnosed with hepatocellular carcinoma at S6/7 and treated with right posterior sectionectomy. After 4 months, tumor recurrence was found at S4, 5 and 8. After transarterial chemoembolization, the patient was prescribed Sorafenib (proprietary name $Nexavar^{(R)}$ ) as well as proceeding with radio-frequency hyperthermia. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (AFP, PIVKA-II), natural killer (NK) cell activity, and numeric rating scales (NRS). Results : After the treatment, tumor size was decreased accompanying by reducing the level of tumor markers (AFP, PIVKA-II). Major clinical symptoms were improved with increasing NK cell activity. There were no adverse events based on National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Conclusion : This case suggests that radio-frequency hyperthermia has synergistic effect for the treatment of hepatocellular carcinoma patient in conjunction with Sorafenib.

• Proceedings of the Zoological Society Korea Conference
• /
• 2005.08a
• /
• pp.19-19
• /
• 2005

• Proceedings of the Zoological Society Korea Conference
• /
• 2001.10a
• /
• pp.212.1-212
• /
• 2001

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
• /
• 2001.10a
• /
• pp.212.2-213
• /
• 2001

No Abstract, See Full Text

• Science of Emotion and Sensibility
• /
• v.10 no.3
• /
• pp.411-418
• /
• 2007

Exposure to low frequency noise(LFN) can lead to vibroacoustic diseases(VADs), which include a systemic disease with lesions in a broad spectrum of organs and a psychiatric condition. It is known that VAD is an established risk factor for the development of many psychological conditions in humans and rodents, including major depression and anxiety disorder. The present study investigated the effects of LFN on neuronal stress responses in the rat brain. The neuronal expression of the proto-oncogene c-fos in the paraventricular nucleus(PVN) of the hypothalamus and tyrosine hydroxylase(TH) in the LC was observed. The immunocytochemical detection of the Fos protein and TH has been used as a marker of neuronal activation in response to stress. In addition, corticosterone concentration was evaluated by using an enzyme-linked immunosorbent assay(ELISA). The LFN groups were exposed to 32.5Hz and 125Hz of noise(4hr/day for 2days). The numbers of c-fos and TH-immunoreactive cells in the PVN and LC were significantly increased in the LFN groups(32.5Hz and 125Hz) compared to the normal group. Corticosterone concentration in plasma was also increased in LFN groups. The present results demonstrated that exposure with LFN produced a pronounced increase in expression of c-Fos and TH in stress-relevant brain areas. These results suggest that the neural characteristics involved in LFN are similar to those activated by typical processive stressors. These results also suggest that the central and peripheral activations by LFN may be related to LFN-related negative behavioral dysfunctions such as VADs.

• Molecules and Cells
• /
• v.38 no.7
• /
• pp.643-650
• /
• 2015

The use of conditioned medium from mesenchymal stem cells may be a feasible approach for regeneration of bone defects through secretion of various components of mesenchymal stem cells such as cytokines, chemokines, and growth factors. Mesenchymal stem cells secrete and accumulate multiple factors in conditioned medium under specific physiological conditions. In this study, we investigated whether the conditioned medium collected under hypoxic condition could effectively influence bone regeneration through enhanced migration and adhesion of endogenous mesenchymal stem cells. Cell migration and adhesion abilities were increased through overexpression of intercellular adhesion molecule-1 in hypoxic conditioned medium treated group. Intercellular adhesion molecule-1 was upregulated by microRNA-221 in mesenchymal stem cells because microRNAs are key regulators of various biological functions via gene expression. To investigate the effects in vivo, evaluation of bone regeneration by computed tomography and histological assays revealed that osteogenesis was enhanced in the hypoxic conditioned medium group relative to the other groups. These results suggest that behavioral changes of endogenous mesenchymal stem cells through microRNA-221 targeted-intercellular adhesion molecule-1 expression under hypoxic conditions may be a potential treatment for patients with bone defects.

• The Korean Journal of Physiology and Pharmacology
• /
• v.14 no.6
• /
• pp.371-376
• /
• 2010

Glycyrrhizae radix (GR) is an herbal medicine that is commonly used in the East Asia for treating a variety of diseases, including stomach disorders. The objective of the present study was to examine the anti-stress effects of GR on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2 h/day) to the rats in the Control and GR groups (400 mg/kg/day, PO). Starting on the eighth day, the rats were tested for spatial memory on the Morris water maze test (MW) and for anxiety on the elevated plus maze (EPM). We studied the changes of the expressions of cholineacetyl transferase (ChAT) and tyrosine hydroxylase (TH) in the locus coerleus (LC) using immunohistochemistry. The results showed that the rats treated with GR had significantly reduced stress-induced deficits on their learning and memory on the spatial memory tasks. In addition, the ChAT immunoreactivities were increased. Gor the EPM, treatment with GR increased the time spent in the open arms (p<0.001) as compared to that of the control group. Moreover, GR treatment also normalized the increases of the TH expression in the LC (p<0.001). In conclusion, administration of GR improved spatial learning and memory and reduced stress-induced anxiety. Thus, the present results suggest that GR has the potential to attenuate the behavioral and neurochemical impairments caused by stress.