• Molecular & Cellular Toxicology
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• v.4 no.4
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• pp.318-322
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• 2008

Obesity is an increasing worldwide health problem that is strongly related to the imbalance of food intake and energy metabolism. It was well-known that several substances in the hypothalamus regulate food intake and energy metabolism. We planned an integrative study to elucidate the mechanism of the development of obesity. Firstly, to find candidate genes with the marvelous effect, the different expression in the hypothalamus between ob/ob and 48-h fasting mice was investigated by using DNA microarray technology. As a result, we found 3 genes [peroxisome proliferator activated receptor, gamma, coactivator 1 alpha (Ppargc1a), calmodulin 1 (Calm1), and complexin 2 (Cplx2)] showing the different hypothalamic expression between ob/ob and 48-h fasting mice. Secondly, a genetic approach on PPARGC1A gene was performed, because PPARGC1A acts as a transcriptional coactivator and a metabolic regulator. Two hundred forty three obese female patients with body mass index (BMI)${\geq}$25 and 285 control female subjects with BMI 18 to<23 were recruited according to the Classification of Korean Society for the Study of Obesity. Among the coding single nucleotide polymorphisms (cSNPs) of PPARGC1A, 2 missense SNPs (rs8192678, Gly482Ser; rs3736265, Thr612Met) and 1 synonymous SNP (rs3755863, Thr528Thr) were selected, and analyzed by PCR-RFLP and pyrosequencing. For the analysis of genetic data, chi-square ($X^2$) test and EH program were used. The rs8192678 was significantly associated with obese women (P<0.0006; odds ratio, 1.5327; 95% confidence interval, 1.2006-1.9568). Haplotypes also showed significant association with obese women ($X^2$=33.28, P<0.0008). These results suggest that PPARGC1A might be related to the development of obesity.

• Journal of Service Research and Studies
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• v.6 no.2
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• pp.51-64
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• 2016

This study is to find a service that improves the subjective happiness of cancer patients that receive radiation therapy. One hundred and one cancer patients undergoing radiation therapy were enrolled in the survey to verify the self-consciousness and symptom distress that could affect the subjective happiness. Independent t-test, one-way analysis of variance, and Pearson correlation were conducted with the SPSS 20.0 program. Symptom distress of cancer patients undergoing radiation therapy showed highest in the order of fatigue, appearance changes, dizziness, loss of appetite, and sleep disorders. And lower symptom distress, higher private self-consciousness were significantly correlated with higher subjective happiness among patients receiving radiation therapy for cancer. Study findings reflect the necessity of an integrative approach combining physical, psychological and emotional interventions during a radiotherapy period. For this cause, it would be necessary to supplement previously existing service programs and organize a patient-friendly system that could affiliate regional cancer centers or Public health centers with the hospitals in which the patients are being treated.

• Transactions of the KSME C: Technology and Education
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• v.2 no.2
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• pp.113-124
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• 2014

In developing an aircraft, configuration determination and requirement proofing depend on flight test results. Since the flight tests require much time and high cost, systematic flight test planning and analysis are needed to reduce cost and development time. This paper presents a desirability function approach to present an integrative measure of vibration levels at important positions and suggests a fractional factorial design which is one of the experimental design methods to help perform systematic flight tests. A method to perform flight tests in stages is also suggested to further reduce the number of flight tests.

• The Journal of the Korea Contents Association
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• v.13 no.6
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• pp.246-259
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• 2013

The purpose of this study was to investigate the differential effects of the determinants of life satisfaction among the elderly and a variety of health, economic, leasure activity, social support and psychological variables were comprehensively examined as determinants of life satisfaction among the elderly. The sample of this study was composed of 347 old people participating in the leasure activity programs operated by 10 facilities for the aged in Seoul. Data were collected using structured questionnaires and analyzed employing structural equation modelling technique as a main data analysis method. It was found that subjective health condition, subjective economic level, productive and consumptive leasure activities, spouse and children support, self-esteem and extraversion had positive effects on life satifaction among the elderly. The theoretical and practical implications of this study were discussed and the directions for future research were suggested.

• Journal of Korea Technology Innovation Society
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• v.8 no.spc1
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• pp.360-390
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• 2005

The paradigm of the corporate innovations has been changed from the intra-company innovations to the inter-company innovations. A prevalent approach to the inter-company innovations is the supply chain management. Three key words of the core concept of supply chain management are the long-term relationship, resource integration, and value creation. Specifically, it means that the supply chain management aims to make value creation through the resource integration for the supply chain entities, based on the long-term relationship between buyers and sellers. To make more effective long-term relationship among the supply chain entities, it is very important for the supply chain entities to analyze followings: i) What variables can influence the long-term relationship, ii) How these variables can influence to the long-term relationship. However, previous researches mostly deals the long-term relationship in the marketing area in fragment, and thus few research efforts have been done for the development of conceptual model using supply chain management theories. In contrast to previous studies, our research tried to develop and examine the integrative research model by introducing both the marketing theories and the supply chain management theories, and thus related hypotheses are derived. A multiple regression analysis was performed to examine the influence of the antecedents of the long-term relationship, for the 87 retailers of grocery supply chains. The empirical results confirm that cultural similarity, reputation, interdependency, and trust positively influence long-term relationship (i.e., partnership orientation and partnership symmetry). And results also confirm that the supply implementation factors such as organization integration, information system integration, and process integration playa moderating role between antecedents and long-term relationship. These findings suggest that companies should perceive the importance of managing the process, organization, information system integration in the long-term relationship implementation process as well as the factors such as cultural similarity, reputation, interdependency, and trust in the long-term relationship establishment process.

• Women's Health Nursing
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• v.5 no.1
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• pp.65-79
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• 1999

The purpose of this study was to figure out a direction for midwifes' expanded roles for integrative woman's health care focused on health promotion & maintenance and primary prevention of women's health disorders including family health in the new millenium as a primary women's health practitioner. Data sources used for analysis were the book published from International Confederation of Midwives including role, code, situation and others from the international aspects : the empirical data from direct contact by participation in the ICM held in Manila, Philipine, May 22-26, 1999 : and documentation of Korean Midwives Association. Historical and current changing perspectives toward woman's health & nurse-midwifery and the reality women's health & nurse-midwifery and the reality of expand role that should be acquired toward the new millenium are discussed. In conclusion, Nurse-midwives are the very primary women's health care providers who can provide not only the exact needs of women who have health related problems, which are developed in the unique socio-cultural context women are belonged to, but also reproductive affairs including labor and delivery as it was midwive's traditional role, not just as practitioner, educator, counselor but conscious raiser for women's right. Futhermore, for this, thorough preparation through various kind of active and contemplated approach such as remodeling roles and education and continuing education system, training for high skilled & technical action, making laws and policy, and others is absolutely required.

• The Journal of the Korea Contents Association
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• v.16 no.1
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• pp.611-619
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• 2016

Prior researches on brand authenticity so far have focused on the scale development for measuring brand authenticity. However, at the point of time it is necessary to consider the utilization of the proposed scale in an integrative approach. Accordingly, this study aims to examine brand authenticity mediated the effect of brand authority and ethicality on purchase and word-of-mouth intention. The survey method was used for this paper, and data from a total of 136 office workers were used for the analysis. And structural equation model was used to analyze the data. The results of this empirical study is summarized as followings. First, brand authority and ethicality do not have a direct effect on purchase and word-of-mouth intention but brand authenticity mediates the effect of brand authority and ethicality. Second, brand authority and ethicality have positive effect on brand authenticity. This study provides information on the purchase and word-of-mouth intention of salary man. Further, it will provide meaning suggestion point of the importance of brand authenticity in establishing the policy of brand management.

• Korean Journal of Plant Taxonomy
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• v.37 no.3
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• pp.309-321
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• 2007

Korea national arboretum has worked with the plant taxonomic society of Korea to make the first fully electronic floristic checklist in Korea. The result is an ever-expanding online plant name index containing scientifically authorative, up-to-date information on the approximately 7,000 taxa including cultivars. With 37 contributing taxonomists, KPNI is the largest collaborative research projects ever assembled in Korea. A comprehensive database model for the taxonomic data from literature and other sources is presented, which was devised for the Korea National Plant Index database project (KPNI). Gwangreung database model is based on an approach using entity-relationsip diagram. It encompasses taxa of all ranks, nothotaxa and hybrid formulae, cultivars, full synonymy, basionyms, Korean name, and other nomenclatural information. Ths paper presents an analysis of KPNI work processes and an overview how we are approaching the construction of Gwangreung databaese model. It can help the system engineers of other biological information systems to develop their database based on the accurate and integrative taxonomic database.

• Korean Journal of Comparative Education
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• v.22 no.4
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• pp.149-178
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• 2012

The initial purpose of Affirmative Action(AA) in the U. S. was to increase access to, and ensure the equitable distribution of, opportunities for racial minority groups in order to redress past discrimination. Over the last several decades, support for AA has grown and waned as structural, political and social currents have shifted. Most recently, AA in university admissions policy was once again tested as The University of Texas at Austin successfully defended its use of AA in admissions and now faces Supreme Court review concerning the lawsuit. Fisher v. University of Texas at Austin. The purpose of this study is to illustrate the evolution of AA in university admissions reflected on major legal cases for and against it. AA is analyzed from the integrative approach based on the historical institutionalism. l.e., influenced by structure, political dynamics, institutions and critical actors.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.60-75
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• 2023

Objectives : A bibliometric approach using network analysis was applied to explore the global trends of research on herbal medicine for atopic treatment. Methods : Articles related to herbal medicine on atopic treatment from 2003 to 2022 were retrieved from Web of Science Core Collection. Extracted records were analyzed according to the publication year, research area, journal title, country, organization, author and keyword. The VOSviewer program was used to visualize the trends and the research hotspots in herbal medicine for atopy. Results : Analysis of 406 articles indicated the consistent increase of using herbal medicine for atopic treatment over the last 20 years. The most productive country and research organization in issuing articles were South Korea and Kyunghee university. Many articles have been published in research areas such as 'integrative complementary medicine' and 'pharmacology pharmacy'. By evaluating the total link strength, the average publication year and the average citations of countries and authors, the influential countries and authors were identified. A network analysis based on the co-occurrence and the publication year of keywords revealed the relevant characteristics and trends of herbal medicine for atopy. The most up-to-date keywords were 'topical application', 'skin barrier' and 'care'. Conclusions : This bibliometric study examined the overall trends and the time-based development of herbal medicine for atopic treatment. The current study would be useful not only for grasping the global network hub of research on herbal medicine for atopic treatment, but also to explore the new directions for future research.