• Proceedings of the Korean Biophysical Society Conference
• /
• 2003.06a
• /
• pp.52-52
• /
• 2003

Junctate is a newly identified integral ER/SR membrane $Ca^{2+}$ binding protein, which is an alternative splicing form of the same gene generating aspartyl $\square$-hydroxylase and junctin. To elucidate the functional role of junctate in heart, transgenic (TG) mice overexpressing mouse cardiac junctate-1 under the control of mouse $\square$$^{~}$ myosin heavy chain promoter were generated. Overexpression of junctate in mouse heart resulted in cardiac hypertrophy, increased fibrosis, bradycardia, arrhythmias and impaired contractility. Overexpression of junctate also led to down-regulation of SERCA2, calsequestrin, calreticulin and RyR, but to up-regulation of NCX and PMCA. The SR $Ca^{2+}$ content decreased and the L-type $Ca^{2+}$ current density and the action potential durations increased in TG cardiomyocytes, which could be the cause for the bradycardia in TG heart. The present work has provided an important example of pathogenesis leading to cardiac hypertrophy and arrhythmia, which was caused by impaired $Ca^{2+}$ handling by overexpression of junctate in heart.n heart.

• Proceedings of the KIPE Conference
• /
• 2005.07a
• /
• pp.134-136
• /
• 2005

The author present a modified multi-loop algorithm Including feedforward for controlling a 55kW stepdown chopper in the power supply of Maglev The gains of the control algorithm were selected based on pole locations formulated from a prototype Bessel transfer function model. The design incorporate tradeoffs in DC-to-DC converter hard-ware para-meters and pole locations. This perturvation is derived by subtracting the desired output voltage from the actual output voltage. The proportional and integral action stabilizes the system and minimizes output voltage error. In order to verify the validity of the proposed multi-loop controller, simulation study was tried using Matlab simulink.

• Journal of Institute of Control, Robotics and Systems
• /
• v.3 no.6
• /
• pp.639-643
• /
• 1997

This paper presents how nonlinear PID control algorithms can be applied on chemical processes for a more stable operation and perfect automation. A pass balance controller is designed to balance the exiting temperatures of a heater and a heat exchange network. The proposed controller has gain-varying integral action and deals with the operational constraints in an efficient manner. Also, the use of a PID gap controller is proposed to maximize energy saving and operation stability and to minimize operator intervention in operation of air fan coolers. The proposed controller adjusts the opening of a louver automatically in such a way that it keeps the air fan pitch position within the desired range. All these nonlinear PID controllers have been implemented on the distributed control system (DCS) for good reliability and operability. Operator acceptance was very high and the implemented controllers have shown good performance and high service factor still now on. The proposed methodology can be directly applied to similar processes without any modification.

• Computers and Concrete
• /
• v.13 no.2
• /
• pp.255-270
• /
• 2014

Impact performance of high-performance concrete (HPC) and SFRC at 28-day and 56-day under the action of repeated dynamic loading was studied. Silica fume replacement at 10% and 15% by mass and crimped steel fiber ($V_f$ = 0.5%- 1.5%) with aspect ratios of 80 and 53 were used in the concrete mixes. Results indicated that addition of fibers in HPC can effectively restrain the initiation and propagation of cracks under stress, and enhance the impact strengths and toughness of HPC. Variation of fiber aspect ratio has minor effect on improvement in impact strength. Based on the experimental data, failure resistance prediction models were developed with correlation coefficient (R) = 0.96 and the estimated absolute variation is 1.82% and on validation, the integral absolute error (IAE) determined is 10.49%. On analyzing the data collected, linear relationship for the prediction of failure resistance with R= 0.99 was obtained. IAE value of 10.26% for the model indicates better the reliability of model. Multiple linear regression model was developed to predict the ultimate failure resistance with multiple R= 0.96 and absolute variation obtained is 4.9%.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2002.08a
• /
• pp.41-46
• /
• 2002

본 논문은 냉, 난방 디지털 온도 조절계(SPC 50)의 Etl의 편차 정 동작에 관한 구현장치 제작과 비례 미.적분기가 At 및 비 At기능에서 설정온도를 $100^{\circ}C$를 유지하는데 기인된 전압전류 및 전력데이터 획득의 요인과 비례미적분 정수 및 노 개선점을 연구하였다. 설정온도를 유지하는 온도변화는 At기능에서 $96.7^{\circ}C\sim102^{\circ}C$ 이며, 비At 기능에서는 $97.6^{\circ}C\sim100.2^{\circ}C$이었다. 온도유지 전압변동은 At기능에서 2V~217V이며, 비 At기능에서 20V~217V 이었다. At와 비 At 기능에서 설정온도 $100^{\circ}C$을 유지하는데 온도를 냉각시키는 환풍기가 온. 오프 되는 시간차는 20초 정도 발생하였다. 온도차 및 전압차는 두 기능간에 비례 미. 적분값 설정이 자동 및 수동이냐에 따라서 차이를 보여주었다. 두 기능에서 설정된 온도값 유지에 따른 전압전류의 승압과 하강의 변동된 변환 데이터는 설정된 온도가 성취되어지는 시간차 및 설정값 유지의 특성을 요인으로 한 PID값과 노의 개선점에 길잡이가 된다.

• The Journal of the Korea Contents Association
• /
• v.14 no.9
• /
• pp.267-274
• /
• 2014

The culture is an integral factor when we deal with the quality of life of members of society, and the cultural right is accepted as the basic right. However, the cultural right of the disabled in our society stays in the conditions of the discrimination and alienation by social prejudices and barriers against people with disabilities, and that results from the lack of understanding as a right. The aim of this study is to further raise awareness about the cultural right of the disabled as the basic human right, make it clear to be a universal right based on that, and insist on implementing 'Affirmative Action' for actualizing the disabled's cultural right to equality. The political measures derived from this study to guarantee and realize the cultural right of the disabled are as follows. First, the target extent of cultural voucher system should be expand to not recipients of national basic livelihood guarantees and near poverty groups, but all the disabled. Second, to take full charge of the cultural support of the disabled as a independent organization, it is necessary to establish Ministry of Culture, Sports and Tourism-affiliated 'Bureau of Culture for Persons with Disabilities'. Third, the nationwide survey on cultural activities and desires of the disabled periodically is required.

• The Journal of the Korean Society for Microbiology
• /
• v.20 no.1
• /
• pp.65-72
• /
• 1985

Vitamin C is known as an integral element for the formation and maintenance of intercellular supporting structures. Ascorbic acid has been used for the treatment of certain poisonings and hypovitaminosis(scurvy) but also known as a powerful reducing agent, and can kill a variety of bacteria and detoxify bacterial exotoxins including various clostridial exotoxins in vitro. For viruses, vitamin C inactivates herpes virus, vaccinia virus and influenza virus and has been used for the prevention and treatment of the common cold. Thus ascorbic acid plays an important role in antimicrobial action. Scurvy also promotes the development of tubercles in experimentally infected guinea pig and the tuberculosis patients require more vitamin C than normal persons. However there is no reports that ascorbic acid could inhibit the growh of M. tuberculosis. In this paper, antibacterial effects of ascorbic acid against M. tuberculosis were studied. The results are as follows: 1. The single use of the ascorbic acid exhibited antibacterial effect in vitro against $5{\times}10^3/ml$ of M. tuberculosis $H_{37}$ Rv at the concentration of ascorbic acid 0.625mg/ml over 3 hours exposure and 0.05mg/ml over 9 hours exposure. 2. In vivo mice administered with ascorbic acid 50mg/day for 5, 10 and 15 days respectively were protected from M. tuberculosis $2LD_{50}$, $3LD_{50}$, $4LD_{50}$ and $5LD_{50}$ given intravenously.

• The Bulletin of The Korean Astronomical Society
• /
• v.40 no.2
• /
• pp.32.3-33
• /
• 2015

There exist scaling relations that link the mass of supermassive black holes with both the velocity dispersion and the mass of the central stellar cusp of their host galaxies. This implies that these two components grow in tandem. Feedback from actively accreting supermassive black holes (AGN), in the form of multi-phase gas outflows, has been argued to be the agent of this co-evolution. Here we employ the powerful GMOS integral field spectroscopy unit on the 8.2m Gemini-North telescope to investigate ionized gas outflows of luminous Type 2 AGN in the local Universe (z<0.1). Our sample of 6 galaxies is drawn from the Sloan Digital Sky Survey (SDSS) and was selected based on their [OIII] dust-corrected luminosity (>1042 erg/s) and signatures of outflows in the [OIII] line profile of their spatially integrated SDSS spectra. These are arguably the best candidates to explore AGN feedback in action since they are < 1% of a large local type 2 AGN SDSS sample selected based on their [OIII] kinematics. We combine a careful spectral decomposition of the [OIII] and $H{\alpha}$ line profiles with spatial information on ~0.5kpc scales to understand the outflow kinematics and energetics in these objects. We find clear evidence for strong outflows in [OIII] and occasionally $H{\alpha}$ that are clearly driven by the ionizing radiation of the AGN. We kinematically and spatially decompose outflowing and rotating ionized gas components. We find [OIII] to be a better tracer of AGN outflows, while $H{\alpha}$ appears to be strongly affected by both stellar rotation and outflows induced by ongoing star formation. The observed kinematics and spatial distribution of the ionized gas imply a large opening angle for the outflow. Finally, we find the projected outflow velocity to decrease as a function of distance, while its dispersion shows a more complex structure with a potentially initially increasing trend (out to 0.5-1kpc distances).

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.15 no.2
• /
• pp.463-477
• /
• 1991

This study proposed a new method to design a robot manipulator control system capable of tracking the trajectories of joint angles in a reasonable accuracy to cover with actual situation of varying payload, uncertain parameters, and time delay. The direct adaptive model following control method has been used to improve existing industrial robot manipulator control system design. The proposed robot manipulator controller is operated by adjusting its gains based on the response of the manipulator in such a way that the manipulator closely matches the reference model trajectories predefined by the designer. The manipulator control system studied has two loops: they are an inner loop on adaptive model following controller to compensate nonlinearity in the manipulator dynamic equation and to decouple the coupling terms and an outer loop of state feedback controller with integral action to guarantee the stability of the adaptive scheme. This adaptation algorithm is based on the hyperstability approach with an improved Lyapunov function. The coupling among joints and the nonlinearity in the dynamic equation are explicitly considered. The designed manipulator controller shows good tracking performance in various cases, load variation, parameter uncertainties. and time delay. Since the proposed adaptive control method requires only a small number of parameters to be estimated, the controller has a relatively simple structure compared to the other adaptive manipulator controllers. Therefore, the method used is expected to be well suited for a high performance robot controller under practical operation environments.

• Journal of Microbiology and Biotechnology
• /
• v.11 no.2
• /
• pp.317-325
• /
• 2001

For heuristic purposes, the relative ratio of urease contents inside and outside cells was surveyed using nine ureB+ strains of Helicobacter pylori. the ratio of the enzyme specific activity appeared to vary greatly between the various H. pylori strains, ranging from 0.5 to 2.5. Besides the above compartment, urease was also richly found in the membrane fraction, especially in either peripheral or integral form. The urease distribution across the H. pylori membrane was significantly influenced by the ambient pH; the specific activity of external urease was highest at pH 5.5 with a narrow plateau, whereas the internal specific activity was highest within a pH range of 4.5 to 6.5 with a broad plateau. These finding strongly suggest that H. pylori urease is secretory and responded to the external pH. However, at pH 4.0 or below, no urease activity was detected in either the internal or external compartment, although an increase in the color development with 2,4,6-trinitrobenzene sulfonate (TNBS) was observed. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) demonstrated that these phenomena may be related to a specific proteolysis in certain proteins, including urease or ${\gamma}$-glutamyl transpeptidase. Interestingly, the effect of ammonium ions n alleviating the enzyme inactivation inside the H. pylori cells was remarkably similar to that of D-glucose. In addition, it would appear that the cation acted as a surrogate of not only $Na^+$ but also $K^+$ thereby increasing the H. pylori P-type ATPase activity. This is of great interest, as it implies that the urease action in H. pylori is indispensible at any locus.