• Journal of Oral Medicine and Pain
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• v.44 no.3
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• pp.83-91
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• 2019

Purpose: Venlafaxine and duloxetine have been shown to be effective in the treatment of neuropathic pain disorders. However, knowledge about the efficacy of venlafaxine and duloxetine on burning mouth syndrome (BMS) is still insufficient. The purpose of this study was to investigate the efficacy of venlafaxine and duloxetine on refractory BMS patients. Methods: Twelve refractory BMS patients who were prescribed venlafaxine or duloxetine were included in this study. These patients did not respond to previous administration of clonazepam, alpha-lipoic acid, gabapentin, and nortriptyline. All participants were the primary type of BMS patients who had no local and systemic factors related to the oral burning sensation. The intensities of oral symptoms following venlafaxine or duloxetine administration were compared with those before administration and at baseline. Results: Venlafaxine and duloxetine were prescribed to four and nine patients, respectively. One patient was prescribed both medications in turn. Among them, only two patients showed improvement of oral symptoms without side effects. In the other ten patients, symptoms failed to improve. Six of them reported that the drug was ineffective, and four of them stopped taking the medications on their own due to intolerable side effects, such as insomnia, constipation, drowsiness, dizziness, and xerostomia. Conclusions: Venlafaxine and duloxetine may only relieve oral symptoms in a minority of refractory BMS patients. Further large-scale studies are needed to determine the potential clinical factors that could predict the efficacy of venlafaxine and duloxetine.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.3
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• pp.17-28
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• 2024

Objectives : The aim of this study is to explore the potential of oriental medicine in managing rosacea through the regulation of the autonomic nervous system. Methods : We reviewed studies on the pathophysiology and medical treatment (both western and oriental medicine) of rosacea, as well as the relationship between rosacea and the autonomic nervous system, using four databases: PubMed, OASIS, RISS, and NDSL. Results : Rosacea is a chronic recurrent inflammatory disease characterized by symptoms such as facial flushing, inflammatory papules, and pustules. In Western medicine, symptomatic treatments like vasoconstrictors, doxycycline, and anti-inflammatory drugs are primarily used. According to the pathophysiological mechanisms of rosacea, the autonomic nervous system is closely related, particularly with sympathetic overactivity causing vasodilation and local inflammation in rosacea patients. Additionally, recent studies report that rosacea patients frequently exhibit neuropsychiatric symptoms such as anxiety, depression, and insomnia, which are closely linked to autonomic dysfunction and contribute to the worsening of skin symptoms. However, current studies on the use of oriental medicine for rosacea focus mainly on anti-inflammatory effects at the local level, similar to conventional treatments. Conclusions : Based on the close involvement of the autonomic nervous system in the pathophysiological mechanisms of rosacea and numerous studies showing that oriental medicine can effectively regulate autonomic function, applying such treatments to rosacea patients may improve not only skin symptoms but also the frequently associated neuropsychiatric symptoms like anxiety, depression and insomnia.

• Journal of The Korean Society of Clinical Toxicology
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• v.12 no.1
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• pp.35-38
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• 2014

Phentermine has been widely used as an appetite suppressant since 2004 in Korea. The authors experienced two cases of acute phentermine overdose and report with the literature review. A 36-year-old man and a 24-year-old woman presented together to the emergency department with taking 13 tablets (390 mg) of phentermine 16 hours ago. They had tachycardia, hypertension and complained visual symptoms, nausea, insomnia and anxiety. These symptoms were resolved by conservative management.

• Sleep Medicine and Psychophysiology
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• v.7 no.2
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• pp.79-83
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• 2000

Sleep disturbances are frequently associated with neurological disorders. Sleep disorders interfere with rehabilitation of patients with neurological disorders such as stroke and may increase the severity of their symptoms and recurrence rate of stroke. The treatment of sleep apnea syndrome is particularly important in managing patients with cerebral infarction of whom 50-80% have moderate to severe sleep apnea. Sleep apnea produces not only poor quality sleep but also excessive daytime sleepiness, fatigue and lack of energy. Sleep problems frequently found in patients with dementia are sleep-wake cycle abnormality, fragmentation of sleep, nocturnal insomnia, decreased slow wave sleep and REM sleep, and sleep disordered breathing. The management of sleep disturbances is very important for controlling symptoms such as nocturnal wandering and sundowning syndrome in patients with dementia. Parkinson's disease and epilepsy are other neurological disorders that may have sleep disturbances.

• Journal of Haehwa Medicine
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• v.24 no.1
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• pp.37-46
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• 2015

Objective : This study aimed to explore the clinical feature of patients with dyspepsia who were treated by an Oriental internal medicine. Methods : We analyzed 130 patients who visited an Korean Medicine Hospital for their dyspepsia-related symptoms, from March 1, 2014 until to February 28, 2015 Results : The sex composition was consisted of 31.5% man and 68.5% woman, and 85.6% of outpatient and 14.4% of inpatient. The 39.2% of patients showed chronic complain (>6 months), and the main causes included stress and fatigue for 46.2% and 31.5% respectively. The accompanied symptoms were mainly fatigue (40.0%), insomnia (36.9%), abnormal stool (34.6%), upper back pain (31.5%), and headache (28.5%). The improvement rate was 68.5% while other (31.5%) showed no change of dysplasia. Conclusion : This study created an important information of patients with dysplasia, which will be critically helpful for development of Korean Medicine-based therapeutics in the future.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.3
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• pp.219-228
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• 2008

Objectives : This study was designed to evaluate the effects of oriental medical treatments on the patient with agitation accompanied constipation. Methods : One patient was admitted who was constipation, agitation, headache, chilling sign, thirst, heat, nausea, insomnia. The patient was diagnosed as constipation and agitation that was caused by heat in the heart and alimentary tract, and was treated with herb-medication, acupuncture, moxa therapy, anal therapy and aroma therapy for about 4 months. And then, we investigated and analyzed the clinical symptoms of the patient. Results : Most of all the clinical symptoms related with agitation accompanied constipation were improved gradually after oriental medical treatments. Conclusions : From the above results, it could be suggested that oriental medical treatments have good effects on agitation and constipation. And it will be necessary to extensively research and develop oriental medical treatments for this disease.

• Journal of Sasang Constitutional Medicine
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• v.25 no.3
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• pp.243-253
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• 2013

Objectives The aim of this study was to examine significant improvement of dizziness, gait disturbance, insomnia and xerostomia after treatment with Jowisengcheong-tang in a Taeeumin patient with olivopontocerebellar atrophy (OPCA). Methods The patient's subjective and objective symptoms were observed daily throughout the hospitalization period using global assessment (G/A), and the Unified Multiple System Atrophy Rating Scale (UMSARS) was used to assess the overall function of patient. Results The symptoms of dizziness and xerostomia decreased from G/A 100 to G/A 10~30 for five days, and the UMSARS score decreased in Part I,II. Conclusions This case showed that Sasang constitutional medicine treatment can be effective treatment method for OPCA. We consider that consistent treatment can contribute to improve the patient's quality of life.

• Sleep Medicine and Psychophysiology
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• v.28 no.2
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• pp.43-52
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• 2021

Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sleep disorder characterized by sensorimotor symptoms such as unpleasant sensations before sleep, akathisia, and periodic limb movements during sleep. It is also closely related to hyperarousal and is often accompanied by insomnia. Although the mechanism is not clear, the understanding of etiology and pathophysiology has greatly expanded through recent advances in genetic and neurobiological research. The most important pathophysiology of RLS/WED is brain iron deficiency. Such iron deficiency in the brain is caused by complex interactions between several genetic factors and various environmental factors, including comorbidities. Iron deficiency in the brain results in dysfunction of several neurotransmitters. A decrease in adenosine activity appears first, followed by an increase in the activity of glutamate and dopamine. A decrease in adenosine activity and an increase in glutamate activity stimulate the brain arousal system, resulting in hyperarousal. In addition, overproduction of dopamine and glutamate leads to dysfunction of the cortical-striatal-thalamic circuit, resulting in symptoms such as akathisia and periodic limb movements during sleep.

• 대한상한금궤의학회지
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• v.12 no.1
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• pp.91-99
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• 2020

Objective: The aim of this study was to evaluate the effects of Gyejigamchoyonggolmoryeo-tang on facial flush. Methods: Facial flushwas evaluated using photographs and questionnaires. The (VAS) and investigator's global assessment were used to measure the improvement in facial flush symptoms. Results: The visual findings were. The VAS score decreased from 10 to 0 after administration of Gyejigamchoyonggolmoryeo-tang for 40 days. In addition, accompanying symptoms such as neck pain, palpitation, and insomnia were improved. These results indicated that Gyejigamchoyonggolmoryeo-tang was effective for emotional facial flush. Conclusions: This study shows the effective treatment of facial flush using Gyejigamchoyonggolmoryeo-tang based on the provisions of the Shanghanlun disease pattern identification diagnostic system.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.2
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• pp.113-122
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• 2024

Objectives : To report the R/O CRPS patient after Korean medicine treatment, suffering severe buring pain and insomnia. Methods : The patient was a 56-year-old female patient and treated with herbal medicines and acupuncture in 32 days. The treatment effect was evaluated by measuring VNRS of pain, sleeping time and change in mood status. Results : The Korean Medical therapy had good effect on the patient. Especially, relaxing mental treatment is effective in improving and maintaining symptoms. Conclusions : The Korean medical treatments appeared to be effective in reducing R/O CRPS symptoms. Further clinical research of patients with CRPS is needed.