• The Korean Journal of Physiology and Pharmacology
• /
• v.3 no.3
• /
• pp.305-313
• /
• 1999

To explore whether $Cl^-$ channel blockers interact with the ATP-sensitive $K^+\;(K_{ATP})$ channel, I have examined the effect of two common $Cl^-$ channel blockers on the $K_{ATP}$ channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the $K_{ATP}$ channel activity in a concentration-dependent manner with $IC_{50}$ of 0.24 and 927 ${\mu}M,$ respectively. The inhibitory action of DIDS was irreversible whereas that of niflumic acid was reversible. Furthermore, DIDS-induced block was not recovered despite exposure to ATP (1 mM). In cell-attached and inside-out patches, DIDS blocked the pinacidil- or 2,4-dinitrophenol (DNP)-induced $K_{ATP}$ channel openings. In contrast, niflumic acid did not block the pinacidil-induced $K_{ATP}$ channel openings in inside-out patches, but inhibited it in cell-attached patches. DIDS and niflumic acid produced additional block in the presence of ATP and did not affect current-voltage relationship and channel kinetics. All these results indicate that DIDS among $Cl^-$ channel blockers specifically blocks the cardiac $K_{ATP}$ channel.

• Journal of Biomedical Engineering Research
• /
• v.16 no.3
• /
• pp.309-316
• /
• 1995

RF (radio-frequency) probes of Nuclear Magnetic Resonance are one of the important factors and should be designed and built properly depending upon the geometry of the samples and the information. In general there are two kinds of rf probes : one encircles the sample while the other is placed on the surface of the sample. However, in case that the samples on human internal organs have a tube shape, the two kinds of rf probes, as specified above, are usually unsuitable for the internal imaging due to the degradation of signal-to-noise ratios (SNR's). In this case a probe should be positioned as close to the area as possible by putting the probe in the tubelike sample to improve filling factor In the present study inside-out probes have been constructed in the three different shapes such as an anti-solenoidal, a saddle and a dual surface types. RF-field distributions have also been calculated depending upon the geometrical changes of anti-solenoid probes. Moreover, the performance of the inside-out probes has been checked by measuring SNR's of the images acquired. The inside-out probes constructed in this study produced better SWR's and rf-field uniformity in the area close to the probes in comparing with any other commercial probes. There is a high feasibility that the constructed probes in the present study are applicable to the diagnosis of human bodies.

• Journal of the Korean Society of Visualization
• /
• v.5 no.2
• /
• pp.48-55
• /
• 2007

Flow structure inside a refrigerating compartment of a scale-down display cooler model was investigated experimentally by using PIV (particle image velocimetry) method, a reliable velocity field measurement technique, in the present study. In addition, we also carried out flow visualization regarding flow structure and particle movement inside a display cooler by using a tracer method. As a result, the mean velocity field measurement shows a large scale vortical flow structure inside a refrigerating compartment due to strong entrainment flow, going through a base plate open gaps.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.22 no.6
• /
• pp.643-648
• /
• 2002

In this study, shearography and ESPI have been used for quantitative analysis of an inside crack of pipeline and both of them appeared suitable to qualitatively detect inside crack. However, shearography needs several effective factors including the amount of shearing, shearing direction and induced load for the quantitative evaluation of the inside crack. In this study, the factors were optimized for the quantitative analysis and the site of cracks has been determined. Although the effective factors in shearography has been optimized, it is difficult to determine the factors exactly because they are related to the details of tracks. On the other hand, ESPI is independent on the details of a crack and only the induced load plays an important role. The out-of-plane displacement was measured under the optimized load and the measured were numerically differentiated, which resulted in an equivalent to the shearogram. The size of cracks can be determined quantitatively without any detail of a crack.

• Cross-Cultural Studies
• /
• v.21
• /
• pp.165-188
• /
• 2010

One of the things that should be done first in establishing the cosmic life culture is to reflect on the old human-oriented culture. If the cosmic life culture absolutizes everything except for humans according to the logic of reason, its foundation will weaken or eventually get lost. Separating humans from the universe is just like separating life from it. Given that all life, whether it is humans or the earth, originated from the universe, such an effort for separation merely values an individual life by excluding all life or whole life. When the human body and the cosmic chi' blood are not in an active flow, it means there is a problem with life. What is in the greatest need in such a case is the sincere human mind that follows the principle of cosmic life. It is like the sincerity found in the pasonri singer, who mellows all the hardships and difficulties in the world out and create songs out of them like the shadow. It is the pansori singer's shadow that changes the universe. It is only when the extreme force of human mind communicates with that of the universe that the cosmic life or cosmic life culture can be created. In that sense, it is urgent to create life out of the universe inside me and create a universe out of all life in and outside me. It is such a grave plan in human history in that it involves finding the "Sanal" which is the core of life living hidden inside the body whose life force gradually goes away or inside the universe, and creating the culture of Bokseung in which it bursts out. The most important thing in life is the flow, and the mankind is currently standing in the life flow of the massive universe's chaosmos. The greatest task the mankind is currently faced with is to think over how to deal with the period of Big Chaos in the massive universe's chaosmos reversely and establish the cosmic life culture anew.

• Cartoon and Animation Studies
• /
• s.42
• /
• pp.53-79
• /
• 2016

The public interest and popularity of animation has already forecasted the value of animation as the leader of pop culture and cultural industry. The trend in animation changed from 2D to 3D animation, a new genre that appeared in the 1990s with the development of computer technology and innovative changes in media, and 3D animation secured its position in the 2000s. Researches on 3D animation are conducted in various ways. Integrating the area it shares with film and the area it shares with design, it is produced and consumed. This study focused on 'formativeness(design)', the basis of character design, and tried to find out how it is recognized by the audience, who actually watch and feel it. Also, it approached basic theory and tried to deduce logic that is easy to understand and can analyze design or formativeness which keeps changing. Lastly, this study regards the parts that viewers are not satisfied with as problems, and tries to find out a developmental direction. Among the animations for theaters that were big hits in 2015, this study focused on the characters of and . It reviewed errors and what was lacking in the previous studies, collected experts' opinions and made adjustment. Using the frame prepared through this process, it conducted a survey on study participants, the viewers, to see how it is perceived by them. Finally, it tried to find out the reasons why the audience felt that way through theoretical reviews and applications.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.32 no.3
• /
• pp.83-84
• /
• 2021

• Elastomers and Composites
• /
• v.33 no.2
• /
• pp.93-102
• /
• 1998

In electric cable industries, the curing extent of the rubber materials covering the electric cores gives an significant effect on their final performance. The curing extent of rubber is controlled mostly by pull-out velocity of cable in the extrusion process. The final curing extent may be different for different radial positions inside the rubber because of the non-uniform temperature distributions during the curing process. In this contribution, the prediction of curing extent distribution throughout the radial direction of rubber is represented when the cable is passing through the steam curing zone with a fixed pull-out velocity. The prediction of the optimum pull-out velocity for the desired curing extent distribution is also reported. The steady-state heat balance was developed for the curing and cooling processes in which the pull-out rubber was cured by high temperature steam and then cooled by ambient water. A few essential material properties such as density, specific heat, and thermal conductivity were measured to analyze the temperature distribution during the curing and cooling processes. The times to reach 90% curing extent at varying temperatures were measured and used to determine the final cure extent distribution inside the rubber.

• Korean Institute of Interior Design Journal
• /
• v.14 no.6 s.53
• /
• pp.95-102
• /
• 2005

The purpose of this study was to analyze the ambiguity of the boundary through the composition of section. The building means the compose of the inside space by physical shell. Inside space that has boundary factors like floor, wall, roof and column is surrounded outside space. The factors which compose the boundary was expressed by architects as various analysis, but it has changed as changing of paradigm and information revolution. The inside space and outside space were connected through the system arrangement, so various space could construct by an aspect of relation. The history of architecture was written as the establishment of in-out space by architectural boundary factors, but the space could not divide definitely, composed complex structure, could experience various recognition. The existing study which is focused on Ambiguity of the Boundary is just focused on contemporary architecture. Ambiguity of the Boundary is developed by using glass. The transparency of glass removed the boundary of space, so it can be created free wall, continuity of view. It was Influenced the boundary of the sight and changed the expression of boundary between the space. This study is to analyze the change of boundary awareness and find the ambiguity of boundary in the section.

• Journal of Chest Surgery
• /
• v.25 no.5
• /
• pp.451-457
• /
• 1992

The hollow fiber oxygenator is the most advanced one for the cardiopulmoanry bypass. They have two different types of the hollow fiber systems according to the way how the blood go through the fibers. One is inside blood flow type and the other outside type. In order to find out which is better to prevent blood cell destruction, we selected 40 valve replacing patients and divided them into 2 groups prospectively. In group I [n=20], inside blood flow type[BCM-7a], CO2 excretion is more effective than group II, that is partly because of the relative large surface area of the BCM-7. In group II [n=20], outside blood flow type [MAXIMAa], they have better quality to preserve platelet count. We also studied about several other items such as SaO2, Hemoglobin and RBC, WBC, fibrinogen, LDH, plasma hemoglobin, haptoglobulin and so on. But we cannot find any differences between two groups with any statistical meanings [p<0.05]. We conclude that both of two oxygenators are excellent in the aspects of gas exchange and blood cell preservation.