• Korean Journal of Fisheries and Aquatic Sciences
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• v.48 no.1
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• pp.1-15
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• 2015

Tissue engineering is an emerging, innovative technology to improve or replace the biological functions of damaged tissues and organs. Scaffolds are important materials for tissue engineering as they support cell attachment, migration, and differentiation. Marine sponges naturally contain scaffolds formed by extracellular matrix proteins (collagen and sponging) and strengthened by a siliceous or calcium carbonate skeleton. Coral skeletons are also derived naturally formed by essential calcium carbonate in the form of aragonite, and are similar to human bone. In addition, collagen extracted from jellyfish is a biosafe alternative to bovine and porcine collagen and gained attention as a potential source for tissue engineering. Moreover, cuttlefish bone is an excellent calcium source and can be used to generate bio-synthetic calcium phosphate. It has become a natural candidate for biomimetic scaffolds. This review describes the use of natural products derived from marine invertebrates for applications in bone tissue engineering based on studies from 2008 to 2014.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.1-11
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• 2009

Since the Committee for Proprietary Medicinal Products (CPMP) of the European Union issued in 1997 a "points to consider" document for the assessment of the potential for QT interval prolongation by non-cardiovascular agents to predict drug-induced torsades de pointes (TdP), the QT liability has become the critical safety issue in the development of pharmaceuticals. As TdP is usually linked to delayed cardiac repolarization, international guideline (ICH S7B) has advocated the standard repolarization assays such as in vitro IKr (hERG current) and in vivo QT interval, or in vitro APD (as a follow up) as the best biomarkers for predicting the TdP risk. However, the recent increasing evidence suggests that the currently used above biomarkers and/or assays are not fully predictive for TdP, but also does not address potential new druginduced TdP due to the selective disruption of hERG protein trafficking to the cell membrane or VT and/or VF with QT shortening. There is, therefore, an urgent need for other surrogate markers or assays that can predict the proarrhythmic potential of drug candidate. In this review, we provide an ideal pre-clinical strategy to predict the potentials of QT liability and lethal arrhythmia of the drug candidates with recent issues in this field in mind, not at the expense of discarding therapeutically innovative drugs.

• Proceedings of the Materials Research Society of Korea Conference
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• 2012.05a
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• pp.51-51
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• 2012

There is a growing interest in innovative chemical synthesis in microreactors owing to high efficiency, selectivity, and yield. In microfluidic systems, the low-volume spatial and temporal control of reactants and products offers a novel method for chemical manipulation and product generation. Glass, silicon, poly(dimethylsiloxane) (PDMS), and plastics have been used for the fabrication of miniaturized devices. However, these materials are not the best due to either of low chemical durability or expensive fabrication costs. In our group, we have recently addressed the demand for economical resistant materials that can be used for easy fabrication of microfluidic systems with reliable durability. We have suggested the use of various specialty polymers such as silicon-based inorganic polymers and fluoropolymer, flexible polyimide (PI) films that have not been used for microfluidic devices, although they have been used for other areas. And inexpensive lithography techniques were used to fabricate Lab-on-a-Chip type of microreactors with differently devised microchannel design. These microreactors were demonstrated for various synthetic reactions: liquid, liquid-gas organic chemical reactions in heterogeneous catalytic processes, syntheses of polymer and non-trivial inorganic materials. The microreactors were inert, and withstand even harsh conditions, including hydrothermal reaction. In addition, various built-in microstructures inside the microchannels, for example Pd decorated peptide nanowires, definitely enhance the uniqueness and performance of microreactors. These user-friendly Lab-on-a-Chip devices are useful alternatives for chemist and chemical engineer to conventional chemical tools such as glass.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.769-781
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• 2020

This study attempts to examine the relationships between transformational leadership, learning orientation, firm innovativeness, and financial performance. Specifically, the moderating effect of learning orientation and firm innovativeness. The data collected from 606 SMEs in Thailand were evaluated using the structural equation modeling, typifying that quantitative research. The results revealed that transformational leadership had a positive effect on learning orientation. Similarly, transformational leadership had a positive effect on firm innovativeness. Further, the study found that transformational leadership had a positive indirect effect on financial performance through the mediation of learning orientation. The results of the study found that transformational leadership had a positive indirect effect on financial performance through the mediation of firm innovativeness. Transformational leadership and learning orientation to improve innovation within the organization, including organizations and leaders among themselves. Especially, innovative firms inculcate ideals of promise to learning, open-mindedness, and shared vision. Furthermore, practitioners can use the findings of this study when they perform their role of leaders to challenge creativity and innovation among followers. Finally, those developments would influence a procedure of evidence procurement, evidence distribution and shared explanation that escalations equally individual and administrative effectiveness owing to its influence going on products.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1112-1114
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• 2009

In this paper, we have studied manufacturing process for liquid crystal displays (LCDs) using plastic substrates. Because the thermal and dimensional stabilities of plastic substrates are decisive issues, both the process and materials were improved to fit the manufacturing requirements of flexible twisted-nematic (TN) and color super-twisted nematic (CSTN) LCDs. Finally, to broaden the flexible display applications, we take advantage of the unique properties of flexible display to design several innovative products.

• Fashion, Industry and Education
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• v.15 no.1
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• pp.59-65
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• 2017

Fashion professionals these days agree that changes in the fashion business are essential and highly value creativity as a genuine source for generating new ideas in fashion products as well as fashion business practices. As fashion professionals deal with problems of which solutions do not exist or that need innovative solutions for brand or product differentiation in the fast-paced environments, interest in creativity and creative problem solving in the field has increased; therefore, fashion educators have realized that there has been an increasing need for incorporating creativity or creative problem solving into the fashion curriculum. In this study, the researcher intended to review previous research on the use of creative problem solving in classrooms in various disciplines including the field of fashion education to provide insights and suggestions for fashion educators to integrate creative problem solving into the fashion education curriculum. Previous attempts to apply creative problem solving to solve issues in fashion classrooms have mostly limited to promoting divergent thinking techniques. It is suggested for fashion educators as well as fashion students to consider creative problem solving as a process consisting of the four distinct stages in which both divergent and convergent thinking techniques should be properly utilized stimulating various thinking strategies.

• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.2
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• pp.227-232
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• 2015

Nowadays, there are many innovative products in the pro-audio market thanks to advanced IT technology, DSP is very important technology to process high quality audio signal in SR(Sound Reinforcement) system. Digital audio technology that converged with IT technology can give new user-experience. In this paper, we present a new digital crossover system for active speakers using DSP and network technology. The prototype of crossover module consists of various audio process module such as filters, delay, phase controls and also it provides user to remote monitoring and remote control features by internet connection.

• Journal of the Korea Furniture Society
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• v.27 no.1
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• pp.49-58
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• 2016

In modern society, designers started feeling moral and social responsibility in the aspect of environment as a position of suggesting something new. Rather than creating another waste to make something innovative, the concept of Upcycling which is about adding design or utilization to the existing recyclable materials to raise their value to products or art works has started settling down. Among them, there have been various researches on the use of offcut waste to be dumped. Such use of waste can be found in Jogakbo (patchwork), one of our traditional boudoir crafts. This could be connected to the concept of the modern Upcycling in the aspect of giving new values to the wasted pieces of fabric through needlework. Therefore, this study suggested Stitch work as new Upcycling furniture by seeking for the common connections between Upcycling and traditional Jogakbo, and then reinterpreting them in the same viewpoint. It was an opportunity not only to rediscover 'the esthetics of waste' by changing the awareness of 'behavior of dumping', but also to reinterpret or reconsider the tradition. Based on this, it is expected to continuously have new attempts to use offcut waste for eco-friendly design in the future, and also to have opportunities to seek for new directions of Upcycling to rediscover new values through the revaluation of valuelessness.

• Archives of design research
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• v.17 no.1
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• pp.179-190
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• 2004

The human effort to make personal privacy and safety from outer environment has brought the improvement of security system through the technological development. Especially as a apartment dwelling and lifestyle is general, the role and function of door lock system is more important than ever. The research for user-centered approach and design on the door lock system should be implemented under the circumstances. This study has focused on the development of making safety as well as easy interface to design door lock system. The price also is competitive as compared with other door lock products. The goal of this study is to propose the alternatives not only to develop door lock design but also to search the innovative way of locking system design.

• Proceedings of the Membrane Society of Korea Conference
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• 1998.10a
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• pp.11-14
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• 1998

1. Introduction : Research progresses in Chemistry and Chemical Engineering have been made during the last decades with important contributions to the industrial development and to the quality of our life. An interesting case is related to the membrane science and technology continuous impact to innovative processes and products, particularly appropriate for a sustainable industrial growth. Membrane operations have been familiar for many years to biologists and chemists working in their laboratorier or studying biological phenomena. Only recently engineers started to operate in' this area. The preparation of asymmetric CA membranes at University of California, Los Angeles in the early 60s is generally recognized as a crucial moment for membranology (1). Loeb and Sourirajan with their discovery of how to increase significantly the permeability of polymeric membranes without significant changes in their selectivity, made realistic the possibility of their use in large scale operations for desalting brackish and sea water by reverse osmosis and for various other molecular separations in different industrial areas. Reverse osmosis is today a well recognized basic unit operations, togheter with ultrafiltration, crossflow microfiltration,. nanofiltration, all pressure driven membrane processes. Already in 1992 more than 4 milIions m$^3$/day were the total capacity of RO desalination plants and in 1995 more than 180.000 m$^2$ of ultrafiltration membranes were installed for the treatment of wheys and milk (2) (3).