• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.3
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• pp.1168-1188
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• 2018

Social Network Aggregators are used to maintain and manage manifold accounts over multiple online social networks. Displaying the Activity feed for each social network on a common dashboard has been the status quo of social aggregators for long, however retrieving the desired data from various social networks is a major concern. A user inputs the query desiring the specific outcome from the social networks. Since the intention of the query is solely known by user, therefore the output of the query may not be as per user's expectation unless the system considers 'user-centric' factors. Moreover, the quality of solution depends on these user-centric factors, the user inclination and the nature of the network as well. Thus, there is a need for a system that understands the user's intent serving structured objects. Further, choosing the best execution and optimal ranking functions is also a high priority concern. The current work finds motivation from the above requirements and thus proposes the design of a query processing system to retrieve information from social network that extracts user's intent from various social networks. For further improvements in the research the machine learning techniques are incorporated such as Latent Dirichlet Algorithm (LDA) and Ranking Algorithm to improve the query results and fetch the information using data mining techniques.The proposed framework uniquely contributes a user-centric query retrieval model based on natural language and it is worth mentioning that the proposed framework is efficient when compared on temporal metrics. The proposed Query Processing System to Retrieve Information from Social Network (QPSSN) will increase the discoverability of the user, helps the businesses to collaboratively execute promotions, determine new networks and people. It is an innovative approach to investigate the new aspects of social network. The proposed model offers a significant breakthrough scoring up to precision and recall respectively.

• Journal of Engineering Education Research
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• v.5 no.1
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• pp.19-26
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• 2002

This paper presents a virtual laboratory system which can be creating efficiencies in the learning process. The proposed virtual laboratory system for electrical circuits provides interactive learning environment under which the multimedia capabilities of world-wide web can be enhanced. The virtual laboratory system is implemented to describe the on-campus laboratory, the learners can obtain similar experimental data through it. In the proposed virtual laboratory system, every activity occurred in the virtual laboratory will be recorded on database and printed it out on the preliminary report form. The database connectivity is made by PHP and the virtual laboratory environment is set up slightly differently for each learner The virtual laboratory system is composed of four important components : Principle classroom, Simulation classroom, Virtual experiment classroom and Management system. Learning efficiencies as well as faculty productivity are increased in this innovative teaching and learning environment.

• Nuclear Engineering and Technology
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• v.45 no.5
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• pp.625-636
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• 2013

Pressing demands of economic competitiveness, the need for large-scale deployment, minimizing the need of human intervention, and experience from the past events and incidents at operating reactors have guided the evolution and innovations in reactor technologies. Indian innovative reactor 'AHWR' is a pressure-tube type natural circulation based boiling water reactor that is designed to meet such requirements, which essentially reflect the needs of next generation reactors. The reactor employs various passive features to prevent and mitigate accidental conditions, like a slightly negative void reactivity coefficient, passive poison injection to scram the reactor in event of failure of the wired shutdown systems, a large elevated pool of water as a heat sink inside the containment, passive decay heat removal based on natural circulation and passive valves, passive ECC injection, etc. It is designed to meet the fundamental safety requirements of safe shutdown, safe decay heat removal and confinement of activity with no impact in public domain, and hence, no need for emergency planning under all conceivable scenarios. This paper examines the role of the various passive safety systems in prevention and mitigation of severe plant conditions that may arise in event of multiple failures. For the purpose of demonstration of the effectiveness of its passive features, postulated scenarios on the lines of three major severe accidents in the history of nuclear power reactors are considered, namely; the Three Mile Island (TMI), Chernobyl and Fukushima accidents. Severe plant conditions along the lines of these scenarios are postulated to the extent conceivable in the reactor under consideration and analyzed using best estimate system thermal-hydraulics code RELAP5/Mod3.2. It is found that the various passive systems incorporated enable the reactor to tolerate the postulated accident conditions without causing severe plant conditions and core degradation.

• Journal of Digital Convergence
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• v.7 no.1
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• pp.157-164
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• 2009

This research focuses on entrepreneurial orientation(EO) of technology spin-offs as they are expected to reduce the gap between their technology and the market. Entrepreneurial orientation is an organizational activity or process that redistributes or combines resources in an innovative way and takes risk to create new values. It helps improve the level of organizational innovation to deal with uncertainty. An empirical study was performed to analyze the EO of spin-offs established by members of university faculties and research institutes in Korea. Antecedent variables to EO are hypothesized to include public policy for university faculty members and researchers at research institutes, the relationship with incubating organizations, and the level of social networking with other firms. The EO and technological performance relationships are also hypothesized. Data from a total of 121 spin-off organizations were collected and a series of multiple regressions were performed. The performance variable included both technological performance, such as the number of newly marketed products and new technology and subjective performance, such as the level of satisfaction with sales amount and profitability. Several important conclusions were drawn from this study. First, while government policy is not related to EO, the policy of a university or a research institute has a significant effect on the level of innovativeness. Second, a high percentage of human resources applied at the incubating organization results in a negative effect on risk taking. The level of cooperation with the incubating organization too is not related to Entrepreneurial Orientation. Third, the intensity of cooperative networking with other firms has a significant effect on risk-taking. Network relationship with government related organizations is not related to Entrepreneurial Orientation. This study analyzes the importance and role of policy of the university and research institute and networking with other firms to improve EO. It also suggests that a high composition of human resources at the incubating organization has a negative relationship with EO.

• Proceedings of the Korean Geotechical Society Conference
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• 2001.10a
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• pp.29-62
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• 2001

Based on the results from investigation of behaviour of pulverized fly ashes (PFA) at laboratory and field, the way how to reduce the environmental impacts to geotechnical practices Is considered and described. In order to reduce discharged industrial by-products, it should primarily be emphasized that an effort are made as much as possible not to put into homing. Secondarily, an effort must be made to increase amount of utilization to geotechnical engineering practices. In addition, from an environmental point of view, we should challenge to create innovative materials which are eligible for controlling other wastes and remedying contamination m soils by using industrial byproducts which belong to wastes This Is a new concept in which the polluting materials can be eliminated by making use of wastes. Based on the above-stated concept, the previous and possible utilization of PFA is classified into: (1 ) reclamation, embankment or backfill material, (2) light weight geo-material, (8) soil stabilization/improvement, and (4) environmental material. The reason why PFA, in particular, slurry PFA has been used and will possibly be used more widely is due to the fact that PFA has the advantages : (i) low specific gravity leading to a light weight geomaterial, (ii) high pozzolanic activity enhancing strength, especially due to cement addition, and (iii) spherical shape of particles producing isotropy and then pumpability. As well as the concept of reducing geo-environmental impacts, the present text mainly describes the successful results at laboratory and field which have been obtained by the authors. The most important issue hi application of byproducts including PFA for geotechnical practices is to prevent leakage of polluted substances from sedimentary deposits, ground and earth structures. As one of possible techniques far achieving this purpose, a method of washing off the polluted substances by hot water is described.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.18 no.1
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• pp.1-41
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• 1992

A new and unique class of nonionic surfactants was synthesized by reacting biological a-tocopherol with ethylene oxide for functional cosmetics. The structures were confirmed by Hl-UMR, FT-lR, TLC and elemental analysis. POV and conjugated diene value study for EPO showed POE(n)TE had antioxidative effect similar to tocopheryl acetate Protective effect on cell membrane in photohemolysis of POE(5)TE, POE(10)TE and POE(18)TE were slightly lower than tocopherol but higher than nonoxynol-12, and POE(10)TE had UV absorption power comparable with tocopherol and homosalate. Biological activity of the hydrophobic group of the new surfactants make them unique and different from those of conventional nonionic surfactants Systematic safety evaluations of POE(n)TEs on the skin and eye proved that they are as safe as tocopherol. The results of physicochemical study showed POE(10)TE had the lowest CMC value, POE(18)TE had the maximum surface tension reduction and the highest foam volume and POE(n)TEs had various HLB values by the degree of ethoxylation. The test resul Is of technological and practical applications of these surfactants for cosmetics showed some POE(n)TEs were superior to conventional surfactants. POE(5)TE in W/O emulsions, POE(10)TE and POE(12)TE in O/W emulsions, POE(12)TE in dispersions, POE(18)TE in solubilizations and POE(50)TE in gelations were shown to be excellent which was considered due to the structural characteristic and formation of liquid crystals of POE(n)TEs. By the development and applications of these excel lent multi-functional surfactants, innovative functional cosmetics were successfully formulated.

• Molecules and Cells
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• v.42 no.11
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• pp.783-793
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• 2019

When endoplasmic reticulum (ER) functions are perturbed, the ER induces several signaling pathways called unfolded protein response to reestablish ER homeostasis through three ER transmembrane proteins: inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6). Although it is important to measure the activity of ATF6 that can indicate the status of the ER, no specific cell-based reporter assay is currently available. Here, we report a new cell-based method for monitoring ER stress based on the cleavage of $ATF6{\alpha}$ by sequential actions of proteases at the Golgi apparatus during ER stress. A new expressing vector was constructed by using fusion gene of GAL4 DNA binding domain (GAL4DBD) and activation domain derived from herpes simplex virus VP16 protein (VP16AD) followed by a human $ATF6{\alpha}$ N-terminal deletion variant. During ER stress, the GAL4DBD-VP16AD(GV)-$hATF6{\alpha}$ deletion variant was cleaved to liberate active transcription activator encompassing GV-$hATF6{\alpha}$ fragment which could translocate into the nucleus. The translocated GV-$hATF6{\alpha}$ fragment strongly induced the expression of firefly luciferase in HeLa Luciferase Reporter cell line containing a stably integrated 5X GAL4 site-luciferase gene. The established double stable reporter cell line HLR-GV-$hATF6{\alpha}$(333) represents an innovative tool to investigate regulated intramembrane proteolysis of $ATF6{\alpha}$. It can substitute active pATF6(N) binding motif-based reporter cell lines.

• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.323-331
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• 2021

The relevance of the study implies the need to explain the main determinants of environmental policy, allowing countries to converge on a common working basis. The purpose of the research is to explore ways in which the environmental aspects of EU regions and territories can be shaped to apply to domestic environmental policy. A total of 997 representatives from the Ukrainian UTCs, who are involved in local environmental policy, participated in the survey. Results of the research. A hierarchy of regional environmental policy objectives has been identified. Three key principles of eco-policy development have been distinguished. The means of the innovative approach strategy implementation have been outlined (formation of the regional market of environmental services; organization of interaction between environmental agencies and market structures; establishment of environmental funds which finance environmental activities; implementation of the "collateral return" system; formation of a system of benefits and loans to enterprises that successfully implement the environmental policy). The means of the prognostic approach implementation strategy to the development of the region's environmental policy have been determined (the use of an orderly and successful long-term strategy of economic development of the region; obligatory consideration in the mechanisms strategy aimed at improvement of environmental management system of the region, interbranch impact of the projects implemented on the region's ecological situation; taking into consideration the economic and geographical peculiarities of the region, the necessary infrastructure, issues of the territorial location of the large enterprises in the region and their impact on the environment). The means of the traditional approach strategy implementation have been outlined (activity programs focused on solution of specific problems, rather than on the implementation of measures for environmental restoration and enhancement; nature conservation problems have interbranch, interdepartmental character due to unity of the region's ecosystem; tracking complexity of changing conditions (water basins, woodlands, air-mass transport), regional boundaries generally do not coincide with natural ecosystems boundaries). The practical significance of the study lies in providing recommendations for the implementation of certain aspects of Ukrainian UTC's environmental policy.

• Journal of the Economic Geographical Society of Korea
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• v.24 no.3
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• pp.259-282
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• 2021

This study analyzes actor networks in regional innovation processes with a focus on actors' activities and finds the determinants of the networks, thereby aiming to provide information useful for regional innovation policy makers. To this end, the study conducted a social network analysis of the national R&D projects data and identified the activities of innovation actors. Finding out the network determinants was QAP analysis. The study suggests three main findings as follows. First, a meaningful difference exists in characteristics of innovation activity by region. Second, the network of innovation actors meaningfully differs from region to region. The centrality of the network was found to be high in universities and businesses in Seoul and Gyeonggi, and in public research institutes in Daejeon. There are regions where all the networks of innovative actors are composed of one component, while some regions are not yet established with the network. Finally, although the networks of innovation actors are influenced by the geographical proximity and the size of the R&D fund, it is notable that the previous continuous relationship forms a strong research network.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.539-549
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• 2019

Background: 20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant. Methods: In this study, an ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass tandem mass spectrometry method was established to identify the metabolites of PPD in human plasma and urine following oral administration in phase IIa clinical trial. Results: A total of 40 metabolites in human plasma and urine were identified using this method. Four metabolites identified were isolated from rat feces, and two of them were analyzed by NMR to elucidate the exact structures. The structures of isolated compounds were confirmed as (20S,24S)-epoxydammarane-12,23,25-triol-3-one and (20S,24S)-epoxydammarane-3,12,23,25-tetrol. Both compounds were found as metabolites in human for the first time. Upon comparing our findings with the findings of the in vitro study of PPD metabolism in human liver microsomes and human hepatocytes, metabolites with m/z 475.3783 and phase II metabolites were not found in our study whereas metabolites with m/z 505.3530, 523.3641, and 525.3788 were exclusively detected in our experiments. Conclusion: The metabolites identified using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry in our study were mostly hydroxylated metabolites. This indicated that PPD was metabolized in human body mainly through phase I hepatic metabolism. The main metabolites are in 20,24-oxide form with multiple hydroxylation sites. Finally, the metabolic pathways of PPD in vivo (human) were proposed based on structural analysis.