• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.221-230
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• 2023

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.

• Journal of the Korea Safety Management & Science
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• v.25 no.1
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• pp.15-21
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• 2023

In modern society, the delivery service market has grown explosively due to rapid changes in social structure and the recent COVID-19 pandemic. Therefore, various problems such as injury to workers and an increase in human accidents are occurring due to the loading and unloading of parcels. In order to solve this problem, domestic company n is developing a "robot-based cargo loading and unloading system". In developing a new technology system, quantitative reliability targets should be set for efficient operation and development. In this paper, reliability analysis was conducted through field data for the pneumatic gripper of the "robot-based cargo loading system". The reliability of the failure data was analyzed to estimate the distribution parameters and MTTF. Random data was derived for the probability of occurrence of a failure with the estimated value. By repeating the simulation to predict the number and year of failures according to the estimated parameters of the probability distribution, it was proposed as a method that reflects realistic probabilities rather than calculating with simple arithmetic using the average MTTF previously used in the field.

• Journal of Yeungnam Medical Science
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• v.41 no.3
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• pp.196-206
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• 2024

Background: This study investigated the prevalence and associated factors of musculoskeletal pain among professional dancers who experienced a lapse in group practice due to coronavirus disease 2019. Methods: General characteristics, practice time, region of musculoskeletal pain due to injury using the visual numeric scale (VNS), and causative motion were surveyed among professional dancers. Pain of VNS 0 to 3 was categorized as "no or minor," 4 to 6 was categorized as "moderate," and 7 to 10 was categorized as "severe." The causal motions of musculoskeletal pain were analyzed according to body region. Factors other than motion associated with pain were also analyzed. Results: In total, 368 participants were included. In the univariate analysis, age and practice time were positively associated with "moderate" pain. Practice time, dance experience, and postural accuracy were positively associated with "severe" pain, as was performing Korean traditional dance. In the multivariable analysis, practice time, group practice, and age were positively associated with pain of VNS 4 to 10, and practice time, group practice, and Korean traditional dance were positively associated with pain of VNS 7 to 10. Conclusion: Among the factors related to dancer training, practice time, group practice, and dance type affect the occurrence of pain.

• Korean Journal of Soil Science and Fertilizer
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• v.31 no.3
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• pp.216-224
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• 1998

The objective of this study was to investigate the effect of sesame monoculture and sesame in rotation (SR) with maize. soybean. barley or rye on reduction of injury by continous cropping in sesame. Field studies were conducted for 3-years (1995~1997) at the experimental field of the Crop Experiment Station. Compared to CS (continuous sesame). SR treatments turned out to keep more organic matter and higher exchangeable cation concentrations in soils. BS (barley and sesame in a 1-year rotation) and RS (rye and sesame in a 1-yea r rotation) treatments had significantly greater available $P_2O_5$ contents in soils than CS, MS (maize and sesame in a 3-year rotation) and SbS (soybean a nd sesame in a 3-year rotation). The pH of the soils under different treatments were not significantly different. SR treatments exhibited significantly lower bulk density and higher pore space than CS. Soil microbial biomass C (SMBC) and N (SMBN) were determined by the chloroform fumigation-extraction method. SMBC and SMBN were significantly higher in soils under BS and RS than those under CS, but only during the 1 year of monitoring. MS and SbS treatments resulted in higher SMBC and SMBN than CS. The occurrence of injury by disease of sesame is the important primary factor of injury by continous cropping, but the disease occurrence with rotation did not decrease in th is experiment. Under CS treatment, the growth and grain of sesame was significantly lower than those under other treatments. Compared to CS, the increments of grain yield of sesame were 68, 63, 57 and 51% for MS, RS, SbS and BS, respectively in the first harvest. In the second harvest, they were 24% for MS, 28% for RS, 20% for SbS and 19% for BS. The average increase ratios during the two years were 41, 41, 34, and 33% for MS, RS, SbS and BS, respectively.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.34 no.s02
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• pp.13-33
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• 1989

Agroclimate should be analyzed and evaluated accurately to make better use of available chimatic resources for the establishment of optimum cropping systems. Introducing of appropriate cultivars and their cultivation techniques into classified agroclimatic zone could contribute to the stability and costs of crop production. To classify the agroclimatic zones, such climatic factors as temperature, precipitation, sunshine, humidity and wind were considered as major influencing factors on the crop growth and yield. For the classification of rice agroclimatic zones, precipitation and drought index during transplanting time, the first occurrence of effective growth temperature (above 15$^{\circ}C$) and its duration, the probability of low temperature occurrence, variation in temperature and sunshine hours, and climatic productivity index were used in the analysis. The agroclimatic zones for rice crop were classified into 19 zones as follows; (1) Taebaek Alpine Zone, (2) Taebaek Semi-Alpine Zone, (3) Sobaek Mountainous Zone, (4) Noryeong Sobaek Mountainous Zone, (5) Yeongnam Inland Mountainous Zone, (6) Northern Central Inland Zone, (7) Central Inland Zone, (8) Western Soebaek Inland Zone, (9) Noryeong Eastern and Western Inland Zone, (10) Honam Inland Zone, (ll) Yeongnam Basin Zone, (12) Yeongnam Inland Zone, (13) Western Central Plain Zone, (14) Southern Charyeong Plain Zone, (15) South Western Coastal Zone, (16) Southern Coastal Zone, (17) Northern Eastern Coastal Zone, (18) Central Eastern Coastal Zone, and (19) South Eastern Coastal Zone. The classification of agroclimatic zones for cropping systems was based on the rice agroclimatic zones considering zonal climatic factors for both summer and winter crops and traditional cropping systems. The agroclimatic zones were identified for cropping systems as follows: (I) Alpine Zone, (II) Mountainous Zone, (III) Central Northern Inland Zone, (IV) Central Northern West Coastal Zone, (V) Cental Southern West Coastal Zone, (VI) Gyeongbuk Inland Zone, (VII) Southern Inland Zone, (VIII) Southern Coastal Zone, and (IX) Eastern Coastal Zone. The agroclimatic zonal characteristics of climatic disasters under rice cultivation were identified: as frequent drought zones of (11) Yeongnam Basin Zone, (17) North Eastern Coastal Zone with the frequency of low temperature occurrence below 13$^{\circ}C$ at root setting stage above 9.1％, and (2) Taebaek Semi-Alpine Zone with cold injury during reproductive stages, as the thphoon and intensive precipitation zones of (10) Hanam Inland Zone, (15) Southern West Coastal Zone, (16) Southern Coastal Zone with more than 4 times of damage in a year and with typhoon path and heavy precipitation intensity concerned. Especially the three east coastal zones, (17), (18), and (19), were subjected to wind and flood damages 2 to 3 times a year as well as subjected to drought and cold temperature injury.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.4
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• pp.352-361
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• 1990

The reducing effect of wind injury was investigated using several wind-break nets in Youngdeok province where cold-wind damage is often occurred during rice growing season. The white-head damage of rice have been often occurred by typhoon during the period between August 15 to September 10 in the cold wind area of the eastern coastal during the last 11 years (1979-1989). This may suggest that the critical period for heading will be by August 15 in the regions. High evaporation coefficient, more than 250 due to typhoon passage over the regions resulted high injury of white head. Generally, the wind injury have been caused by warm and dry westerlies through Fohn apperance in Taebaeg mountains and by cool-humid wind which blows from coast to inland. The frequency of occurrence of the two types of typhoons were 25, 20%, respectively during rice cultivation. The instalation of wind-break net significantly reduced the wind blowing speed, depending on the net mesher with the higher effect in dence net. The distances between the net and cropping area also affect the wind speed: 23% reduction at 1m distance. 34% at 10m and 28% at 20m, respectively. The reducing effect was also observed even at 10 times height of the wind-break net. The instalation of wind-break net gave several effects on climate factor, showing that temperature increased by 0.8$^{\circ}C$(maximum), 0.7$^{\circ}C$(minimum), 0.6$^{\circ}C$(average) : water temperatures increased by 0.5$^{\circ}C$(maximum), 0.6$^{\circ}C$(minimum), 0.5$^{\circ}C$(average) : soil temperature increased 0.4$^{\circ}C$. The earlier heading and increasing growth rate, use of light, culm length, panicle number per hill, spikelet number per panicle, fertility and 1,000 grain weight were observed in the fields with the wind-break nets resulting in 10-15% increase in rice yield using 0.5${\times}$0.5cm nets. The increasing seedlings per hill gave higher grain yield by 13% in the cold wind damage regions of eastern coastals. and the wind-break was more significant in the field without the wind-break net. Wind injury of rice plant in the cold wind regions of eastern coastals in korea could be reduced by selection of tolerant varieties to wind injury, adjustment of transplanting time, and establishment of wind-break nets.

• Journal of Preventive Medicine and Public Health
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• v.10 no.1
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• pp.166-175
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• 1977

The author have performed an epidemiological study on the accidental deaths at industry from 1970 to 1975, in order to seek for the preventive measures of industrial accident with the under-standing of its cause and characteristics of the accidental deaths. The obtained results were as follows; 1. Total number of deaths for 6 years were 361 (350 males, 11 females). and the mean death rate was 33.8 per 100,000 industrial workers during 6 years. By the highest as 52.9 was in 1974 and the lowest as 13.7 in 1970. By the industry group, the death rate of Electricity, Gas and Water was 149.3, Construction 83.9 and the lowest was Manufacturing as 18.3. 2. Standardized mortality rate of the cases by the age group showed that 20-29 years old group was 43.0, 40-49 years old group 38.1, 30-39 years old group 32.0, and the lowest as 17.9 was under 19 years old group. 3. The cumulative percentage of the cases by years of service showed that under 6 months was 60.4%, under 1 year 72.9%, under 2 years 83.1%. 4. By the month of occurrence, the highest was 15.8% which occurred in August and the lowest was 5.8% in February. The highest as 19.1% was on Friday and the lowest as 11.9% on Monday by the day of a week. 5. By the causes of accident, car accidents was 28.3%, fall accidents 19.1%, accidents by a crash 9.1% in that order. By the location of injury, head was 44.6%, multiple injuries 33.0%, chest 10.5%, and back was the lowest as 1.9%. The distribution of the cases by nature of injury shelved that cerebral contusion and hemorrhage was 39.4%, fracture and dislocation 33.2%, asphyxia 8.0% in that order. 6. The cumulative percentage of the cases by the duration from injury to death showed that the injuried day was 74.2%, within 3 days after injury 88.5%, within 7 days 96.1%. Therefore most of the cases were occurred within 7 days after injury. 7. Byythe daily mean wages, most of the cases as 91.7% were under 2,000 won, and more 4,000 won was 1.6% merely.

• Clinical and Experimental Pediatrics
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• v.46 no.10
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• pp.989-995
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• 2003

Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain injury. This study was conducted to explore the effect of post-HI dexamethasone administration on neuronal injury in neonatal rats. Methods : HI was produced in seven-day-old rats by right carotid artery ligation followed by two hours of 8% oxygen exposure. At the end of HI, the animals were injected intraperitoneally either with dexamethasone(0.5 mg/kg) or saline. Neuronal injury was assessed seven days after the HI by the area of infarction, TUNEL reactivity, Bcl-2 and Bax expression in brain. Results : Post-insult dexamethasone administration resulted in reduction of weight gain and a higher mortality rate during seven days after HI. Dexamethasone treatment revealed no effect on the size of brain infarction induced by HI. Bax protein expression increased in dexamethasone treated brain but Bcl-2 protein expression and TUNEL reactivity revealed no significant differences between dexamethasone treated and non treated brain. Increased Bax protein expression suggest upregulation of the apoptosis by dexamethasone. Conclusion : The result suggests the adverse role of Post-HI administration of dexamethasone in neonatal HI.

• Science of Emotion and Sensibility
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• v.12 no.1
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• pp.11-18
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• 2009

The purpose of this study was, first, to extract the risk factor by investigating several cases of accident of senile dementia patient at home, and second, based on these results to provide basic information for the determination of monitoring factor for the care of senile dementia patient. Basic and behavioral characteristics, Short form of Samsung Dementia Questionnaire (S-SDQ), Activities of Daily Living (ADL), and cases of accident were investigated with 55 senile dementia patient at home (16 male, 39 female). Based on these questionnaires, risk factors were extracted and frequency, cooccurrence frequency, and occurring place of risk factors, presence or not, region, and degree of injury were investigated. Frequency between risk factors and behavioral characteristics, ADL, and S-SDQ was analyzed by crosstabulation frequency analysis. Results showed that 12 risk factors were extracted, and the frequency of 'going out' was the highest, and risk factors for injury were 'tumble', 'bump', 'slip', and 'fall'. Cooccurrence frequency analysis showed that the occurrence of 'fall', 'going out', 'fire of gas', and 'violence' with other factors was relatively higher than others. The occurring place of risk factor was the highest in home neighborhood, and the region of injury in knee, and the degree of injury with bruise. Crosstabulation frequency analysis showed that factors which had difference in frequency of risk factor were behavioral disorder, disorder of daily living and ADL. Factor which had difference in frequency due to the degree of behavioral disorder and disorder of daily living was 'going out', and factors which had difference in frequency due to the degree of ADL were 'slip' and 'fire of gas'.

• Food Science and Preservation
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• v.15 no.5
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• pp.635-641
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• 2008

This study was conducted to investigate the optimal sub-zero temperature for storage of two garlic cultivars, the northern ecotype 'Jaerae' and the southern ecotype 'Daeseo'. These cultivars of garlic bulbs were stored at different temperature (room temperature, $0^{\circ}C$, and $-4^{\circ}C$) conditions after predrying. Southern ecotype garlic showed higher weight loss than northern ecotype garlic. Northern ecotype garlic at $-4^{\circ}C$ exhibited less than 5% of weight loss during 10 month storage. Sprouting rate was higher in southern than in northern ecotype at room temperature storage. The value of injury by disease and insect was similar between southern ecotype and northern ecotype for 5 month storage, and then northern ecotype showed higher value of injury by disease and insect than southern ecotype. Hunter 'b' value of northern ecotype garlic was the lowest at $-4^{\circ}C$ storage. Northern ecotype garlic showed no cold injury at freezing point temperature storage. However, southern ecotype garlic had $0{\sim}5.3%$ cold injury occurrence at $-4^{\circ}C$ storage. Respiration and ethylene production exhibited the highest at room temperature storage, those had the slight increase at $0^{\circ}C$ and $-4^{\circ}C$ storages. Northern ecotype showed higher enzymatic pyruvic acid and fructan contents than those of southern ecotype. Enzymatic pyruvic acid content increased and fructan contents decreased during storage time.