• Journal of Trauma and Injury
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• 제21권1호
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• pp.46-52
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• 2008

Purpose: This study was to evaluate the effect of arterial embolization on survival in patients with pelvic bone fractures and arterial bleeding. Methods: From January 2001 to December 2007, in all, 18 patients with pelvic bone fractures that had been treated with interventional arterial embolization were included in this retrospective study. The Injury Severity Score (ISS), the Revised Trauma Score (RTS), the initial hemodynamic status, the blood gas analysis, blood transfusion data, and mortality were the main outcome measurements. Results: Pelvic bone fractures were classified into lateral compression (LC), antero-posterior compression (APC), vertical shear (VS), and combined (CM) type according to the Young-Burgess classification. The Survivor group included 11 patients (61.1%), and the non-survivor group included 7 patients (38.9%). The mean ages for the survivor and the non-survivor groups were 40.0 and 45.6 years (p=0.517). The types of pelvic bone fractures were LC 11 (61.1%), APC 6 (33.3%), and VS 1 (5.6%): LC 7 (63.6%), and APC 4 (36.4%) in the survivor group and LC 4 (57.1%), APC 2 (28.6%), and VS 1 (14.3%) in the non-survivor group. The internal iliac artery was the predominant injured vessel among both the survivors (n = 5, 45.5%) and the non-survivors (n = 4, 57.1%). No differences in initial blood pressures, ISS, and RTS existed between the two groups, but the arterial pH was lower in the non-survivor group (pH 7.09 (${\pm}0.20$) vs 7.30 (${\pm}0.08$), p=0.018). The number of transfused 24-hour units of packed RBC was greater in the non-survivor group ($24.1{\pm}12.5$ vs $14.4{\pm}6.8$, p=0.046). Conclusion: No differences in initial blood pressure and trauma scores existed between survivors and non-survivors with pelvic bone fractures, who had been treated with arterial embolization, but arterial pH was lower the in non-survivors.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.861-870
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• 1997

배 경 : 급성 췌장염의 사망률은 10~18%로 알려져 있으며 사망의 대부분은 급성 호흡 부전과 관련되어 있다. 급성 호흡 부전의 가장 심한 형태인 ARDS의 중요한 췌장염이 알려져 있으나 급성 췌장염 환자들 중 어떤 환자에서 ARDS가 더 잘 발생하는지는 확실히 밝혀져 있지 않다. 급성 췌장염 환자들의 입원 시점에서 ARDS의 발생과 연관된 인자들을 찾아보고자 본 연구를 시행하였다. 연구방법 : 1989년 5월부터 1995년 9월까지 아산 재단 서울 중앙 병원에 입원한 환자 86명 94예를 후향적으로 분석하였다. ARDS는 94예 중 13예(13.8%)에서 발생하였다. 통계 분석은 각 임상 지표들을 단변수 분석과 $x^2$-test를 이용하였다. 연구결과 : 내원 당시 흉부 단순 촬영상 이상 소견이 있는 경우 ARDS가 더 잘 발생하였으며(p<0.05)복부 컴퓨터 촬영 중증 지표가 높을 수록 ARDS가 더 잘 발생하였다(p<0.05). APACHE III score가 높을수록(p<0.01) Murray의 폐손상 점수가 1점 이상인 경우 0점인 경우보다 ARDS발생율이 더 높은 것으로 나타났다. 패혈증이 동반된 경우 그렇지 않은 경우보다 ARDS발생 위험도가 3.5 배 높았으며 (p<0.05) 다장기 부전이 3개 이상인 경우 다장기 부전이 없는 경우보다 ARDS 발생 위험도가 23.3 배 (p<0.01) 높은 것으로 나타났다. 결 론 : 급성 췌장염 환자 중 내원 당시 흉부 단순 촬영상 이상소견이 있거나 APACHE III score가 Murray의 폐손상 점수가 높을 수록 패혈증이 동반된 경우 다장기 부전이 3개 이상 동반된 경우에 ARDS가 더 잘 발생하는 것으로 나타났다.

• Journal of Trauma and Injury
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• 제29권4호
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• pp.139-145
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• 2016

Purpose: The major pelvic trauma results in high mortality with associated fatal other injuries. During early stage of resuscitation, multidisciplinary approach is essential to improve the survival and outcomes. This study aims to report the effect and positive outcome of the trauma team approach on the management of hemodynamically unstable pelvic bone fracture. Methods: This retrospective review included all patients with hemodynamically unstable pelvic bone fracture admitted between March 2007 and December 2015. Patients were divided into group A, which comprised those admitted before the trauma team approach was started, and group B, which comprised those admitted after the approach was started. The advanced trauma life support protocol was followed for all patient. The comparisons between the two groups were based on medical records. Study variables included demographics, initial vital sign, injury severity score, fracture type, and injury mechanism. We analyzed the outcomes in each group with respect to the time interval for doctors' arrival, total length of stay in the emergency department (ED), time interval for computed tomography evaluation, 24-hour mortality, time interval for definitive fixation, and definitive fixation in the time-window of opportunity. Results: Fifty-three patients met the inclusion criteria. No statistically significant differences in demographic data existed between the two groups. The time interval for doctors' arrival (min, $63.09{\pm}50.48$ vs $21.48{\pm}17.75$; p=0.038) and total length of stay in the ED (min, $269.33{\pm}105.96$ vs $115.49{\pm}56.24$; p=0.023) were significantly improved. The 24-hour mortality was not significantly different between the two groups.(%, 14.3 vs 12.0; p=1.000) However, the time interval for definitive fixation and definitive fixation in the time-window of opportunity showed better results. Conclusion: The trauma team approach has positive effects, which include initial resuscitation through multidisciplinary approach and shortening the time interval to definitive fixation, on the management of hemodynamically unstable pelvic bone fracture.

• Journal of Trauma and Injury
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• 제26권3호
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• pp.170-174
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• 2013

Purpose: A flail chest is one of most challenging problems for trauma surgeons. It is usually accompanied by significant underlying pulmonary parenchymal injuries and mayled to a life-threatening thoracic injury. In this study, we evaluated the treatment result for a flail chest to determine the effect of trauma localization on morbidity and mortality. Methods: Between 2004 and 2011, 46 patients(29 males/17 females) were treated for a flail chest. The patients were divided into two group based on the location of the trauma in the chest wall; Group I contained patients with an anterior flail chest due to a bilateral costochondral separation (n=27) and Group II contained patients with a single-side posterolateral flail chest due to a segmental rib fracture (n=19). The location of the trauma in the chest wall, other injuries, mechanical ventilation support, prognosis and ISS (injury severity score) were retrospectively examined in the two groups. Results: Mechanical ventilation support was given in 38 patients(82.6%), and 7 of these 38 patients required a subsequent tracheostomy. The mean ISS for all 46 patients was $19.08{\pm}10.57$. Between the two groups, there was a significant difference in mean ventilator time (p<0.048), but no significant difference in either trauma-related morbidity (p=0.369) or mortality (p=0.189). Conclusion: An anterior flail chest frequently affects the two underlying lung parenchyma and can cause a bilateral lung contusion, a hemopneumothorax and lung hemorrhage. Thus, it needs longer ventilator care than a lateral flail chest does and is more frequently associated with pulmonary complications with poor outcome than a lateral flail chest is. In a severe trauma patient with a flail chest, especially an anterior flail chest, we must pay more attention to the pulmonary care strategy and the bronchial toilet.

• Journal of Trauma and Injury
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• 제21권2호
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• pp.115-119
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• 2008

Purpose: Abrupt abstinence from alcohol in cause of chronic alcohol addiction can trigger alcohol withdrawal syndrome. The authors studied the effect of post-operative alcohol withdrawal syndrome in patients who require intensive care due to trauma. Methods: For the study group, we selected 70 patients who had undergone emergency surgery from May 2003 to March 2007 due to trauma and who had been treated with prophylactic thiamine. Data was collected retrospectively. We excluded those who extended their hospital stay for other than traumatic causes, those who died within 3 days of surgery after trauma, those who transferred to other institutions, and those who received a psychiatric diagnosis. Patient groups were determined by the existence or the non-existence of withdrawal syndrome. Age, sex, injury mechanism, mortality, complications, durations of hospital stay and intensive care, use of mechanical ventilator, and sedative use were investigated. A Chi-square test and The Mann-Whitney method were used for statistical analysis in this study. Results: Twenty-four (24) patients from the 58 who had an ISS of 16 or more showed alcohol withdrawal syndrome, and men were shown to be affected with the syndrome significantly more than women. Although ISS was higher in the group with alcohol withdrawal syndrome, statistically, the difference was not significant (P<0.08). The total hospital stay in the patient group with alcohol withdrawal syndrome was on average 10 days longer. However, the difference was not significant (P<0.054). The duration of intensive care in the patient group with alcohol withdrawal syndrome was significantly longer (P<0.029). The patients with alcohol withdrawal syndrome showed no significant difference in the duration of mechanical ventilator use (P<0.783), or in the duration of sedative use (P<0.284). Respiratory distress, pneumonia, upper airway infection, sepsis, acute renal failure, and mortality in the alcohol withdrawal syndrome group were investigated, but no statistically significant difference were noted. Conclusion: We found that the duration of intensive care in chronic alcohol abusers was longer due to the development of alcohol withdrawal syndrome. We also discovered that, when the patients overcame the symptoms of alcohol withdrawal syndrome after intensive care, no difference was found in the frequency of developing complications, the morbidity, and the mortality. Therefore, we conclude that intensive care in trauma patients who are chronic alcohol abusers decreases the incidence of complications found in patients with post-operative alcohol withdrawal syndrome and does not adversely impact the prognoses for those patients.

• 대한임상독성학회지
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• 제18권2호
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• pp.110-115
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• 2020

Purpose: Acute kidney injury (AKI) in patients with glyphosate poisoning has a poor prognosis. This study aimed to predict the risk factors for AKI in patients with glyphosate poisoning at the emergency department (ED). Methods: Clinical data on glyphosate poisoning patients at ED who were older than 18 years were collected retrospectively between January 2013 and December 2019. The clinical characteristics and clinical outcomes of the AKI group in patients with glyphosate poisoning were compared with the non-AKI (NAKI) group. Results: Of 63 glyphosate poisoning patients, AKI was observed in 15 (23.8%). The AKI patients group showed the following: old age (p=0.038), low systolic blood pressure (p=0.021), large amount of ingestion (p=0.026), delayed hospital visits (p=0.009), high white blood cells (WBC) (p<0.001), high neutrophil counts (p<0.001), high neutrophil-lymphocyte (LN) ratios (p<0.001), high serum potassium (p=0.005), low arterial blood pH (p=0.015), and low pO2 (p=0.021), low bicarbonate (p=0.009), and high Poisoning Severity Score (PSS) (p<0.001). AKI patients required hemodialysis, ventilator care (p<0.001, p=0.002), and inotropics (p<0.001). They also showed more intensive care unit admission (p<0.001), longer hospitalization (p<0.001), and high mortality (p<0.001). Logistic multivariate regression analysis showed that high WBCs (OR, 1.223) and increased LN ratios (OR, 1.414) were independently associated with the occurrence of AKI. Conclusion: In patients with glyphosate poisoning at ED, high WBCs and increased LN ratios can help predict the occurrence of AKI.

• 정신신체의학
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• 제7권2호
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• pp.184-195
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• 1999

연구목적 : 외상성 뇌 손상은 정신과 신체에 만성적 후유증을 남기기 때문에 환자들이 남은 생애를 의미 있는 삶으로 가꾸어 가고자 할 때 그들은 그 동안 추구해 왔던 삶의 의미와 목표를 수정하여 새로운 목표를 세워야 할 것이다. 이에 손상의 증상과 장해가 고정된 후 환자들의 삶의 질과 미래에 대한 심리적 준비 상태는 어떤지, 그러고 이에 영향을 주는 변인들은 무엇인지를 조사하여 재활치료에 도움이 되고자 하였다. 방법 : 경도 또는 고도의 뇌 손상을 받은 후 12개월 이상 경과한 16~65세 사이의 환자 32명, 그리고 환자들과 연령, 성별 및 교육수준이 비슷한 정상 대조군 32명을 대상으로 삶의 목적 검사(PIL)와 주관적(SIP, HISC) 및 객관적 삶의 질 척도들(QOLI, NRS) 을 사용하여 삶의 목적 및 삶의 질 수준을 평가하고, 집단간의 차이와 각 변인들의 영향을 분석하였다. 결과 : 1) 뇌 손상군의 삶의 목적 및 삶의 질 수준은 증상이 안정된 후에도 대조군보다 유의하게 낮았다(p<.01. p<.01). 2) 뇌 손상 환자군의 삶의 목적 수준은 $58.8{\pm}23.2$로서 실존적 공허 수준에 머무르고 있었다. 3) 뇌 손상군의 삶의 목적 수준과 삶의 칠 수준간에는 유의한 상관이 있었다(p<.01). 4) 뇌 손상 환자 중 여자 환자의 삶의 목적 수준은 남자보다 유의하게 낮았고(p<.05), 삶의 목적 수준이 낮은 집단은 높은 집단보다 여자의 비율이 유의하게 높았다(p<.05). 5) 뇌 손상군에서 외상의 심도(갱도와 고도), 결혼상태(결혼과 비결혼), 외상 전 직업상태(고용과 비고용)에 따라 분류한 하위 집단간 삶의 목적 수준은 유의한 차이가 없었다. 결론 : 외상성 뇌 손상 환자들의 삶의 목적 수준은 증상이 안정된 후에도 실존적 공허의 수준에 머무르고 있었고, 삶의 질 수준 역시 현저히 낮았으며, 삶의 목적 수준이 낮을수록 삶의 질도 낮았다. 그리고 성별 차이 외에 인구통계 및 임상적 변인들은 삶의 목적 수준에 영향을 주자 않았다. 따라서 놔 손상 환자들의 효과적인 재활치료를 위해서는 우선 환자들이 자신의 장애를 받아들이고 새로운 삶의 목표를 세우는 데 중점을 두어야 할 것으로 여겨졌다.

• Tuberculosis and Respiratory Diseases
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• 제45권6호
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• pp.1236-1251
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• 1998

연구배경 : 급성폐손상의 병태생리학적 기전에는 염증세포들이 분비하는 다양한 염증성 매개물질들이 매우 중요한 역할을 한다. 이중 특히 tumor necrosis factor-$\alpha$ (TNF-$\alpha$) 는 다른 염증세포들의 화학주성 및 각종 염증성 매개물질 분비에 영향을 미치는 proin-flammatory cytokine으로 작용하는 한편, 직접적으로 세포손상을 야기시키는 세포독성 cytokine으로도 작용하는데, 급성폐손상에서 TNF-$\alpha$와 폐조직 손상과의 직접적인 관련성에 대해서는 아직 구체적으로 확인된 바가 많지 않다. 또한, 최근에 생체내 방어기전으로 스트레스 단백질에 대한 관심이 높아지면서, 단핵구에 내독소를 처치하거나, 동물에 내독소를 투여하기 전에 미리 스트레스 단백질을 합성시킨 경우, 내독소에 의한 손상을 감소시켜 준다는 연구가 보고되었지만, 내독소 자극 자체만으로 스트레스 단백질 합성이 유도되는지는 아직 분명하지 않다. 이에 저자들은 내독소 유도성 급성 폐손상에서 TNF-$\alpha$ 분비와 폐조직 손상을 포함한 일련의 염증반응과의 관계를 분석하고, 생체내 내독소 자극에 대하여 폐포대식세포에서 스트레스 단백질을 포함한 새로운 단백질 합성이 유도되는지 여부를 분석하고자 하였다. 연구방법 : 흰쥐의 기관내로 내독소를 투여한 후 시간별로 기관지폐포세척액내 TNF-$\alpha$농도, 염증세포 백분율 변화, 병리조직학적 소견을 관찰하고, 또한 각 시간대의 폐포대식세포에서 sodium dodesyl sulfate-polyacrylamide gel electrophoresis와 inducible heat stress protein72에 대한 면역화학염색을 시행하여 단백질 합성양상을 분석하는 한편, 폐포대식세포에 다양한 농도의 내독소 자극과 열처리를 가한 후, 배양상층액에서 tumor necrosis factor-a 농도를 측정하고, 폐포대식세포의 단백질 합성양상을 분석하였다. 연구결과 : 내독소 투여 후 tumor necrosis factor-$\alpha$는 첫 1시간째부터 현저하게 증가하여 (p< 0.0001) 3시간째 최고치에 이르렀고 6시간째는 감소하기 시작하여 12시간째는 정상 대조군 수준으로 감소하였다. 내독소 투여 후 염증세포 백분율의 변화는 2시간째부터 시작하여 6시간째 최고에 이르러 12시간째까지 지속하였으며, 장시간째에 정상 대조군 수준으로 회복하였다. 병리조직학적 소견상 폐손상 지표 점수는 내독소 투여후 6시간째 최고치에 이르러 24 시간째까지 지속하였다. 내독소 투여 후 분리한 폐포대식세포에서 첫 1시간째부터 장시간째까지 정상 대조군에서는 관찰할 수 없던 35kDa의 새로운 단백질 띠가 관찰되었으며, 면역화학염색상 inducible heat stress protein72는 관찰되지 않았다. 내독소 자극을 가하지 않은 정상 대조세포군에 비해 내독소 자극을 가한 세포군의 배양상층액에서 tumor necrosis factor-$\alpha$ 농도가 유의하게 높았으며 (p<0.001), 내독소 자극만 가한 세포군에 비해 열충격 전처치후 내독소 자극을 가한 세포군의 배양상층액에서 tumor necrosis factor-$\alpha$ 농도가 10 ${\mu}g/ml$ 내독소 자극군만 제외하고 모두 유의하게 감소하였다 (p<0.05). 내독소 자극만 가한 세포군은 10 ${\mu}g/ml$의 고농도에서만 35 kDa 의 단백질 띠가 합성되었고 inducible heat stress protein72는 관찰되지 않았다. 열충격 전처치후 내독소 자극을 가한 세포군은 모두 inducible heat stress protein72가 관찰되었다. 결 론 : 기관내 내독소 투여에 의한 급성 폐손상에서 tumor necrosis factor-$\alpha$는 폐손상 정도와 밀접한 관련이 있다. 또한 내독소 자극에 의해서는 폐포대식세포에서 inducible heat stress protein72 합성이 유도되지 않으며, 35 kDa의 새로운 단백질 합성이 유도되었는데, tumor necrosis factor-$\alpha$ 농도 및 병리조직소견과의 관계를 볼 때, 급성 폐손상에 있어 35 kDa 단백질이 방어적인 역할을 담당하지는 않을 것으로 보이며, 이에 대해서는 향후 더 연구가 필요할 것으로 생각된다.

• Journal of Korean Neurosurgical Society
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• 제42권5호
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• pp.363-366
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• 2007

Objective : Kyphoplasty performed in the middle thoracic spine presents technical challenges that differ from those in the lower thoracic or lumbar region due to small pedicle size and angular severity for thoracic kyphosis. The purpose of this study was to evaluate the efficacy of balloon kyphoplasty through extrapedicular approach for the treatment of intractable osteoporotic compression fractures in the middle thoracic spine. Methods : The patients who were performed with one level balloon kyphoplasty through extrapedicular approach due to painful osteoporotic compression fractures at T5-T8 from June 2003 to July 2005 were retrospectively analyzed. Imaging and clinical features were analyzed including involved vertebrae level, vertebral height, Injected cement volume, clinical outcome and complications. Results : Eighteen female patients (age ranged from 60 to 77 years old) were included in this study. The average amount of the implanted cement was $4.2{\pm}1.5\;cc$. The mean cobb angle and compression rate were improved from $12.1{\pm}6.5^{\circ}$ to $8.5{\pm}7.2^{\circ}$ and from 30% to 15%, respectively. The mean pain score (visual analogue scale) prior to kyphoplasty was 7.9 and it decreased to 3.0 after the procedure. Cement leakage to the adjacent disc (2 cases) and paravertebral soft tissues (1 case) were seen but there were no major complications such as pneumothorax, segmental arte 이 Injury, pulmonary embolism, or epidural leakage. Conclusion : Balloon kyphoplasty through extrapedicular approach is considered as a safe and effective in treating the middle thoracic regions with low complication rate.

• Journal of Trauma and Injury
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• 제19권1호
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• pp.74-80
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• 2006

Purpose: For prevention and suitable administration, the effect of age on the severity of injuries in traffic accidents should be considered when evaluating a patient, but there have not been enough epidemiological studies that evaluate the age factor in traffic accidents. For that reason, we investigated old-aged patients who were involved in traffic accidents (65 years old or more) and who were admitted to the emergency department of a college hospital in an urban city of Korea. Methods: We collected data from traffic-accident patients who came to the emergency room of a university hospital in Seoul from Jan.1, 2004 to Dec.31, 2005. We compared their abilities to ambulate and the RTSs (Revised trauma scores) by using a LSD (least significant difference), linear regression. Results: A total of 1460 patients were included. The mean RTS of all traffic-accident patients was $7.77{\pm}0.280$. The scores for drivers and passengers, motor-cycle drivers and passengers, bicycle drivers and passengers, and pedestrians were $7.79{\pm}0.21$, $7.78{\pm}0.22$, $7.54{\pm}0.25$, $7.77{\pm}0.20$, and $7.80{\pm}0.21$ respectively (p=0.000). There was no statistically significant difference between the RTS of patients over 65 years and that of other patients. In a regression analysis, the number of patients over 45 ages who were able to ambulate was lower than that of younger people, independently of other influencing factors (B=-0.330, R-square = 0.243, p=0.000). Conclusion: We expected that RTS of old age group more than 65 years old will significantly lower than that of others, but there was no statistically significant difference.