• 지질공학
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• 제25권2호
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• pp.179-188
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• 2015

Although permeating injection is ideal for grouting reservoir embankments, it is usually combined with fracturing injection for grouting, which can disturb the original soil. Compaction with low expansive pressure followed by grout injection can overcome this problem. An expansive compaction (EC) packer was developed in this work to easily apply sequential injection and compaction at a work site. Furthermore, to achieve compaction around the grouting hole, a mixture of expansive admixtures and grout was injected with the EC packer to trigger an increase in volume of the grout material. This work verifies the compaction effect of the EC packer and the expansive admixture. It reports the concepts of the EC packer, the range of expansive compaction, the effectiveness of injection, and the results of indoor tests performed to verify the effectiveness of the expansive admixtures. The indoor testing comprised a preparatory test and the main test. The preparatory test assessed the admixtures for their compaction effects, while the main test measured and analyzed the admixtures' expansive force, pressure, and compaction effect with a mold to verify the effectiveness of the compaction effect.

• International Journal of Computer Science & Network Security
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• 제23권2호
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• pp.199-202
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• 2023

Carriage return (CR) and line feed (LF), also known as CRLF injection is a type of vulnerability that allows a hacker to enter special characters into a web application, altering its operation or confusing the administrator. Log poisoning and HTTP response splitting are two prominent harmful uses of this technique. Additionally, CRLF injection can be used by an attacker to exploit other vulnerabilities, such as cross-site scripting (XSS). Email injection, also known as email header injection, is another way that can be used to modify the behavior of emails. The Open Web Application Security Project (OWASP) is an organization that studies vulnerabilities and ranks them based on their level of risk. According to OWASP, CRLF vulnerabilities are among the top 10 vulnerabilities and are a type of injection attack. Automated testing can help to quickly identify CRLF vulnerabilities, and is particularly useful for companies to test their applications before releasing them. However, CRLF vulnerabilities can also lead to the discovery of other high-risk vulnerabilities, and it fosters a better approach to mitigate CRLF vulnerabilities in the early stage and help secure applications against known vulnerabilities. Although there has been a significant amount of research on other types of injection attacks, such as Structure Query Language Injection (SQL Injection). There has been less research on CRLF vulnerabilities and how to detect them with automated testing. There is room for further research to be done on this subject matter in order to develop creative solutions to problems. It will also help to reduce false positive alerts by checking the header response of each request. Security automation is an important issue for companies trying to protect themselves against security threats. Automated alerts from security systems can provide a quicker and more accurate understanding of potential vulnerabilities and can help to reduce false positive alerts. Despite the extensive research on various types of vulnerabilities in web applications, CRLF vulnerabilities have only recently been included in the research. Utilizing automated testing as a recurring task can assist companies in receiving consistent updates about their systems and enhance their security.

• 대한방사선기술학회지:방사선기술과학
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• 제42권3호
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• pp.209-215
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• 2019

Comparison of the effective dose of the chest and the equivalent dose of the lens site in the radiation workers working at four medical institutions with the PET / CT room located in one metropolitan city and province from April 1 to June 30, 2018 Respectively. Radioactive medicine were measured at the time of dispensing and at the time of injection. In this experiment, the average dispensing time per patient was 5.7 minutes and the average injection time was 3.1 minutes. The equivalent dose at the lens site was $0.78{\mu}Sv/h$ for 1 mCi, and the effective dose for chest was $0.18{\mu}Sv/h$ per 1 mCi. The equivalent dose at the lens site during injection was $0.88{\mu}Sv/h$ per mCi and the effective dose of chest was $0.20{\mu}Sv/h$ per mCi. The daily effective dose of the chest was $0.9{\pm}0.6{\mu}Sv$ and the equivalent dose of the lens site was $3.6{\pm}1.4{\mu}Sv$ during daily dosing for 20 days. The effective dose of the chest during the day was $0.6{\pm}0.5{\mu}Sv$ and the equivalent dose of the lens was $2.2{\pm}1.0{\mu}Sv$. At the time of dispensing, the equivalent dose of the lens was $0.187{\pm}0.035mSv$, the effective dose of the chest was $0.137{\pm}0.055mSv$, the equivalent dose of the lens was $0.247{\pm}0.057mSv$, and the effective dose of the monthly chest was $0.187{\pm}0.021mSv$. As a result of the corresponding sample test, the equivalent dose and the effective dose of the chest, the effective dose of the chest, the effective dose of the chest, the effective dose of the chest, The equivalent dose of the lens and the effective dose of the chest were statistically significant (p<0.05) with a significance of 0.000. However, there was no statistically significant difference (p>0.05) between the equivalent dose and the effective dose of the chest, the equivalent dose of the lens at the time of injection, and the effective dose of the chest at 0.138 and 0.230, respectively.

• 대한약침학회지
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• 제18권1호
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• pp.56-62
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• 2015

Objectives: The purpose of the study is to assess both the approximate lethal dose and the single dose intramuscular injection toxicity of Danggui (Angelica gigantis radix) pharmacopuncture (DGP) in Sprague-Dawley (SD) rats. Methods: The experiments were conducted at the good laboratory practice (GLP) laboratory, Biotoxtech Co., which is a laboratory approved by the ministry of food and drug safety (MFDS). The study was performed according to the GLP regulation and the toxicity test guidelines of the MFDS (2009) after approval of the institutional animal care and use committee of Biotoxtech. Single doses of DGP were injected intramuscularly into the rats in three test groups of 6 week old SD rats (5 male and 5 female rats per groups) in the amounts of 0.1, 0.5, and 1.0 mL/animal for groups 2, 3, and 4, respectively, and normal saline solution in the amount of 1.0 mL/animal was injected intramuscularly into the rats (5 male and 5 female rats) in the control group. Observations of the general symptoms and weight measurements were performed during the 14 day observation period after the injection. Hematologic and serum biochemical examination, necropsy, and a local tolerance test at the injection site were done after the observation period. Results: No death was observed in three test groups (0.1, 0.5 and 1.0 mL/animal group). In addition, the injection of DGP had no effect on general symptoms, weights, hematologic and serum biochemical examination, and necropsy. The results from the local tolerance tests at injection site showed no treatment related effects in the SD rats. Conclusion: The results of single dose intramuscular injection of DGP suggest that the approximate lethal dose is above 1.0 mL/animal for both male and female SD rats and that intramuscular injection of DGP may be safe.

• 지질공학
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• 제30권4호
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• pp.603-615
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• 2020

인공함양의 설계요소 결정은 대수층의 수리지질학적 특성을 고려하여 산정하게 된다. 연구지역의 시험 부지 내 구축된 주입유형별(수직정, Ditch 및 혼합형)로 주입시험을 단계별로 수행한 후 인공함양의 최적 설계요소 인자를 도출 하였다. 주입정의 구경에 따른 주입 효과의 차이가 크지 않은 것으로 분석되었으며 토지 이용의 가용성과 경제성 등을 고려하여 100 mm 규격이 적정한 것으로 평가되었다. 상부 암반까지도 주입 효과가 잘 유지되는 것으로 나타나 주입정 설치심도는 충적층 및 상부 암반층을 대상으로 결정하였다. 한편, Ditch에 의한 주입 방식의 경우에는, 10~30 mm의 여재를 채운 경우에 침투효율과 수리간섭영향이 우수한 주입 성능을 보이는 것으로 분석되었다. 또한, 수직주입정의 간격 차이에 따른 간섭효율 분석 결과, 각 주입공 간격 1 m 당 간섭효율 감쇄계수는 1.75% 산출되었으며, 주입정의 적정 간격은 9~12 m로 분석되었다. 향후 본 연구에서 산정한 인공함양 설계요소를 현장 시공 및 운영에 적용하여 검증한다면 상시 물부족 지역의 용수 확보에 기여할 것으로 본다.

• 터널과지하공간
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• 제26권1호
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• pp.12-23
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• 2016

향후 국내에서 수행될 이산화탄소 지중저장 프로젝트의 성공적인 수행을 위해서는 현장 지질조건에 최적화된 주입 조건을 설계하는 것이 중요하다. 따라서 본 연구에서는 주입량 및 주입온도 등의 주입조건이 격리저장시스템의 역학적 안정성에 미치는 영향을 열-수리-역학 연계해석기법의 하나인 TOUGH-FLAC 해석기법을 이용하여 평가하였다. 저장시스템의 역학적 안정성은 기존 균열의 전단미끄러짐 발생가능성을 활동마찰각 및 응력원을 이용하여 분석하였다. 이산화탄소의 주입온도가 저류층의 초기온도보다 낮은 저온주입의 조건에도 열응력으로 인한 인장균열은 발생하지 않는 것으로 파악되었으나, 저류층에서 전단미끄러짐이 발생하는 결과를 보였다. 단위시간당 이산화탄소 주입량을 변화시킨 시나리오 해석에서는 단계별로 주입량을 감소시키는 주입시나리오에서 기존 균열들의 전단미끄러짐 발생 가능성이 가장 낮은 것으로 평가되었다.

• 대한약침학회지
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• 제18권3호
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• pp.42-48
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• 2015

Objectives: The aim of the study is to investigate both the single-dose intramuscular injection toxicity and the approximate lethal dose of water-soluble Carthami-flos and Cervi cornu parvum pharmacopuncture (WCFC) in male and female Sprague-Dawley (SD) rats. Methods: The study was conducted at Biotoxtech Co. according to the Good Laboratory Practice (GLP) regulation and the toxicity test guidelines of the Ministry of Food and Drug Safety (MFDS) after approval of the Institutional Animal Care and Use Committee. Dosages for the control, high dose, middle dose and low dose groups were 0.5 mL/animal of saline and 0.5, 0.25 and 0.125 mL/animal of WCFC, respectively. WCFC was injected into the muscle of the left femoral region by using a disposable syringe (1 mL, 26 gauge). The general symptoms and mortality were observed 30 minutes, 1, 2, 4, and 6 hours after the first injection and then daily for 14 days after the injection. The body weights of the SD rats were measured on the day of the injection (before injection) and on the third, seventh, and fourteenth days after the injection. Serum biochemical and hematologic tests, necropsy examinations, and histopathologic examinations at the injection site were performed after the observation period. Results: No deaths, abnormal clinical symptoms, or significant weight changes were observed in either male or female SD rats in the control or the test (0.125, 0.25, and 0.5 mL/animal) groups during the observation period. No significant differences in hematology and serum biochemistry and no macroscopic abnormalities at necropsy were found. No abnormal reactions at injection sites were noted on the topical tolerance tests. Conclusion: The results of this single-dose toxicity study show that WCFC is safe, its lethal doses in male and female SD rats being estimated to be higher than 0.5 mL/animal.

• Journal of Oral Medicine and Pain
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• 제38권4호
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• pp.325-331
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• 2013

보툴리눔 톡신은 신경독소로, 운동신경 말단부위에서 분비되는 아세틸콜린의 분비를 차단하여 근육의 위축을 유발하게 된다. 의학계 및 치의학계에서는 이를 이용하여 다양한 질환을 치료하는 것을 시도하고 있다. 치과영역에서는 저작근 수축, 심한 이갈이, 안면 틱, 구강안면 운동장애, 교근비대의 치료 등 과활성 근육성 질환을 치료하는 데 사용하고 있다. 악안면 영역에 보툴리눔 톡신을 주입하고 난 뒤 발생되고 있는 합병증으로는, 자연스럽지 못한 안면표정, 통증의 증가, 두통 등이 유발될 수 있다고 보고되고 있다. 본 증례에서는 교근부에 보툴리눔 톡신 주입 후 발생된 전방 개교합 증상에 대하여 보고하고자 한다.

• Toxicological Research
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• 제19권1호
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• pp.13-19
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• 2003

GX-12 is a naked DNA vaccine developed by the DongA Pharmaceutical Co. Ltd. and Genexine for the treatment of HIV infection. This study was peformed to evaluate the biodistribution and expression of GX-12 mRNA in gonadal tissues, and to investigate the histopathological changes after the repeated intramuscular injection. GX-12 (400 $\mu\textrm{g}$/head) was injected into the left anterior tibialis once a week for four weeks. On day 1, 5, 15, 30 and 45 after the final administration, gonadal tissues (testes, epididymis, seminal vesicles, penis, prostate glands, ovaries, vagina, uterus) and the injection site (muscle) were harvested and examined for the expression of mRNA by RT-PCR. In addition, histopathological examination was peformed at each time point. At the injection site, mRNA expression of GX-12 was detected only at early time points (1 ~ 15 days after injection) but not thereafter. However, in gonadal tissues, mRNA expression was not identified at all time points both in male and female rats. There were no histopathological changes in all reproductive organs and muscle. Based on these results, it is unlikely that the plasmid DNAs of GX-12 was distributed to- and expressed in gonadal tissues, suggesting that the chance of germline integration and transmission is negligible.

• 한국동물위생학회지
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• 제40권3호
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• pp.177-185
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• 2017

In this study, we evaluated the efficacy of a commercial vaccine stress-relieving agent (Anti VS-2 injection) to reduce the adverse effects of foot-and-mouth disease (FMD) vaccination site in 120 pigs on two tested pig farms. The results showed that incidence of pig with abnormal meat, size of abnormal meat and weight of discarded abnormal meat are significantly decreased in Anti VS-2 injection-supplemented FMD vaccinated pig groups (n=60) compared to the non-supplemented FMD vaccinated pig groups (n=60) (P<0.05). And the average economic loss by discard of abnormal meat were estimated 99,382 won or 21,514 won in the non-supplemented FMD vaccinated groups or in the Anti VS-2 injection-supplemented FMD vaccinated groups, respectively, showing that the cost saving effect was 78% (77,869 won). In conclusion, it is expected to reduce the incidence and severity of abnormal meat in the FMD vaccinated pigs and to contribute not only to the reduced economic loss of pig farmers but also to the promotion of food hygiene when the Anti VS-2 injection is mixed with FMD vaccine.