• 대한후두음성언어의학회지
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• 제32권2호
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• pp.94-97
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• 2021

Muscle tension dysphonia (MTD) is a voice disorder characterized by excessive tension of the laryngeal muscles during phonation. Voice therapy is the gold standard of treatment for MTD. However, patients with MTD do not always respond to voice therapy. Multidisciplinary approaches have been attempted to treat intractable MTD such as lidocaine instillation, lidocaine injection to recurrent laryngeal nerve, botox injection and excision of false ventricle using CO₂ laser. Recently, injection laryngoplasty is suggested that assists in more efficient phonation and voice therapy to MTD patients. A patient with intractable MTD underwent lidocaine injection and injection laryngoplasty showed improved voice quality and remained stable until postoperative 3 months without any complications.

• 대한두경부종양학회지
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• 제19권1호
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• pp.21-24
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• 2003

Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.

• Design & Manufacturing
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• 제13권4호
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• pp.1-9
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• 2019

In-mold Coating is a method that can simultaneously perform injection molding and surface coating in injection mold. The material used for coating is two-component polyurethane which is composed of polyol and isocyanate. L-type mixing head can be used to mix polyol and isocyanate uniformly, and inject them inside the mold cavity. The surface quality of the injection molded products by using in-mold coating depends on the mixing uniformity between main agent and hardener. In this study, flow analysis was performed to design a mixing head for uniform mixing of two-component polyurethane. Especially the effects of design parameters of mixing head on mixing uniformity and nozzle pressure were investigated. The parameters of mixing head were mixing chamber diameter, cleaning cylinder diameter, nozzle alignment angle in the horizontal and vertical direction, and cleaning piston position. It was found that optimal design values were mixing chamber diameter of 3.5 mm, cleaning cylinder diameter of 5.0 mm, nozzle horizontal/vertical alignment angles of 140°/160°, and cleaning piston position of 1.8 mm. The optimal values would be used to develop a two-component mixing head achieving an uniform mixing for in-mold coating.

• 대한음성언어의학회:학술대회논문집
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• 대한음성언어학회 2015년도 제42차 춘계학술대회
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• pp.17-17
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• 2015

• 한국동물학회지
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• 제33권3호
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• pp.247-254
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• 1990

GABA antagonist 를 닭의 열린 눈과 닫힌 눈에 차례로 주입한 후 monocular head와 eye optokinetic nystagmus을 관찰하고 코일 기록에 의해서 연구하였다. 주입전 이 visuomotor reflex를 일으키는데 있어서 닭은 N-T 자극에 대해서 보다 T-N 자극에 대해서 더욱 효과적인 OKN을 나타냈다. 열린눈에 주입한 GABA antagonist는 head와 eye OKN의 감소 또는 소멸을 일으키며, GABA antagonist를 닫힌 눈속에 주입했을 때는 head와 eye OKN은 증가 되었다. 이와 같이 GABA antagonist는 monocular OKN의 N-T 성분을 억제하는데 GABAergic 메카니즘이 관련되고 있다는 것을 지시함으로써 head와 eye OKN의 방향적 불균형성을 제거하였다.

• 한국전산유체공학회지
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• 제4권3호
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• pp.21-27
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• 1999

In this paper, tile characteristics of flow resulting from the configurations of piston head and intake-port of the cylinder in a gasoline-direct-injection engine are investigated numerically. Calculations are carried out from intake process to the end of compression. GTT code which includes the third order upwind Chakravarthy-Osher TVD scheme and κ-ε turbulence model with the law of wall as a boundary condition. As a result, a piston head with a smaller radius of curvature and larger radius gives stronger reverse tumble. It is also shown that as the maximum tumble ratio increases by the configuration of the intake-port the tumble ratio at the end of compression stroke increases. It is concluded that flows at the end of compression stroke can be controlled by the optimum design of intake-port and piston head.

• 대한후두음성언어의학회지
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• 제22권1호
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• pp.52-55
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• 2011

Hyperfunction of the upper esophageal sphincter (UES) can cause severe dysphagia. This condition referred as cricopharyngeal dysphagia may occur after head and neck surgery due to altered muscle spasm and stenosis of the pharyngo-esophageal segment. Among various treatment options available, Botulinum toxin A (Botox) injection offers a nonsurgical treatment which is useful especially for debilitated patients, and there has been a recent increase in the clinical use of Botox by otolaryngologists for managing such conditions. A 55-year-old male with base of tongue (BOT) cancer suffered from severe dysphagia after total glossectomy and neck dissection treatment. Videofluoroscopic swallow study (VFSS) and flexible endoscopic evaluation of swallowing (FEES) showed inability to pass food through the UES due to cricopharyngeal spasm. After injection of 10 U of Bot ox into each cricopharyngeus muscles (total 20 U) via EMG-guided percutaneous injection, swallowing function had improved and oral nutrition was possible, with food passing through the UES visualized on VFSS and FEES.

• 대한후두음성언어의학회지
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• 제24권2호
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• pp.112-117
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• 2013

Background and Objectives : This study aimed to determine the clinical effect of $Artecoll^{(R)}$ injection laryngoplasty for patients with vocal atrophy and mild sulcus vocalis. Materials and Method : Forty-one patients with vocal atrophy and/or mild sulcus vocalis received transcutaneous $Artecoll^{(R)}$ injection into the vocal folds under local anesthesia. Subjective evaluations including voice handicap index (VHI) and perceptual grading with Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) scales and objective evaluations including jitter, shimmer, noise-to-harmonic ratio (NHR), speaking fundamental frequency (SFF) and maximum phonation time (MPT) were evaluated before and 3 months after the injection. Results : VHI and Grade, Breathiness and Strain scales in GRBAS showed significant improvement 3 months after injection. SFF and MPT also significantly improved after the injection ; MPT increased and SFF in male patients decreased. Conclusion : Injection laryngoplasty with $Artecoll^{(R)}$ is an effective method for correcting the glottal insufficiency and improving voice quality in patients with vocal atrophy and/or mild sulcus.

• 대한후두음성언어의학회지
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• 제16권2호
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• pp.129-134
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• 2005

Background and Objectives : Artecoll(R) is an injectable soft tissue filler, which is a suspension of polymethylmethacrylate microspheres in $3.5\%$ bovine collagen solution. The authors aimed to determine the clinical of Artecoll of Artecoll(R) as an injection material into the vocal fold to correct the glottal insufficiency caused by unilateral vocal cord paralysis. Materials and Methods : Forty-one consecutive patients with unilateral vocal cord paralysis received percutaneous Artecoll injections under local anesthesia. Acoustic, aerodynamic and stroboscopic analyses were prospectively provided before, 1 week and 3 months after injection. Perceptual GRBAS grading by speech language pathologists and subjective ratings of the hoarseness and aspiration by the patients were also obtained. Results : Aerodynamic parameter(maximal phonation time) were significantly improved after the injection (p<0.05). Acoustic parameters (jitter and shimmer) were improved at the 3rd month follow-up. GRBAS uading and patients own subjective scaling of hoarseness and aspiration also showed significant improvement (p<0.05). Early or delayed significant side effects were not observed. Conclusion : Vocal fold injection with Artecoll is a convenient, safe and useful method of temporarily correcting the glottal insufficiency. Further long-term follow-up studies will answer the usefulness and safety of the Artecoll injection laryngoplasty.

• 대한후두음성언어의학회지
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• 제20권1호
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• pp.17-20
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• 2009

Office based injection laryngoplasty for voice and swallow disorders is increasing steadily. In recent years, the application of injection laryngoplasty is extended to inject medicine, such as cidofovir or botox. The reason why office based injection laryngoplasty is increasing in popularity is several potential advantages when compared with other procedures. It can avoid surgical scar and is easily performed with local anesthesia. However, injection can be performed in a variety of settings, depending on several factors, including the goal of the procedure, patient comfort and anatomy, and physician skill. In this article, we describe indication of injection laryngoplasty and discuss about various techniques for procedure.