• BMB Reports
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• 제32권6호
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• pp.547-553
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• 1999

Aminoacyl-tRNA synthetases are essential enzymes catalyzing the attachment of specific amino acids to cognate tRNAs. In the present work, the substrate analogue L-methionine hydroxamate was used to identify functional residues located in the active site of the E. coli methionyl-tRNA synthetase (MetRS). This compound inhibited bacteria, yeast, and human MetRS activities to a similar degree, suggesting a conserved active site structure and mechanism between MetRSs of different phylogenetic domains. Mutants of the E. coli MetRS resistant to methionine hydroxamate were also isolated. These mutants contained a substitution either at T10, Y15, or Y94. These residues are highly conserved among the different MetRSs and the mutants showed decreased aminoacylation activity, suggesting their functional and structural significances. The putative roles of these residues are discussed on a structural basis.

• 한국지역사회생활과학회지
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• 제25권1호
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• pp.51-64
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• 2014

With a shift in the rural development process toward a bottom-up approach, the need to enhance the endogenous capacity of communities has become the core of rural development. In this regard, scholars have paid close attention to social capital to identify ways to facilitate endogenous rural development but focused mainly on relationships between social capital and local environment. That is, few studies have investigated the relationships between social capital and its various dimensions in the context of rural development initiatives. This study examines the effects of social capital on the problem-solving ability of community residents'rural development initiatives and assesses the types of social capital associated with such initiatives to propose optimal path for improving this ability. To distinguish between major dimensions of social capital, a questionnaire was developed by considering various stages of the rural development process. The survey considered a sample of 59 employees from public rural development institutions. According to the results, four paths were significant at the 5% level. Among these four paths, three set common goals. The effective channel was the path [common goals${\Rightarrow}$network${\Rightarrow}$cooperation${\Rightarrow}$problem-solving ability]. The key factor in improving problem-solving skills, the endogenous ability of community residents to facilitate rural development initiatives. The results suggest that governments should strengthen education and training programs to help residents set their common goals.

• 한국식생활문화학회지
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• 제38권4호
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• pp.239-245
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• 2023

The objective of this study was to explore how different types of rewards affect customers' inclinations to engage in environmental activities promoted through restaurant social media platforms. In addition, we investigated the potential moderating role of customer level of participation within the social media community. A total of 202 valid responses obtained by distributing a self-administered survey among restaurant patrons were subjected to hierarchical regression analysis to examine relationships between variables. The findings underscored the significant influence of economic and social rewards on shaping customer intent to participate in environmental initiatives promoted within restaurant social media communities. Furthermore, the study revealed that the extent of customer participation within the social media community moderated the relationship between rewards and their likelihood to partake in environmentally conscious behaviors. These results have meaningful implications for restaurant managers seeking to promote environmental initiatives effectively through social media platforms and within their establishments.

• 한국프랜차이즈경영연구
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• 제14권4호
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• pp.51-65
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• 2023

Purpose: As social interest in environmental issues increases, pro-environmental initiatives are becoming more active in many industry sectors. This study explores how a firm's perceived green brand image affects consumer loyalty through brand trust and attachment. Research design, data, and methodology: The data of 363 respondents aged 20 to 59 who purchased the franchise lunchbox in the last three months were analyzed using SPSS 25.0 and SmartPLS 4.0. Result: Green brand image affects consumer loyalty through cognitive trust, affective trust, and brand attachment. Regarding serial mediations, cognitive trust affects brand attachment only through affective trust and, in turn, consumer loyalty. Conclusions: This study employs the hierarchy of effects theory to explore the role of the perceived green image of the franchise lunchbox brand in prompting consumer loyalty through brand trust and attachment. The eco-friendly initiatives are imperative in establishing a green brand image, given their critical roles in generating consumer brand trust and attachment as well as consumer loyalty in the franchise lunchbox industry. The franchise lunchbox firms should implement environmental initiatives and effectively communicate and actively inform these initiatives to raise perceptions of green brand image and build cognitive brand trust.

• 아태비즈니스연구
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• 제15권2호
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• pp.181-205
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• 2024

Purpose - This study aims to examine the direct impact of corporate social responsibility initiatives on firm technological innovation and the moderating effect on the relationship between firm technological innovation and corporate value. Design/methodology/approach - This study collected 13,298 firm-year data by selecting A-share companies listed on the China Shenzhen Stock Exchange and Shanghai Stock Exchange from 2010-2017. This study runs the multivariate regression using random effect generalized least squares (GLS) regression model. Findings - The research results of this study are as follows. First, corporate social responsibility initiatives do not increase the firm technological innovation, but rather reduce it. Second, firm technological innovation generally improves corporate value, whether it is book value or market value. Third, corporate social responsibility initiatives reduce the positive influence of firm technological innovation on corporate value. Research implications or Originality - There may be discussions on whether Chinese patent application data is a good indicator of the innovation of Chinese companies, but previous studies prove that the number of patent applications has a significant correlation with R&D expenditures or financial performance. However, there is a clear limitation in that it is not possible to confirm the result of registration after a patent application, but it is expected that such limitations can be overcome by using patent registration information or detailed citation documents in the future.

• Journal of Information Display
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• 제2권3호
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• pp.48-53
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• 2001

Carbon nanotube emitters, prepared by screen printing, have demonstrated a great potential towards low-cost, largearea field emission displays. Carbon nanotube paste, essential to the screen printing technology, was formulated to exhibit low threshold electric fields as well as an emission uniformity over a large area. Two different types of triode structures, normal gate and undergate, have been investigated, leading us to the optimal structure designing. These carbon nanotube FEDs demonstrated color separation and high brightness over 300 $cd/m^2$ at a video-speed operation of moving images. Our recent developments are discussed in details.

• 과학기술학연구
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• 제14권1호
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• pp.117-137
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• 2014

최근 출연(연)의 사회문제 해결형 R&D 사업이 점차 증가하고 있다. 그러나 출연(연)은 사회문제 해결에 적합한 R&D 시스템을 구축하지 못하여 많은 시행착오를 겪고 있다. 이에 본 연구에서는 사회문제 해결형 R&D 수행에 있어 주요 영향요인으로 작용하고 있는 출연(연)의 평가시스템 개선방향에 대해서 논의하고자 하였다. 이를 위해 먼저 사회문제 해결형 R&D에 관해 고찰하고, 출연(연)의 평가시스템 현황 및 사회문제 해결형 R&D 관점에서 한계를 도출한 후, 효과적 추진을 위한 개선방향을 제시하였다. 그리고 마지막으로 본 연구가 주는 함의와 한계를 논의함으로써 마무리하였다. 본 연구는 사회문제 해결 관점의 평가지표를 제시하고 활용방안을 모색한 최초의 연구로서 향후 관련분야 연구의 초석이 될 것으로 기대한다.

• 한국정보시스템학회지:정보시스템연구
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• 제27권2호
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• pp.197-219
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• 2018

Purpose The purpose of this study is to examine what motivates users to adopt one of the emerging applications for collaborative consumption of sharing economy. Using the self-determination theory, motivation theory and TAM(Technology Acceptance Model) as the theoretical framework, this study illustrates important factors that influence adoption of collaborative consumption service. We develops the ICTs(Information and Communications Technologies) initiatives and motivation model to collaborative consumption. Design/methodology/approach This paper makes use of a quantitative methodology using survey questionnaire that allows for the measurement of the eight constructs(System Availability, Contents Quality, Design & Personalization, Security & Privacy, Emotional & Social Value, Economic Value, Attitude, Adoption & Consumption) contained in the hypothesized theoretical model on the basis of the prior literatures. Data collected from a sample of 227 respondents who have used the collaborative consumption services and provided the foundation for the examination of the proposed relationships in the model. Findings This study has the following implications for the users and providers of CC platforms and services. The ICTs initiatives (System Availability, Contents Quality, Design & Personalization, Security & Privacy) are the influential factors that motivate the emotional and social value to CC. On the other hand, The ICTs initiatives (System Availability, Contents Quality) are not very significant factors of economic value to CC. The empirical analysis result indicate that there are significant causal effect among emotional & social value, economic value, and adoption to CC. This study provides important theoretical implications for innovation adoption research through an empirical examination of the relationship between ICTs initiatives, motivation factors to collaborative consumption in the sharing economy.

• Molecules and Cells
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• 제41권10호
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• pp.900-908
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• 2018

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. Although TZDs are synthetic ligands for $PPAR{\gamma}$, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.

• Asia Marketing Journal
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• 제8권1호
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• pp.19-47
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• 2006

디지털 환경이 보편화됨에 따라 고객들은 기업과의 관계에 있어서 보다 적극적이고 참여적으로 변화하고 있다. 이에 따라 과거 산업 혁명 이후에 형성된 기업위주의 고객-기업 간의 관계가 깨지고 고객들이 고객- 기업 간의 관계를 주도하는 현상들을 주변에서 쉽게 찾아볼 수 있게 되었다. 이에 본 연구에서는 고객이 주도하는 새로운 고객-기업간 관계구조의 형성 가능성에 대하여 디지털 환경을 중심으로 구체적으로 모델을 설정하고 실증을 통하여 그 가능성을 검토하였다. 연구의 결과 디지털 환경의 정보개방성, 연결성, 공동체 상호작용, 구조 명확성의 특성이 고객의 정보 공유 의도에 영향을 미치는 것으로 나타났으며, 가상 커뮤니티를 기반으로 한 연구에서는 고객의 정보 공유로 인하여 축적된 제품 속성 정보와 소비 경험 정보가 집단 효능감을 매개로 고객들의 적극적인 관계 구조 변화 노력인 리버스 마케팅에 영향을 미치는 것으로 나타났다. 따라서 디지털 환경은 장기적으로 고객 주도적인 고객-기업 간의 관계가 형성될 수 있는 기반을 마련하여 주고 있다고 볼 수 있으며, 점차 고객-기업 간의 관계의 주도권은 고객으로 이전될 수 있음을 확인하였다. 또한, 향후 연구 과제로서 고객-기업 간 관계가 고객 주도적으로 변화한 이후의 마케팅 프로세스와 기업의 마케팅 시스템에 대한 연구가 필요함을 제안하고 있다.