• Tuberculosis and Respiratory Diseases
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• 제69권3호
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• pp.163-170
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• 2010

Background: Pulmonary tuberculosis remains a health concern in Korea despite major progress in the development of new strategies for diagnosing and treating tuberculosis. In particular, the diagnosis of newly developed pulmonary tuberculosis is on the rise in elderly persons. The aim of this study was to investigate the clinical, radiographic characteristics, and treatment outcomes of pulmonary tuberculosis in the elderly. Methods: The medical records of 113 young (<65 years old) and 112 elderly (${\geq}65$ years old) pulmonary tuberculosis patients diagnosed at Chungnam National University hospital between January 2007 and December 2008 were reviewed. Results: There was no difference in the prevalence of typical symptoms between the younger and the elderly group. Dypsnea was the only symptom that occurred more frequently in the elderly group (16.8% vs 5.5%, p=0.008). On radiological study, pneumonic infiltration type was more common in the elderly group (28.6% vs 16.8%, p=0.035). Sputum Acid fast bacilli smear positivity rate was similar between the 2 groups. Elderly patients with anti-tuberculosis medication had more frequent adverse drug reactions; however, there was no significant difference between the 2 groups in the number of patients required to stop medication due to an adverse drug reaction. There were more patients lost to follow-up in the elderly group (22/112, 19.6% vs 11/113, 9.7%, p=0.036). Conclusion: The majority of elderly patients did not complete the treatment, resulting in a poorer outcome. Therefore, we need to make an effort to support the continued screening of elderly patients by making this economically feasible.

• 한국환경농학회지
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• 제24권2호
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• pp.180-184
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• 2005

오수유입수 관개답에서 작물 및 토양에 미치는 영향을 평가하기 위하여 익산천 하천부지논에서 2002년부터 2003년까지 벼를 대상으로 농가관행시비량과 50%감비량구 및 무비구를 두어 재배한 후 오수유입수 관개답에 대한 환경영향평가를 실시한 결과는 다음과 같다. 오수 유입답 담수일수별 논물 중 $NH_4-N$ 함량을 분얼기와 유수형성기에 비교한 결과 1일 담수는 $40{\sim}52%$, 4일 담수는 $88{\sim}98%$까지 각각 감소되었고 유수형성기가 분얼기보다 크게 감소되었다. 시비수준별 논물유출수의 성분함량변화는 농가관행시비보다 50% 감비시용이 $NH_4-N$는 17%, $NO_3-N$는 40%정도 감소되는 것으로 나타났고 지하수 침투수중 양분함량은 벼 재배기간 중 50% 감비가 관행시비보다 K는 18% 정도, $NO_3-N$는 4% 정도 감소되었다. 오수유입수 관개답에서 벼 재배 후 토양 층위별 질소 및 유효인산 증감정도는 농가관행시비시 작토층에 유효인산성분이 가장 많게 축적되었고, 50% 감비에서는 유효인산 집적량이 현저히 감소되었다. 토층 $50cm{\sim}100cm$에서도 농가관행 시비구에서 인산 및 질소가 집적되는 경향이었다. 토양 중 중금속 집적량은 대부분 성분이 자연 함유량 이하였으나 Cu와 Pb함량이 약간 증가되었다. 시비수준별 백미수량은 50%감비 시용구에서 농가 관행시용대비 98%가 생산되었고 완전미 비율은 증가되었다.

• 대한환경공학회지
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• 제33권7호
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• pp.536-543
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• 2011

다목적 여과저류지에 하상여과를 적용하기 위한 인공하천의 최적설계를 찾기 위해서 하천수의 에너지경사와 Manning의 평균유속공식을 이용하여 물 흐름에 대한 수학적 모델을 수립하였고, Euler의 방법을 이용한 수치해법으로 해석하였다. 모델을 이용하여 다양한 시나리오에 대한 모사를 수행함으로써 하상여과용 인공하천의 여러 설계요소를 검토하였다. 검토결과 면적이 100 ha인 강변저류지의 경우, 인공하천의 종단경사는 2/10,000, 하상에서의 침투율은 $2.5m^3/m^2-day$가 적당한 것을 알 수 있었다. 이 경우 수심은 1 m 이내이고 하상에서의 Manning의 조도계수는 0.026 정도로 예측되었으며, 인공하천의 길이가 길수록 유리함을 알 수 있었다. 한편, 인공하천에 빠른 유속을 발생시킴으로써 하상여과에 수반하는 하상의 폐색을 방지하는 방법은 효율적이지 않음을 알 수 있었고, 낙차가 큰 보의 주변에서 본 설비의 효율이 더 좋아짐을 알 수 있었다.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.548-553
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• 2017

우리나라의 급속한 산업화는 도시침수, 하천 건천화, 지하수 고갈, 수질오염 등의 많은 문제를 야기하였으며, 최근 이에 대한 대안으로 저영향개발 기법이 제시되고 있다. 저영향개발 기법은 도시의 불투수 면적을 줄이고 녹지면적을 확보하여 자연 상태의 물순환체계를 구축하기 위한 도시개발 기법이다. 이에 본 연구는 토지이용계획 단계에서 적용가능한 저영향 개발 설계기술을 개발하고 비점오염 저감효과를 정량적으로 검증하는데 목적을 두고 연구를 진행하였으며 구체적으로는 토지이용계획 단계에서 적용가능한 저영향개발 설계요소를 도출하고 실제 대상지에 적용, 비점오염 저감효과를 LIDMOD2 프로그램을 이용하여 분석하였다. 분석결과 기존 토지이용계획안에 비해 저영향개발을 적용한 토지이용계획안의 경우 불투수율과 연간 표면 유출량은 각각 19.8%, 19.0% 감소하고, 연간 침투량은 164.1% 증가하는 것으로 나타났다. 비점오염 발생량의 경우 T-N, T-P, BOD 모두 18.7~22.8% 감소하는 것으로 나타났다. 따라서 저영향개발을 적용한 토지이용계획안은 기존 토지 이용계획안에 비해 각 용도별 연면적 변화 없이도 비점오염 저감효과가 상당히 큰 것으로 판단된다. 따라서 비점오염 저감효과를 극대화하기 위해서는 기존 LID시설 위주의 계획에서 나아가 토지이용계획 단계에서부터 저영향 개발기법을 적용하여 관련 계획을 수립할 필요가 있다.

• 한국환경과학회지
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• 제20권6호
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• pp.783-788
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• 2011

Different from the main land of South Korea, Jeju Island has been in difficulties for measuring discharge. Due to high infiltration rate, most of streams in Jeju Island are usually in the dried state except six streams with the steady base flow, and the unique geological characteristics such as steep slope and short traveling distance of runoff have forced rainfall runoff usually to occur during very short period of time like one or two days. While discharge observations in Jeju Island have been conducted only for 16 sites with fixed electromagnetic surface velocimetry, effective analysis and validation of observed discharge data and operation of the monitoring sites still have been limited due to very few professions to maintain such jobs. This research is sponsored by Ministry of Land, Transport and Maritime Affairs to build water cycle monitoring and management system of Jeju Island. Specifically, the research focuses on optimizing discharge measurement techniques adjusted for Jeju Island, expanding the monitoring sites, and validating the existing discharge data. First of all, we attempted to conduct discharge measurements in streams with steady base flow, by utilizing various recent discharge monitoring techniques, such as ADCP, LSPIV, Magnetic Velocimetry, and Electromagnetic Wave Surface Velocimetry. ADCP has been known to be the most accurate in terms of discharge measurement compared with other techniques, thus that the discharge measurement taken by ADCP could be used as a benchmark data for validation of others. However, there are still concerns of using ADCP in flood seasons; thereby LSPIV would be able to be applied for replacing ADCP in such flooded situation in the stream. In addition, sort of practical approaches such as Magnetic Velocimetry, and Electromagnetic Wave Surface Velocimetry would also be validated, which usually measure velocity in the designated parts of stream and assume the measured velocity to be representative for whole cross-section or profile at any specified location. The result of the comparison and analysis will be used for correcting existing discharge measurement by Electromagnetic Wave Surface Velocimetry and finding the most optimized discharge techniques in the future.

• Journal of Periodontal and Implant Science
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• 제25권3호
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• pp.478-486
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• 1995

Periodontal therapy for treatment of periodontitis involves the elimination of bacterial plaque and elimination of the anatomic defects by regenerative procedure. The purpose of this study was to evaluate on the biological effect of magnolia and Ginkgo biloba extract to the antimicrobial, antiinflammatory and cellular activity. Antimicrobial assay was performed with the diffusion method of the extract by measuring of growth inhibitory zone of B. cereus from blood agar plate. Effect of the extract to cellular activity of gingival fibroblast were examined using MTT method and measured the result with optical density on 570nm by ELISA reader. Inhibitory effects of $PGE_2$ production from gingival fibroblast was performed with the addition of $IL-l{\beta}$ and the extract to the well and examined to the product of $PGE_2$ from cell by ELISA reader. In vivo anti-inflammatory effect was performed with injection examined with clinically and histologically for their extent of mecrosis and inflammation. Antimicrobial activity of Magnolia extract showed significantly higher activity than that of control. However, GBE did not showed significant activity to compare with control, and mixture of Magnolia and GBE extract showed significantly higher activity than that of control. The effect of cellular activity to gingival fibroblast showed no significant differences of between control and Magnolia extract. However, GBE showed significantly higher rate of cellular activity to compare with control and even to PDGF-BB, and also showed same degree of cellular activity even though mixed with Magnolia extract. The inhibitory effect of $PGE_2$ production showed significantly reduction of $PGE_2$ production to compare with control, but its inhibitory effect was not much strong to compare with Indomethacin. In vivo, antiinflammatory effect of Magnolia extract to P. gingivalis injection of Hamster buccal check showed significantly reduction of inflammatory cell infiltration and tissue necrosis, but GBE showed no effect on the inhibition of inflammatory process. These results suggested that Magnolia and GBE extract possessed different kind of biological activity and also can be compensated on their activity with each other for elimination of bacterial plaque and anatonical defect.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4121-4126
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• 2013

Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying $O_2$. Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

• 지구물리
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• 제9권4호
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• pp.321-331
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• 2006

최근 급격한 인구증가와 산업화, 도시화로 포장지역의 증가에 따른 불투수지역의 증가로 유역의 유출 특성의 변화를 유발시키고 있다. 도시화 유역의 효율적인 관리를 위해서는 유역에 대한 정확한 지형인자 및 수문관련 인자들이 추출되어야 함에 따라 본 연구에서는 지리정보체계와 유전자알고리즘의 결합을 통하여 입력정보의 정확성을 향상시키고, 매개변수를 추정하였다. 이러한 목적에 따라 본 연구에서는 전형적인 한국의 도시화하천으로서 본류와 상류로부터 오전천, 당정천 등의 지류를 지니고 있는 안양천을 연구대상으로 선정하여 유출량 해석에 XP-SWMM을 적용하였고, 이의 적용과정을 개선하기 위하여 지리정보체계와 유전자 알고리즘을 적용하였다. XP-SWMM 매개변수들의 민감도 분석을 통하여 도시 유출의 거동특성을 조사하였으며, 이를 바탕으로 매개변수들의 개선규칙을 설정하였고 이러한 규칙 및 사실등을 통하여 유전자 알고리즘을 구성하였다. GIS를 이용하여 지형도로부터 각각의 소유역에 대하여 면적, 경사도, 유역폭 등 수문정보를 얻었고, 토지이용도와 토양도로부터 불투수비, 토지이용상태, 침투능에 대한 정보를 얻었다. 도시유출 모형인 XP-SWMM을 선택하여 모의 후 민감도 분석을 통해 선정된 매개변수에 대하여 보정은 자동보정으로 무작위 탐색법의 일종인 유전자알고리즘(Genetic Algorithm, GA)을 사용하여 매개변수들을 추정하였고, 이의 적용성을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2137-2140
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• 2016

Background: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. Materials and Methods: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin $35mg/m^2$ and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin $25mg/m^2$ and gemcitabine $1gm/m^2$ day 1 and 8, 3 weekly for 3 cycles). Radiological assessment was according to RECIST criteria by evaluating downstaging of liver involvement and lymphadenopathy into complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Results: A total of 40 patients were evaluated from January 2012 to December 2014 (CTRT=25, NACT=15). Pretreatment CT scans revealed involvement of hilum (19), liver infiltration (38), duodenum involvement (n=22), colon involvement (n=11), N1 involvement (n=11), N2 disease (n=8), paraaortic LN (n=15), and no lymphadenopathy (n=6). After neoadjuvant therapy, liver involvement showed CR in 11(30%), PR in 4 (10.5%), SD in 15 (39.4%) and lymph node involvement showed CR in 17 (50%), PR in 6 (17.6%), SD in 4 (11.7 %). Six patients (CTRT=2, NACT=4) with 66.6 % and 83% downstaging of liver and lymphnodes respectively underwent extended cholecystectomy. There was 16.6 % and 83.3% rates of histopathological CR of liver and lymph nodes. All resections were R0. Conclusions: Neoadjuvant therapy in unresectable gall bladder cancer results in a 15% resectability rate. This approach has a strong potential in achieving R0 and node negative disease. Radiologic downstaging (CR+PR) of liver involvement is 40.5% and lymphadenopathy is 67.5%. Nodal regression could serve as a predictor of response to neoadjuvant therapy.

• Journal of Periodontal and Implant Science
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• 제30권2호
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• pp.359-374
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• 2000

Cyclosporine A(CsA) is a widely used immunosuppressant for transplant patients and is also used for the treatment of a wide variety of systemic diseases with immunologic disorders. However, its use is frequently limited because of complications such as nephrotoxicity or gingival hyperplasia. Although several hypotheses have been postulated for CsA-induced gingival hyperplasia, i.e. various cytokine effects of inflammatory cells, existence of plaque or CsA itself, but its pathogenesis is still unclear. For experimental chronic CsA toxicity, salt depletion has been shown to increased susceptibility of rodents to the effects of CsA, and this maneuver facilitates production of arteriolopathy and interstitial fibrosis in kidney that mimic the changes found in human. The purpose of this study was to evaluate pathogenesis of CsA-induced gingival hyperplasia by comparing changes between CsA administration groups of normal standard diet and those of low salt diet group. Specific pathogen-free, 20 to 25 days old(120 to 150 g), male Fisher-344 rats(KIST, Korea), 120 to 150g of body weight, were assigned to four groups of six animals each after one week of adaptation period for powder food. Group 1 received olive oil($300{\mu}l/g\;of\;diet$) with normal standard diet(0.4% of sodium)(NSD). Group 2 received CsA(Cypol-N, Jonggundang, Korea; $300{\mu}g/g\;of\;diet$) with normal standard diet(NSD+CsA). Group 3 received same amount of olive oil with low salt diet(0.05 % of sodium, Teklad Premier, U.S.A.)(LSD). Group 4 received same dose of CsA with low salt diet(LSD+CsA). Rats were pair fed and were sacrificed after six weeks. Renal histologic lesions associated with CsA, consisted of cortical interstitial fibrosis, tubular atrophy and hyalinization of arterioles and the impairment of renal function including increase of serum creatinine and decrease of glomerular filtration rate was more severe in low salt diet group. These were proved as the results of activated of renin-angiotensin system in the kidney by low salt condition. Meanwhile the degree of gingival hyperplasia at incisor and molar tooth was less severe in low salt diet group compared with normal sodium diet group. Hyperplastic gingiva showed mild epithelial hyperplasia and expanded underlyng stroma which consisted of matrix increasement, capillary proliferation and dilatation. While the number and the activation of fibroblasts were increased, inflammatory cells were rare in the stroma. The immunohistochemistry for TGF-${\beta}_1$ in the kidney and gingiva revealed stronger positive in LSD+CsA in kidney but in gingiva of NSD+CsA. These results suggested followings; Gingival hyperplasia can be developed without inflammatory cells infiltration and seemed not induced by CsA by itself. The major role for gingival hyperplasia by CsA would be the secondary effect of TGF-${\beta}$, which maybe upregulated by CsA administration. Low salt diet can attenuate this hyperplasia perhaps by decreasing the activation of $TGF-{\beta}$.