• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2323-2326
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• 2015

It is urgently necessary to be aware of the distribution and risk areas of liver fluke, Opisthorchis viverrini, for proper allocation of prevention and control measures. This study aimed to investigate the human behavior, and environmental factors influencing the distribution in Surin Province of Thailand, and to build a model using stepwise multiple regression analysis with a geographic information system (GIS) on environment and climate data. The relationship between the human behavior, attitudes (<50%; $X_{111}$), environmental factors like population density ($148-169pop/km^2$; $X_{73}$), and land use as wetland ($X_{64}$), were correlated with the liver fluke disease distribution at 0.000, 0.034, and 0.006 levels, respectively. Multiple regression analysis, by equations OV= -0.599 + 0.005(population density ($148-169pop/km^2$); $X_{73}$) + 0.040 (human attitude (<50%); $X_{111}$) +0.022 (land used (wetland; X64), was used to predict the distribution of liver fluke. OV is the patients of liver fluke infection, R Square= 0.878, and, Adjust R Square= 0.849. By GIS analysis, we found Si Narong, Sangkha, Phanom Dong Rak, Mueang Surin, Non Narai, Samrong Thap, Chumphon Buri, and Rattanaburi to have the highest distributions in Surin province. In conclusion, the combination of GIS and statistical analysis can help simulate the spatial distribution and risk areas of liver fluke, and thus may be an important tool for future planning of prevention and control measures.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4655-4660
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• 2012

Opuntia humifusa, member of the Cactaceae family, was previously demonstrated to have radical scavenging, anti-inflammatory and anti-proliferative effects in in vitro models. It was suggested that O. humifusa could function in the prevention of carcinogenesis. To investigate the in vivo chemopreventive effect of O. humifusa, mice were fed a diet containing either 1% or 3% following 7, 12-dimethylbenz[a] anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) induction of skin carcinogenesis. Significant decrease in the numbers of papilloma and epidermal hyperplasia were observed in mice fed with O. humifusa, compared to the control group. O. humifusa also upregulated high total antioxidant capacity and level of phase II detoxifying enzyme such as superoxide dismutase and glutathione S-transferase activity in the skin. Lipid peroxidation activity level was measured in skin cytosol and significantly inhibited in 3% OH fed group compared to the control group. These results suggest that O. humifusa exerts chemopreventive effects on chemical carcinogenesis in mouse skin and that prevention effects are associated with reduction of oxidative stress via the modulation of cutaneous lipid peroxidation, enhancing of total antioxidant capacity especially in phase II detoxifying enzyme system and partial apoptotic influence.

• 한국조리학회지
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• 제12권2호
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• pp.151-167
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• 2006

This study shows the differences among residents’ consciousness for general infectious disease and sterilization mediated by vermin. We categorized both industry-related people who work in restaurants, hygiene service shops, whole sales, government organizations, PC shops, factories, department stores and non-industry-related people who work in schools, general offices into two groups for this study. The discovery of vermin held 86% of total exam cases. The vermin included mosquitoes, cockroaches, ants, flies, and so on. People thought these vermin might mediate bacteria infection to human. 80.3% of persons thought mite might exist in blankets, beds and couches. Among 66.6% of total experience of vermin damage, the main damage came from mosquitoes. Frequently used methods of prevention from vermin damage were as follows: "spray of effective chemicals", "install traps" and " report to a prevention company" in order. It indicated that people did not take special actions to repel vermin in spite of their knowing seriousness of damage. Furthermore, just half cases were executed regular sanitization.

• 한국화재소방학회논문지
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• 제31권3호
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• pp.144-150
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• 2017

국가 간 교류 확대와 기후변화 등으로 감염병의 국내유입도 증가하고 있는 추세이다. 또한 사회적 환경변화로 감염병 발생 가능성의 증가에 대한 국민적 관심과 불안은 크게 증가하고 있다. 이러한 감염병 발생은 경제에도 심각한 위협이 되고 있으므로 감염병 예방과 확산 방지를 위한 다각적인 노력이 필요하다. 현재 많은 의료 기관에서는 전염병이 발생했을 때, 질병관리본부 등 상급 기관으로의 신속한 보고가 매우 중요하며 또한 일반 환자와 감염된 의심환자를 공간적으로 나누는 시설이 여의치 않아 병원 내에서 감염이 확대될 위험성이 높은 편이다. 본 연구에서는 감사원의 중동증후군(MERS)의 감사 결과를 토대로 감염병 발생 보고, 감염자의 분리 방법 및 감염 확대를 막는 방법 등을 고찰하여 예방 및 확산 방지를 위한 개선방안에 대해서 연구하였다.

• 미생물학회지
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• 제44권3호
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• pp.221-227
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• 2008

Bordetella pertussis는 유아의 호흡기감염질환인 백일해의 원인균으로 배신도입에 의해 발생률이 크게 낮아졌다. 그러나 최근에 일부 백신접종률이 높은 국가에서 증가된 백일해 발생건수가 보고되고 있으며, 그 추정 원인 중에 하나는 백신주와 유행주 사이의 유전형 흑은 혈청형 변이 이다. 따라서 분리주에 대한 변이 현황을 유전형 혹은 혈청형 분석을 통하여 확인하는 것이 필요하고 국내에서 백일해 발병증가에 대한 가능성을 추정해야 한다. 이에 본 연구에서는 $1999\sim2006$년 사이에 분리된 국내 백일해 분리균주의 변이 양상을 agglutinogen과 fimbriae에 대한 혈청형 조사를 통해 확인하였다. 그 결과 agg 1과 fim 2가 국내 분리주에서 가장 많이 발견되는 혈청형이었고, 두 항원 모두 시대에 따른 혈청형 변이 현상이 확인되었으며, 특히 agglutinogen의 경우는 백신균주(agg 1,2)와는 다른 유형(agg 1)이 증가되는 유형으로 나타났다. 그러나 fimbriae의 경우는 백신균주(fim 2)와 동일한 유형이 증가되어 차이를 나타내었다. 이러한 결과는 백일해 발병증가가 나타나는 국가들에서도 확인되는 현상으로 국내에서의 백일해 발병증가에 대한 보다 정확한 예측을 위해서는 항원결정기 유전자에 대한 변이정도 및 정상인에서의 항체가 분포양상 등에 대한 연구가 필요할 것으로 사료된다.

• Clinical and Experimental Pediatrics
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• 제54권12호
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• pp.489-500
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• 2011

Compared to the past decades, in recent decades, environmental and hygienic conditions in the Republic of Korea have improved along with socioeconomic developments, and the incidence of most infectious diseases, especially vaccine-preventable diseases, has greatly decreased due to active immunization with the developed level of health care. However, the incidence of some diseases has been increasing, and new diseases have been emerging. To cope with such changes actively, the government put the "Law for Control and Prevention of Infectious Diseases" into effect; this law was entirely revised on December 30, 2010. In this report, I review the past and recent status of infectious diseases in the Republic of Korea, following the introduction of this law, on the basis of data in the "National Notifiable Disease Surveillance System", which had been accumulated between the years 1960 and 2010.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4367-4372
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• 2014

We here document discovery of expression profile of myeloid derived suppressor cells (MDSCs) in chronic hepatitis B (CHB) patients and changes in the course of disease. The study population was composed of 75 outpatient HBV cases and 15 healthy control cases. Peripheral blood samples were collected for separation of mononuclear cells. Levels of MDSCs labeled with Lin-DR-CD11b+CD33+ obtained from peripheral blood mononuclear cells (PBMC), were revealed to have significant differences between the CHB and other groups. They were 0.414% for health control cases and 0.226% for CHB cases (Z=-2.356, p=0.0189). It also observed that the group of HBeAg positive cases had significant difference in MDSCs/PBMC median ($X^2=11.877$, p=0.003), compared with group of HBeAg negative cases and the healthy control group. It suggested considerable MDSCs might be involved in HBeAg immune tolerance. In addition, negative correlations between MDSCs/PBMC and parameters of ALT, AST and TBil, while positive correlation between MDSCs/PBMC and ALB parameter were found. Multiple comparisons between the four phases and health control phase again, there was a statistically sifnificant difference ($X^2=17.198$, p=0.002). Taken together, these findings may provide a new immunotherapy strategy for reduced the expression levels of MDSCs in CHB patients, through induction of an autoimmune response to virus removal.

• 한국보건간호학회지
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• 제35권1호
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• pp.19-32
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• 2021

Purpose: This study was aimed to identify the influencing factors on the COVID-19 infection prevention behavior of adults residing in Gyeongsangnam-do by examining relationships between anxiety, health belief and COVID-19 infection prevention behavior. Methods: The participants of this study were recruited from a website, and the total number of participants was 186. The self-report questionnaires were distributed during July 2020. Results: Multiple regression analysis revealed the significant factors affecting the COVID-19 infection prevention behavior of adult residing in Gyeongsangnam-do were perceived barriers(��=-3.68, p<.001), perceived benefits(��=3.39, p=.001), perceived susceptibility(��=2.83, p=.005), sex(��=2.59, p=.010). The total explanatory power of the study variables for COVID-19 infection prevention behavior was 35.0%(F=17.61, p<.001). Conclusions: Based on these findings, in order to promote COVID-19 infection prevention behavior, there is needed to reduce obstacles for carrying out infection prevention behaviors, and develop multi-faceted promotional strategies for infection prevention behaviors.

• 산업융합연구
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• 제18권6호
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• pp.9-17
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• 2020

COVID 19로 인해 전세계적으로 많은 팬데믹 현상이 일어나고 있다. 2020년 1월 이후 전세계적으로 확진자가 큰 폭으로 상승을 하고 잇으며, 각국의 의료시스템이 마비가 되고 있다. 한국은 선제적으로 잘 대응을 하여 K-방역이라는 명칭에 걸맞게 잘 대처를 하고 있다. 그러나 아직까지 법률과 행정적인 한계점에 대한 인식이 부족하다고 할 수 있다. 이에 본 연구에서는 현행 감염병 예방 및 관리체계에 대하여 형사정책적인 관점에서 "감염병의 예방 및 관리에 관한 법률"을 중심으로 우리 법제의 문제점 및 한계를 검토하고, 주요 국가에서의 제도와의 비교･분석을 통해, 감염병 예방 및 관리를 위한 효과적이고 실효적인 형사정책적 대응방안을 제시하고자 한다.

• Parasites, Hosts and Diseases
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• 제56권6호
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• pp.597-602
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• 2018

Histomonas meleagridis is a facultative anaerobic parasite, which can cause a common poultry disease known as histomoniasis. The species and age of the birds impacts on the susceptibility, with turkey being the most susceptible species. Chickens are less susceptible to H. meleagridis than turkeys and usually serve as reservoir hosts. Here, the diagnosis of an outbreak of histomoniasis in backyard Sanhuang chickens is described. The primary diagnosis was made based on clinical symptoms, general changes at necropsy, histopathology, and the isolation and cultivation of parasites. The pathogen was further confirmed by cloning, PCR identification, and animal inoculation tests. A strain of H. meleagridis, named HM-JSYZ-C, with a higher pathogenicity level in chickens was obtained. The study lays a foundation for further investigations into H. meleagridis and histomoniasis in chickens.