• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 1996년도 춘계학술발표회논문집(2)
• /
• pp.233-240
• /
• 1996

Analyses of the viscous and end effects on electromagnetic (EM) pumps of annular linear induction type for the sodium coolant circulation in Liquid Metal Fast Breeder Reactors have been carried out based on the MHD laminar flow analysis and the electromagnetic field theory. A one-dimensional MHD analysis for the liquid metal flowing through an annular channel has been performed on the basis of a simplified model of equivalent current sheets instead of three-phase currents in the discrete primary windings. The calculations show that the developed pressure difference resulted from electromagnetic and viscous forces in the liquid metal is expressed in terms of the slip, and that the viscous loss effects are negligible compared with electromagnetic driving forces except in the low-slip region where the pumps operate with very high flow velocities comparable with the synchronous velocity of the electromagnetic fields, which is not applicable to the practical EM pumps. A two-dimensional electromagnetic field analysis based on an equivalent current sheet model has found the vector potentials in closed form by means of the Fourier transform method. The resultant magnetic fields and driving forces exerted on the liquid metal reveal that the end effects due to finiteness of the pump length are formidable. In addition, a two-dimensional numerical analysis for vector potentials has been performed by the SOR iterative method on a realistic EM pump model with discretely-distributed currents in the primary windings. The numerical computations for the distributions of magnetic fields and developed pressure differences along the pump axial length also show considerable end effects at both inlet and outlet ends, especially at high flow velocities. Calculations of each magnetic force contribution indicate that the end effects are originated from the magnetic force caused by the induced current ( u x B ) generated by the liquid metal movement across the magnetic field rather than the one (E) produced by externally applied magnetic fields by three-phase winding currents. It is concluded that since the influences of the end effects in addition to viscous losses are extensive particularly in high-velocity operations of the EM pumps, it is necessary to find ways to suppress them, such as proper selection of the pump parameters and compensation of the end effects.

• 플랜트 저널
• /
• 제12권4호
• /
• pp.37-43
• /
• 2016

원자력발전소의 사고 대처 부하에 전력을 공급하는 전원계통은 다양한 조건에서도 일정 전압이 유지됨을 분석을 통하여 입증한다. 이를 위하여 발전소를 일정부하 운전 상태로 유지하고, 대용량 전동기(원자로냉각재펌프(RCP), 기기냉각수펌프(CCWP))를 각각 기동하여 기동 전 후 안전관련 모선의 전압을 측정하였다. 현장 시험으로 확보된 자료(예, 전압, 전류, 역율 등)는 기존 전력계통해석 모델의 운전 조건으로 재입력하고 재분석을 수행하였다. 이는, 기존 전력계통분석에 사용된 분석기법과 가정들을 실질적인 측정과 결과 분석으로 입증하는 과정이다. 결국, 두 경우의 전압 강하는 발전소 안전에 중요한 기기의 전압이 허용전압 이하로 저하되지 않음과 두 값의 비교 결과가 요구되는 제한치 이내임을 검증한다.

• Archives of Pharmacal Research
• /
• 제28권10호
• /
• pp.1196-1202
• /
• 2005

Omeprazole (OMP) is a proton pump inhibitor used as an oral treatment for acid-related gastrointestinal disorders. In the liver, it is primarily metabolized by cytochrome P-450 (CYP450) isoenzymes such as CYP2C19 and CYP3A4. 5-Hyroxyomeprazole (5-OHOMP) and omeprazole sulfone (OMP-SFN) are the two major metabolites of OMP in human. Cimetidine (CMT) inhibits the breakdown of drugs metabolized by CYP450 and reduces, the clearance of coad-ministered drug resulted from both the CMT binding to CYP450 and the decreased hepatic blood flow due to CMT. Phenobarbital (PB) induces drug metabolism in laboratory animals and human. PB induction mainly involves mammalian CYP forms in gene families 2B and 3A. PB has been widely used as a prototype inducer for biochemical investigations of drug metabolism and the enzymes catalyzing this metabolism, as well as for genetic, pharmacological, and toxicological investigations. In order to investigate the influence of CMT and PB on the metabolite kinetics of OMP, we intravenously administered OMP (30 mg/kg) to rats intraperitoneally pretreated with normal saline (5 mL/kg), CMT (100 mg/kg) or PB (75 mg/kg) once a day for four days, and compared the pharmacokinetic parameters of OMP. The systemic clearance ($CL_{t}$) of OMP was significantly (p<0.05) decreased in CMT-pretreated rats and significantly (p<0.05) increased in PB-pretreated rats. These results indicate that CMT inhibits the OMP metabolism due to both decreased hepatic blood flow and inhibited enzyme activity of CYP2C19 and 3A4 and that PB increases the OMP metabolism due to stimulation of the liver blood flow and/or bile flow, due not to induction of the enzyme activity of CYP3A4.

• 대한한의학방제학회지
• /
• 제31권4호
• /
• pp.389-413
• /
• 2023

Objectives : This study aimed to review the current trends in experimental studies on the use of natural products for treatment of gastroesophageal reflux disease (GERD). Methods : Experimental studies assessing the efficacy of natural products against GERD were searched on PubMed. Articles were selected based on predefined inclusion and exclusion criteria and then analyzed for experimental methods, interventions, and result analysis techniques. Results : A total 37 studies were included in this review. Predominantly, in vivo experiments were conducted to induce GERD through surgery, involving the ligation of the pylorus and the transitional junction between the corpus and the forestomach using 7-week-old male Sprague-Dawley rats. The acute induction model, sacrificing animals after a single administration following GERD induction, was mainly used.The utilization of cell experiments was relatively infrequent, with a focus on assessing antioxidant and anti-inflammatory effects via the treatment of the RAW 264.7 cell line with lipopolysaccharides treatment. Glycyrrhizae Radix et Rhizoma, Pinelliae Tuber, Ginseng Radix and Zingiberis Rhizoma were used as single ingredients, and herbal formula, STW-5 (iberogast), Rikkunshito (六君子湯), Banhasasim-tang (半夏瀉心湯), and Hewei Jiangni granule (和胃降逆湯) were used. Outcome analysis methods encompassed Macroscopic evaluation, esophageal function assessment, blood biomarker analysis, histological examination, protein analysis, gene expression analysis, and gastric juice analysis. Proton pump inhibitors were predominantly employed as positive controls. Conclusions : This study revealed the current trends in non-clinical research evaluating natural products for GERD. Based on the results of this study, we expect that non-clinical research on clinically effective natural products will be revitalized.

• 조명전기설비학회논문지
• /
• 제24권2호
• /
• pp.92-100
• /
• 2010

최근에는 파워툴(Power tools)과 가전 제품에 있어서 전자적인 전류(commutation)를 사용하는 새로운 형태의 브러시리스 전동기인 플럭스 스위칭 전동기(Hux switching motor)에 대한 관심이 점차적으로 증가되고 있으며, 특히 팬과 펌프 시장에 있어서는 그린 정책으로 인하여 플럭스 스위칭 전동기에 대한 관심이 급격히 증가되고 있다. 플럭스 스위칭 전동기는 유도전동기에 비해서는 높은 전력 밀도(power density)와 상대적으로 높은 효율,그리고 브러시리스 DC 전동기에 비해서는 간단한 전동기 구조와 가격 경쟁력이라는 장점을 가지고 있다. 따라서 본 논문에 서는 팬 용도로 제작된 12/6 폴을 가지는 플럭스 스위칭 전동기의 동작원리와 고효율 드라이브의 타당성을 검증하기 위해서 TMS320F2812 DSP를 이용한 실험 결과를 제시한다.

• 한국치위생학회지
• /
• 제17권3호
• /
• pp.381-394
• /
• 2017

Objectives: This study aims to evaluate carbonated drinks induced dental caries with qualitative analysis and to compare with oral organic acids including lactate, acetate, propionate, formate, butyrate, pyruvate and valerate which cause caries when taking either 10% sucrose drinks or carbonated drinks. Methods: Saliva was collected from six study subjects before and after (start, 5, 10, 30 minutes) taking water intake upon (A) 10% sucrose intake, (B) 10% sucrose intake, and (C) carbonated drink intake, then they were centrifuged at 1,200 rpm followed by removing bacteria and enzymes with syringe filtering, performing a qualitative analysis with HPLC conductivity detection (GP50 gradient pump, ED 50 detector) after saliva pre-treatment under isocratic 100 mM NaOH mobile phase. Results: Higher risk of dental caries was evaluated in order of C>B>A, with the results of total oral organic acids' concentration, lactates of organic acids and organic acids produced after 5 minutes from the 3 types of drinks intake. Conclusions: Carbonated beverages were estimated to develop higher dental caries induction than beverages containing 10% sucrose because of the high organic acid concentration in the mouth after its intake.

• 대한치과마취과학회지
• /
• 제10권2호
• /
• pp.190-196
• /
• 2010

Difficult airway management including difficult intubation, difficult ventilation and difficult mask ventilation is a life threatening issue during anesthesia care. A 23-year-old woman with Treacher Collins syndrome was scheduled for distraction osteogenesis. She had hypoplasia of mandible and malar bone, bilateral deformities of auricles with partial deafness and antimongoloid slant of the palpebral fissures. A 56-year-old woman with mandibular hypoplasia due to childhood trauma was scheduled for distraction osteogenesis. She had a history of difficult intubation. We anticipated a difficult intubation and ventilation. Fiberoptic bronchoscopic guided awake intubation was selected for anesthesia induction. After intravenous injection of midazolam and remifentanil, 10% lidocaine pump spray on the pharyngolarynx with a direct laryngoscope and on the nasal canal. However fiberoptic bronchoscopic guided awake intubation was failed due to severe gag reflex. After intravenous injection of propofol and remifentanil using the target controlled infusion (TCI), mask ventilation was easily performed and, after intravenous injection of vecuronium, fiberoptic bronchoscopic guided intubation was easily performed using a wire reinforced endotracheal tube. The operation was completed successfully without any adverse events.

• 드라이브 ㆍ 컨트롤
• /
• 제17권3호
• /
• pp.15-25
• /
• 2020

The cycle time and power saving effect of a hydraulic hybrid injection molding machine using a servo motor are considered in this paper. In order to verify control characteristics, such as pressure and speed, experiments were performed with the hydraulic hybrid injection molding machine, clamping force of 110 ton. The power consumption and production cycle time of a conventional hydraulic injection molding machine were measured to compare its performances with the hydraulic hybrid injection molding machine. An injection molding machine with a clamping force of 1300 ton was used as the conventional machine, the hybrid machine was implemented by replacing its induction motors with servo motors. In the remodeled hybrid machine, experiments were performed to investigate how the displacement of the mold clamping pump affects the power consumption and production cycle time. The results showed that the production cycle time of the hybrid injection molding is similar to a conventional hydraulic injection molding machine but with a significant energy saving of about 40%.

• 조명전기설비학회논문지
• /
• 제23권6호
• /
• pp.89-95
• /
• 2009

최근에는 파워툴(power tools)과 가전 제풀에 있어서 전자적인 전류(commutation)를 사용하는 새로운 형태의 브러시리스 전동기인 플럭스 스위칭 전동기(Flux switching motor)에 대한 관심이 점차적으로 증가되고 있으며, 특히 팬과 펌프 시장에 있어서는 그린 정책으로 인하여 플럭스 스위칭 전동기에 대한 관심이 급격히 증가되고 있다. 플럭스 스위칭 전동기는 유도전동기에 비해서는 높은 전력 밀도(power density)와 상대적으로 높은 효율, 그리고 브러시리스 DC 전동기에 비해서는 간단한 전동기 구조와 가격 경쟁력이라는 장점을 가지고 있다. 따라서 본 논문에서는 팬 용도로 제작된 12/6 폴을 가지는 플럭스 스위칭 전동기의 드라이브 설계와 동작원리에 대해서 나타내고, 팬 용도로 제작된 프로토타입 플럭스 스위칭 전동기의 타당성을 검증하기 위해서 IMS320F2812 DSP와 일반적인 인버터를 이용한 실험 결과를 제시한다.

• Journal of Digestive Cancer Research
• /
• 제6권1호
• /
• pp.6-10
• /
• 2018

The importance of signal transducer and activator of transcription 3 (STAT3) signaling in gastric carcinogenesis was firmly evaluated in the previous studies. Fully activated STAT3 induces various target genes involving tumor invasion and epithelial-mesenchymal transition (EMT), and mediates interaction between cancer cells and microenvironmental immune cells. Thus, suppression of STAT3 activity is an important issue for inhibition of gastric carcinogenesis and invasion. Unfortunately, data from clinical studies of direct inhibitor targeting STAT3 have been disappointing. SH2-containing protein tyrosine phosphatase 1 (SHP-1) effectively dephosphorylates and inhibits STAT3 activity, which has not been extensively studied gastric cancer research field. However, by summarizing recent data, it is evident that protein and gene expression of SHP-1 are minimal in gastric cancer cells, and induction of SHP-1 effectively downregulates phosphorylated STAT3 and inhibits cellular invasion in gastric cancer cells. Several SHP-1 inducers have been investigated in the experimental studies, including proton pump inhibitor, arsenic trioxide, and other natural compounds. Taken together, we suggest that modulation of SHP-1/STAT3 signaling axis may present a new way for treatment of gastric cancer, and development of effective SHP-1 inducer may be an important task in the future search field of gastric cancer.