• Journal of Electrical Engineering and information Science
• /
• 제2권6호
• /
• pp.90-94
• /
• 1997

The joints between the superconducting wires are inevitably needed from the requirement of a high magnetic stability with respect to time in the superconducting MRI magnet. In this study, a new superconducting joint using Cu/Nb-Ti sleeve has been tried on the MRI type Nb-Ti superconducting wires. The transformer induction type apparatus was made and applied to measure the joint resistance. A very low joint resistance of 10\ulcorner $\Omega$ could be successfully obtained from this joint method. It was confirmed that the initial rapid current decay occurs before the very stable current decay due to only superconducting joint. Some unstable part in the joint like exposed filaments causes the initial induced current to lower and influence on the increase of the joint resistance.

• 운동영양학회지
• /
• 제15권4호
• /
• pp.153-161
• /
• 2011

The maintenance of skeletal muscle mass is very important for the prevention of life style-related diseases and the improvement of quality of life. It is well-known that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. It has been reported that many molecules are involved in the regulation of protein synthesis in response to resistance exercise and nutrition. Understanding the molecular mechanisms regulating muscle protein synthesis is crucial for the development of appropriate interventions. The role of intracellular signaling pathways through the mammalian target of rapamycin (mTOR), a serine/threonine protein kinase in the regulation of muscle protein synthesis, has been extensively investigated for these years. Control of protein synthesis by mTOR is mediated through phosphorylation of downstream targets that modulate translation initiation and elongation step. In contrast, upstream mediators regulating mTOR and protein synthesis in response to resistance exercise and amino acid still needed to be determined. In this brief review, we discuss the current progress of intracellular mechanisms for exercise- and amino acid-induced activation of mTOR pathways and protein synthesis in skeletal muscle.

• 한국환경독성학회:학술대회논문집
• /
• 한국환경독성학회 2001년도 춘계심포지움 및 학술발표회
• /
• pp.140-140
• /
• 2001

Porins are major outer membrane proteins which produce non-specific aqueous channels across the membrane that permit the diffusion into the bacterial cells of hydrophilic compounds including sugars, amino acids, and antibiotics. In some gram-negative organisms, antibiotic resistance can be induced by mutational loss of channel that causes a decrease in outer membrane permeability. (omitted)

• 대한전기학회논문지
• /
• 제35권2호
• /
• pp.55-61
• /
• 1986

This paper describes the generation region and suppression effect of the abnormal field voltage induced when the synchronous generator is switched to the infinite bus, the critical value of negative field current is calculated by simmulation which has parameters of the phase difference and voltatge ratio between the bus and the generator. The suppression effect of discharge resistance connected in parallel with the field circuit is also investigated. According to this study, the optimal value of discharge resistance which can suppress effectively the abnormal field voltage may be calculated.

• Archives of Pharmacal Research
• /
• 제21권1호
• /
• pp.76-78
• /
• 1998

• Corrosion Science and Technology
• /
• 제8권2호
• /
• pp.74-80
• /
• 2009

The high alkaline property in the concrete pore solution protects the embedded steel in concrete from corrosion due to aggressive ions attack. However, a continuous supply of those ions, in particular, chlorides altogether with a pH fall in electrochemical reaction on the steel surface eventually depassivate the steel to corrode. To mitigate chloride-induced corrosion in concrete structures, finely grained mineral admixtures, for example, pulverized fuel ash (PFA), ground granulated blast furnace slag (GGBS) and silica fume (SF) have been often advised to replace ordinary Portland cement (OPC) partially as binder. A consistent assessment of those partial replacements has been rarely performed with respect to the resistance of each binder to corrosion, although the studies for each binder were extensively looked into in a way of measuring the corrosion rate, influence of microstructure or chemistry of chlorides ions with cement hydrations. The paper studies the behavior of steel corrosion, chloride transport, pore structure and buffering capacity of those cementitious binders. The corrosion rate of steel in mortars of OPC, 30% PFA, 60% GGBS and 10% SF respectively, with chloride in cast ranging from 0.0 to 3.0% by weight of binder was measured at 7, 28 and 150 days to determine the chloride threshold level and the rate of corrosion propagation, using the anodic polarization technique. Mercury intrusion porosimetry was also applied to cement pastes of each binder at 7 and 28 days to ensure the development of pore structure. Finally, the release rate of bound chlorides (i.e. buffering capacity) was measured at 150 days. The chloride threshold level was determined assuming that the corrosion rate is beyond 1-2 mA/$m^3$ at corrosion and the order of the level was OPC > 10% SF > 60% GGBS > 30% PFA. Mercury intrusion porosimetry showed that 10% SF paste produced the most dense pore structure, followed by 60% GGBS, 30% PFA and OPC pastes, respectively. It was found that OPC itself is beneficial in resisting to corrosion initiation, but use of pozzolanic materials as binders shows more resistance to chloride transport into concrete, thus delay the onset of corrosion.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4475-4482
• /
• 2014

Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. Bag-1 (Bcl-2-associated anthanogene) is one anti-apoptotic protein involved in drug resistance impacting on therapeutic efficiency. Elevated levels of this protein are related with increase cell proliferation rates, motility and also cancer development. For this reason, we aimed to understand the role of Bag-1 expression in Cisplatin-induced apoptosis in HeLa cervix cancer cells. Cisplatin decreased cell viability in time- and dose-dependent manner in wt and Bag-1L+HeLa cells. Although, $10{\mu}M$ Cisplatin treatment induced cell death within 24h by activating caspases in wt cells, Bag-1L stable transfection protected cells against Cisplatin treatment. To assess the potential protective role of Bag-1, we first checked the expression profile of interacting anti-apoptotic partners of Bag-1. We found that forced Bag-1L expression prevented Cisplatin-induced apoptosis through acting on Mcl-1 expression, which was reduced after Cisplatin treatment in wt HeLa cells. This mechanism was also supported by the regulation of heat shock protein (Hsp) family members, Hsp90 and Hsp40, which were involved in the regulation Bag-1 interactome including several anti-apoptotic Bcl-2 family members and c-Raf.

• 전기학회논문지
• /
• 제67권3호
• /
• pp.406-412
• /
• 2018

This paper describes the fabrication process of laser induced graphene (LIG) and its transfer method on to a flexible and stretchable PDMS substrate. By irradiating CO2 laser on a polyimide(PI) film surface, a localized high temperature is created, resulting in a three-dimensional porous graphene network structure with good conductivity. This LIG electrode is relatively easy to fabricate and since it is very weak the LIG electrode was transferred to a flexible PDMS substrate to increase the sturdiness as well as possible use in flexible applications. Sheet resistance, thickness, and electrochemical activity of the fabricated in-situ LIG electrodes have been examined and compared with the LIG electrodes after transferring to PDMS elastomer. The properties of the LIG electrodes were also examined depending on the $CO_2$ laser power. As the irradiated laser power increased, the LIG electrode resistance decreases and the LIG electrode thickness increased. At 4.8 W of laser power, the average sheet resistance and thickness of the fabricated LIG electrodes were approximately $31.7{\Omega}/{\Box}$ and $62.67{\mu}m$, respectively. Moreover, the electrochemical activity of the fabricated LIG electrode at 4.8 W of laser power showed a high oxidation current of $28.2{\mu}A$ after transferring to PDMS.

• 식물병연구
• /
• 제22권3호
• /
• pp.202-207
• /
• 2016

쌀은 세계에서 가장 중요한 작물 중의 하나이지만 충분한 비타민을 제공하지 않고, 벼 도열병과 흰잎마름병은 전 세계적으로 가장 큰 피해를 주고 있는 병해이다. 리보플라빈, 비타민 B2는 인간의 건강에 필수적인 영양소이며, 식물의 병원균에 대한 식물의 방어 활성화로 알려져 있다. 본 연구에서는 BioDoctor (Hyunnong Co., Ltd., Gokseong, Korea)라는 리보플라빈 기반 제품을 벼에 경엽살포했을 때, 주요 병해에 대한 저항성 유도 및 벼 체내에 비타민 함량이 증가되는지에 대한 가능성을 조사하였다. 온실검정에서 BioDoctor 제품 500배와 1,000배로 희석하여 경엽처리 결과 벼 도열병과 흰잎마름병에 대해 현저한 병 저항성을 유도하였다. 또한, BioDoctor를 처리한 알곡과 잎에서 통계적으로 유의한 수준으로 리보플라빈 함량이 검출되었다. 본 연구는 비타민인 리보플라빈이 함유된 BioDoctor가 벼 도열병과 흰잎마름병에 대해 병 저항성을 유도할 뿐만 아니라 쌀 곡류 내에 비타민 함량을 증가시키는 큰 잠재력을 가지고 있는 것으로 나타났다.

• BMB Reports
• /
• 제55권6호
• /
• pp.293-298
• /
• 2022

Antipsychotics have been widely accepted as a treatment of choice for psychiatric illnesses such as schizophrenia. While atypical antipsychotics such as aripiprazole are not associated with obesity and diabetes, olanzapine is still widely used based on the anticipation that it is more effective in treating severe schizophrenia than aripiprazole, despite its metabolic side effects. To address metabolic problems, metformin is widely prescribed. Hypothalamic proopiomelanocortin (POMC) neurons have been identified as the main regulator of metabolism and energy expenditure. Although the relation between POMC neurons and metabolic disorders is well established, little is known about the effects of olanzapine and metformin on hypothalamic POMC neurons. In the present study, we investigated the effect of olanzapine and metformin on the hypothalamic POMC neurons in female mice. Olanzapine administration for 5 days significantly decreased Pomc mRNA expression, POMC neuron numbers, POMC projections, and induced leptin resistance before the onset of obesity. It was also observed that coadministration of metformin with olanzapine not only increased POMC neuron numbers and projections but also improved the leptin response of POMC neurons in the olanzapine-treated female mice. These findings suggest that olanzapine-induced hypothalamic POMC neuron abnormality and leptin resistance, which can be ameliorated by metformin administration, are the possible causes of subsequent hyperphagia.