• Journal of the Korean GEO-environmental Society
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• v.16 no.10
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• pp.5-14
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• 2015

Suction affects the unsaturated soil as the negative pore pressure, and leads to increases of the yield stress and the plastic shear stiffness of the soil skeleton due to the growth in interparticle stress. Hence, in this study, in order to account for these effects of suction under the dynamic loading condition such as the earthquake, the element simulation of the cyclic triaxial test using induced stress-strain relation based on cyclic elasto-plastic constitutive model extended for unsaturated soil considering the $1^{st}$ and the $2^{nd}$ yield functions was conducted. Through the stress path, stress-strain relation and relation between volumetric strain and axial strain, it was seen in all the cases that the simulation results demonstrated a good agreement with the experimental results. It is expected that the results of this study possibly contribute to the accuracy improvement on the prediction of unsaturated soil behavior under the dynamic loading condition.

• Journal of Korean Association for Spatial Structures
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• v.7 no.4
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• pp.89-96
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• 2007

The fundamental frequency maximization of beam structures is carried out by using strain energy based topology optimization technique. It mainly uses the modal strain energy distributions induced by the mode shapes of the structures. The modal strain energy to be minimized is employed as the objective function and the initial volume of structures is adopted as the constraint function. The resizing algorithm devised from the optimality criteria method is used to update the hole size of the cell existing in each finite element. The beams with three different boundary conditions are used to investigate the optimum topologies against natural mode shapes. From numerical test, it is found to be that the optimum topologies of the beams produced by the adopted technique have hugh increases in some values of natural frequencies and especially the technique is very effective to maximize the fundamental frequency of the structures.

• Asian-Australasian Journal of Animal Sciences
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• v.8 no.4
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• pp.325-328
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• 1995

The experiment was conducted to study the comparative pathology of hemic system among three different broiler chicken strains i.e. Hubbard (H), Lohmann (L) and Indian River (IR) suffering from experimentally induced Hydropericardium Syndrome (HPS). For this 50 chicks of each strain were inoculated with HPS inoculum at the age of 21 days and other 50 chicks of each broiler strain were kept as uninoculated control. After slaughtering each bird of both groups was subjected to pathological examination of heart, spleen and aorta and also for determining routine haematological parameters. The maximum values of Total Erythrocyte Count (TEC), heterophils and thrombocytes and the minimum values of Total Leukocyte Count (TLC) and Hemoglobin (Hb) content were found in H broiler strain. Percentage of monocytes, basophils and eosinophils also showed maximum decrease in H broiler chicken strain. Gross pathological lesions in the inoculated birds revealed that the heart showed ballooning due to distention of pericardial sac with pericardial fluid. Haemorrhages on the epicardium and flabbiness of the myocardium. Under the microscope, degenerative changes in myocardial tissue were seen. Lesions in the spleen included splenomegaly and haemorrhagic spots. Aorta showed flabbiness of the wall and disruption of endothelium. It is concluded that there is a marked difference in susceptibility of HPS among three different commercial broiler strains. The Hubbard broiler strain is more susceptible which is followed by the Indian River and Lohmann respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.11
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• pp.1797-1808
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• 2020

Objective: This study assessed the effects of probiotics on cecal microbiota, gene expression of intestinal tight junction proteins, and immune response in the cecal tonsil of broiler chickens challenged with Salmonella enterica subsp. enterica. Methods: One-day-old broiler chickens (n = 240) were randomly allocated to four treatments: negative control (Cont), multi-strain probiotic-treated group (Pro), Salmonella-infected group (Sal), and multi-strain probiotic-treated and Salmonella-infected group (ProSal). All chickens except those in the Cont and Pro groups were gavaged with 1×10⁸ cfu/mL of S. enterica subsp. enterica 4 days after hatching. Results: Our results indicated that body weight, weight gain, and feed conversion ratio of birds were significantly reduced (p<0.05) by Salmonella challenge. Chickens challenged with Salmonella decreased cecal microbial diversity. Chickens in the Sal group exhibited abundant Proteobacteria than those in the Cont, Pro, and ProSal groups. Salmonella infection downregulated gene expression of Occludin, zonula occludens-1 (ZO1), and Mucin 2 in the jejunum and Occludin and Claudin in the ileum. Moreover, the Sal group increased gene expression of interferon-γ (IFN-γ), interleukin-6 (IL-6), IL-1β, and lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) and reduced levels of transforming growth factor-β4 and IL-10 compared with the other groups (p<0.05). However, chickens receiving probiotic diets increased Lactobacillaceae abundance and reduced Enterobacteriaceae abundance in the ceca. Moreover, supplementation with probiotics increased the mRNA expression of Occludin, ZO1, and Mucin 2 in the ileum (p<0.05). In addition, probiotic supplementation downregulated the mRNA levels of IFN-γ (p<0.05) and LITAF (p = 0.075) and upregulated IL-10 (p = 0.084) expression in the cecal tonsil. Conclusion: The administration of multi-strain probiotics modulated intestinal microbiota, gene expression of tight junction proteins, and immunomodulatory activity in broiler chickens.

• Journal of the Society of Naval Architects of Korea
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• v.50 no.1
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• pp.41-48
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• 2013

Several fatigue damages have recently been reported which cannot be resolved in the context of the existing fatigue design procedure, and they are suspected to be the cracks induced by the low cycle fatigue mechanism. To tackle the problem, a series of material tests together with fatigue tests have been carried out, and elasto-plastic notch strain analysis using nonlinear kinematic hardening model has been performed. The cyclic stress-strain curves are obtained and the nonlinear kinematic hardening model was calibrated based on the obtained material data. Also, the fatigue test with non-load-carrying cruciform fillet welded joint has been performed in low cycle fatigue regime. Then, the notch strain analyses have been carried out to find the precise elasto-plastic behavior of the material at the notch root of the cruciform joint. The variation of the material property from the base metal via HAZ up to the weld metal was taken into account using spatial variation of the material property. Then the detail elasto-plastic behavior of the welded joint subjected to the repeated cyclic loading has been investigated further through the comparison with the prediction with Neuber's rule. The calibration of the nonlinear kinematic hardening model and nonlinear notch strain analyses have been performed using the commercial FE program ABAQUS.

• Korean Journal of Veterinary Research
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• v.53 no.3
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• pp.163-167
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• 2013

Avian pathogenic Escherichia coli (APEC) are known to cause extraintestinal disease in poultry, leading to substantial losses in the industry. IutA, iron-regulated aerobactin receptor is firmly associated with APEC. To assess the potential of IutA to induce protective immune responses, attenuated Salmonella Typhimurium strain expressing IutA was constructed and administered orally to BALB/c mice. The IutA-specific immune responses were measured with sera, vaginal and fecal samples by an enzyme-linked immunosorbent assay. We found that the Salmonella-IutA vaccine induced significantly higher immune responses as compared to the control inoculated with the attenuated S. Typhimurium containing the plasmid only. The IutA-specific immune responses were increased by second immunization at third week after initial immunization, whereas triple immunization induced lower immune responses than those induced by the double immunization. The Salmonella-IutA vaccine induced a nature of immunity biased to the Th1-type, as judged by the ratio of IutA-specific IgG isotypes (IgG2a/IgG1). Overall, these results suggest that the Salmonella-IutA vaccine appear to be suitable candidate for a vaccine against APEC.

• Design & Manufacturing
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• v.12 no.1
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• pp.1-6
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• 2018

In this study, we calculated the redistribution of vacancy concentration in metal specimens induced by stress-induced diffusion at a high temperature. To deduce the governing equation, we associated the unit volume change equation of strains with a differential equation of vacancy concentration as a function of stress using the stress-strain relationship. In this governing equation, we considered stress as the only chemical potential parameter to stay in the scope of this study, which provided the vacancy concentration equation as of stress gradient in metals. The equation was then mathematically delineated to derive a analytical solution for a transient, one-dimensional diffusion case. With the help of Korhonen's approximation and the boundary conditions, we successfully deduced a general solution from the governing equation. To visualize the feasibility of our solutions, we applied the solution to two different stress-induced cases - a rod with fixed concentrated stresses at both ends and a rod with varying concentrated stresses at both ends. Although it is necessary to legitimatized the model in the future for improvement, our results showed that the model can be used to interpret the location of structural defects, the formation of vacancy, and furthermore the high temperature behavior of metals.

• Journal of Microbiology and Biotechnology
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• v.10 no.3
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• pp.375-380
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• 2000

The preliminary screening of several cyanobacteria, using mice bioassay, reveale the production of a hepatotoxin by the cyanobacterium Scytonema sp. strain BT 23 isolated from soil. An intraperitoneal injection of the crude toxin (LD50 56 mg/kg body wt) from this strain caused the death of the mice within 40 min, and the anmals showed slinical signs of mice within 40 min, and the animals showed clinical signs of hepatotoxicity. The toxin was purified and partially characterized. The active fraction appears to be nonpolar in nature and shows absorption peaks at 240 and 285 nm. The purified toxin had an LD50 of TEX>$100<\mu\textrm{g}/kg$ body wt and the test mice died within 40 min of toxin administration. The toxin-treated mice showed a 1.65-fold increase in liver weight at 40 min and the liver color chnged to dark red due to intrahepatic hemorrhage and pooling of blood. Furthermore, the administration of the toxin to test mice induced a 2.58, 2.63, and 2.30-fold increse in the activity of the serum enzymes alanine aminotransferase, lactate dehydrogenase, and alkaline phosphatase, respectively. Further experiments with the 14C-labeled toxin revealed a maximum accumulation of the toxin in the liver. The clinical symptoms in the mice were similar to those produced by microcystin-L.R. These results suggest that hepatotoxins may also be produced in non bloom-forming planktonic cyanobacteria.

• 한국생물공학회:학술대회논문집
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• 2003.04a
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• pp.460-465
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• 2003

A bacterium, named as strain KL34, producing extracellular pectinase was isolated from soil. The mophological cheracteristics of the isolated bacterium were gram-negative, rod-shaped and endospore unformed. Production of pectinase of strain KL34 was induced only by polygalacturonic acid added to the culture media as a sole carbon source. Pectinase activity of KL34 reached a maximum value in the culture conditions of pH 8.5 at $25^{\circ}C$. Optimal medium for pectinase production was determined to the composition of 2% polygalacturonic acid, 0.25% yeast extract, 0.02% $K_2HPO_4$, 0.02% $CaCl_2$, and 0.05% KCl per liter. The pectinase activity in the culture supernatant reached the highest amount of 54 U/ml after 3 days cultivation in the optimal media.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.6
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• pp.1069-1076
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• 2002

The high temperature creep behavior of heat machine systems such as aircraft engines, boilers and turbines in power plants and nuclear reactor components have been considered as an important and needful fact. There are considerable research results available for the design of high temperature tube materials in power plants. However, few studies on the Initial Strain Method (ISM) capable of securing repair, maintenance, cost loss and life loss have been made. In this method, 3 long time prediction Of high temperature creep characteristics can be dramatically induced through a short time experiment. The purpose of present study is to investigate the high temperature creep lift of Udimet 720, SCM 440-STD61 and 1Cr-0.5Mo steel using the ISM. The creep test was performed at 40$0^{\circ}C$ to $700^{\circ}C$ under a pure loading. In the prediction of creep life for each materials, the equation of ISM was superior of Larson-Miller Parameter(LMP). Especially, the long time prediction of creep life was identified to improve the reliability.