• Journal of Dairy Science and Biotechnology
• /
• 제39권4호
• /
• pp.145-156
• /
• 2021

Antibiotics are used in many sectors, including the dairy industry, to prevent bacterial infections in humans, animals, and plants. When bacterial cells are exposed to stressors, such as antibiotic exposure, a subpopulation of the cells becomes dormant. This helps the pathogen to revive and reconstitute its pathogenicity. Thus, eradicating the dormant cells may be an effective strategy to reduce the development of antibiotic resistance in bacteria caused by the abuse of antibiotics. In recent years, a large number of indole-related compounds have been reported to eradicate persister cells. In this review, we provide a summary of the mechanisms of persister cell formation and resuscitation, and the ability of indole and substituted indoles to eradicate persister cells.

• Bulletin of the Korean Chemical Society
• /
• 제22권6호
• /
• pp.545-546
• /
• 2001

• 농업과학연구
• /
• 제43권5호
• /
• pp.777-787
• /
• 2016

In the present study, we aimed to investigate the effect of dietary supplementation of palm kernel meal (PKM), as a fermentable carbohydrate source, on the growth performance, meat quality, concentration of odorous compound, and changes in bacterial community in swine manure. Swine (average initial body weight of $51.36{\pm}1.02kg$) were fed diet which included three levels of PKM (0, 2 and 4%), and their manure samples were collected from the slurry pit. Growth performance and meat quality were not affected by PKM treatments (p > 0.05). Levels of phenols and indoles were decreased in the 2 and 4% PKM treatments compared to 0% PKM (control; p < 0.05). Especially, compared to the control, the 2% PKM group showed decreased levels of phenols by 35% and indoles by 34%. Among the dominant bacterial genera, the main change in relative abundance occurred in those belonging to the Firmicutes phylum in PKM treatments. Terrisporobacter and Clostridium were decreased in the PKM groups compared to the control. However, the relative abundance of Intestinibacter, AM406061_g, Coprococcus_g2, Phascolarcotobacterium, EF401875_g, Lactobacillus, and Streptococcus were increased in the PKM group compared to control. Taken together, administration of PKM had a beneficial effect on reducing production of odorous compounds in swine manure, possibly by modulating the communities of predominantly carbohydrate-utilizing bacteria in the large intestine of swine.

• Bulletin of the Korean Chemical Society
• /
• 제35권9호
• /
• pp.2611-2612
• /
• 2014

• Bulletin of the Korean Chemical Society
• /
• 제32권12호
• /
• pp.4163-4164
• /
• 2011

• Bulletin of the Korean Chemical Society
• /
• 제29권7호
• /
• pp.1418-1420
• /
• 2008

• Asian-Australasian Journal of Animal Sciences
• /
• 제28권9호
• /
• pp.1362-1370
• /
• 2015

This study was performed to investigate the effect of different levels of dietary crude protein (CP) on composition of odorous compounds and bacterial communities in pig manure. A total of 48 male pigs (average initial body weight 45 kg) fed diets containing three levels of dietary CP (20%, 17.5%, and 15%) and their slurry samples were collected from the pits under the floor every week for one month. Changes in composition of odorous compounds and bacterial communities were analyzed by gas chromatography and 454 FLX titanium pyrosequencing systems, respectively. Levels of phenols, indoles, short chain fatty acid and branched chain fatty acid were lowest (p<0.05) in CP 15% group among three CP levels. Relative abundance of Bacteroidetes phylum and bacterial genera including Leuconostoc, Bacillus, Atopostipes, Peptonphilus, Ruminococcaceae_uc, Bacteroides, and Pseudomonas was lower (p<0.05) in CP 15% than in CP 20% group. There was a positive correlation (p<0.05) between odorous compounds and bacterial genera: phenol, indole, iso-butyric acid, and iso-valeric acid with Atopostipes, p-cresol and skatole with Bacteroides, acetic acid and butyric acid with AM982595_g of Porphyromonadaceae family, and propionic acid with Tissierella. Taken together, administration of 15% CP showed less production of odorous compounds than 20% CP group and this result might be associated with the changes in bacterial communities especially whose roles in protein metabolism.

• Fibers and Polymers
• /
• 제4권2호
• /
• pp.66-70
• /
• 2003

Temporarily solubilized azo disperse dyes based on 1,2-substituted indoles were synthesized and characterized. Dispersant-free dyeing of polyester by using the synthesized dyes has been investigated. The colour yields of the dyes on the polyester fabric were found to be highly dependent on the dyeing pH, optimum results being obtained at pH 5. The dyes exhibited good to excellent fastness properties on polyester while lightfastness was moderate.

• Bulletin of the Korean Chemical Society
• /
• 제26권12호
• /
• pp.1962-1964
• /
• 2005

Zirconium(IV) chloride is found to be an efficient catalyst for the electrophilic addition reaction of indole with aldehydes/ketones to afford the corresponding bis(indolyl methanes in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles and simple experimental and work-up procedures.

• 약학회지
• /
• 제23권3_4호
• /
• pp.187-189
• /
• 1979

A new method for the synthesis of azido and thiocyanatoindoles by iodine and sodium azide or sodium thiocyanate in acetonitile at room temperature or 60.deg.C was found. Azidoindoles (3-azido-3-methyl -2-phenylindolenine, 3-azido-2,3-diphenylindolenine, 2-azidomethyl-3-metbylindole and 1-azido-1,2,3,4-tetrahyrocarbazole) and thiocyanatoindoles(3-thiocyanatoindole, 2-phenyl-3-thiocyanato indole, 3-methyl-2-phenyl-6-thiocyanatoindole and 2, 3-diphenyl-6-thiocyanatoindole) were prepared by this method in good yields.