• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.215-222
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• 2020

Metformin is a recommended first-line therapy drug for type 2 diabetes patients. However, compared to other oral antidiabetic drugs (OAD), metformin has a large unit dosage, with bioavailability of 40-60%. This limiting bioavailability is because metformin is absorbed only in the upper gastrointestinal tract as a BCS class 3 drug. Hence, we propose that applying the Gastroretentive Drug Delivery System (GRDDS) and extending drug release time in the stomach will result in improved bioavailability. We selected the swelling type delivery system, as it is considered the most stable gastroretention technology compared to other GRDDSs. We modified the swelling excipient by using a natural swelling excipient to form a swelling tablet made of carrageenan and hydroxypropyl methylcellulose (HPMC). Our results indicate that the swelling complex tablet made of carrageenan and HPMC has a good swelling ability and shows required sustained release in a dissolution pattern. In addition, the carrageenan complex has a better swelling ability than the marketed metformin tablet, as determined by the ratio, (swelling ability)/(excipient weight). Taken together, our results indicate that the carrageenan complex can be developed as a good swelling excipient. Further optimizations are required for the commercialization of the carrageenan complex.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.8
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• pp.1107-1115
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• 2009

The strengthened regulations for atmospheric emissions from ships like MARPOL Annex VI have caused a necessity of new, alternative power system in ships for the low pollutant emissions and the high energy efficiency. This paper attempts to investigate the configuration of SOFC/GT hybrid power system for marine applications like LNG tanker and to analyze the influence of design parameters on the system performance. The simulation results provide the basic data for the design and efficiency improvement of SOFC/GT hybrid system and indicate the guidelines for the safe system operation.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.56 no.2
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• pp.83-93
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• 2020

In fisheries, the importance of designing efficient fish cages is being emphasized as aquaculture has become more production than capture fishing. Particularly, the gravity cage system is one of the popular fish cage system in Korea. Currently, gravity cages of various shapes and sizes are being widely designed and installed in offshore and inland seas. The cage is subject to external forces, such as currents and waves, and the shape of the structure and tension on the ropes changes according to these external forces. Thus, it is important to accurately calculate these dynamic behavior, including the external forces and tension on the structure during the design stage. In this study, three types of cage systems with an equal internal volume of 8000 ㎥ were analyzed using mass-spring models and their behavior was interpreted through simulations. These simulations were used to analyze the behavior and tension of the ropes in response to currents and waves to aid in the selection of individual cage sizes for a given total volume. The numerical calculation results indicate that depending on the flow rate, the most resistant system is System 1, which has eight strays, and System 2 and System 3 have 69.4% and 54.8% of the resistance of System 1. Further, total resistance increased as the number of cages increased for all flow rates.

• Smart Structures and Systems
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• v.25 no.6
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• pp.719-732
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• 2020

Real-time hybrid simulation (RTHS) which combines physical experiment with numerical simulation is an advanced method to investigate dynamic responses of structures subjected to earthquake excitation. The desired displacement computed from the numerical substructure is applied to the experimental substructure by a servo-hydraulic actuator in real time. However, the magnitude decay and phase delay resulted from the dynamics of the servo-hydraulic system affect the accuracy and stability of a RTHS. In this study, a robust stability analysis procedure for a general single-degree-of-freedom structure is proposed which considers the uncertainty of servo-hydraulic system dynamics. For discussion purposes, the experimental substructure is a portion of the entire structure in terms of a ratio of stiffness, mass, and damping, respectively. The dynamics of the servo-hydraulic system is represented by a multiplicative uncertainty model which is based on a nominal system and a weight function. The nominal system can be obtained by conducting system identification prior to the RTHS. A first-order weight function formulation is proposed which needs to cover the worst possible uncertainty envelope over the frequency range of interest. Then, the Nyquist plot of the perturbed system is adopted to determine the robust stability margin of the RTHS. In addition, three common delay compensation methods are applied to the RTHS loop to investigate the effect of delay compensation on the robust stability. Numerical simulation and experimental validation results indicate that the proposed procedure is able to obtain a robust stability margin in terms of mass, damping, and stiffness ratio which provides a simple and conservative approach to assess the stability of a RTHS before it is conducted.

• Journal of Korean Society of Disaster and Security
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• v.16 no.3
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• pp.45-56
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• 2023

In this study, the application of ANC (Active Noise Control) technology to address inter-floor noise was explored. To achieve this, an ANC system was developed to manage the heavy impact sound within the frequency range of 40 to 500 Hz. The ANC system utilized an adaptive filter employing a feedforward approach based on the Fx-LMS algorithm. To set up the ANC system, a comprehensive analysis of various variables within the system was performed using computational simulations. This process enabled the identification of optimal filter settings and system configuration arrangements. In addition, the ANC system was implemented in the inter-floor noise test room at the Korea Conformity Laboratories (KCL). Through a certified standard testing procedure, it was confirmed that the ANC system led to a 4 dB reduction in inter-floor noise when the system was activated compared to when it was turned off. The results of this study indicate that the developed ANC system has an effect significant enough to elevate the rating criteria by one level for heavy impact sound.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.6
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• pp.909-914
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• 2008

A coupling capacitor voltage transformer(CCVT) is used in an extra or ultra high voltage system to obtain the standard low voltage signal for protection. To avoid the phase angle error between the primary and secondary voltages, a tuning reactor is connected between a capacitor and a voltage transformer. The inductance of the reactor is designed based on the power system frequency. If a fault occurs on the power system, the secondary voltage of the CCVT contains some errors due to a dc offset component and harmonic components resulting from the fault. The errors become severe in the case of a close-in fault. This paper proposes an algorithm for compensating the secondary voltage of a CCVT in the time-domain. From the measured secondary voltage of the CCVT, the secondary and primary currents are obtained; then the voltage across the capacitor and the inductor is calculated and then added to the measured secondary voltage to obtain the correct primary voltage. Test results indicate that the proposed algorithm can compensate the distorted secondary voltage of the CCVT irrespective of the fault distance, the fault inception angle, and the burden of the CCVT.

• Economic and Environmental Geology
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• v.30 no.6
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• pp.531-541
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• 1997

Unconsolidated sediments of Youngjong Island were investigated to consider the vertical distribution of clay minerals and their origin. At least three sedimentation units can be recognized by color, magnetic susceptibility, and pH. X-ray diffraction analysis of clay size fraction reveals that illite is the most abundant phase (52.06%), and chlorite (27.16%), kaolinite (16.92%), smectite (3.86%) occur next to it. Detailed XRD study suggests that illitic materials contain fairly large amount of ordinary muscovite derived from the mica schist in Youngjong Island and adjacent area. The relative amount of kaolinite and chlorite is less than those of samples from estuary mouth of several rivers that flow to Yellow Sea and South Sea. Especially smectite content of the present sample is much higher than those of estuary sediments. These indicate that the unconsolidated sediments of tidal-flat deposit in Youngjong Island are largely affected by marine influence and partly affected by sediment in influx from China. However, some degree of source of this unconsolidated sediments is inland origin from adjacent estuary sediment and in situ or nearby weathered materials.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.10
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• pp.1482-1486
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• 2003

In order to compare effects of feeding systems on rumen fermentation characteristics and nutrient digestion, steers were fed either total mixed ration (TMR) or separate concentrate-roughage ration (CR). Total tract digestibility of nutrients was higher in steers receiving TMR. Especially, DM, ADF and NDF in TMR were digested to a greater extent than those in CR. Rumen pH was not influenced by the feeding systems. Holstein steers on TMR had higher ruminal $NH_3$-N than those on CR. Feeding system did not alter VFA production but TMR feeding resulted in lower A/P ratio. TMR feeding tended to increase the number of bacteria and protozoa in the rumen fluid. Also steers fed TMR generally had higher fiber degrading enzyme activities, which might be the result of increased number of cellulolytic microbes in the rumen of animals on TMR. Our results indicate that TMR may provide more favorable condition for nutrient digestion both in the rumen and in the total tract of steers.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.9
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• pp.1328-1333
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• 2009

To evaluate different housing systems, 80 gilts were randomly allocated at puberty to four treatments: i) sow stall in gestation followed by farrowing crate (SC), ii) group housing with individual feeding in gestation followed by farrowing crate (GC), iii) ESF (Electronic Sow Feeding) system in gestation followed by farrowing crate (EC), and iv) ESF system followed by group farrowing pen (EG). The results showed that stalled sows had a longer interval between puberty and second estrus (p<0.001). The sows kept in the ESF system gained more body weight (p<0.01) and backfat (p<0.05) prior to service, and more backfat during gestation (p<0.05), but also had greater backfat losses in the subsequent lactation (p<0.01). Sows changing from loose housing to confinement at farrowing had longer gestation length (p<0.001). Total litter size did not differ significantly between gestation treatments, but the number of stillborn piglets was significantly higher in the SC treatment (p<0.01). After weaning, SC sows had the longest interval for rebreeding (p<0.001). Some EG sows came into heat before weaning, giving this treatment the shortest interval. These results indicate that gestation confinement in sow stalls had several detrimental effects on sow performance relative to group housing.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.04a
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• pp.423-430
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• 2004

A new active neuro-control strategy for seismic response reduction using modal states is proposed. In order to apply the neuro-control strategy to the given structural system it is needed to select state variables used as inputs into the neural network. If the degrees of freedom of the analytical model is large, there are so many possible combinations of the state variables. And selecting state variables is very complicated and troublesome task for the designer. In order to avoid this problem, the proposed control system adopts modal states as inputs. Since the modal states contain the information of the whole structural system's behavior, it is proper to use modal states as inputs of the neuro-controller. The simulation results show that the proposed the proposed active neuro-control strategy is quite effective to reduce seismic responses. In addition, the consuming time for training proposed neuro-controller is quite shorter than that for the conventional neuro- controller. The results of this investigation, therefore, indicate that the proposed active neuro-control strategy using modal states as the inputs could be effectively used for control seismically excited structures.