• 제목/요약/키워드: Index n

검색결과 3,516건 처리시간 0.034초

Modification of the TNM Staging System for Stage II/III Gastric Cancer Based on a Prognostic Single Patient Classifier Algorithm

  • Choi, Yoon Young;Jang, Eunji;Seo, Won Jun;Son, Taeil;Kim, Hyoung-Il;Kim, Hyeseon;Hyung, Woo Jin;Huh, Yong-Min;Noh, Sung Hoon;Cheong, Jae-Ho
    • Journal of Gastric Cancer
    • /
    • 제18권2호
    • /
    • pp.142-151
    • /
    • 2018
  • Purpose: The modification of the cancer classification system aimed to improve the classical anatomy-based tumor, node, metastasis (TNM) staging by considering tumor biology, which is associated with patient prognosis, because such information provides additional precision and flexibility. Materials and Methods: We previously developed an mRNA expression-based single patient classifier (SPC) algorithm that could predict the prognosis of patients with stage II/III gastric cancer. We also validated its utilization in clinical settings. The prognostic single patient classifier (pSPC) differentiates based on 3 prognostic groups (low-, intermediate-, and high-risk), and these groups were considered as independent prognostic factors along with TNM stages. We evaluated whether the modified TNM staging system based on the pSPC has a better prognostic performance than the TNM 8th edition staging system. The data of 652 patients who underwent gastrectomy with curative intent for gastric cancer between 2000 and 2004 were evaluated. Furthermore, 2 other cohorts (n=307 and 625) from a previous study were assessed. Thus, 1,584 patients were included in the analysis. To modify the TNM staging system, one-grade down-staging was applied to low-risk patients according to the pSPC in the TNM 8th edition staging system; for intermediate- and high-risk groups, the modified TNM and TNM 8th edition staging systems were identical. Results: Among the 1,584 patients, 187 (11.8%), 664 (41.9%), and 733 (46.3%) were classified into the low-, intermediate-, and high-risk groups, respectively, according to the pSPC. pSPC prognoses and survival curves of the overall population were well stratified, and the TNM stage-adjusted hazard ratios of the intermediate- and high-risk groups were 1.96 (95% confidence interval [CI], 1.41-2.72; P<0.001) and 2.54 (95% CI, 1.84-3.50; P<0.001), respectively. Using Harrell's C-index, the prognostic performance of the modified TNM system was evaluated, and the results showed that its prognostic performance was better than that of the TNM 8th edition staging system in terms of overall survival (0.635 vs. 0.620, P<0.001). Conclusions: The pSPC-modified TNM staging is an alternative staging system for stage II/III gastric cancer.

중환자실로 입원한 폐결핵 환자의 임상 양상과 예후 인자 (Clinical Characteristics and Prognostic Factors in Patients with Pulmonary Tuberculosis Admitted to Intensive Care Units)

  • 강지영;김명숙;김주상;강현희;김승수;김용현;김진우;이상학;김석찬;문화식
    • Tuberculosis and Respiratory Diseases
    • /
    • 제68권5호
    • /
    • pp.259-266
    • /
    • 2010
  • Background: Pulmonary tuberculosis (TB), requiring the intensive care unit (ICU) care, has been a high-mortality condition until now. In the present study, we aimed to investigate clinical features and parameters associated with TB mortality. Methods: From August 2003 to December 2008, patients with microbiologically or histologically confirmed pulmonary TB then admitted to the ICU, were retrospectively enrolled into the study. Upon enrollment, their medical records were reviewed. Results: Forty three patients (30 males, 13 females) were included and their mean age was 63.8 years (range: 17~87 years). Twelve patients died, an overall in-hospital mortality of 27.8%. The main reason for the ICU care was dyspnea or hypoxemia requiring mechanical ventilation (n=17). Other diagnoses for ICU care were hemoptysis, monitoring after procedures, neurologic dysfunction, shock, and gastrointestinal bleeding. On univariate analysis, the factors affecting the mortality were malnutrition-related parameters including low body mass index, hypoalbuminemia, lymphocytopenia, and hypocholersterolemia, as well as severity-related variables such as high acute physiology and chronic health evaluation (APACHE) score, number of involved lobes, and high C-reactive protein. In addition, respiratory failure requiring mechanical ventilation and acute respiratory distress syndrome contributed to patient fatality. It was shown on multivariate analysis that respiratory failure and hypoalbuminemia were significantly independent variables associated with the mortality. Conclusion: Acute respiratory failure is the most common reason for the ICU care and also the most important factor in predicting poor outcome. In addition, our data suggest that the parameters associated with malnutrition could be possible factors contributing to mortality.

동해안 석호의 육수학적 조사(1): 청초호 (The Limnological Survey of Lagoons in the Eastern Coast of Korea (1): Lake Chungcho)

  • 이상균;권상용;김동진;김범철;허우명
    • 생태와환경
    • /
    • 제34권3호통권95호
    • /
    • pp.206-214
    • /
    • 2001
  • 1998년부터 2000년까지 겨울 결빙기를 제외한 청초호의 수질 및 영양상태의 판정결과 부영양화가 심각한 것으로 조사되었다. 투명도는 0.4${\sim}$1.3 m로 비교적 낮은 값을 보였으며, COD농포는 전 조사지점에서 $3.0{\pm}1.0\;mgO_2/L$이었다. 염분은 $29.3{\pm}5.5\;ppt$로 매우 높았으며, 수심 약 0.5${\sim}$l.5 m에서 염분에 의한 화학성층(chemocline)이 형성되어 심층에 산소공급이 제한되었다. 또한 표층보다 심층수의 수온이 높은 수온역전현상이 관찰되기도 하였다. 표층수의 총인은 0.048${\sim}$0.253 mgP/L, 총질소는 0.9${\sim}$2.4 mgN/L의 범위로 나타났으며, 청초호에서의 TN/TP 비는 대체적으로 20 이하로 질소가 수중 생물의 성장과 생성에 제한 요소로 작용할수도 있음을 시사하였다. 그러나 일반적으로 인과 질소의 농도가 높게 유지되어 총질소와 총인의 비로서 제한 요소를 파악하는 것은 무리가 따르는 것으로 판단된다. 유입수가 유입되는 정점 1보다는 해수의 영향이 많은 연안으로 갈수록 점차 TN/TP비가 감소하여 해수의 영향이 클수록 인함량에 대한 질소함량비가 상대적으로 감소하는 것으로 사료된다. 조사기간 식물플랑크톤의 경우는 연중 녹조류인 Microspora sp.가 우점하였으며, 식물플랑크톤에의한 Chl. a값은 매년 감소하는 반면 부유물질의 농도는 점차 증가하여 무기현탁물의 부유물질에 대한 기여도가 점차 증가하고 있음을 알 수 있다. 청초호의 엽록소 a농도는 각 정점 평균 $14.0{\pm}25.0\;mg/m^3$으로 나타나 U.S.EPA 기준으로 볼 때 부영양호로 분류되며, 여름 성장기엽록소 a, 투명도,및 총인의 평균치를 이용한 부영양화도지수 (TSI)도 평균 59${\sim}$77로 부영양 상태로 나타났다.

  • PDF

장안산과 팔공산 구간(전북 장수)의 식물상 및 보전관리방안 (Conservation Management Methods and Vascular Plants of the Trail from Jangansan to Palgongsan, Jangsu, Jeonbuk)

  • 오현경;한윤희;박경욱
    • 한국환경복원기술학회지
    • /
    • 제16권1호
    • /
    • pp.227-244
    • /
    • 2013
  • The vascular plants in the trail from Jangansan to Palgongsan were listed 389 taxa (8.0% of all 4,881 taxa of Korean vascular plants); 84 families, 226 genera, 325 species, 1 subspecies, 55 varieties and 8 forms. Furthermore, hemicryptophytes (H) were 110 taxa (28.3%), geophytes (G) were 77 taxa (19.8%), megaphanerophytes (MM) were 48 taxa (12.3%), nanophanerophytes (N) were 47 taxa (12.1%) showed high proportional ratio in life form. So, resource plants of 237 taxa of edible (60.9%), 278 taxa of medicinal (71.5%), 229 taxa of ornamental (58.9%) and 178 taxa of the others (45.8%). Based on the list of rare plants, 7 taxa (1.8% of all 389 taxa of flora and 1.2% of all 571 taxa of rare plants); Paeonia japonica (VU), Viola albida, Viola diamantica, Lilium distichum, Disporum ovale, Tricyrtis dilatata, Iris ensata var. spontanea (LC), etc. Based on the list of endemic plants, 7 taxa (1.8% of all 389 taxa of flora and 2.1% of all 328 taxa of endemic plants); Salix koriyanagi, Aconitum pseudolaeve var. erectum, Thalictrum actaefolium var. brevistylum, Philadelphus schrenckii, Asperula lasiantha, Weigela subsessilis, Carex okamotoi, etc. Based on the list of specific plants, 46 taxa (11.8% of all 389 taxa of flora and 4.3% of all 1,071 taxa of specific plants); 2 taxa (Wisteria floribunda for. floribunda, Cardamine yezoensis, etc.) in class IV, 6 taxa (Acer palmatum, Ulmus davidiana, etc.) in class III, 14 taxa (Ligularia fischeri, Cymopterus melanotilingia, etc.) in class II, 24 taxa (Ilex macropoda, Fraxinus mandshurica, etc.) in class I. Based on the list of naturalized plants, 6 families, 16 genera, 18 taxa (Phytolacca americana, Robinia pseudoacacia, Oenothera odorata, Erechtites hieracifolia, Festuca arundinacea, etc.) and invasive alien plants were 3 taxa; Rumex acetocella, Ambrosia artemisiifolia, Aster pilosus. Naturalization rate (NR) was 4.6% of all 389 taxa of vascular plants and urbanization index (UI) was 5.6% of all 321 taxa of naturalized plants.

한국인 제2형 당뇨병 환자를 위한 칼로리별 표준식단 적용효과 (Application Effect in Standard Diet by Calorie for Korean Type 2 Diabetic Patients)

  • 심기현;한영실
    • 한국식품조리과학회지
    • /
    • 제21권1호
    • /
    • pp.64-74
    • /
    • 2005
  • To develop the diet for Korean type 2 diabetic patients, a consumer survey was conducted (N=35) and was analyzed statistically. The survey compared the results of a questionnaire, somatometry, and blood parameters before and 8 weeks after the experiment. It was divided into Diabetic diet enforcement group (DDE) vs. Non diabetic diet enforcement group (NDDE). There was no significant difference in body weight, body mass index (BMI), body fat, triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the subjects before and 8 weeks after the experiment. DDE's average fasting glucose (FBG) and post prandial 2 hours blood glucose (PP2) were significantly decreased before and after the experiment (p<0.05). NDDE's average FBG and PP2 showed no significant difference. In terms of Hemoglobin $A_lC\;(HbA_1C)$ content, DDE's had significantly decreased level both before and after the experiment (p<0.05), while there was no significant difference in the NDDE group. Cholesterol and High density lipoprotein cholesterol (HDL-C) were significantly different in DDE (p<0.05) both before and after the experiment. Whereas in the case of NDDE, there was no significant difference on the cholesterol and HDL-C, while DDE's showed a significant difference before and after the experiment. In terms of patients distribution depending on their treatment (p<0.05), NDDE had no significant difference before and after the experiment. For an item asking blood glucose control, DDE had significant difference before and after the experiment (p<0.01), while NDDE had no significant difference. For program satisfaction (p<0.05) and health (p<0.001), both the groups changed significantly after the experiment. But there was no significant difference in applying it to their real life after the experiment. Based on these results, DDE had the decreased blood glucose levels, $HbA_1C$, and cholesterol and increased HDL-C, with decreased rate of the patients taking oral hypoglycemic agents. In addition, many of the patients who participated in the experiment were found to be satisfied with the program, in terms of having less trouble in glucose control and exhibited improvement in health. Hence, based on the above results it was concluded that program was a very successful one for the treatment of diabetes.

사방공작물의 시공이 저서성대형무척추동물의 군집구조 및 섭식기능군에 미치는 영향 (Effects of Debris Barrier on Community Structure and Functional Feeding Groups of the Benthic Macroinvertebrate)

  • 서준표;이헌호
    • 한국산림과학회지
    • /
    • 제101권3호
    • /
    • pp.480-487
    • /
    • 2012
  • 본 연구는 산지계류에 시공한 사방공작물이 저서성대형무척추동물상에 미치는 영향을 밝히기 위하여 실시하였다. 연구대상지는 상시유수가 흐르는 양호한 수질환경을 가진 김천지역의 산지계류 1개소를 선정하였으며, 현장조사는 2009년 2월부터 2010년 10월까지 총 6회에 걸쳐 사방시설물 시공 전후를 기준으로 실시하였다. 그 결과, 저서성대형무척추동물상은 시공 전 1차 조사에서 총 4문 4강 9목 22과 36종이 나타났으나, 시공 후 6차 조사에서 2문2강 7목 18과 30종으로 다소 감소하였다. E.P.T 분류군(종, 개체수)의 점유비율은 시공 전에는 하루살이목(50.0%, 85.0%), 날도래목(35.3%, 10.0%), 강도래목(14.8%, 5.0%)의 크기 순으로 나타났으며, 시공 후에는 날도래목(50.3%, 68.0%), 하루살이목(42.1%, 29.4%), 강도래목(7.5%, 2.7%)의 크기 순으로 변화하였다. 다양도지수, 풍부도지수, 균등도 지수, 우점도지수는 사방시설물 시공 직후 2차 조사에서 모두 나쁘게 나타났으나, 이후 시간이 경과될수록 각 지수들의 값이 다시 좋아지는 경향을 보였다. 섭식기능군은 시공 전 GC군이 60.7%로 가장 높았고, 시공 후 SC(53.1%), FC(35.4%)군이 급증하였으며, 3차 조사부터 안정화 되어가는 양상을 보였다. 본 연구결과, 대부분의 사방공작물은 시공직후에 계류의 저서성대형무척추동물상에 크게 영향을 미치는 것으로 나타났으나, 약 18개월이 경과한 후에 점차 원래의 모습으로 안정화 되어가는 것으로 나타났다.

사방댐 준설이 저서성 대형무척추동물 군집에 미치는 영향 (The Influence of Sediment Control Dam Dredging on Benthic Macroinvertebrate Communities of Mountain Stream)

  • 김봉성;이창우;서을원;이종은
    • 한국산림과학회지
    • /
    • 제101권3호
    • /
    • pp.454-460
    • /
    • 2012
  • 본 연구는 사방댐의 준설이 저서성 대형무척추동물 군집에 미치는 영향을 파악하기 위해 경북북부지역 예천, 영주, 봉화의 산간계류에 위치한 사방댐을 대상으로 준설 전 후로 조사하였다. 조사는 실험수계 3곳과 대조수계 2곳의 사방댐을 기준으로 상류와 하류로 설정하여 2011년 5월부터 8월까지 이루어졌다. 실험수계에서 준설 전 4문 6강 11목 31과 56종이 출현하였으나, 준설 후 4문 5강 10목 27과 51종으로 감소하였다. 이와 같이 사방댐 준설후 발생한 저서성 대형무척추동물의 미소서식처 파괴는 종수 및 개체수의 감소로 이어졌으며, 특히 실험수계의 상류지점에서는 종수가 평균 38% 감소하였다. 전반적으로 준설 후 실험수계에서 종풍부도지수와 종다양도지수가 감소했지만, 우점도지수는 증가하였다. 실험수계의 상류지점에서 미소서식처의 파괴와 정수역이 형성되었으며, 유속이 감소하고 하상구조는 모래나 실트로 단순해졌다. 그에 따라 상류지점의 섭식기능군과 서식기능군의 종조성은 단순해졌으며, 상 하류 군집의 차이가 커졌다. 또한 상류지점에서는 유속이 느리거나 정수역을 선호하는 깔따구류(Chironomidae spp.), 부채장수잠자리류(Gomphidae spp.), 하루살이류(Ephemeridae spp.)의 개체수 비율이 크게 증가하였으며, 군집의 균형성을 나타내는 EPT/C 지수가 감소하였다.

갈수기와 홍수기의 김해 딴섬지역 지하수의 지구화학 특성 (Geochemical Characteristics of Groundwater for Dry and Rainy Seasons in Ddan-sum Island)

  • 김규범;전항탁;신선호;박준형
    • 한국지반환경공학회 논문집
    • /
    • 제13권9호
    • /
    • pp.31-44
    • /
    • 2012
  • 김해 딴섬 지역 지하수는 갈수기와 홍수기의 계절에 따른 지구화학 특성의 변화를 보인다. 농번기인 4월의 이온의 공간적 분포를 보면 $Fe^{2+}$, Fe(total), $Mn^{2+}$, $Ca^{2+}$, $Mg^{2+}$, $SiO_2$, ${HCO_3}^-$${NO_3}^-$는 딴섬의 중앙부에서 높고 $Na^+$$K^+$는 딴섬 중앙부가 낮은값을 보이는데 높은 ${HCO_3}^-$${NO_3}^-$는 딸기 재배용 비료에 의한 오염을 지시한다. 4월에 비하여 8월의 이온 농도의 지역별 편차가 적고 비료 등에 의한 인위적인 영향이 적어 강우에 의한 계절적 요인이 나타난다. 지하수의 수질 유형을 보면, 딴섬 중앙부는 함양 특성을 부분적으로 보이며 외곽부는 하천수와 상호 혼합되는 특성을 보여준다. Fe 및 Mn 이온 종에 대한 포화지수 계산결과, Fe의 광물종인 적철석, 침철석은 모두 과포화상태에 있어서 침전 가능한 상태이며, 능철석과 $Fe(OH)_3$, 일부는 불포화 상태로써 용존 이온상태로 존재할 가능성이 있다. Mn의 광물종인 능망간석은 불포화상태 및 과포화상태가 공존하며, 수망간석, 연망간석 및 수산화망 간석은 불포화상태로써 용존 이온 상태로 존재할 가능성이 크다.

Relative Genetic Effects of Duroc and Taoyuan Breeds on the Economic Traits of Their Hybrids

  • Yen, N.T.;Tai, C.;Cheng, Y.S.;Huang, M.C.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제14권4호
    • /
    • pp.447-454
    • /
    • 2001
  • For determining the relative genetic effects of Duroc (D) and Taoyuan (T) breeds on the economic traits of their hybrids, 72 litters of pigs, from four mating types, namely TT (T♂$\times$T♀), DD (D♂$\times$D♀) and D-T hybrids (TD, T♂$\times$D♀ and DT, D♂$\times$T♀) were used in this study. The various crossbreeding parameters were estimated by comparisons among mating types using linear contrasts of least-square analysis. The results of reproductive traits analysis showed that T breed had contributed superior genetic effects on the total number of piglets at birth (TBN) (p<0.10) and number of live piglets at 21 days (LP21) (p<0.05) to the D-T hybrids. Estimates of maternal genetic effects showed that the T females were superior in TBN (p<0.05), but inferior in average birth weight (ABW) and average litter birth weight (LBW) (p<0.01) to the D females. Direct heterosis effects were significant for LBW, LP21 and LWT21 (p<0.01). Least-squares analysis of other economic traits showed that T breed had relative negative effects on all growth traits, withers height (WH), body type index (BTI), average backfat thickness (ABF), carcass length (LENG), loin eye area (longissimus) (LEARA), and lean percentage (LEAN) of D-T hybrids (p<0.05). Estimates of direct genetic effects showed that the D breed was superior to the T breed in all growth and carcass traits except the average backfat (BF). Estimates of maternal genetic effects showed that average body weight at 180 days (WT180) of progenies from T sows were lighter than from D sows. Progenies from D females had larger and leaner carcass than those from T females. Direct heterosis effects were significant for average daily weight gains from 150 to 180 days ($ADG_{150-180}$) (p<0.05) and for average body weights at 150 (WT150), and 180 days (WT180), average daily weight gains from birth to 150 and 180 days ($ADG_{150}$ and $ADG_{180}$, respectively), WH, body length (BL), ABF, BTI, and LENG (p<0.01). The results showed that D-T hybrids tended to have superior TBN and LP21 than D breed, and to be superior in all growth and most conformation and carcass traits to the T breed.

Effect of Xylanase on Performance and Apparent Metabolisable Energy in Starter Broilers Fed Diets Containing One Maize Variety Harvested in Different Regions of China

  • O'Neill, H.V. Masey;Liu, N.;Wang, J.P.;Diallo, A.;Hill, S.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제25권4호
    • /
    • pp.515-523
    • /
    • 2012
  • The objective of this study was to investigate the variability in broiler performance, apparent metabolisable energy (AME) and ileal digestible energy (IDE) between five different maize samples fed with and without xylanase at 16,000 U/kg. Various in vitro characterisations were conducted to determine if any could predict performance or AME. Samples of the maize were harvested in five diverse regions and fed individually in a mash diet as follows (g/kg): test maize 608.3; soya bean meal (SBM) 324.1; poultry fat 25.2; salt 4.6; met 2.6; lys 1.6; thr 0.5; limestone 9.7, dical 18.4; vit/min 5.0; CP 210 and ME (kcal/kg) 3,085. The diets were fed to 720 broilers with 6 replicates, each containing 12 birds per treatment, from 0 to 18 d of age. Maize samples were analysed for starch, protein, crude fibre, fat, protein solubility index (PSI) and vitreousness using near infra red reflectance spectroscopy (NIR). They were also assayed using an in vitro starch digestibility method. The results showed that there was no effect of harvest region on the feed intake (FI), body weight gain (BWG) or feed conversion ratio (FCR) of the broilers over the 18 d period (p = 0.959, 0.926, 0.819 respectively). There was an improvement in all parameters with the addition of xylanase (FI p = 0.011; BWG and FCR p<0.001). There was a significant positive effect of xylanase on IDE, AME, IDE Intake (IDEI) and AME intake (AMEI) (p<0.0001 in all cases). Although there was no significant effect of maize source, there was a strong trend towards variability in IDE (p = 0.066) and AME (p = 0.058). There were no significant correlations (p<0.05) between any proximate or physiochemical values and any performance or AME values. This may suggest that none of those selected were suitable predictors for performance or AME. The broilers performed well according to the breed guidelines, with slightly increased FI, increased BWG and similar FCR prior to the addition of xylanase. When FCR and BWG were analysed with FI as a covariate, xylanase addition remained significant suggesting that the improvement in BWG and FCR was driven by an increase in digestibility and nutrient availability.