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Combined effects of dietary zinc at 3 years of age and obesity at 7 years of age on the serum uric acid levels of Korean children

  • Lee, Sung Hee;Lee, Hye Ah;Park, Eun Ae;Cho, Su Jin;Oh, Se Young;Park, Bohyun;Park, Hyesook
    • Nutrition Research and Practice
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    • v.14 no.4
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    • pp.365-373
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    • 2020
  • BACKGROUND/OBJECTIVES: To assess the longitudinal associations of the antioxidant capacity of zinc and body mass index (BMI) with serum uric acid (SUA) in South Korean children. SUBJECTS/METHODS: Using follow-up data from the Ewha Birth and Growth Cohort, we included subjects who were seen at 3 and 7 years of age (n = 183; 90 boys, 93 girls). Daily zinc intake and BMI were assessed at 3 and 7 years of age. SUA measured at 7 years was used as the outcome variable. Using a general linear model, the effects of dietary zinc intake and BMI on SUA were assessed. We also assessed the combined effect of early dietary zinc intake and BMI on SUA in children. RESULTS: The dietary zinc intake at 3 years of age was negatively correlated (ρ = -0.18, P = 0.04), whereas the BMI at 7 years of age was positively correlated (r = 0.18, P = 0.01), with the SUA level at 7 years of age. The dietary zinc intake level at 3 years of age and the BMI level at 7 years of age were, together, significantly related to SUA in children at 7 years of age. SUA was lower in group 1 (normal-weight, high-zinc group) than in the other two groups (group 2: normal-weight, low-zinc and overweight, high-zinc group; and group 3: overweight, low-zinc group). Our results demonstrate the combined effect of zinc intake and BMI on SUA. The combined association remained significant in both the crude and adjusted models (P < 0.01). CONCLUSIONS: SUA was related to combined BMI and dietary zinc intake, and increased zinc intake and normal body weight had a beneficial effect on reducing SUA in children.

Efficient Multi-Step k-NN Search Methods Using Multidimensional Indexes in Large Databases (대용량 데이터베이스에서 다차원 인덱스를 사용한 효율적인 다단계 k-NN 검색)

  • Lee, Sanghun;Kim, Bum-Soo;Choi, Mi-Jung;Moon, Yang-Sae
    • Journal of KIISE
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    • v.42 no.2
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    • pp.242-254
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    • 2015
  • In this paper, we address the problem of improving the performance of multi-step k-NN search using multi-dimensional indexes. Due to information loss by lower-dimensional transformations, existing multi-step k-NN search solutions produce a large tolerance (i.e., a large search range), and thus, incur a large number of candidates, which are retrieved by a range query. Those many candidates lead to overwhelming I/O and CPU overheads in the postprocessing step. To overcome this problem, we propose two efficient solutions that improve the search performance by reducing the tolerance of a range query, and accordingly, reducing the number of candidates. First, we propose a tolerance reduction-based (approximate) solution that forcibly decreases the tolerance, which is determined by a k-NN query on the index, by the average ratio of high- and low-dimensional distances. Second, we propose a coefficient control-based (exact) solution that uses c k instead of k in a k-NN query to obtain a tigher tolerance and performs a range query using this tigher tolerance. Experimental results show that the proposed solutions significantly reduce the number of candidates, and accordingly, improve the search performance in comparison with the existing multi-step k-NN solution.

Supplementary Effects of Black Rice (Oryza sativa L.) Aleurone Layer Extract on Body Fat, Serum Lipid, and Serum Hormone Levels in Ovariectomized Rats (흑미 호분층 추출물의 급여가 난소절제 흰쥐의 체내 지방, 혈중 지질 및 관련 호르몬 수준에 미치는 영향)

  • Choi, Bong-Kyoum;Nam, Song-Yee;Lee, Young-Min;Kim, Jung-Bong;Choe, Jeong-sook;Lee, Hae-Jeung;Lee, Sung-Joon;Lee, Sung-Hyen
    • The Journal of the Korea Contents Association
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    • v.15 no.9
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    • pp.599-605
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    • 2015
  • This study was conducted to evaluate suppressive effects of black rice aleurone layer extract (BRE) on body fat, serum lipid, and hormone levels in ovariectomized rats. The rats were divided into five groups (n=8/group): sham operated group (S); ovariectomized control group (OVX); ovariectomized group treated with isoflavone 10 mg/kg B.W. (IF); ovariectomized group treated with BRE 30 or 90mg/kg B.W. (BRE-30 or -90). High fat diet (45% calories from fat) was fed to all rats for 12 weeks. Body weight gain, body fat weight, and adiposity index increased in the OVX group, but they significantly decreased in IF or BRE supplementation. Serum triacylglycerol and leptin levels decreased in BRE groups while serum adiponectin level significantly increased compared to that of the OVX group. Hepatic total lipid, triglyceride, and cholesterol levels increased in the OVX group, but they decreased in BRE supplementation (p>0.05). These data suggest that black rice aleurone layer may be a useful food source to decrease obesity and its related diseases by modulating lipid metabolism in estrogen-deficiency model.

Chemical Constituents of Domestic Quercus spp. Barks (국내산 참나무속 수종 수피의 추출성분)

  • Kim, Jin-Kyu;Kwon, Dong-Joo;Lim, Soon-Sung;Bae, Young-Soo
    • Journal of the Korean Wood Science and Technology
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    • v.38 no.4
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    • pp.359-374
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    • 2010
  • This study was carried out to investigate the chemotaxonomical correlation and chemical constituents of domestic Quercus spp. barks. The barks of Q. mongolica, Q. aliena, Q. serrata, Q. acutissima, Q. dentata, and Q. variabilis were collected in the experimental forest of Kangwon National University. The combined extracts were successively fractionated with n-hexane, methylene chloride and ethyl acetate using a separation funnel. A portion of the ethyl acetate and H2O soluble materials of each species were chromatographed on a Sephadex LH-20 column using various aqueous MeOH and EtOH-hexane as washing solvents. Spectrometric analysis such as NMR and MS, including TLC, were performed to characterize the structures of the isolated compounds. Ellagic acid (0.03 g), (+)-catechin (4.59 g), taxifolin (3.35 g), and glucodistylin (20.52 g) were isolated from Q. mongolica bark. Gallic acid (0.18 g), (+)-catechin (8.52 g), (+)-gallocatechin (0.09 g), taxifolin (0.54 g), and glucodistylin (3.28 g) were characterized from Q. acutissima bark. Gallic acid (0.38 g), ellagic acid (0.11 g), (+)-catechin (2.01 g), (+)-gallocatechin (0.12 g), and glucodistylin (0.39 g) were identified from Q. dentata bark. Ellagic acid (1.51 g), (+)-catechin (21.91 g), and glucodistylin (3.91 g) were purified from Q. aliena bark. Ellagic acid (0.84 g), (+)-catechin (0.82 g), taxifolin (4.02 g), and glucodistylin (21.50) were isolated from Q. serrata bark. Gallic acid (0.24 g), caffeic acid (0.05 g), (+)-catechin (0.32 g), and glucodistylin (0.65 g) were purified from Q. variabilis bark. (+)-Catechin and glucodistylin were isolated from all the barks. Glucodistylin can be a taxonomic index on Quercus spp.

Environmental Characteristics of the Seawater and Surface Sediment in the vicinity of Pusan Harbor Area in Winter (겨울철 부산항 주변해역의 수질과 표층퇴적물 환경특성)

  • PARK Young-Chul;YANG Han-Soeb;LEE Pil-Yong;KIM Pyoung-Joong
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.28 no.5
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    • pp.577-588
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    • 1995
  • The chemical constituents for the seawater and sediment were measured to evaluate pollution in the sea around Pusan Harbor in winter, n992. The average value of trophic state index (TSI) was 19.4 at the outside of Buk Harbor, 50,4 at the inside of Buk Harbor, 56,3 at the Nam Harbor and 5,0 at the Kamchun Harbor. The high correlation found in salinity-nutrients diagram with AOU suggested that the enrichment of nutrients in Pusan Harbor during winter was mainly due to the influx of terrestrial effluents and partially by regenerated nutrients from suspended organic matters in the water column. The mean values of total ignition loss (TIL), COD and total sulfide in the surface sediments were$12.1\%$, 17.5 mg/g.dry wt. and 1.18 mg/g.dry wt. respectively. The highest level of those parameters was shown mostly at the inside of Buk Harbor. The mean concentration of total organic carbon (TOC), total organic nitrogen (TON), and total phosphorus were 24.9 mg/g.dry wt., 1.3mg/g.dry wt. and 0.69 mg/g. dry wt., respectively, Both of the highest level for TOC and total phosphorus have found at the Nam Harbor. On the other hand, the Highest level for TON was found at the inside of Buk Harbor. The TOC/TON atomic ratio with a range of 10.2-60.2 (mean value of 22.5) strongly indicated the active role of the input from the terrestrial organic pollutants.

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Validation of Age Estimation Methods Using Pulpal Volume Changes in Radiographs for Korean Adults

  • Lee, Tae-Hoon;Hong, Jung-Hun;Lee, Sang-Seob;Kwon, Jeong-Seung;Choi, Jong-Hoon
    • Journal of Oral Medicine and Pain
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    • v.39 no.2
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    • pp.69-77
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    • 2014
  • Purpose: It aims to verify the applicability of existing age estimation methods derived from data of foreign population groups to Korean population groups. Moreover it is to suggest a new way applicable to practical age estimation on the basis of newly calculated regression formulae from data of Korean population groups and develop a subsidiarily applicable method to the existing method. Methods: Ratio of pulp cavity to dental crown was calculated by measuring the height and width of dental crowns and pulp cavities at the cervical line from 4,034 first and second upper molars, first and second upper premolars, first and second lower molars and first and second lower premolars on both left and right sides of 400 patients who had been treated in Dental Hospital of Yonsei University College of Dentistry, and regression equations were derived from the values of the ratio. Results: The equation with correlation coefficients the highest among females was as follows: age=$107.96-75.684{\times}{\sharp}17$ TCHI-$53.741{\times}{\sharp}26$ TCVI-$40.664{\times}{\sharp}45$ TCVI-$56.307{\times}{\sharp}46$ TCVI. Randomized anohter Korean female subjects (n=20) are applicated to the new equation. Mean of error of estimate is 10.322 years, standard deviation is 12.852 years. Minimum of error of estimate is 1.018 years, maximum is 21.365 years Conclusions: The error range of age estimation was found to be slightly wider when the existing regression formulae of Drusini were applied to Korean population groups. Also age estimation in females using the ratio of pulp cavity to dental crown measured with the length and width of dental crowns and pulp cavities from maxillomandibular molars was observed to have the highest reliability in the research. However, we consider that advanced equations of regression are needed to apply to both molars and premolars of males and females in the future.

The Comparative Study on the Effect of HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom Pharmacopuncture for Cervical Pain Caused by Traffic Accidents: A Randomized Controlled Trial (교통사고 후 발생한 경항통 환자에 대한 황련해독탕약침과 분리정제봉약침의 치료 효과 비교연구: 무작위 배정)

  • Lee, Yu-Chen;Nam, Dae-Jin;Huh, Gun;Lee, Jae-Eun;Kim, Binnara;Song, Eun-Mo;Lee, Eun-Jung;Lee, Jung-Min;Oh, Min-Seok
    • Journal of Korean Medicine Rehabilitation
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    • v.24 no.4
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    • pp.145-153
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    • 2014
  • Objectives The purpose of this study is to compare the effects of HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom pharmacopuncture on cervical pain caused by traffic accident. Methods The clincal study was conducted to traffic accident patients who had admitted to Dae-Jeon University Cheonan Oriental Hospital from May 17, 2014 to September 2, 2014. The patients were simple randomization and divided into two groups. In one group, patients were treated with the oriental medicine and HWANGRYUNHAEDOKTANG Pharmacopuncture, While in the other group, patients were treated with the oriental medicine therapy and Essential Bee Venom pharmacopuncture therapy. visual analogue scale (VAS), pain threshold and neck disablity index (NDI) were used To estimate the efficacy of Pharmacopuncture treatment. Results 1) HWANGRYUNHAEDOKTANG Pharmacopuncture Group showed significant decrease of VAS and NDI after 3rd times treatment than before treatment (p<0.001). Essential Bee Venom Pharmacopuncture showed significant decrease of VAS, NDI and improve ment of pain threshold after 3rd times treatment than before treatment (p<0.01, p<0.001). 2) There was no significant difference between HWANGRYUNHAEDOKTANG Pharmacopuncture group and Essential Bee Venom Pharmacopuncture group in VAS, pain threshold and NDI. Conclusions We found out that HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom Pharmacopuncture treatment are considered to be effective and useful in cervical pain caused by traffic accident.

The Domestic Trend of Failed Back Surgery Syndrome: Definition, Treatment Trials and Instruments for Assessment (척추수술 실패 증후군에 대한 국내 연구 동향: 정의, 치료 방법, 평가 도구를 중심으로)

  • Choi, Hee-Seung;Cha, Yun-Yeop;Park, Won-Hyung;Shin, Woo-Suk;Jung, Dong-Hoon;Son, Seol-Ki;Kim, Jong-Su;Kim, Shin-Woong;Kim, Se-Jun
    • Journal of Korean Medicine Rehabilitation
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    • v.24 no.4
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    • pp.41-48
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    • 2014
  • Objectives The present study examines the domestic trend of Failed Back Surgery Syndrome (FBSS) in Korea. Methods The studies on FBSS were investigated via searching Korean web databases. As a result, 41 research papers were found and they were analyzed according to the year of publishment, the titles of journals which have the papers, the types of study, the definition of FBSS, employed treatment trials, and the instruments for assessment. Results The number of the research papers on FBSS published was increased since 2005. The studies on FBSS were mainly published in the Korean Journal of Pain. The most popular type of the studies were the case report and the most studies defined FBSS as persistent or recurring low back pain with or without sciatica after receiving spine surgeries. Various surgical and conservative treatments were employed in the studies and Visual Analogue Scale (VAS), Numeric Rating Scale (NRS), Oswestry Disability Index (ODI) were used as primary means of assessments. Conclusions Reviewing the domestic trends of studies on FBSS and examining the definition of FBSS is essential for the future studies because there is no clear criteria for making diagnosis of FBSS. Therefore, the further studies on FBSS need to be more elaborate with the definition of FBSS, and it is also necessary to apply more assessment tools for the better understanding of FBSS from various aspects. Ultimately, this review is anticipated to benefit the future in-depth study on FBSS.

Validity and Reliability of the Assessment Tool for Measuring Communication Skills of Dental Hygienist (치과위생사의 커뮤니케이션 기술 측정을 위한 평가 도구의 타당도와 신뢰도)

  • Moon, Hak-Jin;Lee, Soo-Young;Lim, Soon-Ryun
    • Journal of dental hygiene science
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    • v.14 no.2
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    • pp.198-206
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    • 2014
  • The purpose of this study was to develop and validate tool for measuring the communication skills of dental hygienist. The survey was modified and revised to fit into Korean culture. Also the reliability and validity was tested in order to ensure the survey was properly evaluating communication skills of dental hygienists. A survey was conducted with outpatients in dental clinics located in Seoul, Gyeonggi, and Daejeon area. The 483 answers out of the total collected answers were used for the final analysis of the study, using PASW Statistics 18.0 and IBM SPSS AMOS 7.0 to measure the validity and reliability. The factor analysis showed that the communication skill of the dental hygienists was composed of three elements, namely 'being caring and respectful' communications, 'sharing information' communications and 'tending to comfort' communications to reduce pain and anxiety. The validity of the model examined by a confirmatory factor analysis satisfied most of the relevant requirements. All of the factors had the conceptual reliability and variant extracted index above the minimum requirements, ensuring reliability and concentrated validity. Also, the value of the square of the correlations between all latent factors which was larger than the square of the correlation between all of the factors, thus proving the discriment validity. Cronbach's ${\alpha}$ was 0.8, which shows high reliability level. In conclusion, it was proven that dental hygienist's communication skill measurement tool has high validity and reliability. Further, this study can be used to improve dental hygienists' communication skills. Therefore, this will improve oral health of clients and manage them.

Association between Perceived Periodontal Status and Sexual Function in Adult Men (성인 남성의 주관적 치주건강상태와 성기능의 관련성)

  • Cheon, Sae Hee;Jeong, Seong Hwa
    • Journal of dental hygiene science
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    • v.14 no.2
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    • pp.132-139
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    • 2014
  • The aim of this study was to investigate the association between perceived periodontal status and sexual function among adult men. Three hundred thirty adult male participated in this study living at Changwon and Jinju. All the participants surveyed the socio-demographic characteristics, perceived periodontal status, stress, and international index of erectile function (IIEF) using self-administrated questionnaire. The univariate and multivariate analyze were adapted to access the crude and adjusted associations using PASW Statistics 18.0. In univariate analysis, there were significant differences between perceived periodontal status and IIEF and most of socio-demographic characteristics (p<0.05), but no significant differences between stress and all of socio-demographic characteristics (p>0.05). The sexual function was negatively correlated with perceived periodontal status (r=-0.228, p<0.001) and stress (r=-0.257, p<0.001), respectively. In multivariate analysis, perceived periodontal status was significantly associated with sexual function (b=-0.889, p=0.030) after adjusting for socio-demographic characteristics and stress. Therefore, it is found that perceived periodontal status negatively influenced on sexual function in adult men.