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Genome-wide association study of carcass weight in commercial Hanwoo cattle

  • Edea, Zewdu;Jeoung, Yeong Ho;Shin, Sung-Sub;Ku, Jaeul;Seo, Sungbo;Kim, Il-Hoi;Kim, Sang-Wook;Kim, Kwan-Suk
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.3
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    • pp.327-334
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    • 2018
  • Objective: The objective of the present study was to validate genes and genomic regions associated with carcass weight using a low-density single nucleotide polymorphism (SNP) Chip in Hanwoo cattle breed. Methods: Commercial Hanwoo steers (n = 220) were genotyped with 20K GeneSeek genomic profiler BeadChip. After applying the quality control of criteria of a call rate ${\geq}90%$ and minor allele frequency (MAF) ${\geq}0.01$, a total of 15,235 autosomal SNPs were left for genome-wide association (GWA) analysis. The GWA tests were performed using single-locus mixed linear model. Age at slaughter was fitted as fixed effect and sire included as a covariate. The level of genome-wide significance was set at $3.28{\times}10^{-6}$ (0.05/15,235), corresponding to Bonferroni correction for 15,235 multiple independent tests. Results: By employing EMMAX approach which is based on a mixed linear model and accounts for population stratification and relatedness, we identified 17 and 16 loci significantly (p<0.001) associated with carcass weight for the additive and dominant models, respectively. The second most significant (p = 0.000049) SNP (ARS-BFGL-NGS-28234) on bovine chromosome 4 (BTA4) at 21 Mb had an allele substitution effect of 43.45 kg. Some of the identified regions on BTA2, 6, 14, 22, and 24 were previously reported to be associated with quantitative trait loci for carcass weight in several beef cattle breeds. Conclusion: This is the first genome-wide association study using SNP chips on commercial Hanwoo steers, and some of the loci newly identified in this study may help to better DNA markers that determine increased beef production in commercial Hanwoo cattle. Further studies using a larger sample size will allow confirmation of the candidates identified in this study.

A Study on Improving the Position Accuracy of the Magnetic North used in Surveillance Imaging Equipments (통합형 구조의 감시정찰 영상장비에서 자북의 위치 정확도 개선에 관한 연구)

  • Shin, Young-Don;Lee, Jae-Chon
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.4
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    • pp.219-228
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    • 2013
  • The surveillance imaging equipments are functioning to observe the shape of the target in real time or to measure its location precisely. The roles of such equipments are becoming more important in today's weapon systems.The aforementioned imaging equipments can be classified based on the modes of operations such as fixed, installed on cars, or composite of those. Also, according to different concepts of sensor operation, a separate type uses independent housing for each sensor whereas in a composite type a set of multiple sensors are housed into a unit altogether. The sensors in general have magnetism, thereby introducing the possible negative effects, particularly in the composite types, in locating the reference position, which is carried out by the digital compass. The use of shielding material/housing could be an option but results in increased weight and reduced portability, restricting its use in composite type equipments. As such, the objective of this paper is to study on how to reduce such magnetic effects on the position location. To do so, in the absence of magnetic shielding, a variety of sensor positions were first modeled. By combing the result with the fact that the functions of PAN & Tilt are used in the equipments, a new position location algorithm is proposed. The use of the new algorithm can automate the position location process as compared to the manual process of the existing approach. In the algorithm developed, twelve locations are measured in connection with both the azimuth and elevation angles in comparison to the six locations alone around the azimuth angle. As a result, it turns out that the measurement range has been widened but the measurement time reduced. Also, note that the effect of errors the operators may make during measurement could be reduced.

Balance-Swap Optimization of Economic Load Dispatch Problem using Quadratic Fuel Cost Function (이차 발전비용함수를 사용한 경제급전문제의 균형-교환 최적화)

  • Lee, Sang-Un
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.14 no.4
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    • pp.243-250
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    • 2014
  • In this paper, I devise a balance-swap optimization (BSO) algorithm to solve economic load dispatch with a quadratic fuel cost function. This algorithm firstly sets initial values to $P_i{\leftarrow}P_i^{max}$, (${\Sigma}P_i^{max}$ > $P_d$) and subsequently entails two major processes: a balance process whereby a generator's power i of $_{max}\{F(P_i)-F(P_i-{\alpha})\}$, ${\alpha}=_{min}(P_i-P_i^{min})$ is balanced by $P_i{\leftarrow}P_i-{\alpha}$ until ${\Sigma}P_i=P_d$; and a swap process whereby $_{max}\{F(P_i)-F(P_i-{\beta})\}$ > $_{min}\{F(P_i+{{\beta})-F(P_j)\}$, $i{\neq}j$, ${\beta}$ = 1.0, 0.1, 0.1, 0.01, 0.001 is set at $P_i{\leftarrow}P_i-{\beta}$, $P_j{\leftarrow}P_j+{\beta}$. When applied to 15, 20, and 38-generators benchmark data, this simple algorithm has proven to consistently yield the best possible results. Moreover, this algorithm has dramatically reduced the costs for a centralized operation of 73-generators - a sum of the three benchmark cases - which could otherwise have been impossible for independent operations.

Changes in the Usage of Dental Technology CAD/CAM (치과기공 CAD/CAM 사용에 대한 실태변화)

  • Nah, Jung-Sook
    • Journal of Technologic Dentistry
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    • v.37 no.4
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    • pp.271-284
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    • 2015
  • Purpose: The purpose of this study was to examine the usage of CAD/CAM, which is one of dental technologist duties, in an effort to look for any possible changes in the usage of CAD/CAM. It's specifically meant to compare the results of this study with those of Lee Jong-do, Park Kwang-Sig(2011)'s study in March, 2011, to determine if there were any changes over the past four years. The selected variables that were investigated were the ownership of CAD/CAM, awareness of it, the route of acquiring the first information on it, the merits and demerits of its usage, usage experience and educational experience about it. Methods: An online survey was conducted on the dental technologists who worked in urban communities including metropolitan cities to find out the usage of CAD/CAM in 2015 from July 15 to 31, 2015, after existing questionnaire items were modified. The collected data were analyzed by IBM SPSS statistics 22.0, and statistical data on frequency, percentage, mean and standard deviation for each item were obtained. To figure out the characteristics of the subjects and the relationship between their occupational characteristics and the usage of CAD/CAM, crosstabs, independent-samples t-test and one-way ANOVA were utilized. As for the usage of CAD/CAM in 2011, the results of Lee Jong-do, Park Kwang-Sig(2011)'s study were selected, and then a comparative analysis was made. The level of significance was all set at .05. Total 250 questionnaires were distributed to them, and 190(76.0%) were returned. After excluding 23 whose answers were uncertain or seemed to lack reliability, total 167(66.8%) were used in final analysis. Results: As a result of analyzing the usage of CAD/CAM that was one of dental technologist duties, there was a great increase in the ownership of CAD/CAM in their workplaces from 2.4 percent in 2011 to 71.7 percent in 2015, and there was an improvement in awareness about it and the necessity of its usage as well. In 2011, the Internet and mass media were the most common route that they got to know about it. They had a strong tendency to acquire related knowledge through education in 2015, and there were some changes in the products that they used or preferred. In both years, the great merit of CAD/CAM was the simplified manufacturing process of restoration, and it had another great advantages in 2015 such as the improved quality of restoration or improved environments for dental technology. Concerning disadvantages, high price was a big problem in 2011. In 2015, not only price but the burden of material costs, frequent breakdown, poor demand among dental clinics and a lack of CAD/CAM professionals were pointed out a lot. In the future, this researcher intends to make research to seek ways of improving CAD/CAM professionals. Conclusion: There was more awareness of CAD/CAM in 2015 than in 2011 when the changes in awareness of it were analyzed, and the finding suggest the necessity of sustained education and concern.

An Empirical Study on the Determinants of Customer Renewal Behavior for Tire Rental Servitization (제조기업의 서비스화 제공 형태와 고객 특성이 재계약에 미치는 요인에 관한 실증 연구: 타이어 렌탈 중심으로)

  • Hyun, Myungjin;Kim, Jieun
    • The Journal of the Korea Contents Association
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    • v.20 no.4
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    • pp.508-517
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    • 2020
  • Servitization presents an innovative model to create business value in the automotive industries. This study set out to introduce a servitization model based on the rental business of the tire industry and identify determinants to affect the renewal of contracts around the service types of servitization and the characteristics of customers. Independent variables include the service types, demographics and regions, and inflow channels in 163,742 contracts by case companies in the nation in 2016~2019 with the renewal of contracts as a dependent variable. Correlations between variables were analyzed through cross-tabulation and binary logistic regression analysis. The findings show that the contract renewal rate had positive(+) relations with customized service and negative(-) ones with vehicle maintenance service. There were differences in the contract renewal rate according to such customer characteristics as gender and region, but no clear correlations were found in the age group and vehicle type(domestic/foreign). Of the inflow channels, offline channels tended to have a higher renewal rate than online channels. At open malls, contract renewal increased by 8.4 times due to contract switches at offline channels. Based on these findings, the study discussed directions for practical strategies with regard to the development of new service, implementation of customer-centric servitization, and management of sales channels according to the servitization of manufacturers.

Relationships between Depression, Oral Dryness, and Oral Health-Related Quality of Life among Elderly in Korea

  • Mun, So-Jung;Park, Su-Kyung;Heo, Ji-Eun;Jeung, Da-Yee;Chung, Won-Gyoun;Choi, Ma-I;Jeon, Hyun-Sun
    • Journal of dental hygiene science
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    • v.19 no.4
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    • pp.245-253
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    • 2019
  • Background: This study aimed to analyze correlations between depression, cognitive function, oral health state, ability to perform activities of daily living, oral dryness symptoms, and oral health-related quality of life, and determine factors influencing the latter. Methods: This was a cross-sectional study based on questionnaires completed by 260 participants with suspected dementia, residing in South Korea. Psychiatrists, psychiatric nurses, and dental hygienists visited clinics in the participating regions for examination and questionnaire administration. General characteristics, the geriatric depression scale, ability to perform activities of daily living, cognitive function, oral health state, and oral health-related quality of life were analyzed. Independent t-tests, one-way analysis of variance (ANOVA), correlation analysis and multiple regression analysis were conducted, identifying factors affecting oral health-related quality of life. Data analysis was performed using SPSS ver. 20.0 (IBM Corp., USA), and the significance was set at p<0.05. Results: Approximately 65.0% of participants were female, 63.5% were in their 70s, and 90.0% had health insurance. About 21.5%, 42.0%, and 36.5% were normal, slightly impaired, and had dementia, respectively. High cognitive impairment was associated with poor oral health. Sex, education levels, marital status, and living arrangements influenced oral health-related quality of life. According to the regression analysis, geriatric depression and oral dryness affected the Geriatric Oral Health Assessment Index scores. Conclusion: In conclusion, oral dryness and depression levels among elders influenced oral health-related quality of life. The results showed that to enhance elders' oral health-related quality of life, it is essential to not only improve their oral health state, but also relieve oral health problems, especially oral dryness, and take into consideration their psychological aspects.

The Interrelationship between Dealing Partners in Conventional Marketing Channel (관습적 마아케팅경로에 있어서 구성원의 상호관계에 관한 연구)

  • 김수관
    • The Journal of Fisheries Business Administration
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    • v.22 no.1
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    • pp.53-75
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    • 1991
  • The objectives of this study are to conceptualize theoretically and to examine empirically the interrelationships among channel member's satisfaction, dependence, and performance being immanent between dealing partners, by integrating behavioral and economic approach to explain comprehensively the interrelationship between dealing partners in conventional marketing channel which have not studied in previous studies. To attain above objectives, latent variables and observed variables which had been immanent between licenced dealers and wholesalers in fish marketing channel were found out by exploratory study, and pre-test was conducted to select the proper variables, and then the model which could explain the interrelationships among the variables was set up. Three categories of varables were considered in this study. Namely, economic and noneconomic factors were identified as independent variable, the degree of satisfaction and dependence to dealing partner as intervening variable, and performance as dependent variable. The data for the study was obtained from a survey questionnaire of 214 licenced dealers who work in Pusan, Yusoo, and Kunsan and 190 wholesalers who work in whole country. Among them, 264 anayzable questionnaires(including 154 licenced dealers and 110 wholesalers)were collected. Statistical procedure to analyze the data was carried out by LISREL version 7. Major findings obtained from the results of the analysis are as follows. First, economic variables have a great influence on the degree of both licenced dealers' and wholesalers' satisfaction. Among economic variables, the degree of keeping wholesalers' payment date have greater influence on the degree of licenced dealers' satisfaction, and licenced dealers' faculty being able to send good fish in quality have greater influence on the degree of wholesaler's satisfaction than other variables. In short, licenced dealers make great account of wholesalers' payment, and wholesalers make great account of licenced dealers' faculty being able to send good fish in quality in dealing relationship. Second, noneconomic variables have more relevance to the degree of dependence in both sides than economic variables. This means that noneconomic variables as well as economic variables can be a factor to keep up the dealing relationship. Third, the degree of satisfaction and dependence have influence on performance in both sides. In the licenced dealers' side, the degree of dependence have greater influence on performance than the degree of satisfaction, on the other hand, in wholesalers' side, the degree of satisfaction have greater influence on performance than the degree of dependence. This means that wholesalers can easily substitute their dealing partner for another licenced dealer comparatively.

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Optimization of LC-MS/MS for the Analysis of Sulfamethoxazole by using Response Surface Analysis (반응표면분석법을 이용한 설파메톡사졸의 액체크로마토그래프-텐덤형 질량분석 최적화)

  • Bae, Hyo-Kwan;Jung, Jin-Young
    • Journal of Korean Society of Environmental Engineers
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    • v.31 no.9
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    • pp.825-830
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    • 2009
  • Pharmaceutical compounds enter the water environment through the diverse pathways. Because their concentration in the water environment was frequently detected in the level of ppt to ppb, the monitoring system should be optimized as much as possible for finding appropriate management policies and technical solutions. One Factor At a Time (OFAT) approach approximating the response with a single variable has been preferred for the optimization of LC-MS/MS operational conditions. However, it is common that variables in analytical instruments are interdependent. Therefore, the best condition could be found by using the statistical optimization method changing multiple variables at a time. In this research, response surface analysis (RSA) was applied to the LC-MS/MS analysis of emerging antibiotic compound, sulfamethoxazole, for the best sensitivity. In the screening test, fragmentation energy and collision voltage were selected as independent variables. They were changed simultaneously for the statistical optimization and a polynomial equation was fit to the data set. The correlation coefficient, $R^2$ valuerepresented 0.9947 and the error between the predicted and observed value showed only 3.41% at the random condition, fragmentation energy of 60 and collision voltage of 17 eV. Therefore, it was concluded that the model derived by RSA successfully predict the response. The optimal conditions identified by the model were fragmentation energy of 116.6 and collision voltage of 10.9 eV. This RSA can be extensively utilized for optimizing conditions of solid-phase extraction and liquid chromatography.

A Study on Relationship between Point Load Strength Index and Abrasion Rate of Sediment Particle (퇴적물 입자의 점하중강도지수와 마식율의 관계에 대한 연구)

  • Kim, Jong-Yeon
    • Journal of the Korean Geographical Society
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    • v.43 no.6
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    • pp.808-823
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    • 2008
  • Sediment abrasion in rivers is caused by the interaction between bedrock channel bed and sediment particles transported through the river. Abrasion rate of sediment particles in rivers is controlled by two major factors; Sediment transport conditions including hydraulic conditions form the erosive forces and physical and chemical strengths of the particles form a resistance force against abrasion and other erosional processes. Physical experiments were performed to find the role of each variable on sediment abrasion process. Total 266 sediment particles were used in this experiment. All sediment particles were divided into 11 independent sediment groups with sediment particle size and sediment loads. Each sediment groups were abraded in tumbling mill for up to 8 hours. Changes in weight were recorded by run and total: 2,128 cases of abrasion rate were recoded. Physical strength of rock particles was measured with point load strength index. It is found that sediment abrasion rate has a negative functional relationship point load strength index ($I_{a(50)}$) ($R^2=0.22$). It was suggested that physical strength of sediment particles set the "maximum possible abrasion rate'. As sediment flux increases, abrasion rates of sediment particles with similar point load strength index were changed. It could be concluded that not only physical characteristics of sediment particles, but also sediment transport conditions control sediment abrasion rates.

Activation of Paraspinal, Abdominal, and Hip Muscles During Various Low Back Stabilization Exercises in Males and Females

  • Yoo, Won-Gyu;Lee, Hyun-Ju
    • Physical Therapy Korea
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    • v.11 no.4
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    • pp.19-29
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    • 2004
  • Many muscles of the trunk and hip are capable of contributing to the stabilization and protection of the lumbar spine. To have optimal effectiveness, a training program should include dynamic back/stomach/hip exercises. This study was designed to assess the L5 level paraspinal, external abdominal oblique, and gluteus maximus muscle activities during various low back stabilization exercises. Participants were 26 healthy adults (13 males, 13 Females), aged 21 to 28 years. The surface electromyography (EMG) was recorded from the L5 level paraspinal, external abdominal oblique, and gluteus maximus muscles. The recorded signal was averaged and normalized to the maximal electromyographic amplitude obtained during the maximal voluntary contraction. The measurements were taken during 3 low back stabilization exercises. One-way analysis of variance with repeated measures was used to examine the difference, and a post hoc test was performed with least significant difference. A level of significance was set at p<.05. The significance of difference between men and women, and between the electromyographic recording sites was evaluated by an independent t-test. The EMG activity for the externus oblique and gluteus maximus muscles had significant differences among 3 exercises (p<.05). In males, the EMG activity for the external abdominal oblique muscle had significantly increased differences during exercises 1 and exercise 2 (p<.05). The gluteus maximus muscle had significantly increased differences during exercise 2 and exercise 3 (p<.05). In females, the multifidus muscle had significantly increased difference during exercise 3 (p<.05), the external abdominal oblique muscle had significantly increased difference during exercise 1 (p<.05). and the gluteus maximus muscle had significantly decreased difference during exercise 3 (p<.05). The results were that the external abdominal oblique muscle was apparently activated during the curl-up exercise in females and males, and the multifidus muscle was apparently activated during the bridging exercise in females and during the sling exercise in males and females.1)In comparison of the %MVC between males and females, exercise 2 and exercise 3 apparently activated of the multifidus and gluteus maximus muscles in both males and females (p<.05). The EMG activity of the gluteus maximus muscle of the males significantly increased during exercise 2 and exercise 3 (p<.05). The EMG activity the multifidus muscle of the females was significantly increased during exercise 2 and exercise 3 (p<.05). More research is needed to understand the nature of motor control problems in the deep muscles in patients with low back pain.

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